IL94602A - Polypeptides and polypeptide equivalents - Google Patents

Polypeptides and polypeptide equivalents

Info

Publication number
IL94602A
IL94602A IL9460290A IL9460290A IL94602A IL 94602 A IL94602 A IL 94602A IL 9460290 A IL9460290 A IL 9460290A IL 9460290 A IL9460290 A IL 9460290A IL 94602 A IL94602 A IL 94602A
Authority
IL
Israel
Prior art keywords
pro
lys
val
gly
polypeptide
Prior art date
Application number
IL9460290A
Other languages
English (en)
Hebrew (he)
Other versions
IL94602A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898913346A external-priority patent/GB8913346D0/en
Priority claimed from GB898913349A external-priority patent/GB8913349D0/en
Priority claimed from GB898921613A external-priority patent/GB8921613D0/en
Priority claimed from GB898924717A external-priority patent/GB8924717D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL94602A0 publication Critical patent/IL94602A0/xx
Publication of IL94602A publication Critical patent/IL94602A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL9460290A 1989-06-09 1990-06-03 Polypeptides and polypeptide equivalents IL94602A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898913346A GB8913346D0 (en) 1989-06-09 1989-06-09 Polypeptide analogues
GB898913349A GB8913349D0 (en) 1989-06-09 1989-06-09 Polypeptides
GB898921613A GB8921613D0 (en) 1989-09-25 1989-09-25 Polypeptides-1st update
GB898924717A GB8924717D0 (en) 1989-11-02 1989-11-02 Polypeptides

Publications (2)

Publication Number Publication Date
IL94602A0 IL94602A0 (en) 1991-04-15
IL94602A true IL94602A (en) 1996-06-18

Family

ID=27450350

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9460290A IL94602A (en) 1989-06-09 1990-06-03 Polypeptides and polypeptide equivalents

Country Status (16)

Country Link
US (4) US5464822A (fr)
EP (1) EP0402068B1 (fr)
JP (1) JP2989853B2 (fr)
AT (1) ATE131493T1 (fr)
AU (1) AU636148B2 (fr)
CA (1) CA2018592C (fr)
DE (1) DE69024104T2 (fr)
DK (1) DK0402068T3 (fr)
ES (1) ES2080800T3 (fr)
FI (1) FI106471B (fr)
GR (1) GR3018401T3 (fr)
IE (1) IE70520B1 (fr)
IL (1) IL94602A (fr)
NO (1) NO177716C (fr)
NZ (1) NZ233974A (fr)
PT (1) PT94326B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO177716C (no) * 1989-06-09 1995-11-08 Zeneca Ltd Fremgangsmåte for fremstilling av terapeutisk aktive polypeptider, DNA-sekvens, ekspresjonsvektor og antistoff
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
EP0458536B1 (fr) * 1990-05-24 1998-03-18 Zeneca Limited Agent thérapeutique pour la prévention et le traitement du syndrome de détresse respiratoire chez l'adulte
EP0458537B1 (fr) * 1990-05-24 1999-03-31 Zeneca Limited Usage d'une composition thérapeutique pour le traitement de la bronchite
US5734014A (en) * 1992-08-11 1998-03-31 Tsumura & Co. Elafin derivative
US8606851B2 (en) 1995-06-06 2013-12-10 Wayport, Inc. Method and apparatus for geographic-based communications service
US5835061A (en) 1995-06-06 1998-11-10 Wayport, Inc. Method and apparatus for geographic-based communications service
EP0834556A1 (fr) * 1996-09-25 1998-04-08 Academisch Ziekenhuis Leiden Procédés de culture de cellules
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2001064031A2 (fr) * 2000-03-01 2001-09-07 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Traitement de blessures
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
EP2163652B2 (fr) 2002-01-28 2023-05-31 Life Technologies Corporation Production des extraits biologiques bruts utilisant protease, convenant pour la synthèse de cDNA
AU2003223718B2 (en) * 2002-04-25 2007-08-16 The Scripps Research Institute Treatment and prevention of pulmonary conditions
FR2849375B1 (fr) * 2002-12-30 2006-10-20 Jean Noel Thorel Compositions cosmetiques, par exemple pour traiter le vieillissement cutane photo-induit
EP1620121A2 (fr) * 2003-05-07 2006-02-01 VIB vzw Utilisation d'un domaine polypeptidique pour moduler le potentiel tumorigene et metastatique de cellules cancereuses
WO2006122404A1 (fr) * 2005-05-16 2006-11-23 Her Majesty The Queen In Right As Represented By The Minister Of Health Inhibition du vih par la trappine-2 (elafine)
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
EP2955233A1 (fr) 2008-12-19 2015-12-16 Life Technologies Corporation Inhibiteurs de proteinase K, methodes et compositions d'iceux
GB201003559D0 (en) 2010-03-03 2010-04-21 Proteo Biotech Ag Novel use of elafin
EP4452303A4 (fr) * 2021-12-20 2025-11-12 Tiakis Biotech Ag Utilisation d'élafine dans le traitement de la covid-19

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746729A (en) * 1986-07-30 1988-05-24 Kuettner Klaus E Cartilage-derived leukocyte elastase-inhibitor
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
WO1990009737A1 (fr) * 1989-02-23 1990-09-07 The Center For Blood Research Inhibiteur de l'elastase humaine
NO177716C (no) * 1989-06-09 1995-11-08 Zeneca Ltd Fremgangsmåte for fremstilling av terapeutisk aktive polypeptider, DNA-sekvens, ekspresjonsvektor og antistoff

Also Published As

Publication number Publication date
EP0402068B1 (fr) 1995-12-13
DE69024104T2 (de) 1996-06-13
FI902880A0 (fi) 1990-06-08
NZ233974A (en) 1993-05-26
ES2080800T3 (es) 1996-02-16
DE69024104D1 (de) 1996-01-25
AU636148B2 (en) 1993-04-22
IL94602A0 (en) 1991-04-15
PT94326B (pt) 1997-01-31
US5464822A (en) 1995-11-07
AU5680890A (en) 1990-12-13
FI106471B (fi) 2001-02-15
CA2018592C (fr) 2002-08-27
PT94326A (pt) 1991-02-08
EP0402068A1 (fr) 1990-12-12
ATE131493T1 (de) 1995-12-15
IE70520B1 (en) 1996-12-11
JP2989853B2 (ja) 1999-12-13
US6893843B2 (en) 2005-05-17
NO177716B (no) 1995-07-31
NO902444L (no) 1990-12-10
NO177716C (no) 1995-11-08
US6245739B1 (en) 2001-06-12
GR3018401T3 (en) 1996-03-31
US20020187535A1 (en) 2002-12-12
DK0402068T3 (da) 1996-04-22
CA2018592A1 (fr) 1990-12-09
IE902006L (en) 1990-12-09
JPH03148299A (ja) 1991-06-25
NO902444D0 (no) 1990-06-01
US20060068480A1 (en) 2006-03-30

Similar Documents

Publication Publication Date Title
EP0402068B1 (fr) Polypeptides et analogues de polypeptides ayant une activité inhibitrice vis-à-vis de l'élastase humaine
Zanetti et al. The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics.
KR100243989B1 (ko) 사람 쿠니즈형 프로테아제 저해인자
JP2810743B2 (ja) アプロチニン同族体およびその製造方法
JP3345420B2 (ja) 新規のヒトクニツ型プロテアーゼインヒビター及びその変異体
JPH08505280A (ja) インターロイキン1βプロテアーゼおよびインターロイキン1βプロテアーゼ阻害剤
HU218104B (hu) Humán, Kunitz-típusú proteázgátló változatai
Tosi et al. Molecular cloning of human C1 inhibitor: sequence homologies with α1-antitrypsin and other members of the serpins superfamily
HUT70292A (en) Human kunitz-type protease inhibitor variants
HUT75358A (en) Methods of prouducing effective recombinant serine protease inhibitors and uses of these inhibitors
JPH0866194A (ja) ヒト腫瘍壊死因子ミューテインをコードする遺伝子
JP2916228B2 (ja) 遺伝子操作した組み換えアプロチニン変異型、均質に処理されたアプロチニン変異型の微生物調製の方法およびその治療学的使用
IE903245A1 (en) Proteins having anticoagulant activity
Bourbonnais et al. Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease
AU8172787A (en) Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same
JP2769083B2 (ja) エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
Dalbøge et al. Cloning and expression of an interleukin-1β precursor and its conversion to interleukin-1β
EP0264118B1 (fr) Méthode de préparation de protéines
CA1341318C (fr) Clones d'adn de l'inhibiteur de l'activateur du plasminogene placentaire humain
US5231010A (en) Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
EP0714408A1 (fr) Inhibiteurs de la tryptase
JP2623807B2 (ja) セリンプロテアーゼおよびセリンプロテアーゼ遺伝子
JPH0841098A (ja) 新規阻害剤
JPH1156365A (ja) 変異体ケクスタチン

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
HP Change in proprietorship
KB Patent renewed
KB Patent renewed