IL88122A0 - Heterocyclic derivatives and pharmaceutical compositions containing them - Google Patents
Heterocyclic derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL88122A0 IL88122A0 IL88122A IL8812288A IL88122A0 IL 88122 A0 IL88122 A0 IL 88122A0 IL 88122 A IL88122 A IL 88122A IL 8812288 A IL8812288 A IL 8812288A IL 88122 A0 IL88122 A0 IL 88122A0
- Authority
- IL
- Israel
- Prior art keywords
- aryl
- alkyl
- group
- benzyl
- independently selected
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- -1 xanthenyl dibenzofuranyl Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- ASNHGEVAWNWCRQ-UHFFFAOYSA-N 4-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OCC1(O)COC(O)C1O ASNHGEVAWNWCRQ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005239 aroylamino group Chemical group 0.000 abstract 1
- 125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL88122A0 true IL88122A0 (en) | 1989-06-30 |
Family
ID=10625806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL88122A IL88122A0 (en) | 1987-10-23 | 1988-10-21 | Heterocyclic derivatives and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0313397B1 (de) |
| JP (1) | JP2501631B2 (de) |
| CN (1) | CN1035113A (de) |
| AT (1) | ATE90089T1 (de) |
| AU (1) | AU604165B2 (de) |
| DD (1) | DD283140A5 (de) |
| DE (1) | DE3881472T2 (de) |
| DK (1) | DK586588A (de) |
| ES (1) | ES2054825T3 (de) |
| FI (1) | FI884879A7 (de) |
| GB (1) | GB8724912D0 (de) |
| HU (1) | HU202230B (de) |
| IL (1) | IL88122A0 (de) |
| MC (1) | MC1983A1 (de) |
| NZ (1) | NZ226671A (de) |
| PL (1) | PL158305B1 (de) |
| PT (1) | PT88829B (de) |
| ZA (1) | ZA887900B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| KR100215627B1 (ko) * | 1990-06-07 | 1999-08-16 | 레슬리 제인 에드워즈 | 치료용 헤테로사이클 화합물 |
| EP0494774A1 (de) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazol-substituierte 5-Kettenglieder heteroaromatische Verbindungen |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| TW263508B (de) * | 1991-02-12 | 1995-11-21 | Pfizer | |
| GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| DE69230803T2 (de) * | 1991-11-25 | 2000-12-07 | Pfizer Inc., New York | 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten |
| EP0545478A1 (de) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclische Verbindungen als Tachykininantagoniste |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (de) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| DE69330713T2 (de) * | 1992-03-13 | 2002-07-04 | Merck Sharp & Dohme Ltd., Hoddesdon | Imidazol-, triazol- und tetrazolderivate |
| GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| PL172405B1 (en) * | 1992-04-07 | 1997-09-30 | Pfizer | Derivatives of indole |
| US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
| UA34452C2 (uk) * | 1992-04-10 | 2001-03-15 | Пфайзер Інк. | Похідні ациламіноіндолу, що проявляють серотонінову 5-нт1 агоністичну активність та похідні аміноіндолу як проміжні сполуки |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| ES2116411T3 (es) * | 1992-06-05 | 1998-07-16 | Merck Sharp & Dohme | La sal sulfato de un triazol sustituido, composiciones farmaceuticas de la misma y su uso en terapia |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
| CA2138649A1 (en) * | 1992-07-24 | 1994-02-03 | Raymond Baker | Imidazole, triazole and tetrazole derivatives |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| TW251284B (de) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
| GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
| JP3262800B2 (ja) * | 1994-06-01 | 2002-03-04 | ゼネカ・リミテッド | 療用複素環化合物 |
| CA2194984C (en) * | 1994-07-26 | 2002-07-02 | John Eugene Macor | 4-indole derivatives as serotonin agonists and antagonists |
| WO1996017842A1 (en) * | 1994-12-06 | 1996-06-13 | Merck Sharp & Dohme Limited | Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists |
| GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
| GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| WO2000000490A2 (en) * | 1998-06-26 | 2000-01-06 | Eli Lilly And Company | 5-ht1f agonists |
| RU2320663C2 (ru) | 2002-06-21 | 2008-03-27 | Сувен Лайф Сайенсиз Лимитед | Новые арилалкилиндолы с аффинностью к серотониновым рецепторам, пригодные в качестве лекарственных средств, способ их получения и содержащие их фармацевтические композиции |
| AU2003249582B2 (en) | 2002-06-21 | 2006-08-03 | Suven Life Sciences Limited | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity |
| PT1567492E (pt) | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| US7875605B2 (en) | 2002-11-28 | 2011-01-25 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| SI1581538T1 (sl) | 2002-12-18 | 2007-08-31 | Suven Life Sciences Ltd | Tetraciklični 3-substituirani indoli z afiniteto za receptor serotonina |
| DE102005018191A1 (de) * | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| CA3010568C (en) | 2016-01-27 | 2023-10-17 | Instar Technologies A.S. | Oromucosal nanofiber carriers for therapeutic treatment |
| CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833153A (en) | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 EP EP88309943A patent/EP0313397B1/de not_active Expired - Lifetime
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 MC MC882012A patent/MC1983A1/fr unknown
- 1988-10-21 FI FI884879A patent/FI884879A7/fi not_active Application Discontinuation
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK586588D0 (da) | 1988-10-21 |
| DE3881472T2 (de) | 1993-12-16 |
| AU604165B2 (en) | 1990-12-06 |
| DD283140A5 (de) | 1990-10-03 |
| EP0313397A1 (de) | 1989-04-26 |
| GB8724912D0 (en) | 1987-11-25 |
| ES2054825T3 (es) | 1994-08-16 |
| PL158305B1 (en) | 1992-08-31 |
| AU2418188A (en) | 1989-04-27 |
| PL275423A1 (en) | 1989-08-07 |
| ATE90089T1 (de) | 1993-06-15 |
| JP2501631B2 (ja) | 1996-05-29 |
| CN1035113A (zh) | 1989-08-30 |
| ZA887900B (en) | 1990-06-27 |
| DE3881472D1 (de) | 1993-07-08 |
| FI884879A0 (fi) | 1988-10-21 |
| PT88829B (pt) | 1993-01-29 |
| HUT50163A (en) | 1989-12-28 |
| NZ226671A (en) | 1991-09-25 |
| HU202230B (en) | 1991-02-28 |
| MC1983A1 (fr) | 1989-11-23 |
| EP0313397B1 (de) | 1993-06-02 |
| FI884879A7 (fi) | 1989-04-24 |
| DK586588A (da) | 1989-04-24 |
| JPH01146882A (ja) | 1989-06-08 |
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