IL95235A - PG031 protein and the process for its preparation - Google Patents

PG031 protein and the process for its preparation

Info

Publication number: IL95235A
Authority: IL; Israel
Prior art keywords: protein; receptor; human; cells; dna
Prior art date: 1989-08-03

Application number

IL9523590A

Other languages

English (en)

Hebrew (he)

Other versions

IL95235A0 (en

Original Assignee

Kishimoto Tadamitsu

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-03

Filing date

1990-07-30

Publication date

1995-11-27

1990-07-30 Application filed by Kishimoto Tadamitsu filed Critical Kishimoto Tadamitsu

1991-06-10 Publication of IL95235A0 publication Critical patent/IL95235A0/xx

1995-11-27 Publication of IL95235A publication Critical patent/IL95235A/en

Links

108090000623 proteins and genes Proteins 0.000 title claims abstract description 100
102000004169 proteins and genes Human genes 0.000 title claims abstract description 96
238000000034 method Methods 0.000 title claims abstract description 36
230000008569 process Effects 0.000 title claims abstract description 16
238000002360 preparation method Methods 0.000 title description 5
102000004889 Interleukin-6 Human genes 0.000 claims abstract description 85
108090001005 Interleukin-6 Proteins 0.000 claims abstract description 85
229940100601 interleukin-6 Drugs 0.000 claims abstract description 85
102000010781 Interleukin-6 Receptors Human genes 0.000 claims abstract description 68
108010038501 Interleukin-6 Receptors Proteins 0.000 claims abstract description 67
230000005540 biological transmission Effects 0.000 claims abstract description 20
238000001962 electrophoresis Methods 0.000 claims abstract description 5
238000004519 manufacturing process Methods 0.000 claims abstract description 5
229920002401 polyacrylamide Polymers 0.000 claims abstract 2
241000282414 Homo sapiens Species 0.000 claims description 41
125000003275 alpha amino acid group Chemical group 0.000 claims description 22
239000002773 nucleotide Substances 0.000 claims description 7
125000003729 nucleotide group Chemical group 0.000 claims description 7
239000013604 expression vector Substances 0.000 claims description 5
238000012258 culturing Methods 0.000 claims description 3
102000003839 Human Proteins Human genes 0.000 claims description 2
108090000144 Human Proteins Proteins 0.000 claims description 2
239000013613 expression plasmid Substances 0.000 abstract 2
101000599056 Homo sapiens Interleukin-6 receptor subunit beta Proteins 0.000 abstract 1
235000018102 proteins Nutrition 0.000 description 81
210000004027 cell Anatomy 0.000 description 73
108020004414 DNA Proteins 0.000 description 18
108091028043 Nucleic acid sequence Proteins 0.000 description 17
239000002299 complementary DNA Substances 0.000 description 15
101001076408 Homo sapiens Interleukin-6 Proteins 0.000 description 14
210000000170 cell membrane Anatomy 0.000 description 14
102000052611 human IL6 Human genes 0.000 description 13
102000005962 receptors Human genes 0.000 description 12
108020003175 receptors Proteins 0.000 description 12
210000004748 cultured cell Anatomy 0.000 description 8
206010035226 Plasma cell myeloma Diseases 0.000 description 7
239000013592 cell lysate Substances 0.000 description 7
108020004999 messenger RNA Proteins 0.000 description 7
201000000050 myeloid neoplasm Diseases 0.000 description 7
210000001744 T-lymphocyte Anatomy 0.000 description 6
125000000539 amino acid group Chemical group 0.000 description 6
238000000376 autoradiography Methods 0.000 description 6
238000010353 genetic engineering Methods 0.000 description 6
239000000126 substance Substances 0.000 description 6
239000013598 vector Substances 0.000 description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
210000003719 b-lymphocyte Anatomy 0.000 description 5
238000007796 conventional method Methods 0.000 description 5
238000011534 incubation Methods 0.000 description 5
244000005700 microbiome Species 0.000 description 5
239000013612 plasmid Substances 0.000 description 5
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
235000001014 amino acid Nutrition 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 description 4
UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 4
239000012528 membrane Substances 0.000 description 4
230000035755 proliferation Effects 0.000 description 4
238000011160 research Methods 0.000 description 4
239000000523 sample Substances 0.000 description 4
238000012216 screening Methods 0.000 description 4
239000007787 solid Substances 0.000 description 4
238000000636 Northern blotting Methods 0.000 description 3
229920002684 Sepharose Polymers 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
210000004408 hybridoma Anatomy 0.000 description 3
230000002209 hydrophobic effect Effects 0.000 description 3
238000002955 isolation Methods 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
230000006798 recombination Effects 0.000 description 3
238000005215 recombination Methods 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
108700031361 Brachyury Proteins 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
102000018697 Membrane Proteins Human genes 0.000 description 2
108010052285 Membrane Proteins Proteins 0.000 description 2
101001076414 Mus musculus Interleukin-6 Proteins 0.000 description 2
108010076504 Protein Sorting Signals Proteins 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
230000004913 activation Effects 0.000 description 2
150000001413 amino acids Chemical group 0.000 description 2
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
210000004899 c-terminal region Anatomy 0.000 description 2
238000010367 cloning Methods 0.000 description 2
239000012228 culture supernatant Substances 0.000 description 2
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 2
230000008021 deposition Effects 0.000 description 2
230000004069 differentiation Effects 0.000 description 2
239000003814 drug Substances 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
230000004151 fermentation Effects 0.000 description 2
239000012634 fragment Substances 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
238000009396 hybridization Methods 0.000 description 2
238000001114 immunoprecipitation Methods 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
230000003834 intracellular effect Effects 0.000 description 2
229960004452 methionine Drugs 0.000 description 2
230000035515 penetration Effects 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
238000000746 purification Methods 0.000 description 2
230000003362 replicative effect Effects 0.000 description 2
108091008146 restriction endonucleases Proteins 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
229940104230 thymidine Drugs 0.000 description 2
108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
208000011691 Burkitt lymphomas Diseases 0.000 description 1
238000011740 C57BL/6 mouse Methods 0.000 description 1
241000283707 Capra Species 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
108091026890 Coding region Proteins 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
241000699802 Cricetulus griseus Species 0.000 description 1
241000701022 Cytomegalovirus Species 0.000 description 1
241001131785 Escherichia coli HB101 Species 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
101000984200 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily A member 3 Proteins 0.000 description 1
102000002265 Human Growth Hormone Human genes 0.000 description 1
108010000521 Human Growth Hormone Proteins 0.000 description 1
239000000854 Human Growth Hormone Substances 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
102100025556 Leukocyte immunoglobulin-like receptor subfamily A member 3 Human genes 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
108090000143 Mouse Proteins Proteins 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241001494479 Pecora Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000011543 agarose gel Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
238000013459 approach Methods 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
239000012295 chemical reaction liquid Substances 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
230000007123 defense Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
230000004927 fusion Effects 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
230000011132 hemopoiesis Effects 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000003053 immunization Effects 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
239000012907 medicinal substance Substances 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
239000000178 monomer Substances 0.000 description 1
229940126619 mouse monoclonal antibody Drugs 0.000 description 1
210000000822 natural killer cell Anatomy 0.000 description 1
239000005445 natural material Substances 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
210000000287 oocyte Anatomy 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
239000000047 product Substances 0.000 description 1
239000012264 purified product Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000004366 reverse phase liquid chromatography Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000008054 signal transmission Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
210000004989 spleen cell Anatomy 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Plant Pathology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9523590A 1989-08-03 1990-07-30 PG031 protein and the process for its preparation IL95235A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP20023089		1989-08-03
JP2140069A JP2898064B2 (ja)	1989-08-03	1990-05-31	ヒトｇｐ１３０蛋白質

Publications (2)

Publication Number	Publication Date
IL95235A0 IL95235A0 (en)	1991-06-10
IL95235A true IL95235A (en)	1995-11-27

Family

ID=26472699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9523590A IL95235A (en)	1989-08-03	1990-07-30	PG031 protein and the process for its preparation

Country Status (10)

Country	Link
US (1)	US5132403A (de)
EP (1)	EP0411946B1 (de)
JP (1)	JP2898064B2 (de)
KR (1)	KR0178384B1 (de)
AT (1)	ATE147099T1 (de)
AU (1)	AU635296B2 (de)
CA (1)	CA2022610C (de)
DE (1)	DE69029545T2 (de)
ES (1)	ES2096580T3 (de)
IL (1)	IL95235A (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5262522A (en) *	1991-11-22	1993-11-16	Immunex Corporation	Receptor for oncostatin M and leukemia inhibitory factor
BR9206940A (pt) *	1991-12-18	1995-11-28	Icu Medical Inc	Válvula médica
JPH05304986A (ja) *	1992-04-28	1993-11-19	Tosoh Corp	ｇｐ１３０蛋白質に対するモノクロ−ナル抗体
IT1261787B (it) *	1993-06-23	1996-06-03	Angeletti P Ist Richerche Bio	Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.
US5891998A (en) *	1993-06-23	1999-04-06	Istituto Di Ricerche Di Biologica Molecolare P. Angeletti S.P.A.	Interleukin-6 receptor agonists
US5783672A (en) *	1994-05-26	1998-07-21	Immunex Corporation	Receptor for oncostatin M
US5952748A (en) *	1994-06-23	1999-09-14	Elin Motoren Gmbh	High speed motor with two-phase cooling system
GB9419021D0 (en) *	1994-09-21	1994-11-09	Applied Research Systems	Therapeutic protein
PT783893E (pt)	1994-10-07	2012-05-24	Chugai Pharmaceutical Co Ltd	Inibição do crescimento anormal das células sinoviais usando antagonistas de il-6 como componente ativo
JP3458512B2 (ja)	1995-02-23	2003-10-20	東ソー株式会社	骨密度の変動推定方法又は骨そしょう症の診断方法及びこれに用いる試薬キット
US5674995A (en) *	1995-06-07	1997-10-07	Gen-Probe Incorporated	Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5747470A (en) *	1995-06-07	1998-05-05	Gen-Probe Incorporated	Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
AU705122B2 (en) *	1995-06-07	1999-05-13	Gen-Probe Incorporated	Oligonucleotides specific for cytokine signal transducer gp130 mRNA
JP3824173B2 (ja) *	1995-11-07	2006-09-20	株式会社カネカ	自己抗原
EP2011514B1 (de)	1997-03-21	2012-02-29	Chugai Seiyaku Kabushiki Kaisha	Präventives oder therapeutisches Mittel mit einem IL-6-Antagonisten als Wirkstoff für durch sensibilisierte T-Zellen vermittelte Erkrankungen
AU4952400A (en)	1999-06-02	2000-12-28	Chugai Research Institute For Molecular Medicine, Inc.	Novel hemopoietin receptor protein nr10
AU7078200A (en) *	1999-08-27	2001-03-26	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
DE60025241T2 (de)	1999-09-27	2007-01-11	Chugai Seiyaku K.K.	HäMOPOIETINREZEPTOR-PROTEIN, NR12
US7175988B2 (en) *	2001-02-09	2007-02-13	Human Genome Sciences, Inc.	Human G-protein Chemokine Receptor (CCR5) HDGNR10
UA80091C2 (en)	2001-04-02	2007-08-27	Chugai Pharmaceutical Co Ltd	Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
GB0210539D0 (en) *	2002-05-08	2002-06-19	Univ Edinburgh	Control of es cell self renewal and lineage specification, and medium therefor
GB2401040A (en)	2003-04-28	2004-11-03	Chugai Pharmaceutical Co Ltd	Method for treating interleukin-6 related diseases
US8470316B2 (en)	2005-10-14	2013-06-25	Chugai Seiyaku Kabushiki Kaisha	Agents for suppressing damage to transplanted islets after islet transplantation
JP4837358B2 (ja) *	2005-10-19	2011-12-14	株式会社野村工電社	ボトル飲用水充填装置
US8945558B2 (en)	2005-10-21	2015-02-03	Chugai Seiyaku Kabushiki Kaisha	Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
AR057582A1 (es)	2005-11-15	2007-12-05	Nat Hospital Organization	Agentes para suprimir la induccion de linfocitos t citotoxicos
TW200803894A (en)	2005-11-25	2008-01-16	Univ Keio	Prostate cancer therapeutic agents
US8771686B2 (en)	2006-01-27	2014-07-08	Chugai Seiyaku Kabushiki Kaisha	Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody
EP2025346B1 (de)	2006-04-07	2016-08-10	Osaka University	Mittel zur förderung der muskelregeneration
CN103272232B (zh)	2006-06-08	2018-07-24	中外制药株式会社	炎性疾病的预防或治疗药
WO2008020079A1 (en)	2006-08-18	2008-02-21	Ablynx N.V.	Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
US9725514B2 (en)	2007-01-23	2017-08-08	Shinshu University	Chronic rejection inhibitor
US20080283557A1 (en) *	2007-05-17	2008-11-20	Julianne Desautels	Spout for food stuff container
CN101939025B (zh)	2007-12-05	2015-03-25	中外制药株式会社	搔痒症治疗药
TWI528973B (zh)	2008-06-05	2016-04-11	Chugai Pharmaceutical Co Ltd	Nerve infiltration inhibitor
EP2226633A1 (de)	2009-03-06	2010-09-08	Charité - Universitätsmedizin Berlin	Verwendungen und Verfahren zur Identifikation einer zytoprotektiven Verbindung mit gp130 oder LIFRalpha
KR101470690B1 (ko)	2009-04-10	2014-12-10	아블린쓰 엔.브이.	Ｉｌ－６ｒ에 대한 개선된 아미노산 서열 및 ｉｌ－６ｒ 관련 질환 및 질병의 치료를 위한 그를 포함하는 폴리펩티드
WO2010115995A2 (en)	2009-04-10	2010-10-14	Ablynx Nv	Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
WO2011149046A1 (ja)	2010-05-28	2011-12-01	独立行政法人国立がん研究センター	膵癌治療剤
HRP20221490T1 (hr)	2010-05-28	2023-02-03	Chugai Seiyaku Kabushiki Kaisha	Poboljšanje antitumorskog odgovora t stanice
EP3311837A1 (de)	2011-09-23	2018-04-25	Ablynx NV	Verlängerte hemmung der interleukin-6-vermittelten signalisierung
WO2014200018A1 (ja)	2013-06-11	2014-12-18	独立行政法人国立精神・神経医療研究センター	再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法
EP3209327A1 (de)	2014-10-21	2017-08-30	Ablynx N.V.	Behandlung von il-6r-bedingten erkrankungen
TWI805046B (zh)	2015-02-27	2023-06-11	日商中外製藥股份有限公司	Il-6受體抗體用於製備醫藥組成物的用途
EP3620531A4 (de)	2017-05-02	2021-03-17	National Center of Neurology and Psychiatry	Verfahren zur vorhersage und beurteilung der therapeutischen wirkung bei erkrankungen im zusammenhang mit il-6 und neutrophilen
WO2019151418A1 (ja)	2018-01-31	2019-08-08	元一加藤	Ｉｌ－６阻害剤を含有する喘息の治療剤
JP7501876B2 (ja)	2019-04-17	2024-06-18	国立大学法人広島大学	Ｉｌ－６阻害剤及びｃｃｒ２阻害剤を組み合わせて投与することを特徴とする泌尿器がんの治療剤
CA3156713A1 (en)	2019-11-20	2021-05-27	Daisuke Kameoka	Antibody-containing preparation
KR102351174B1 (ko) *	2020-05-11	2022-01-14	(주)아이테오솔루션즈	랜 포트의 혼동을 방지하는 어댑터 및 이를 포함하는 랜 포트 보안 장치
US11897951B2 (en)	2020-12-18	2024-02-13	Ablynx N.V.	Polypeptides comprising immunoglobulin single variable domains targeting IL-6 and TNF-α

1990
- 1990-05-31 JP JP2140069A patent/JP2898064B2/ja not_active Expired - Lifetime
- 1990-07-30 IL IL9523590A patent/IL95235A/en active IP Right Grant
- 1990-07-31 AU AU60039/90A patent/AU635296B2/en not_active Expired
- 1990-08-01 KR KR1019900011808A patent/KR0178384B1/ko not_active Expired - Lifetime
- 1990-08-02 AT AT90308530T patent/ATE147099T1/de not_active IP Right Cessation
- 1990-08-02 ES ES90308530T patent/ES2096580T3/es not_active Expired - Lifetime
- 1990-08-02 DE DE69029545T patent/DE69029545T2/de not_active Expired - Lifetime
- 1990-08-02 EP EP90308530A patent/EP0411946B1/de not_active Expired - Lifetime
- 1990-08-02 US US07/561,564 patent/US5132403A/en not_active Expired - Lifetime
- 1990-08-02 CA CA002022610A patent/CA2022610C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69029545D1 (de)	1997-02-13
CA2022610A1 (en)	1991-02-04
EP0411946A2 (de)	1991-02-06
IL95235A0 (en)	1991-06-10
KR910004801A (ko)	1991-03-29
ES2096580T3 (es)	1997-03-16
KR0178384B1 (ko)	1999-04-01
DE69029545T2 (de)	1997-07-24
JPH0429997A (ja)	1992-01-31
AU6003990A (en)	1991-02-07
ATE147099T1 (de)	1997-01-15
EP0411946A3 (en)	1992-02-12
AU635296B2 (en)	1993-03-18
CA2022610C (en)	2001-01-30
US5132403A (en)	1992-07-21
JP2898064B2 (ja)	1999-05-31
EP0411946B1 (de)	1997-01-02

Legal Events

Date	Code	Title
1996-05-14	FF	Patent granted
1996-10-31	FF	Patent granted
2004-09-27	KB	Patent renewed
2008-11-27	KB	Patent renewed

Publication	Publication Date	Title
US5132403A (en)	1992-07-21	Human gp130 protein
CA2021594C (en)	2002-01-08	Antibody to human interleukin-6 receptor
JP2866706B2 (ja)	1999-03-08	腫瘍壊死因子結合蛋白
KR0144861B1 (ko)	1998-07-01	인간 b세포 자극인자-2에 대한 수용체 단백질
US5670373A (en)	1997-09-23	Antibody to human interleukin-6 receptor
US7211259B1 (en)	2007-05-01	4-1BB polypeptides and DNA encoding 4-1BB polypeptides
EP0760857B9 (de)	2006-09-06	Onkostatin- m rezeptor
JP3255699B2 (ja)	2002-02-12	ヒトＩＬ−２レセプターγ鎖分子
JPH04164099A (ja)	1992-06-09	Ｔｎｆ結合タンパク質
JP2898040B2 (ja)	1999-05-31	ｇｐ１３０蛋白質に対する抗体
IE903467A1 (en)	1991-04-10	Granulocyte-colony stimulating factor receptors
KR20040075105A (ko)	2004-08-26	인터페론 α 활성을 선택적으로 차단하는 인터페론α/β수용체에 대한 항체
US5821078A (en)	1998-10-13	Nucleic acid encoding interferon-α/β binding protein
US5358867A (en)	1994-10-25	DNA cloning and expression of an L7 protein which modulates the 2'-5' oligosynthetase and H2-K*K response to type-I interferon
US5223611A (en)	1993-06-29	DNA encoding for human GP130 protein
KR100382628B1 (ko)	2004-02-25	인터페론α/β결합단백질과이의제조및용도
CA2071622A1 (en)	1992-12-22	Anti-tcf-ii monoclonal antibodies and method for the measurement of tcf-ii by applying the antibodies
EP0265847B1 (de)	1994-09-14	Mit dem TRF (Interleukin-5) reagierender monoklonaler Antikörper
IE902930A1 (en)	1991-02-27	Human gp130 protein
Chapot et al.	1989	A monoclonal antibody directed against the β1-adrenergic receptor from turkey erythrocyte membranes
KR100255331B1 (ko)	2000-05-01	인간 b세포 자극인자-2에 대한 수용체 단백질에 특이적인 항체 및 이를 생산하는 하이브리도마
Carter	1987	Assessment of binding domains of mouse interferon gamma using synthetic peptides and antibodies
JPH05244990A (ja)	1993-09-24	ラットｉｌ−１抗体及びラットｉｌ−１の測定法