IL88766A - Microorganisms with irreversible mutations and medicinal preparations containing them - Google Patents

Microorganisms with irreversible mutations and medicinal preparations containing them

Info

Publication number: IL88766A
Authority: IL; Israel
Prior art keywords: aro; gene; bacterium; attenuated; reverting
Prior art date: 1987-12-23

Application number

IL8876688A

Other languages

English (en)

Hebrew (he)

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-23

Filing date

1988-12-22

Publication date

1995-07-31

1988-12-22 Application filed by Wellcome Found filed Critical Wellcome Found

1995-07-31 Publication of IL88766A publication Critical patent/IL88766A/en

Links

230000002238 attenuated effect Effects 0.000 title claims abstract description 38
244000005700 microbiome Species 0.000 title claims abstract description 12
230000035772 mutation Effects 0.000 title claims description 41
239000008194 pharmaceutical composition Substances 0.000 title description 4
108090000623 proteins and genes Proteins 0.000 claims abstract description 65
229960005486 vaccine Drugs 0.000 claims abstract description 22
239000000427 antigen Substances 0.000 claims abstract description 13
102000036639 antigens Human genes 0.000 claims abstract description 13
108091007433 antigens Proteins 0.000 claims abstract description 13
125000003118 aryl group Chemical group 0.000 claims abstract description 11
244000052769 pathogen Species 0.000 claims abstract description 5
241000894006 Bacteria Species 0.000 claims description 43
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims description 37
238000000034 method Methods 0.000 claims description 17
239000013612 plasmid Substances 0.000 claims description 17
241000607142 Salmonella Species 0.000 claims description 6
230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 5
210000000349 chromosome Anatomy 0.000 claims description 5
239000003550 marker Substances 0.000 claims description 5
108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
238000002703 mutagenesis Methods 0.000 claims description 4
231100000350 mutagenesis Toxicity 0.000 claims description 4
239000013598 vector Substances 0.000 claims description 4
238000010367 cloning Methods 0.000 claims description 3
241000588807 Bordetella Species 0.000 claims description 2
241000606790 Haemophilus Species 0.000 claims description 2
241001467018 Typhis Species 0.000 claims description 2
230000001717 pathogenic effect Effects 0.000 claims 1
229940031348 multivalent vaccine Drugs 0.000 abstract description 2
230000037361 pathway Effects 0.000 abstract description 2
239000004098 Tetracycline Substances 0.000 description 19
229960002180 tetracycline Drugs 0.000 description 19
229930101283 tetracycline Natural products 0.000 description 19
235000019364 tetracycline Nutrition 0.000 description 19
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150000001491 aromatic compounds Chemical class 0.000 description 14
230000001419 dependent effect Effects 0.000 description 14
239000002609 medium Substances 0.000 description 13
150000003522 tetracyclines Chemical class 0.000 description 13
238000010276 construction Methods 0.000 description 10
238000012217 deletion Methods 0.000 description 10
230000037430 deletion Effects 0.000 description 10
239000006166 lysate Substances 0.000 description 10
238000011725 BALB/c mouse Methods 0.000 description 8
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 7
230000000295 complement effect Effects 0.000 description 6
LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 6
OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 6
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 5
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KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
101150111062 C gene Proteins 0.000 description 4
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238000001990 intravenous administration Methods 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000002953 phosphate buffered saline Substances 0.000 description 4
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MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
208000037386 Typhoid Diseases 0.000 description 3
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QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
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238000002360 preparation method Methods 0.000 description 3
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239000011677 pyridoxine Substances 0.000 description 3
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LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 2
108010020183 3-phosphoshikimate 1-carboxyvinyltransferase Proteins 0.000 description 2
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
229910002016 Aerosil® 200 Inorganic materials 0.000 description 2
241001167018 Aroa Species 0.000 description 2
108020004414 DNA Proteins 0.000 description 2
101100491986 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) aromA gene Proteins 0.000 description 2
241000282412 Homo Species 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
241001529936 Murinae Species 0.000 description 2
241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229940024606 amino acid Drugs 0.000 description 2
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235000019359 magnesium stearate Nutrition 0.000 description 2
239000000463 material Substances 0.000 description 2
238000010172 mouse model Methods 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
238000012216 screening Methods 0.000 description 2
241000894007 species Species 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
201000008827 tuberculosis Diseases 0.000 description 2
WTFXTQVDAKGDEY-UHFFFAOYSA-N (-)-chorismic acid Natural products OC1C=CC(C(O)=O)=CC1OC(=C)C(O)=O WTFXTQVDAKGDEY-UHFFFAOYSA-N 0.000 description 1
HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
101100163490 Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) aroA1 gene Proteins 0.000 description 1
229920001453 Arcel Polymers 0.000 description 1
229920003084 Avicel® PH-102 Polymers 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
241000588832 Bordetella pertussis Species 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
238000009631 Broth culture Methods 0.000 description 1
241000242722 Cestoda Species 0.000 description 1
241000606161 Chlamydia Species 0.000 description 1
108010003662 Chorismate synthase Proteins 0.000 description 1
108091026890 Coding region Proteins 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
101710146739 Enterotoxin Proteins 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
206010016952 Food poisoning Diseases 0.000 description 1
208000019331 Foodborne disease Diseases 0.000 description 1
241000710198 Foot-and-mouth disease virus Species 0.000 description 1
206010018612 Gonorrhoea Diseases 0.000 description 1
241000606768 Haemophilus influenzae Species 0.000 description 1
229920003085 Kollidon® CL Polymers 0.000 description 1
241000589902 Leptospira Species 0.000 description 1
201000009906 Meningitis Diseases 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000204031 Mycoplasma Species 0.000 description 1
241000588653 Neisseria Species 0.000 description 1
241000588652 Neisseria gonorrhoeae Species 0.000 description 1
241000244206 Nematoda Species 0.000 description 1
201000005702 Pertussis Diseases 0.000 description 1
235000014676 Phragmites communis Nutrition 0.000 description 1
206010035148 Plague Diseases 0.000 description 1
241000711798 Rabies lyssavirus Species 0.000 description 1
241000702670 Rotavirus Species 0.000 description 1
241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
241000701835 Salmonella virus P22 Species 0.000 description 1
241000607760 Shigella sonnei Species 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
241000282887 Suidae Species 0.000 description 1
101710182223 Toxin B Proteins 0.000 description 1
241000242541 Trematoda Species 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
239000008272 agar Substances 0.000 description 1
229960004050 aminobenzoic acid Drugs 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
101150102858 aroD gene Proteins 0.000 description 1
101150108612 aroQ gene Proteins 0.000 description 1
235000015241 bacon Nutrition 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
201000006824 bubonic plague Diseases 0.000 description 1
239000000872 buffer Substances 0.000 description 1
244000309466 calf Species 0.000 description 1
108010079058 casein hydrolysate Proteins 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
WTFXTQVDAKGDEY-HTQZYQBOSA-N chorismic acid Chemical compound O[C@@H]1C=CC(C(O)=O)=C[C@H]1OC(=C)C(O)=O WTFXTQVDAKGDEY-HTQZYQBOSA-N 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
229940071221 dihydroxybenzoate Drugs 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000000147 enterotoxin Substances 0.000 description 1
231100000655 enterotoxin Toxicity 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
210000003495 flagella Anatomy 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
238000003304 gavage Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
229940047650 haemophilus influenzae Drugs 0.000 description 1
244000052637 human pathogen Species 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
230000028993 immune response Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
230000003902 lesion Effects 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
235000013923 monosodium glutamate Nutrition 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
239000007935 oral tablet Substances 0.000 description 1
229940096978 oral tablet Drugs 0.000 description 1
229940126578 oral vaccine Drugs 0.000 description 1
230000003071 parasitic effect Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000008506 pathogenesis Effects 0.000 description 1
230000002688 persistence Effects 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
238000007747 plating Methods 0.000 description 1
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
238000005215 recombination Methods 0.000 description 1
230000006798 recombination Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229940115939 shigella sonnei Drugs 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229940073490 sodium glutamate Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
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238000011144 upstream manufacturing Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
230000035899 viability Effects 0.000 description 1
108700026220 vif Genes Proteins 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
230000001018 virulence Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Engineering & Computer Science (AREA)
Mycology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL8876688A 1987-12-23 1988-12-22 Microorganisms with irreversible mutations and medicinal preparations containing them IL88766A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878730037A GB8730037D0 (en)	1987-12-23	1987-12-23	Vaccines

Publications (1)

Publication Number	Publication Date
IL88766A true IL88766A (en)	1995-07-31

Family

ID=10628973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8876688A IL88766A (en)	1987-12-23	1988-12-22	Microorganisms with irreversible mutations and medicinal preparations containing them

Country Status (21)

Country	Link
EP (1)	EP0322237B1 (es)
JP (1)	JP2602970B2 (es)
KR (1)	KR970010759B1 (es)
AT (1)	ATE103331T1 (es)
AU (1)	AU619519B2 (es)
BR (1)	BR8807376A (es)
CA (1)	CA1327331C (es)
DE (1)	DE3888652T2 (es)
DK (1)	DK174952B1 (es)
ES (1)	ES2061700T3 (es)
GB (1)	GB8730037D0 (es)
HK (1)	HK1000469A1 (es)
HU (2)	HU216449B (es)
IE (1)	IE65176B1 (es)
IL (1)	IL88766A (es)
MY (1)	MY104367A (es)
NZ (1)	NZ227472A (es)
PH (1)	PH31428A (es)
RU (1)	RU2114172C1 (es)
WO (1)	WO1989005856A1 (es)
ZA (1)	ZA889605B (es)

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IE61635B1 (en) *	1990-03-13	1994-11-16	Trinity College Dublin	Improvements in vaccines
GB9007194D0 (en) *	1990-03-30	1990-05-30	Wellcome Found	Live vaccines
ATE180280T1 (de) *	1991-03-05	1999-06-15	Wellcome Found	Expression rekombinanter proteine in attenuierten bakterien
TW201794B (es) *	1991-05-03	1993-03-11	American Cyanamid Co
JPH08506963A (ja) *	1993-02-22	1996-07-30	ザジェネラルホスピタルコーポレーション	生ワクチン菌株における異種抗原
US6036953A (en) *	1996-11-29	2000-03-14	The General Hospital Corporation	Heterologous antigens in live cell V. cholerae strains
GB9711964D0 (en) *	1997-06-09	1997-08-06	Medical Res Council	Live attenuated vaccines
WO1999013053A1 (en)	1997-09-10	1999-03-18	Vion Pharmaceuticals, Inc.	Genetically modified tumor-targeted bacteria with reduced virulence
US6080849A (en)	1997-09-10	2000-06-27	Vion Pharmaceuticals, Inc.	Genetically modified tumor-targeted bacteria with reduced virulence
EP0913480A3 (en) *	1997-11-03	2001-07-11	Smithkline Beecham Corporation	Chorismate synthase
US6905691B1 (en)	1997-12-11	2005-06-14	Celltech Pharma Europe Limited	Vaccines containing attenuated bacteria
GB9806449D0 (en)	1998-03-25	1998-05-27	Peptide Therapeutics Ltd	Attenuated bacteria useful in vaccines
US6962696B1 (en)	1999-10-04	2005-11-08	Vion Pharmaceuticals Inc.	Compositions and methods for tumor-targeted delivery of effector molecules
GB0121998D0 (en)	2001-09-11	2001-10-31	Acambis Res Ltd	Attenuated bacteria useful in vaccines
RU2255763C2 (ru) *	2003-06-04	2005-07-10	ФГУП Государственный Научный Центр прикладной микробиологии	Вакцина против сальмонеллеза свиней
JP4623625B2 (ja)	2003-07-24	2011-02-02	株式会社AMBiS	ヘテロ型５量体組換えワクチン
FR2898276B1 (fr) *	2006-03-08	2008-07-25	Univ Claude Bernard Lyon	Nouveaux vaccins destines au traitement ou a la prevention des infections par parasites de la famille des taenidae et en particulier du genre echinococcus
BR112013015009B1 (pt) *	2010-12-22	2020-11-10	Intervet International B.V	vacina para proteger um animal contra uma doença clínica decorrente de uma infecção com bordetella bronchiseptica
WO2012123269A1 (en)	2011-03-11	2012-09-20	Proyecto De Biomedicina Cima, S.L.	Immunogenic compositions and methods for their use
US10676723B2 (en)	2015-05-11	2020-06-09	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

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US4337314A (en) *	1979-05-23	1982-06-29	Research Corporation	Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype
US4735801A (en) *	1982-09-07	1988-04-05	Board Of Trustees Of Leland Stanford Jr. University	Novel non-reverting salmonella live vaccines

1987
- 1987-12-23 GB GB878730037A patent/GB8730037D0/en active Pending
1988
- 1988-12-22 PH PH37971A patent/PH31428A/en unknown
- 1988-12-22 MY MYPI88001526A patent/MY104367A/en unknown
- 1988-12-22 ES ES88312203T patent/ES2061700T3/es not_active Expired - Lifetime
- 1988-12-22 RU SU4742131A patent/RU2114172C1/ru active
- 1988-12-22 HU HU89702A patent/HU216449B/hu unknown
- 1988-12-22 KR KR1019880017199A patent/KR970010759B1/ko not_active Expired - Lifetime
- 1988-12-22 EP EP88312203A patent/EP0322237B1/en not_active Expired - Lifetime
- 1988-12-22 IL IL8876688A patent/IL88766A/en unknown
- 1988-12-22 AT AT88312203T patent/ATE103331T1/de not_active IP Right Cessation
- 1988-12-22 NZ NZ227472A patent/NZ227472A/en unknown
- 1988-12-22 BR BR888807376A patent/BR8807376A/pt not_active Application Discontinuation
- 1988-12-22 DE DE3888652T patent/DE3888652T2/de not_active Expired - Lifetime
- 1988-12-22 ZA ZA889605A patent/ZA889605B/xx unknown
- 1988-12-22 HU HU89702A patent/HUT55242A/hu unknown
- 1988-12-22 IE IE383988A patent/IE65176B1/en not_active IP Right Cessation
- 1988-12-22 WO PCT/GB1988/001143 patent/WO1989005856A1/en not_active Ceased
- 1988-12-22 AU AU29193/89A patent/AU619519B2/en not_active Expired
- 1988-12-22 CA CA000586868A patent/CA1327331C/en not_active Expired - Lifetime
- 1988-12-22 JP JP1501160A patent/JP2602970B2/ja not_active Expired - Lifetime
1989
- 1989-08-22 DK DK198904126A patent/DK174952B1/da not_active IP Right Cessation
1997
- 1997-10-15 HK HK97101924A patent/HK1000469A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK174952B1 (da)	2004-03-22
HU216449B (hu)	1999-06-28
NZ227472A (en)	1992-07-28
MY104367A (en)	1994-03-31
ZA889605B (en)	1990-08-29
ATE103331T1 (de)	1994-04-15
HU890702D0 (en)	1991-01-28
KR970010759B1 (ko)	1997-06-30
AU2919389A (en)	1989-07-19
DE3888652D1 (de)	1994-04-28
AU619519B2 (en)	1992-01-30
DE3888652T2 (de)	1994-07-07
HK1000469A1 (en)	1998-03-27
ES2061700T3 (es)	1994-12-16
PH31428A (en)	1998-11-03
DK412689A (da)	1989-08-22
JP2602970B2 (ja)	1997-04-23
GB8730037D0 (en)	1988-02-03
HUT55242A (en)	1991-05-28
BR8807376A (pt)	1990-03-20
EP0322237A1 (en)	1989-06-28
RU2114172C1 (ru)	1998-06-27
WO1989005856A1 (en)	1989-06-29
KR890010200A (ko)	1989-08-07
IE65176B1 (en)	1995-10-04
JPH02502785A (ja)	1990-09-06
IE883839L (en)	1989-06-23
DK412689D0 (da)	1989-08-22
EP0322237B1 (en)	1994-03-23
CA1327331C (en)	1994-03-01

Legal Events

Date	Code	Title
1996-05-14	KB	Patent renewed
2003-02-12	KB	Patent renewed
2007-02-12	KB	Patent renewed

Publication	Publication Date	Title
EP0322237B1 (en)	1994-03-23	Vaccines
EP0400958B1 (en)	1995-09-13	Live vaccines
US5804194A (en)	1998-09-08	Vaccines containing a salmonella bacteria attenuated by mutation of the htra gene
HK1000469B (en)	1998-03-27	Vaccines
CA2099841C (en)	2003-02-25	Expression of recombinant proteins in attenuated bacteria
Roberts et al.	1990	Construction and characterization in vivo of Bordetella pertussis aroA mutants
PT512260E (pt)	2001-12-28	Vectores "pur a" estaveis e suas utilizacoes
US5811105A (en)	1998-09-22	Vaccines containing bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
AU659995C (en)	1997-12-18	Live vaccines
Dougan	1994	Genetics as a route toward mucosal vaccine development
Stocker	1992	Attenuated Salmonella sp. as Live Vaccines and as Presenters of Heterologous Antigens