IL91778A - A method for reducing the heterogeneity of monoclonal antibodies - Google Patents
A method for reducing the heterogeneity of monoclonal antibodiesInfo
- Publication number
- IL91778A IL91778A IL9177889A IL9177889A IL91778A IL 91778 A IL91778 A IL 91778A IL 9177889 A IL9177889 A IL 9177889A IL 9177889 A IL9177889 A IL 9177889A IL 91778 A IL91778 A IL 91778A
- Authority
- IL
- Israel
- Prior art keywords
- antibodies
- incubation
- heterogeneity
- culture
- hours
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25078788A | 1988-09-28 | 1988-09-28 | |
| US25078888A | 1988-09-28 | 1988-09-28 | |
| US25078688A | 1988-09-28 | 1988-09-28 | |
| US07/364,056 US5126250A (en) | 1988-09-28 | 1989-06-09 | Method for the reduction of heterogeneity of monoclonal antibodies |
| CA000613379A CA1332367C (en) | 1988-09-28 | 1989-09-26 | Method for the reduction of heterogeneity of monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL91778A true IL91778A (en) | 1994-10-07 |
Family
ID=27508376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9177889A IL91778A (en) | 1988-09-28 | 1989-09-26 | A method for reducing the heterogeneity of monoclonal antibodies |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0361902B1 (de) |
| JP (1) | JP2925181B2 (de) |
| CN (1) | CN1041392A (de) |
| AR (1) | AR242986A1 (de) |
| AT (1) | ATE101876T1 (de) |
| AU (1) | AU615576B2 (de) |
| BG (1) | BG60017B2 (de) |
| CA (1) | CA1332367C (de) |
| DE (1) | DE68913251T2 (de) |
| DK (1) | DK475389A (de) |
| ES (1) | ES2049332T3 (de) |
| IE (1) | IE63562B1 (de) |
| IL (1) | IL91778A (de) |
| MX (1) | MX170441B (de) |
| NZ (1) | NZ230786A (de) |
| PL (1) | PL162260B1 (de) |
| RO (1) | RO105652B1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4793360A2 (de) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur kontrolle der blut-pharmazeutizität von antikörpern |
| EP1878747A1 (de) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-hergestellte Antikörper |
| EP2031064A1 (de) * | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| EP3127921A1 (de) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstition in cdr |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| TWI544077B (zh) | 2009-03-19 | 2016-08-01 | 中外製藥股份有限公司 | Antibody constant region change body |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| MY163081A (en) * | 2010-12-28 | 2017-08-15 | Chugai Pharmaceutical Co Ltd | Animal cell culturing method |
| PL3489254T3 (pl) | 2012-04-30 | 2023-01-30 | Biocon Limited | Ukierunkowujące/immunomodulujące białko fuzyjne i sposoby jego otrzymywania |
| MY186864A (en) * | 2013-03-12 | 2021-08-26 | Biocon Ltd | Fusion immunomodulatory proteins and methods for making same |
| EP3009518B1 (de) | 2013-06-11 | 2020-08-12 | National Center of Neurology and Psychiatry | Verfahren zur vorhersage einer posttherapeutischen prognose von patienten mit schubförmig remittierender multipler sklerose (rrms) und verfahren zur bestimmung der anwendbarkeit der neuartigen therapie |
| TWI759261B (zh) | 2015-02-27 | 2022-04-01 | 日商中外製藥股份有限公司 | Ｉｌ－６受體抗體用於製備醫藥組成物的用途 |
| JP6875683B2 (ja) | 2015-05-19 | 2021-05-26 | 国立研究開発法人国立精神・神経医療研究センター | 多発性硬化症（ｍｓ）患者の新規治療適用判断方法 |
| EP3500586B1 (de) * | 2016-10-17 | 2021-02-24 | Enzene Biosciences Ltd. | Kontinuierliches verfahren zur reduzierung der heterogenität von therapeutischem protein |
| EP3620531A4 (de) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | Verfahren zur vorhersage und beurteilung der therapeutischen wirkung bei erkrankungen im zusammenhang mit il-6 und neutrophilen |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| TWI822728B (zh) | 2018-01-31 | 2023-11-21 | 加藤元一 | 含有il-6抑制劑的哮喘治療劑 |
| AU2020259884A1 (en) | 2019-04-17 | 2021-10-07 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
| US12558423B2 (en) | 2020-05-29 | 2026-02-24 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing formulation |
-
1989
- 1989-09-26 BG BG089846A patent/BG60017B2/bg unknown
- 1989-09-26 IL IL9177889A patent/IL91778A/en not_active IP Right Cessation
- 1989-09-26 RO RO141765A patent/RO105652B1/ro unknown
- 1989-09-26 NZ NZ230786A patent/NZ230786A/xx unknown
- 1989-09-26 AR AR89310004A patent/AR242986A1/es active
- 1989-09-26 CA CA000613379A patent/CA1332367C/en not_active Expired - Fee Related
- 1989-09-27 AT AT89309851T patent/ATE101876T1/de not_active IP Right Cessation
- 1989-09-27 DK DK475389A patent/DK475389A/da not_active Application Discontinuation
- 1989-09-27 IE IE309489A patent/IE63562B1/en not_active IP Right Cessation
- 1989-09-27 EP EP89309851A patent/EP0361902B1/de not_active Expired - Lifetime
- 1989-09-27 ES ES89309851T patent/ES2049332T3/es not_active Expired - Lifetime
- 1989-09-27 DE DE68913251T patent/DE68913251T2/de not_active Expired - Fee Related
- 1989-09-27 MX MX017721A patent/MX170441B/es unknown
- 1989-09-27 AU AU42343/89A patent/AU615576B2/en not_active Ceased
- 1989-09-27 PL PL89281598A patent/PL162260B1/pl unknown
- 1989-09-28 CN CN89107508.9A patent/CN1041392A/zh active Pending
- 1989-09-28 JP JP1256890A patent/JP2925181B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX170441B (es) | 1993-08-23 |
| PL162260B1 (pl) | 1993-09-30 |
| AU615576B2 (en) | 1991-10-03 |
| NZ230786A (en) | 1991-11-26 |
| IE893094L (en) | 1990-03-28 |
| CA1332367C (en) | 1994-10-11 |
| JPH02163096A (ja) | 1990-06-22 |
| JP2925181B2 (ja) | 1999-07-28 |
| DK475389D0 (da) | 1989-09-27 |
| DE68913251D1 (de) | 1994-03-31 |
| EP0361902A2 (de) | 1990-04-04 |
| BG60017B2 (bg) | 1993-06-30 |
| CN1041392A (zh) | 1990-04-18 |
| AR242986A1 (es) | 1993-06-30 |
| IE63562B1 (en) | 1995-05-17 |
| EP0361902A3 (en) | 1990-08-16 |
| AU4234389A (en) | 1990-04-05 |
| DK475389A (da) | 1990-03-29 |
| ATE101876T1 (de) | 1994-03-15 |
| DE68913251T2 (de) | 1994-06-23 |
| ES2049332T3 (es) | 1994-04-16 |
| RO105652B1 (ro) | 1992-11-30 |
| EP0361902B1 (de) | 1994-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5126250A (en) | Method for the reduction of heterogeneity of monoclonal antibodies | |
| EP0361902B1 (de) | Verfahren zur Verringerung der Heterogenität von monoklonalen Antikörpern | |
| US4954437A (en) | Cell encoding recombinant human erythropoietin | |
| KR0157983B1 (ko) | 아미드화 효소 발현계 | |
| CA2280791A1 (en) | Immunological detection of prions | |
| JPH06113832A (ja) | ジゴキシンに対し高い親和性を有するモノクローナル抗体を産生するハイブリッドセルライン及びその製造法 | |
| WO1986004336A1 (en) | Monoclonal antibodies against core proteins of lymphadenopathy-associated-viruses | |
| JPH0638743A (ja) | 抗プロテインｃモノクローナル抗体およびそれを産生するハイブリドーマ | |
| AU712759B2 (en) | TNF-alpha converting enzyme | |
| EP0162034B1 (de) | Verfahren zur Isolierung von monoklonalen Antikörpern aus Hybridomas-Kulturen | |
| EP0169239A1 (de) | Cdna-klone von menschlichem erythropoietin | |
| US5236836A (en) | Autoantibodies which enhance the rate of a chemical reaction | |
| EP0300459A2 (de) | Menschlicher pankreatischer sekretorischer Trypsininhibitor | |
| EP0132021B1 (de) | TGF-Polypeptide, davon derivierte antigene Oligopeptide, davon erhaltene Antikörper | |
| EP0519728A2 (de) | Anti-TCF-II monoklonale Antikörper und ihre Verwendung zur Bestimmung von TCF-II | |
| JPH10226700A (ja) | Ｍｉａの検出のためのイムノアッセイ | |
| EP0445750A1 (de) | Monoklonaler Antikörper gegen mit Krebs assoziierte humane Galactosyltransferase | |
| Cone | Non-MHC-restricted T cell antigen-binding proteins | |
| EP0559428B1 (de) | Neue Polypeptide, deren kodierende DNS | |
| Wunderlich et al. | Use of recombinant fusion proteins for generation and rapid characterization of monoclonal antibodies: Application to the Kunitz domain of human β amyloid precursor protein | |
| JP3865364B2 (ja) | コンドロイチナーゼ画分 | |
| JP4361578B2 (ja) | コンドロイチン硫酸リアーゼｉｉに対するモノクローナル抗体 | |
| EP0336441B1 (de) | Anti-CPBII-monoklonaler Antikörper | |
| WO2000009739A1 (en) | Monoclonal antibody against canine trypsin | |
| EP0420151A1 (de) | Antirhodopsiner monoklonaler Antikörper and seine Verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |