IL91773A - 2'-Halomethylidene 2'-ethenylidene and 2'-ethynyl adenosine derivatives process for the preparation of certain of these compounds and pharmaceutical compositions containing them - Google Patents

2'-Halomethylidene 2'-ethenylidene and 2'-ethynyl adenosine derivatives process for the preparation of certain of these compounds and pharmaceutical compositions containing them

Info

Publication number
IL91773A
IL91773A IL9177389A IL9177389A IL91773A IL 91773 A IL91773 A IL 91773A IL 9177389 A IL9177389 A IL 9177389A IL 9177389 A IL9177389 A IL 9177389A IL 91773 A IL91773 A IL 91773A
Authority
IL
Israel
Prior art keywords
compound
group
hydrogen
deoxy
adenosine
Prior art date
Application number
IL9177389A
Other languages
English (en)
Other versions
IL91773A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL91773A0 publication Critical patent/IL91773A0/xx
Publication of IL91773A publication Critical patent/IL91773A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9177389A 1988-09-27 1989-09-25 2'-Halomethylidene 2'-ethenylidene and 2'-ethynyl adenosine derivatives process for the preparation of certain of these compounds and pharmaceutical compositions containing them IL91773A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24991188A 1988-09-27 1988-09-27
US38939189A 1989-08-03 1989-08-03

Publications (2)

Publication Number Publication Date
IL91773A0 IL91773A0 (en) 1990-06-10
IL91773A true IL91773A (en) 1994-02-27

Family

ID=26940460

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9177389A IL91773A (en) 1988-09-27 1989-09-25 2'-Halomethylidene 2'-ethenylidene and 2'-ethynyl adenosine derivatives process for the preparation of certain of these compounds and pharmaceutical compositions containing them

Country Status (18)

Country Link
EP (1) EP0365849B1 (es)
JP (1) JP2968002B2 (es)
KR (1) KR0146333B1 (es)
CN (1) CN1046334A (es)
AR (1) AR248283A1 (es)
AT (1) ATE111477T1 (es)
AU (1) AU621664B2 (es)
CA (1) CA1336903C (es)
DE (1) DE68918215T2 (es)
DK (1) DK171237B1 (es)
ES (1) ES2063796T3 (es)
FI (1) FI94763C (es)
HU (1) HU204843B (es)
IE (1) IE63561B1 (es)
IL (1) IL91773A (es)
NO (1) NO171857C (es)
NZ (1) NZ230766A (es)
PT (1) PT91803B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
DK0640092T3 (da) * 1992-05-12 1996-12-30 Merrell Pharma Inc Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
WO1996001834A1 (en) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
WO2000074686A1 (en) * 1999-06-09 2000-12-14 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
EP1480982A4 (en) * 2002-02-14 2007-08-01 Pharmasset Inc MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES
KR102072041B1 (ko) 2011-12-22 2020-01-31 앨리오스 바이오파마 인크. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
US5047520A (en) * 1987-03-19 1991-09-10 Yamasa Shoyu Kabushiki Kaisha 2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives

Also Published As

Publication number Publication date
JP2968002B2 (ja) 1999-10-25
FI894546A7 (fi) 1990-03-28
KR0146333B1 (ko) 1998-08-01
JPH02160769A (ja) 1990-06-20
KR900004736A (ko) 1990-04-12
NO893826L (no) 1990-03-28
IE893080L (en) 1990-03-27
IE63561B1 (en) 1995-05-17
AU621664B2 (en) 1992-03-19
FI94763C (fi) 1995-10-25
PT91803B (pt) 1995-05-31
EP0365849B1 (en) 1994-09-14
DK171237B1 (da) 1996-08-05
FI894546A0 (fi) 1989-09-26
FI94763B (fi) 1995-07-14
HU204843B (en) 1992-02-28
NZ230766A (en) 1992-07-28
DK473289D0 (da) 1989-09-26
PT91803A (pt) 1990-03-30
ATE111477T1 (de) 1994-09-15
DE68918215T2 (de) 1995-02-02
EP0365849A3 (en) 1990-12-27
DK473289A (da) 1990-03-28
HUT50844A (en) 1990-03-28
DE68918215D1 (de) 1994-10-20
NO171857C (no) 1993-05-12
CA1336903C (en) 1995-09-05
EP0365849A2 (en) 1990-05-02
AR248283A1 (es) 1995-07-12
NO893826D0 (no) 1989-09-26
NO171857B (no) 1993-02-01
AU4176089A (en) 1990-04-05
IL91773A0 (en) 1990-06-10
ES2063796T3 (es) 1995-01-16
CN1046334A (zh) 1990-10-24

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Legal Events

Date Code Title Description
RH1 Patent not in force
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.