MC1983A1 - Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes - Google Patents

Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes

Info

Publication number
MC1983A1
MC1983A1 MC882012A MC2012A MC1983A1 MC 1983 A1 MC1983 A1 MC 1983A1 MC 882012 A MC882012 A MC 882012A MC 2012 A MC2012 A MC 2012A MC 1983 A1 MC1983 A1 MC 1983A1
Authority
MC
Monaco
Prior art keywords
formula
radical
compound
given
aryl
Prior art date
Application number
MC882012A
Other languages
English (en)
French (fr)
Inventor
Duncan Robertson Alan
Richard Martin Graeme
Susan Buckingham Janet
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC1983A1 publication Critical patent/MC1983A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
MC882012A 1987-10-23 1988-10-21 Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes MC1983A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878724912A GB8724912D0 (en) 1987-10-23 1987-10-23 Indole derivatives

Publications (1)

Publication Number Publication Date
MC1983A1 true MC1983A1 (fr) 1989-11-23

Family

ID=10625806

Family Applications (1)

Application Number Title Priority Date Filing Date
MC882012A MC1983A1 (fr) 1987-10-23 1988-10-21 Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes

Country Status (18)

Country Link
EP (1) EP0313397B1 (de)
JP (1) JP2501631B2 (de)
CN (1) CN1035113A (de)
AT (1) ATE90089T1 (de)
AU (1) AU604165B2 (de)
DD (1) DD283140A5 (de)
DE (1) DE3881472T2 (de)
DK (1) DK586588A (de)
ES (1) ES2054825T3 (de)
FI (1) FI884879A7 (de)
GB (1) GB8724912D0 (de)
HU (1) HU202230B (de)
IL (1) IL88122A0 (de)
MC (1) MC1983A1 (de)
NZ (1) NZ226671A (de)
PL (1) PL158305B1 (de)
PT (1) PT88829B (de)
ZA (1) ZA887900B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
EP0494774A1 (de) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazol-substituierte 5-Kettenglieder heteroaromatische Verbindungen
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (de) * 1991-02-12 1995-11-21 Pfizer
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
BR9206810A (pt) * 1991-11-25 1995-10-31 Pfizer Derivados de indol
EP0545478A1 (de) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclische Verbindungen als Tachykininantagoniste
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives
TW288010B (de) * 1992-03-05 1996-10-11 Pfizer
DE69330713T2 (de) * 1992-03-13 2002-07-04 Merck Sharp & Dohme Ltd., Hoddesdon Imidazol-, triazol- und tetrazolderivate
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
SK280193B6 (sk) 1992-04-07 1999-09-10 Pfizer Inc. Indolové deriváty predstavujúce 5-ht1 agonisty, fa
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
US5498626A (en) * 1992-04-10 1996-03-12 Pfizer Inc. Acylaminoindole derivatives as 5-ht1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
RO114326B1 (ro) * 1992-06-05 1999-03-30 Merck Sharp & Dohme Limited Ho Sarea sulfat a unui triazol substituit, procedeu de obtinere a acesteia, compozitie farmaceutica si procedeu de obtinere a acesteia
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process
EP0651749A1 (de) * 1992-07-24 1995-05-10 MERCK SHARP & DOHME LTD. Imidazol-, triazol- und tetrazolderivate
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
TW251284B (de) * 1992-11-02 1995-07-11 Pfizer
GB9226537D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
LT3594B (en) 1993-07-29 1995-12-27 Merck Sharp & Dohme Imidazole,triazole and tetrazole derivatives
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
US6423731B2 (en) 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
GB9407447D0 (en) * 1994-04-14 1994-06-08 Glaxo Group Ltd Chemical compounds
WO1995032966A1 (en) * 1994-06-01 1995-12-07 Zeneca Limited Indole derivatives as prodrugs of 5-ht1-like receptor agonists
EP0773942A1 (de) * 1994-07-26 1997-05-21 Pfizer Inc. 4-indolderivate als serotonin agonisten und antagonisten
WO1996017842A1 (en) * 1994-12-06 1996-06-13 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
GB9516143D0 (en) 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
US5998438A (en) * 1996-11-26 1999-12-07 Allelix Biopharmaceuticals, Inc. 5-cyclo indole compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
AU2003249584B9 (en) 2002-06-21 2008-05-15 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
BRPI0315959C1 (pt) 2002-11-28 2021-05-25 Suven Life Sciences Ltd composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto
DK1581538T3 (da) 2002-12-18 2007-06-25 Suven Life Sciences Ltd Tetracykliske 3-substituerede indoler med serotoninreceptoraffinitet
DE102005018191A1 (de) 2005-04-19 2006-10-26 Grünenthal GmbH Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
US12194158B2 (en) 2016-01-27 2025-01-14 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
CN112759550A (zh) * 2019-11-04 2021-05-07 上海科技大学 一种平滑受体拮抗剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225726B1 (de) 1985-11-08 1991-04-17 Glaxo Group Limited Indolderivate
GB8600397D0 (en) 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
PT88829B (pt) 1993-01-29
FI884879A0 (fi) 1988-10-21
NZ226671A (en) 1991-09-25
DD283140A5 (de) 1990-10-03
DK586588D0 (da) 1988-10-21
EP0313397A1 (de) 1989-04-26
ATE90089T1 (de) 1993-06-15
AU2418188A (en) 1989-04-27
DK586588A (da) 1989-04-24
HU202230B (en) 1991-02-28
PL275423A1 (en) 1989-08-07
AU604165B2 (en) 1990-12-06
DE3881472T2 (de) 1993-12-16
JPH01146882A (ja) 1989-06-08
ZA887900B (en) 1990-06-27
FI884879A7 (fi) 1989-04-24
JP2501631B2 (ja) 1996-05-29
HUT50163A (en) 1989-12-28
DE3881472D1 (de) 1993-07-08
CN1035113A (zh) 1989-08-30
IL88122A0 (en) 1989-06-30
GB8724912D0 (en) 1987-11-25
PL158305B1 (en) 1992-08-31
ES2054825T3 (es) 1994-08-16
EP0313397B1 (de) 1993-06-02

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