IL95196A - Method of discontinuous production of L-carnitine by a microbiological process - Google Patents

Method of discontinuous production of L-carnitine by a microbiological process

Info

Publication number: IL95196A
Authority: IL; Israel
Prior art keywords: carnitine; butyrobetaine; betaine; added; crotonobetaine
Prior art date: 1989-07-28

Application number

IL9519690A

Other languages

English (en)

Other versions

IL95196A0 (en

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-28

Filing date

1990-07-26

Publication date

1995-05-26

1990-07-26 Application filed by Lonza Ag filed Critical Lonza Ag

1991-06-10 Publication of IL95196A0 publication Critical patent/IL95196A0/xx

1995-05-26 Publication of IL95196A publication Critical patent/IL95196A/en

Links

238000000034 method Methods 0.000 title claims abstract description 32
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims description 43
238000004519 manufacturing process Methods 0.000 title claims description 10
230000002906 microbiologic effect Effects 0.000 title claims description 9
GUYHPGUANSLONG-SNAWJCMRSA-N (E)-4-(trimethylammonio)but-2-enoate Chemical compound C[N+](C)(C)C\C=C\C([O-])=O GUYHPGUANSLONG-SNAWJCMRSA-N 0.000 claims abstract description 20
229910052799 carbon Inorganic materials 0.000 claims description 27
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 25
KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 21
229910052757 nitrogen Inorganic materials 0.000 claims description 15
229960003237 betaine Drugs 0.000 claims description 12
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
244000005700 microbiome Species 0.000 claims description 7
239000001963 growth medium Substances 0.000 claims description 6
241000589180 Rhizobium Species 0.000 claims description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
241000589516 Pseudomonas Species 0.000 claims description 4
239000008103 glucose Substances 0.000 claims description 4
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
241000589158 Agrobacterium Species 0.000 claims description 2
241000588724 Escherichia coli Species 0.000 claims description 2
241000235070 Saccharomyces Species 0.000 claims description 2
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
150000007524 organic acids Chemical class 0.000 claims description 2
235000000346 sugar Nutrition 0.000 claims description 2
150000005846 sugar alcohols Chemical class 0.000 claims description 2
KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 3
JHPNVNIEXXLNTR-UHFFFAOYSA-O 4-(trimethylammonio)butanoic acid Chemical compound C[N+](C)(C)CCCC(O)=O JHPNVNIEXXLNTR-UHFFFAOYSA-O 0.000 abstract 1
239000000243 solution Substances 0.000 description 22
229910001868 water Inorganic materials 0.000 description 14
JHPNVNIEXXLNTR-UHFFFAOYSA-N 4-(trimethylammonio)butanoate Chemical compound C[N+](C)(C)CCCC([O-])=O JHPNVNIEXXLNTR-UHFFFAOYSA-N 0.000 description 12
239000000203 mixture Substances 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
239000002609 medium Substances 0.000 description 7
235000015097 nutrients Nutrition 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
239000002028 Biomass Substances 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 5
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
238000000909 electrodialysis Methods 0.000 description 4
238000004128 high performance liquid chromatography Methods 0.000 description 4
150000002500 ions Chemical class 0.000 description 4
-1 iron ions Chemical class 0.000 description 4
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
235000013343 vitamin Nutrition 0.000 description 4
239000011782 vitamin Substances 0.000 description 4
229940088594 vitamin Drugs 0.000 description 4
229930003231 vitamin Natural products 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
102000008109 Mixed Function Oxygenases Human genes 0.000 description 3
108010074633 Mixed Function Oxygenases Proteins 0.000 description 3
150000001768 cations Chemical class 0.000 description 3
230000002328 demineralizing effect Effects 0.000 description 3
235000013619 trace mineral Nutrition 0.000 description 3
239000011573 trace mineral Substances 0.000 description 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
229910014460 Ca-Fe Inorganic materials 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000002253 acid Substances 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
150000001450 anions Chemical class 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
238000005115 demineralization Methods 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
230000004151 fermentation Effects 0.000 description 2
229930195712 glutamate Natural products 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
238000005342 ion exchange Methods 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
229910052742 iron Inorganic materials 0.000 description 2
238000002955 isolation Methods 0.000 description 2
238000000746 purification Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
150000003722 vitamin derivatives Chemical class 0.000 description 2
PHIQHXFUZVPYII-LURJTMIESA-O (S)-carnitinium Chemical compound C[N+](C)(C)C[C@@H](O)CC(O)=O PHIQHXFUZVPYII-LURJTMIESA-O 0.000 description 1
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 1
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
102000016938 Catalase Human genes 0.000 description 1
108010053835 Catalase Proteins 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
229930195714 L-glutamate Natural products 0.000 description 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 1
241000221961 Neurospora crassa Species 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
241000589774 Pseudomonas sp. Species 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
239000005864 Sulphur Substances 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical group [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000012190 activator Substances 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
235000011114 ammonium hydroxide Nutrition 0.000 description 1
229940072107 ascorbate Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229940054333 biotin 2 mg Drugs 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
229960001231 choline Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
108700003601 dimethylglycine Proteins 0.000 description 1
YBGBJYVHJTVUSL-UHFFFAOYSA-L disodium;2-oxopentanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CCC(=O)C([O-])=O YBGBJYVHJTVUSL-UHFFFAOYSA-L 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
229940000252 folic acid 2 mg Drugs 0.000 description 1
238000010353 genetic engineering Methods 0.000 description 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
238000005259 measurement Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000007003 mineral medium Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229960003966 nicotinamide Drugs 0.000 description 1
235000005152 nicotinamide Nutrition 0.000 description 1
239000011570 nicotinamide Substances 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229960003581 pyridoxal Drugs 0.000 description 1
235000008164 pyridoxal Nutrition 0.000 description 1
239000011674 pyridoxal Substances 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
238000001223 reverse osmosis Methods 0.000 description 1
229940047034 riboflavin 5 mg Drugs 0.000 description 1
GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical compound [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940068459 sodium pantothenate Drugs 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
239000011721 thiamine Substances 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
229940047044 vitamin b 12 5 mg Drugs 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Magnetic Record Carriers (AREA)
Television Signal Processing For Recording (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

IL9519690A 1989-07-28 1990-07-26 Method of discontinuous production of L-carnitine by a microbiological process IL95196A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH281389		1989-07-28

Publications (2)

Publication Number	Publication Date
IL95196A0 IL95196A0 (en)	1991-06-10
IL95196A true IL95196A (en)	1995-05-26

Family

ID=4242178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9519690A IL95196A (en)	1989-07-28	1990-07-26	Method of discontinuous production of L-carnitine by a microbiological process

Country Status (15)

Country	Link
EP (1)	EP0410430B1 (fr)
JP (1)	JPH0751071B2 (fr)
AT (1)	ATE132535T1 (fr)
AU (1)	AU625525B2 (fr)
BR (1)	BR9003672A (fr)
CA (1)	CA2021869C (fr)
DD (1)	DD296702A5 (fr)
DE (1)	DE59010027D1 (fr)
DK (1)	DK0410430T3 (fr)
ES (1)	ES2081878T3 (fr)
FI (1)	FI102083B1 (fr)
IE (1)	IE902689A1 (fr)
IL (1)	IL95196A (fr)
MX (1)	MX170707B (fr)
NO (1)	NO178235C (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1261230B (it) *	1993-04-08	1996-05-09	Sigma Tau Ind Farmaceuti	Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
KR100346293B1 (ko) *	1993-10-08	2002-11-30	론자 아게	부티로베타인/크로토노베타인-l-카르니틴대사유전자와l-카르니틴의미생물학적제조에사용되는그것의용도
ZA200704132B (en) *	2004-11-09	2008-09-25	Univ Stellenbosch	Method of producing a carnitine-synthesising micro-organism
KR100713103B1 (ko) *	2005-07-07	2007-05-02	씨제이 주식회사	뉴로스포라 크라사 유래 ｌ-카르니틴 생합성 관련 유전자를포함하는 엔테로박테리아세 속 미생물 및 이를 이용한ｌ-카르니틴의 제조방법
US8604237B2 (en)	2009-11-18	2013-12-10	Lonza Ltd	Methods for the production of L-carnitine
EP2325164A1 (fr)	2009-11-18	2011-05-25	Lonza Ltd.	Procédés pour la production de L-carnitine
KR102329115B1 (ko)	2014-05-30	2021-11-19	엘지전자 주식회사	의류처리장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59192095A (ja) *	1983-04-13	1984-10-31	Ajinomoto Co Inc	Ｌ−カルニチンの製造法
FI86889C (fi) *	1984-03-29	1992-10-26	Lonza Ag	Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
CH664374A5 (de) *	1985-02-27	1988-02-29	Lonza Ag	Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.

1990
- 1990-07-24 CA CA002021869A patent/CA2021869C/fr not_active Expired - Lifetime
- 1990-07-24 MX MX021712A patent/MX170707B/es unknown
- 1990-07-24 IE IE268990A patent/IE902689A1/en not_active IP Right Cessation
- 1990-07-24 JP JP2196017A patent/JPH0751071B2/ja not_active Expired - Fee Related
- 1990-07-25 ES ES90114287T patent/ES2081878T3/es not_active Expired - Lifetime
- 1990-07-25 EP EP90114287A patent/EP0410430B1/fr not_active Expired - Lifetime
- 1990-07-25 DK DK90114287.7T patent/DK0410430T3/da active
- 1990-07-25 AT AT90114287T patent/ATE132535T1/de not_active IP Right Cessation
- 1990-07-25 DE DE59010027T patent/DE59010027D1/de not_active Expired - Lifetime
- 1990-07-26 FI FI903742A patent/FI102083B1/fi active IP Right Grant
- 1990-07-26 IL IL9519690A patent/IL95196A/en active IP Right Grant
- 1990-07-26 AU AU59837/90A patent/AU625525B2/en not_active Expired
- 1990-07-27 NO NO903338A patent/NO178235C/no not_active IP Right Cessation
- 1990-07-27 DD DD90343118A patent/DD296702A5/de not_active IP Right Cessation
- 1990-07-27 BR BR909003672A patent/BR9003672A/pt unknown

Also Published As

Publication number	Publication date
FI903742A0 (fi)	1990-07-26
IL95196A0 (en)	1991-06-10
EP0410430B1 (fr)	1996-01-03
ES2081878T3 (es)	1996-03-16
FI102083B (fi)	1998-10-15
JPH0376591A (ja)	1991-04-02
ATE132535T1 (de)	1996-01-15
FI102083B1 (fi)	1998-10-15
NO178235C (no)	1996-02-14
NO178235B (no)	1995-11-06
NO903338D0 (no)	1990-07-27
NO903338L (no)	1991-01-29
MX170707B (es)	1993-09-08
CA2021869A1 (fr)	1991-01-29
AU625525B2 (en)	1992-07-16
DK0410430T3 (da)	1996-01-29
DE59010027D1 (de)	1996-02-15
AU5983790A (en)	1991-01-31
IE902689A1 (en)	1991-02-27
CA2021869C (fr)	2000-09-05
BR9003672A (pt)	1991-08-27
DD296702A5 (de)	1991-12-12
EP0410430A2 (fr)	1991-01-30
JPH0751071B2 (ja)	1995-06-05
EP0410430A3 (en)	1991-08-21

Legal Events

Date	Code	Title
1996-10-31	FF	Patent granted
2000-10-31	KB	Patent renewed
2004-09-27	KB	Patent renewed
2008-11-27	KB	Patent renewed

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