IL87343A0 - 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indole derivatives,their preparation and their application in therapy - Google Patents

2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indole derivatives,their preparation and their application in therapy

Info

Publication number: IL87343A0
Authority: IL; Israel
Prior art keywords: group; denotes; application; formula; pyrido
Prior art date: 1987-08-07

Application number

IL87343A

Other languages

English (en)

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-07

Filing date

1988-08-04

Publication date

1989-01-31

1988-08-04 Application filed by Synthelabo filed Critical Synthelabo

1989-01-31 Publication of IL87343A0 publication Critical patent/IL87343A0/xx

Links

BSCWDKWCQFYZPW-UHFFFAOYSA-N 2-(piperidin-4-ylmethyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole Chemical class C1CC(C2=CC=CC=C2N2)=C2CN1CC1CCNCC1 BSCWDKWCQFYZPW-UHFFFAOYSA-N 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
101150111293 cor-1 gene Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL87343A 1987-08-07 1988-08-04 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indole derivatives,their preparation and their application in therapy IL87343A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8711291A FR2619111B1 (fr)	1987-08-07	1987-08-07	Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
IL87343A0 true IL87343A0 (en)	1989-01-31

Family

ID=9354027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87343A IL87343A0 (en)	1987-08-07	1988-08-04	2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indole derivatives,their preparation and their application in therapy

Country Status (17)

Country	Link
US (1)	US4977159A (da)
EP (1)	EP0302788B1 (da)
JP (1)	JPS6466185A (da)
KR (1)	KR890003756A (da)
AT (1)	ATE72436T1 (da)
AU (1)	AU597188B2 (da)
DE (1)	DE3868301D1 (da)
DK (1)	DK437788A (da)
FI (1)	FI883669A7 (da)
FR (1)	FR2619111B1 (da)
GR (1)	GR3003920T3 (da)
HU (1)	HU198931B (da)
IL (1)	IL87343A0 (da)
NO (1)	NO166129C (da)
NZ (1)	NZ225706A (da)
PT (1)	PT88206B (da)
ZA (1)	ZA885788B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4978669A (en) *	1989-06-08	1990-12-18	Neurex Corporation	Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
US5229517A (en) *	1990-09-27	1993-07-20	Hoechst-Roussel Pharmaceuticals Incorporated	2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5102889B1 (en) *	1990-09-27	1993-05-11		2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5455254A (en) *	1991-02-15	1995-10-03	Mondadori; Cesare	Substituted benzofuranylpiperidine as a nootropic agent
RU2095339C1 (ru) *	1991-10-17	1997-11-10	Циба-Гейги АГ	Производные гидрохинона в свободном виде или в виде соли, способы их получения, производные пиперидина и способы их получения
US5693807A (en) *	1992-10-14	1997-12-02	Ciba-Geigy Corporation	Substituted hydroquinone derivatives
FR2715659B1 (fr) *	1994-02-03	1996-03-22	Synthelabo	Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
CN1109880A (zh) *	1994-02-03	1995-10-11	合成实验室公司	3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
AU3831495A (en) *	1994-10-20	1996-05-15	American Home Products Corporation	Indole derivatives useful as serotonergic agents
US6255302B1 (en)	1998-12-17	2001-07-03	American Home Products Corporation	1,4-piperazine derivatives
CO5180550A1 (es)	1999-04-19	2002-07-30	Smithkline Beecham Corp	Inhibidores de fab i
CO5370679A1 (es) *	1999-06-01	2004-02-27	Smithkline Beecham Corp	Inhibidores fab 1
US6762201B1 (en)	1999-10-08	2004-07-13	Affinium Pharmaceuticals, Inc.	Fab I inhibitors
US6730684B1 (en)	1999-10-08	2004-05-04	Affinium Pharmaceuticals, Inc.	Fab I inhibitors
HU230030B1 (hu) *	1999-10-08	2015-05-28	Debiopharm International Sa	Fab I inhibitorok
DE60037345T2 (de)	1999-12-10	2008-11-13	Pfizer Products Inc., Groton	Pyrrolo(2,3-d)pyrimidin-Verbindungen
EP1560584B1 (en) *	2001-04-06	2009-01-14	Affinium Pharmaceuticals, Inc.	Fab i inhibitors
AU2002360561A1 (en) *	2001-12-11	2003-06-23	Sepracor, Inc.	4-substituted piperidines, and methods of use thereof
AU2003278529A1 (en) *	2002-11-21	2004-06-15	Pfizer Products Inc.	3-amino-piperidine derivatives and processes for their preparation
EP1575951B1 (en)	2002-12-06	2014-06-25	Debiopharm International SA	Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en)	2003-03-17	2004-09-30	Affinium Pharmaceuticals, Inc.	Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
JP2006525347A (ja) *	2003-04-29	2006-11-09	オシエントファーマシューティカルズ	抗生テトラヒドロ−β−カルボリン誘導体
DK1828167T3 (da)	2004-06-04	2014-10-20	Debiopharm Int Sa	Acrylamidderivater som antibiotiske midler
JP5468899B2 (ja)	2006-07-20	2014-04-09	アフィニウムファーマシューティカルズ，インク．	Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
EP2125802A4 (en)	2007-02-16	2014-08-20	Debiopharm Int Sa	SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
AU2013279021C1 (en)	2012-06-19	2017-03-16	Debiopharm International Sa	Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
RS61312B1 (sr)	2016-02-26	2021-02-26	Debiopharm Int Sa	Lek za lečenje infekcija dijabetskog stopala
TN2021000159A1 (en)	2019-02-14	2023-04-04	Debiopharm Int Sa	Afabicin formulation, method for making the same and uses thereof
SG11202113174SA (en)	2019-06-14	2021-12-30	Debiopharm Int Sa	Medicament and use thereof for treating bacterial infections involving biofilm

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4539407A (en) *	1983-12-13	1985-09-03	American Home Products Corporation	β-Carboline anticonvulsants
US4663456A (en) *	1985-09-16	1987-05-05	American Home Products Corporation	2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders

1987
- 1987-08-07 FR FR8711291A patent/FR2619111B1/fr not_active Expired - Fee Related
1988
- 1988-08-03 DE DE8888402024T patent/DE3868301D1/de not_active Expired - Fee Related
- 1988-08-03 EP EP88402024A patent/EP0302788B1/fr not_active Expired - Lifetime
- 1988-08-03 AT AT88402024T patent/ATE72436T1/de not_active IP Right Cessation
- 1988-08-04 IL IL87343A patent/IL87343A0/xx unknown
- 1988-08-05 DK DK437788A patent/DK437788A/da not_active Application Discontinuation
- 1988-08-05 NO NO883487A patent/NO166129C/no unknown
- 1988-08-05 KR KR1019880010017A patent/KR890003756A/ko not_active Withdrawn
- 1988-08-05 US US07/228,751 patent/US4977159A/en not_active Expired - Fee Related
- 1988-08-05 ZA ZA885788A patent/ZA885788B/xx unknown
- 1988-08-05 FI FI883669A patent/FI883669A7/fi not_active Application Discontinuation
- 1988-08-05 HU HU884105A patent/HU198931B/hu not_active IP Right Cessation
- 1988-08-05 JP JP63197011A patent/JPS6466185A/ja active Pending
- 1988-08-05 NZ NZ225706A patent/NZ225706A/en unknown
- 1988-08-05 AU AU20445/88A patent/AU597188B2/en not_active Ceased
- 1988-08-05 PT PT88206A patent/PT88206B/pt not_active IP Right Cessation
1992
- 1992-02-27 GR GR920400343T patent/GR3003920T3/el unknown

Also Published As

Publication number	Publication date
FI883669A0 (fi)	1988-08-05
DK437788A (da)	1989-02-07
NO166129C (no)	1991-06-05
ATE72436T1 (de)	1992-02-15
HUT48242A (en)	1989-05-29
DK437788D0 (da)	1988-08-05
NZ225706A (en)	1990-04-26
FR2619111A1 (fr)	1989-02-10
FR2619111B1 (fr)	1991-01-11
NO883487L (no)	1989-02-08
EP0302788A1 (fr)	1989-02-08
JPS6466185A (en)	1989-03-13
HU198931B (en)	1989-12-28
AU597188B2 (en)	1990-05-24
NO883487D0 (no)	1988-08-05
ZA885788B (en)	1989-04-26
US4977159A (en)	1990-12-11
DE3868301D1 (de)	1992-03-19
PT88206B (pt)	1995-05-04
PT88206A (pt)	1989-06-30
EP0302788B1 (fr)	1992-02-05
GR3003920T3 (da)	1993-03-16
NO166129B (no)	1991-02-25
KR890003756A (ko)	1989-04-17
AU2044588A (en)	1989-02-09
FI883669A7 (fi)	1989-02-08

Publication	Publication Date	Title
ZA885788B (en)	1989-04-26	2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indole derivatives,their preparation and their application in therapy
GR3015616T3 (en)	1995-06-30	Aryl-heteroaryl-carbinol derivatives having an analgesic activity.
SG45280A1 (en)	1998-01-16	Methods for inhibiting smooth muslce cell proliferation and restinosis
EP1288199A4 (en)	2005-10-12	INHIBITORS OF MMP-12
IE892189L (en)	1990-01-07	Derivatives of (aza) naphthalenesultam, their preparation¹and compositions containing them
DK0507672T3 (da)	1997-12-15	N-cyclohexylbenzamid-derivater samt deres fremstilling og terapeutiske anvendelse
AU534786B2 (en)	1984-02-16	4-phenoxypiperidines
LV10868A (lv)	1995-10-20	Oksadiazolilalkilpurina atvasinajumi
AU2734892A (en)	1993-04-29	Quinoline derivatives, process for their preparation, and their therapeutic applications
SG19795G (en)	1995-08-18	Piperidyl-substituted indoles
GB9300195D0 (en)	1993-03-03	Piperazine derivatives
DE3376749T2 (da)	1988-06-30
PT87300A (pt)	1988-05-01	Benzo-und thieno-3,4-dihydro-pyridinderivate verfahren zu ihrer herstellung und diese verbindungen enthalte arzneimittel
ES2128572T3 (es)	1999-05-16	Utilizacion de los derivados de cefem como agentes antimetastaticos.
NZ335975A (en)	2000-11-24	Heterocyclic substituted pyrrolidine amide derivatives useful in treating respiratory diseases
NO982549L (no)	1998-08-06	5-naftalen-1-yl-1,3-dioksan-derivater, fremstilling og terapeutisk anvendelse derav
ES2055155T3 (es)	1994-08-16	Procedimiento para la obtencion de aciloxiacetidinonas opticamente activas.