IL94830A - Pharmaceutical and antioxidative compositions containg indenoindoles some such compounds and process for their preparation - Google Patents

Pharmaceutical and antioxidative compositions containg indenoindoles some such compounds and process for their preparation

Info

Publication number: IL94830A
Authority: IL; Israel
Prior art keywords: indole; tetrahydro; cis; formula; thii
Prior art date: 1989-06-22

Application number

IL9483090A

Other languages

English (en)

Other versions

IL94830A0 (en

Original Assignee

Univ Bath

Univ Cincinnati

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-22

Filing date

1990-06-21

Publication date

1996-07-23

1990-06-21 Application filed by Univ Bath, Univ Cincinnati filed Critical Univ Bath

1991-04-15 Publication of IL94830A0 publication Critical patent/IL94830A0/xx

1996-07-23 Publication of IL94830A publication Critical patent/IL94830A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Toxicology (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL9483090A 1989-06-22 1990-06-21 Pharmaceutical and antioxidative compositions containg indenoindoles some such compounds and process for their preparation IL94830A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8902274A SE8902274D0 (sv)	1989-06-22	1989-06-22	Indenoidole compounds ii

Publications (2)

Publication Number	Publication Date
IL94830A0 IL94830A0 (en)	1991-04-15
IL94830A true IL94830A (en)	1996-07-23

Family

ID=20376370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9483090A IL94830A (en)	1989-06-22	1990-06-21	Pharmaceutical and antioxidative compositions containg indenoindoles some such compounds and process for their preparation

Country Status (34)

Country	Link
EP (1)	EP0409410B1 (is)
JP (1)	JP3064411B2 (is)
KR (1)	KR920702679A (is)
CN (1)	CN1033029C (is)
AT (1)	ATE135688T1 (is)
BG (1)	BG60317B2 (is)
CA (1)	CA2060897A1 (is)
DD (1)	DD297960A5 (is)
DE (1)	DE69025998T2 (is)
DK (1)	DK0409410T3 (is)
DZ (1)	DZ1428A1 (is)
ES (1)	ES2084660T3 (is)
FI (1)	FI100800B (is)
GR (1)	GR3019779T3 (is)
HR (1)	HRP920903B1 (is)
HU (1)	HUT59097A (is)
IE (1)	IE74682B1 (is)
IL (1)	IL94830A (is)
IS (1)	IS3590A7 (is)
LT (1)	LT3675B (is)
LV (1)	LV10253B (is)
MX (1)	MX21244A (is)
MY (1)	MY107311A (is)
NO (1)	NO177932C (is)
NZ (1)	NZ234175A (is)
PL (1)	PL167761B1 (is)
PT (1)	PT94468B (is)
RO (1)	RO111573B1 (is)
RU (1)	RU2104270C1 (is)
SE (1)	SE8902274D0 (is)
SI (1)	SI9011223B (is)
WO (1)	WO1990015799A1 (is)
YU (1)	YU122390A (is)
ZA (1)	ZA904827B (is)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU9301104D0 (en) *	1990-10-16	1993-07-28	Univ Bath	Method for producing tetrahydro-indeno-indole derivatves and pharmaceutical preparatives containing it
JPH0656669A (ja) *	1992-06-11	1994-03-01	Asahi Breweries Ltd	活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) *	1993-07-16	1993-07-16	Ab Astra	Use of indenoindole compounds
CA2128283A1 (fr) *	1993-07-20	1995-01-21	Paul Caubere	(thia)cycloalkyl¬b\|indoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6288099B1 (en)	1998-12-04	2001-09-11	American Home Products Corporation	Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
JP2002531569A (ja) *	1998-12-04	2002-09-24	ワイス	新規なカリウムチャンネル開放物質としての置換ベンゾフラノインドール及びインデノインドール
FR2826009B1 (fr) *	2001-06-13	2003-08-15	Servier Lab	Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2612442A1 (en)	2005-07-14	2007-01-18	Irm Llc	Heterotetracyclic compounds as tpo mimetics
DE102006047231B4 (de) *	2006-10-04	2009-02-12	Hemmerling, Hans-Jörg, Dr.	Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
EP2722042B1 (en) *	2011-06-16	2019-05-29	Korea Research Institute of Chemical Technology	Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
PT3882244T (pt)	2012-12-14	2025-04-04	Univ Leuven Kath	Composto, sal farmaceuticamente aceitável ou isómero ótico do mesmo, método para a sua preparação e composição farmacêutica para prevenção ou tratamento de doenças virais que contenha o mesmo como ingrediente ativo
KR102894005B1 (ko)	2020-04-20	2025-12-03	노파르티스 아게	항바이러스 1,3-다이-옥소-인덴 화합물
CN115916763B (zh)	2020-04-20	2025-06-03	诺华股份有限公司	抗病毒素1,3-二氧代茚化合物

1989
- 1989-06-22 SE SE8902274A patent/SE8902274D0/xx unknown
1990
- 1990-06-13 IS IS3590A patent/IS3590A7/is unknown
- 1990-06-20 HU HU904825A patent/HUT59097A/hu unknown
- 1990-06-20 CA CA002060897A patent/CA2060897A1/en not_active Abandoned
- 1990-06-20 JP JP2508940A patent/JP3064411B2/ja not_active Expired - Fee Related
- 1990-06-20 MX MX21244A patent/MX21244A/es unknown
- 1990-06-20 PL PL90285752A patent/PL167761B1/pl unknown
- 1990-06-20 RU SU5010937A patent/RU2104270C1/ru active
- 1990-06-20 AT AT90306718T patent/ATE135688T1/de active
- 1990-06-20 DZ DZ900114A patent/DZ1428A1/fr active
- 1990-06-20 EP EP90306718A patent/EP0409410B1/en not_active Expired - Lifetime
- 1990-06-20 WO PCT/GB1990/000949 patent/WO1990015799A1/en not_active Ceased
- 1990-06-20 RO RO149127A patent/RO111573B1/ro unknown
- 1990-06-20 DK DK90306718.9T patent/DK0409410T3/da active
- 1990-06-20 ES ES90306718T patent/ES2084660T3/es not_active Expired - Lifetime
- 1990-06-20 DE DE69025998T patent/DE69025998T2/de not_active Expired - Fee Related
- 1990-06-20 IE IE224790A patent/IE74682B1/en not_active IP Right Cessation
- 1990-06-21 IL IL9483090A patent/IL94830A/en not_active IP Right Cessation
- 1990-06-21 ZA ZA904827A patent/ZA904827B/xx unknown
- 1990-06-21 NZ NZ234175A patent/NZ234175A/xx unknown
- 1990-06-21 MY MYPI90001050A patent/MY107311A/en unknown
- 1990-06-21 DD DD90341939A patent/DD297960A5/de not_active IP Right Cessation
- 1990-06-22 YU YU122390A patent/YU122390A/sh unknown
- 1990-06-22 CN CN90104933A patent/CN1033029C/zh not_active Expired - Fee Related
- 1990-06-22 SI SI9011223A patent/SI9011223B/sl unknown
- 1990-06-22 PT PT94468A patent/PT94468B/pt not_active IP Right Cessation
1991
- 1991-12-19 FI FI915999A patent/FI100800B/fi active
- 1991-12-20 NO NO915049A patent/NO177932C/no unknown
- 1991-12-20 BG BG095667A patent/BG60317B2/bg unknown
- 1991-12-23 KR KR1019910701951A patent/KR920702679A/ko not_active Ceased
1992
- 1992-10-02 HR HRP-1223/90A patent/HRP920903B1/xx not_active IP Right Cessation
1993
- 1993-06-14 LV LVP-93-568A patent/LV10253B/xx unknown
- 1993-08-30 LT LTIP912A patent/LT3675B/lt not_active IP Right Cessation
1996
- 1996-04-29 GR GR960401159T patent/GR3019779T3/el unknown

Also Published As

Publication number	Publication date
MX21244A (es)	1994-03-31
BG60317B2 (bg)	1994-07-25
IE902247A1 (en)	1991-01-16
CN1033029C (zh)	1996-10-16
PL285752A1 (en)	1991-03-11
ES2084660T3 (es)	1996-05-16
NO915049D0 (no)	1991-12-20
HRP920903B1 (en)	1998-06-30
CN1051554A (zh)	1991-05-22
HRP920903A2 (hr)	1994-04-30
SI9011223B (sl)	1998-08-31
HUT59097A (en)	1992-04-28
NO915049L (no)	1992-02-21
IL94830A0 (en)	1991-04-15
SE8902274D0 (sv)	1989-06-22
NO177932B (no)	1995-09-11
EP0409410A1 (en)	1991-01-23
PT94468B (pt)	1997-12-31
DE69025998T2 (de)	1996-08-08
DE69025998D1 (de)	1996-04-25
LTIP912A (en)	1995-03-27
HU904825D0 (en)	1992-03-30
YU122390A (sh)	1992-09-07
IE74682B1 (en)	1997-07-30
WO1990015799A1 (en)	1990-12-27
MY107311A (en)	1995-11-30
IS3590A7 (is)	1990-12-23
EP0409410B1 (en)	1996-03-20
FI100800B (fi)	1998-02-27
DD297960A5 (de)	1992-01-30
RU2104270C1 (ru)	1998-02-10
ZA904827B (en)	1991-04-24
JP3064411B2 (ja)	2000-07-12
CA2060897A1 (en)	1990-12-23
GR3019779T3 (en)	1996-07-31
DZ1428A1 (fr)	2004-09-13
NZ234175A (en)	1992-12-23
JPH04505923A (ja)	1992-10-15
KR920702679A (ko)	1992-10-06
LV10253B (en)	1995-04-20
LV10253A (lv)	1994-10-20
SI9011223A (en)	1997-10-31
FI915999A0 (fi)	1991-12-19
DK0409410T3 (da)	1996-04-29
IE902247L (en)	1990-12-22
PT94468A (pt)	1991-02-08
PL167761B1 (pl)	1995-10-31
AU5836990A (en)	1991-01-08
LT3675B (en)	1996-01-25
AU644084B2 (en)	1993-12-02
RO111573B1 (ro)	1996-11-29
NO177932C (no)	1995-12-20
ATE135688T1 (de)	1996-04-15

Legal Events

Date	Code	Title
1996-12-05	FF	Patent granted
1997-03-18	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
EP0409410B1 (en)	1996-03-20	Indenoindole compounds
US5185360A (en)	1993-02-09	Dihydroindenoindole compounds and methods for using the same
US5516788A (en)	1996-05-14	Tetrahydroindenoindole compounds useful in the treatment of conditions associated with free radical formation
AP339A (en)	1994-05-02	Indenoindoles compounds.
AU644084C (en)	1995-01-05	Indenoindole compounds II
JPH11504616A (ja)	1999-04-27	ジベンズ［ｃｄ，ｆ］インドール誘導体
WO2003068741A1 (en)	2003-08-21	Indole derivatives substituted with long-chain alcohols and medicaments containing them