IL94349A - Protonase inhibitors of biconin from humans that have undergone modification - Google Patents

Protonase inhibitors of biconin from humans that have undergone modification

Info

Publication number: IL94349A
Authority: IL; Israel
Prior art keywords: bikunin; leu; sequence; amino acid; lys
Prior art date: 1989-05-13

Application number

IL94349A

Other languages

English (en)

Hebrew (he)

Other versions

IL94349A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-13

Filing date

1990-05-10

Publication date

1998-01-04

1990-05-10 Application filed by Bayer Ag filed Critical Bayer Ag

1991-03-10 Publication of IL94349A0 publication Critical patent/IL94349A0/xx

1998-01-04 Publication of IL94349A publication Critical patent/IL94349A/en

Links

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238000010369 molecular cloning Methods 0.000 description 1
231100000219 mutagenic Toxicity 0.000 description 1
230000003505 mutagenic effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
210000001322 periplasm Anatomy 0.000 description 1
SXADIBFZNXBEGI-UHFFFAOYSA-N phosphoramidous acid Chemical compound NP(O)O SXADIBFZNXBEGI-UHFFFAOYSA-N 0.000 description 1
ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
238000011533 pre-incubation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
108010065349 preinvertase Proteins 0.000 description 1
230000009465 prokaryotic expression Effects 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
230000009979 protective mechanism Effects 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
230000013878 renal filtration Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
230000036303 septic shock Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
FRGKKTITADJNOE-UHFFFAOYSA-N sulfanyloxyethane Chemical compound CCOS FRGKKTITADJNOE-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Zoology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Physics & Mathematics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Heart & Thoracic Surgery (AREA)
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IL94349A 1989-05-13 1990-05-10 Protonase inhibitors of biconin from humans that have undergone modification IL94349A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3915689		1989-05-13
DE4001244		1990-01-18

Publications (2)

Publication Number	Publication Date
IL94349A0 IL94349A0 (en)	1991-03-10
IL94349A true IL94349A (en)	1998-01-04

Family

ID=25880860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL94349A IL94349A (en)	1989-05-13	1990-05-10	Protonase inhibitors of biconin from humans that have undergone modification

Country Status (17)

Country	Link
US (1)	US5407915A (pt)
EP (1)	EP0401508B1 (pt)
JP (2)	JP3126975B2 (pt)
KR (1)	KR0156246B1 (pt)
AT (1)	ATE114332T1 (pt)
AU (1)	AU623769B2 (pt)
CA (1)	CA2016627C (pt)
DE (1)	DE59007737D1 (pt)
DK (1)	DK0401508T3 (pt)
ES (1)	ES2066033T3 (pt)
GR (1)	GR3015124T3 (pt)
HU (1)	HU214985B (pt)
IE (1)	IE65710B1 (pt)
IL (1)	IL94349A (pt)
NZ (1)	NZ233635A (pt)
PH (1)	PH27530A (pt)
PT (1)	PT94016B (pt)

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US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US7078383B2 (en) *	1988-09-02	2006-07-18	Dyax Corp.	ITI-D1 Kunitz domain mutants as HNE inhibitors
US5663143A (en) *	1988-09-02	1997-09-02	Dyax Corp.	Engineered human-derived kunitz domains that inhibit human neutrophil elastase
EP0486001A1 (en) *	1990-11-13	1992-05-20	Mochida Pharmaceutical Co., Ltd.	Recombinant urinary trypsin inhibitor fragments and drug composition
DE69233760D1 (de) *	1991-03-01	2009-06-25	Dyax Corp	Inhibitoren der menschlichen Elastase von Neutrophilen
US5451659A (en) *	1991-11-08	1995-09-19	Mochida Pharmaceutical Co., Ltd.	Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
IL104327A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Variant of human kunitz-type protease inhibitor
JP2769083B2 (ja) *	1993-02-22	1998-06-25	日清食品株式会社	エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
JP3570558B2 (ja) *	1993-05-01	2004-09-29	持田製薬株式会社	Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5650394A (en) *	1993-11-04	1997-07-22	Adeza Biomedical	Use of urinastatin-like compounds to prevent premature delivery
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP0737207B1 (en) *	1994-01-11	2004-09-22	Dyax Corporation	Inhibitors of human plasmin derived from the kunitz domains
AU4868096A (en) *	1995-02-23	1996-09-11	Adeza Biomedical Corporation	Polypeptides derived from urinastatin having calcium channel blocking activity and their use to delay premature delivery
WO1997033996A2 (en) *	1996-03-11	1997-09-18	Bayer Corporation	Human bikunin
US20070140979A1 (en) *	1998-12-22	2007-06-21	Bayer Aktiengesellschaft	Method for accelerating the rate of mucociliary clearance
ATE254473T1 (de) *	1998-12-22	2003-12-15	Bayer Ag	Verwendung eines serinproteaseinhibitors vom kunitz-typ zur beschleunigung der schleimauflöserate
US6660482B1 (en) *	2000-02-28	2003-12-09	Rhode Island Hospital	Inter-alpha-trypsin inhibitor as a marker for sepsis
KR20040004562A (ko) *	2001-03-27	2004-01-13	어웨어, 인크.	수신기 투과성 ｑ-모드
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
PT2298278E (pt)	2002-06-07	2016-02-25	Dyax Corp	Prevenção e redução da perda de sangue e resposta inflamatória
WO2004019968A1 (en)	2002-08-28	2004-03-11	Dyax Corp.	Methods for preserving organs and tissues
PT1587907E (pt) *	2003-01-07	2011-04-08	Dyax Corp	Biblioteca de domínios de kunitz
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
JP2013516389A (ja) *	2009-01-06	2013-05-13	ダイアックスコーポレーション	カリクレイン阻害剤による粘膜炎治療
ES2905545T3 (es)	2010-01-06	2022-04-11	Takeda Pharmaceuticals Co	Proteínas de unión a calicreína plasmática
KR102011156B1 (ko)	2011-01-06	2019-08-16	다이액스 코포레이션	혈장 칼리크레인 결합 단백질
CA2939639C (en)	2014-02-24	2023-01-24	Takeda Gmbh	Uti fusion proteins
IL247942B (en)	2014-03-27	2022-09-01	Dyax Corp	Compositions and methods for drops in macular edema as a result of diabetes
US11286307B2 (en)	2015-12-11	2022-03-29	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
AU2021209045A1 (en)	2020-01-13	2022-07-28	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
JP7778077B2 (ja)	2020-03-05	2025-12-01	ダイアメディカユーエスエーインコーポレイテッド	ウリナスタチンポリペプチド

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AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) *	1986-06-10	1989-11-03	Transgene Sa	Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2601033B1 (fr) *	1986-07-02	1990-01-19	Transgene Sa	Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
EP0255011A3 (en) *	1986-07-29	1988-11-23	Miles Inc.	Human inter-alpha-trypsin inhibitor gene

1990
- 1990-05-01 AT AT90108284T patent/ATE114332T1/de not_active IP Right Cessation
- 1990-05-01 DE DE59007737T patent/DE59007737D1/de not_active Expired - Fee Related
- 1990-05-01 DK DK90108284.2T patent/DK0401508T3/da active
- 1990-05-01 EP EP90108284A patent/EP0401508B1/de not_active Expired - Lifetime
- 1990-05-01 ES ES90108284T patent/ES2066033T3/es not_active Expired - Lifetime
- 1990-05-02 PH PH40464A patent/PH27530A/en unknown
- 1990-05-10 IL IL94349A patent/IL94349A/en not_active IP Right Cessation
- 1990-05-10 NZ NZ233635A patent/NZ233635A/en unknown
- 1990-05-11 PT PT94016A patent/PT94016B/pt active IP Right Grant
- 1990-05-11 JP JP02120186A patent/JP3126975B2/ja not_active Expired - Fee Related
- 1990-05-11 CA CA002016627A patent/CA2016627C/en not_active Expired - Fee Related
- 1990-05-11 IE IE171390A patent/IE65710B1/en not_active IP Right Cessation
- 1990-05-11 HU HU903010A patent/HU214985B/hu not_active IP Right Cessation
- 1990-05-11 AU AU54970/90A patent/AU623769B2/en not_active Ceased
- 1990-05-12 KR KR1019900006865A patent/KR0156246B1/ko not_active Expired - Fee Related
1993
- 1993-03-05 US US08/027,602 patent/US5407915A/en not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940403586T patent/GR3015124T3/el unknown
2000
- 2000-09-13 JP JP2000278172A patent/JP2001112492A/ja active Pending

Also Published As

Publication number	Publication date
ES2066033T3 (es)	1995-03-01
EP0401508A2 (de)	1990-12-12
JP3126975B2 (ja)	2001-01-22
CA2016627A1 (en)	1990-11-13
GR3015124T3 (en)	1995-05-31
EP0401508A3 (de)	1991-03-27
DK0401508T3 (da)	1995-05-15
JPH03255099A (ja)	1991-11-13
EP0401508B1 (de)	1994-11-23
CA2016627C (en)	2000-08-22
AU623769B2 (en)	1992-05-21
ATE114332T1 (de)	1994-12-15
JP2001112492A (ja)	2001-04-24
PT94016A (pt)	1991-01-08
IE65710B1 (en)	1995-11-15
HU214985B (hu)	1998-08-28
IL94349A0 (en)	1991-03-10
KR0156246B1 (ko)	1998-11-16
PH27530A (en)	1993-08-18
PT94016B (pt)	1997-05-28
AU5497090A (en)	1990-11-15
DE59007737D1 (de)	1995-01-05
IE901713L (en)	1990-11-13
HU903010D0 (en)	1990-09-28
NZ233635A (en)	1991-12-23
US5407915A (en)	1995-04-18
KR900017607A (ko)	1990-12-19

Legal Events

Date	Code	Title
1998-06-15	FF	Patent granted
1998-11-26	KB	Patent renewed
2000-08-31	KB	Patent renewed
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5407915A (en)	1995-04-18	Human Bikunin variants as proteinase inhibitors, and medicaments containing these
US5373090A (en)	1994-12-13	Aprotinin analogues and a process for the production thereof
US5436153A (en)	1995-07-25	Human amyloid protein precursor homolog and Kunitz-type inhibitor
HU218104B (hu)	2000-06-28	Humán, Kunitz-típusú proteázgátló változatai
US5464822A (en)	1995-11-07	Polypeptides and polypeptide analogues
CZ164694A3 (en)	1994-12-15	Human variant of kunitz-type protease inhibitor
CZ164894A3 (en)	1994-12-15	Novel human inhibitor of kunitz-type protease and variants thereof
SI9520043A (en)	1997-08-31	Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors.
WO1994012637A2 (en)	1994-06-09	Novel human amyloid protein precursor homologue and kunitz-type inhibitors
US5378614A (en)	1995-01-03	Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
US5278285A (en)	1994-01-11	Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology
US5164482A (en)	1992-11-17	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
US5817484A (en)	1998-10-06	Thermoresistant α-1-antitrypsin mutein
EP1616007B1 (en)	2013-07-24	Inhibitor proteins of a protease and use thereof
US5876971A (en)	1999-03-02	Thrombin inhibitor from the saliva of protostomia
AU705267B2 (en)	1999-05-20	Process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence
IE890559L (en)	1989-08-23	A hirudin derivative
WO1994016085A9 (en)	1994-09-01	Hybrid proteins having cross-linking and tissue-binding activities
US5231010A (en)	1993-07-27	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
EP0662514A1 (en)	1995-07-12	Hirustasin, an antistasin type serine proteinase inhibitor from Hiruda