IL90533A - 5-phenyl-8-nitro-2,3,4,5-tetrahydro-1h-3- benzazepine derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

5-phenyl-8-nitro-2,3,4,5-tetrahydro-1h-3- benzazepine derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL90533A
IL90533A IL9053389A IL9053389A IL90533A IL 90533 A IL90533 A IL 90533A IL 9053389 A IL9053389 A IL 9053389A IL 9053389 A IL9053389 A IL 9053389A IL 90533 A IL90533 A IL 90533A
Authority
IL
Israel
Prior art keywords
bridge
benzazepines
hydroxy
hydrogen
benzazepine
Prior art date
Application number
IL9053389A
Other languages
English (en)
Other versions
IL90533A0 (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL90533A0 publication Critical patent/IL90533A0/xx
Publication of IL90533A publication Critical patent/IL90533A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL9053389A 1988-06-15 1989-06-05 5-phenyl-8-nitro-2,3,4,5-tetrahydro-1h-3- benzazepine derivatives, their preparation and pharmaceutical compositions containing them IL90533A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK325188A DK325188D0 (da) 1988-06-15 1988-06-15 Hidtil ukendte benzazepinderivater

Publications (2)

Publication Number Publication Date
IL90533A0 IL90533A0 (en) 1990-01-18
IL90533A true IL90533A (en) 1994-05-30

Family

ID=8120790

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9053389A IL90533A (en) 1988-06-15 1989-06-05 5-phenyl-8-nitro-2,3,4,5-tetrahydro-1h-3- benzazepine derivatives, their preparation and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (2) US5010074A (de)
EP (1) EP0347672B1 (de)
JP (1) JP2769718B2 (de)
AT (1) ATE102188T1 (de)
AU (1) AU622911B2 (de)
CA (1) CA1317938C (de)
DE (1) DE68913367T2 (de)
DK (1) DK325188D0 (de)
ES (1) ES2061794T3 (de)
FI (1) FI93354C (de)
IE (1) IE891932L (de)
IL (1) IL90533A (de)
NO (1) NO173865C (de)
NZ (1) NZ229521A (de)
PT (1) PT90883B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
US5158948A (en) * 1990-11-16 1992-10-27 Abbott Laboratories Tetracyclic spirobenzazepine dopamine antagonists
US5470850A (en) * 1992-02-24 1995-11-28 Novo Nordisk A/S 2,3,4,5-tetrahydro-1H-3-benzazepines
DK23392D0 (da) * 1992-02-24 1992-02-24 Novo Nordisk As Heterocykliske forbindelser, deres anvendelse og fremstilling
EP1011679B1 (de) * 1997-03-12 2003-07-30 Addex Pharmaceuticals SA Verwendung von 8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepinen zur herstellung von pharmazeutischen zusammenstellungen zur behandlung von schlafstörungen
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
DE60321354D1 (de) * 2002-08-29 2008-07-10 Schering Corp Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen
KR100897642B1 (ko) 2002-12-20 2009-05-14 글락소 그룹 리미티드 신경 장애 치료용 벤즈아제핀 유도체
WO2005035504A2 (en) * 2003-05-22 2005-04-21 Schering Corporation 5-h -benzo [d] naphth [2, 1-b] azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792043B (en) * 1978-05-08 1980-05-28 Scherico Ltd Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4327023A (en) * 1980-01-31 1982-04-27 Smithkline Corporation Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
AU588080B2 (en) * 1986-01-16 1989-09-07 Schering Corporation Fused benzazepines
EP0244088A3 (de) * 1986-04-03 1989-03-15 Smithkline Beecham Corporation 1-Phenyl-3-benzazepin-Verbindungen und diese enthaltende Arzneimittel zur Behandlung von Störungen des gastrointestinalen Bewegungsvermögens

Also Published As

Publication number Publication date
PT90883B (pt) 1994-12-30
FI93354B (fi) 1994-12-15
NO892476D0 (no) 1989-06-14
US5025009A (en) 1991-06-18
NO892476L (no) 1989-12-18
FI892946A0 (fi) 1989-06-15
ATE102188T1 (de) 1994-03-15
JPH0240364A (ja) 1990-02-09
NO173865C (no) 1994-02-16
AU622911B2 (en) 1992-04-30
JP2769718B2 (ja) 1998-06-25
PT90883A (pt) 1989-12-29
FI892946A7 (fi) 1989-12-16
CA1317938C (en) 1993-05-18
US5010074A (en) 1991-04-23
DK325188D0 (da) 1988-06-15
DE68913367D1 (de) 1994-04-07
NO173865B (no) 1993-11-08
IL90533A0 (en) 1990-01-18
EP0347672A1 (de) 1989-12-27
EP0347672B1 (de) 1994-03-02
AU3635989A (en) 1989-12-21
IE891932L (en) 1989-12-15
ES2061794T3 (es) 1994-12-16
NZ229521A (en) 1991-12-23
FI93354C (fi) 1995-03-27
DE68913367T2 (de) 1994-06-01

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Legal Events

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