NO173865C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,3,4,5-tetrahydro-1h-3-benzazepiner - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,3,4,5-tetrahydro-1h-3-benzazepiner

Info

Publication number: NO173865C
Authority: NO; Norway
Prior art keywords: bridge; benzazepines; tetrahydro; preparation; therapeutically active
Prior art date: 1988-06-15

Application number

NO892476A

Other languages

English (en)

Norwegian (no)

Other versions

NO892476D0 (no

NO892476L (no

NO173865B (no

Inventor

Frederik Christian Groenvald

Peter Hoengaard Andersen

Peter Faarup

Erling Guddal

Kristian Tage Hansen

Louis Brammer Hansen

Erik Bardum Nielsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-15

Filing date

1989-06-14

Publication date

1994-02-16

1989-06-14 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1989-06-14 Publication of NO892476D0 publication Critical patent/NO892476D0/no

1989-12-18 Publication of NO892476L publication Critical patent/NO892476L/no

1993-11-08 Publication of NO173865B publication Critical patent/NO173865B/no

1994-02-16 Publication of NO173865C publication Critical patent/NO173865C/no

Links

MWVMYAWMFTVYED-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1CNCCC2=CC=CC=C21 MWVMYAWMFTVYED-UHFFFAOYSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO892476A 1988-06-15 1989-06-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,3,4,5-tetrahydro-1h-3-benzazepiner NO173865C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK325188A DK325188D0 (da)	1988-06-15	1988-06-15	Hidtil ukendte benzazepinderivater

Publications (4)

Publication Number	Publication Date
NO892476D0 NO892476D0 (no)	1989-06-14
NO892476L NO892476L (no)	1989-12-18
NO173865B NO173865B (no)	1993-11-08
NO173865C true NO173865C (no)	1994-02-16

Family

ID=8120790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO892476A NO173865C (no)	1988-06-15	1989-06-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,3,4,5-tetrahydro-1h-3-benzazepiner

Country Status (15)

Country	Link
US (2)	US5010074A (de)
EP (1)	EP0347672B1 (de)
JP (1)	JP2769718B2 (de)
AT (1)	ATE102188T1 (de)
AU (1)	AU622911B2 (de)
CA (1)	CA1317938C (de)
DE (1)	DE68913367T2 (de)
DK (1)	DK325188D0 (de)
ES (1)	ES2061794T3 (de)
FI (1)	FI93354C (de)
IE (1)	IE891932L (de)
IL (1)	IL90533A (de)
NO (1)	NO173865C (de)
NZ (1)	NZ229521A (de)
PT (1)	PT90883B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK67489D0 (da) *	1989-02-14	1989-02-14	Novo Industri As	Nye benzazepinderivater
US5158948A (en) *	1990-11-16	1992-10-27	Abbott Laboratories	Tetracyclic spirobenzazepine dopamine antagonists
US5470850A (en) *	1992-02-24	1995-11-28	Novo Nordisk A/S	2,3,4,5-tetrahydro-1H-3-benzazepines
DK23392D0 (da) *	1992-02-24	1992-02-24	Novo Nordisk As	Heterocykliske forbindelser, deres anvendelse og fremstilling
EP1011679B1 (de) *	1997-03-12	2003-07-30	Addex Pharmaceuticals SA	Verwendung von 8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepinen zur herstellung von pharmazeutischen zusammenstellungen zur behandlung von schlafstörungen
US6277844B1 (en)	1998-09-14	2001-08-21	Sydney Spector	Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB0130576D0 (en) *	2001-12-20	2002-02-06	Cenes Ltd	Dopamine D1 receptor agonist pro-drug compounds & derivatives
DE60321354D1 (de) *	2002-08-29	2008-07-10	Schering Corp	Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen
KR100897642B1 (ko)	2002-12-20	2009-05-14	글락소 그룹 리미티드	신경 장애 치료용 벤즈아제핀 유도체
WO2005035504A2 (en) *	2003-05-22	2005-04-21	Schering Corporation	5-h -benzo [d] naphth [2, 1-b] azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA974989A (en) *	1968-03-11	1975-09-23	Wallace And Tiernan Inc.	Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4210749A (en) *	1974-11-12	1980-07-01	Pennwalt Corporation	Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792043B (en) *	1978-05-08	1980-05-28	Scherico Ltd	Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4284556A (en) *	1980-01-31	1981-08-18	Smithkline Corporation	7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4327023A (en) *	1980-01-31	1982-04-27	Smithkline Corporation	Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) *	1985-04-22	1985-04-23	Novo Industri As	Nitrogenholdige forbindelser
AU588080B2 (en) *	1986-01-16	1989-09-07	Schering Corporation	Fused benzazepines
EP0244088A3 (de) *	1986-04-03	1989-03-15	Smithkline Beecham Corporation	1-Phenyl-3-benzazepin-Verbindungen und diese enthaltende Arzneimittel zur Behandlung von Störungen des gastrointestinalen Bewegungsvermögens

1988
- 1988-06-15 DK DK325188A patent/DK325188D0/da not_active Application Discontinuation
1989
- 1989-06-05 IL IL9053389A patent/IL90533A/en unknown
- 1989-06-09 ES ES89110490T patent/ES2061794T3/es not_active Expired - Lifetime
- 1989-06-09 DE DE68913367T patent/DE68913367T2/de not_active Expired - Lifetime
- 1989-06-09 AT AT89110490T patent/ATE102188T1/de not_active IP Right Cessation
- 1989-06-09 EP EP89110490A patent/EP0347672B1/de not_active Expired - Lifetime
- 1989-06-12 US US07/365,250 patent/US5010074A/en not_active Expired - Lifetime
- 1989-06-13 NZ NZ229521A patent/NZ229521A/en unknown
- 1989-06-13 CA CA000602684A patent/CA1317938C/en not_active Expired - Lifetime
- 1989-06-14 NO NO892476A patent/NO173865C/no not_active IP Right Cessation
- 1989-06-14 AU AU36359/89A patent/AU622911B2/en not_active Expired
- 1989-06-15 JP JP1150662A patent/JP2769718B2/ja not_active Expired - Lifetime
- 1989-06-15 IE IE891932A patent/IE891932L/xx not_active IP Right Cessation
- 1989-06-15 PT PT90883A patent/PT90883B/pt not_active IP Right Cessation
- 1989-06-15 FI FI892946A patent/FI93354C/fi active IP Right Grant
1990
- 1990-02-07 US US07/477,450 patent/US5025009A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT90883B (pt)	1994-12-30
FI93354B (fi)	1994-12-15
NO892476D0 (no)	1989-06-14
US5025009A (en)	1991-06-18
NO892476L (no)	1989-12-18
FI892946A0 (fi)	1989-06-15
ATE102188T1 (de)	1994-03-15
JPH0240364A (ja)	1990-02-09
AU622911B2 (en)	1992-04-30
JP2769718B2 (ja)	1998-06-25
PT90883A (pt)	1989-12-29
FI892946A7 (fi)	1989-12-16
CA1317938C (en)	1993-05-18
US5010074A (en)	1991-04-23
DK325188D0 (da)	1988-06-15
DE68913367D1 (de)	1994-04-07
NO173865B (no)	1993-11-08
IL90533A0 (en)	1990-01-18
EP0347672A1 (de)	1989-12-27
EP0347672B1 (de)	1994-03-02
AU3635989A (en)	1989-12-21
IE891932L (en)	1989-12-15
IL90533A (en)	1994-05-30
ES2061794T3 (es)	1994-12-16
NZ229521A (en)	1991-12-23
FI93354C (fi)	1995-03-27
DE68913367T2 (de)	1994-06-01

Legal Events

Date	Code	Title	Description
2009-07-06	MK1K	Patent expired

Publication	Publication Date	Title
FI113651B (fi)	2004-05-31	Menetelmä terapeuttisesti käyttökelpoisten bentsimidatsoliyhdisteiden valmistamiseksi
NO173865C (no)	1994-02-16	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,3,4,5-tetrahydro-1h-3-benzazepiner
NO161564C (no)	1989-08-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
AU626740B2 (en)	1992-08-06	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
HU9201887D0 (en)	1992-08-28	Process for the production of //aralkyl-piperidine-4-yl/-methyl/-2a,3,4,5-tetrahydro-1-/2h/-acenaphtylene-1-on derivatives and of medical preparations containing them as active agents
NO173991C (no)	1994-03-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
ES2035915T3 (es)	1993-05-01	Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.
DE3775666D1 (de)	1992-02-13	Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung.
GR3007079T3 (de)	1993-07-30
GR3005176T3 (de)	1993-05-24
NO894384L (no)	1990-05-07	Forbindelser for behandling av urininkontinens.
GR3006108T3 (de)	1993-06-21
ATE56432T1 (de)	1990-09-15	Substituierte 1,3,4,9-tetrahydropyrano(3,4b>indole-1-essigs\|ure.
DE69827706D1 (de)	2004-12-30	5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
AU7748487A (en)	1988-03-03	2-amino-3-aroyl-omega-oxobenzenebutanoic acids and esters
DE69410159D1 (de)	1998-06-18	Neue Verbindung, Leustroducsin H, ihre Herstellung und therapeutische Verwendung