IL95638A - 2-Substituted-5, 6-dialkyl-4, 5, 6, 7-tetrahydroimidazo (4,5,1-jk)-(1,4)-benzodiazepines, their preparation and pharmaceutical compositions containing them and some novel intermediates therefor - Google Patents

2-Substituted-5, 6-dialkyl-4, 5, 6, 7-tetrahydroimidazo (4,5,1-jk)-(1,4)-benzodiazepines, their preparation and pharmaceutical compositions containing them and some novel intermediates therefor

Info

Publication number: IL95638A
Authority: IL; Israel
Prior art keywords: formula; hydrogen; reaction; compound; aryl
Prior art date: 1989-09-13

Application number

IL9563890A

Other languages

English (en)

Other versions

IL95638A0 (en

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-13

Filing date

1990-09-11

Publication date

1995-01-24

1990-09-11 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1990-09-11 Priority to IL10807490A priority Critical patent/IL108074A/en

1991-06-30 Publication of IL95638A0 publication Critical patent/IL95638A0/xx

1993-12-17 Priority to IL10807493A priority patent/IL108074A0/xx

1995-01-24 Publication of IL95638A publication Critical patent/IL95638A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL9563890A 1989-09-13 1990-09-11 2-Substituted-5, 6-dialkyl-4, 5, 6, 7-tetrahydroimidazo (4,5,1-jk)-(1,4)-benzodiazepines, their preparation and pharmaceutical compositions containing them and some novel intermediates therefor IL95638A (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IL10807490A IL108074A (en)	1989-09-13	1990-09-11	5-alkyl-2,3,4,5- tetrahydro-1h-(1,4) benzodiazepin-5-amine derivatives
IL10807493A IL108074A0 (en)	1989-09-13	1993-12-17	Tetrahydro (1.4) benzodiazepines

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40662589A	1989-09-13	1989-09-13

Publications (2)

Publication Number	Publication Date
IL95638A0 IL95638A0 (en)	1991-06-30
IL95638A true IL95638A (en)	1995-01-24

Family

ID=23608794

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL9563890A IL95638A (en)	1989-09-13	1990-09-11	2-Substituted-5, 6-dialkyl-4, 5, 6, 7-tetrahydroimidazo (4,5,1-jk)-(1,4)-benzodiazepines, their preparation and pharmaceutical compositions containing them and some novel intermediates therefor
IL10807490A IL108074A (en)	1989-09-13	1990-09-11	5-alkyl-2,3,4,5- tetrahydro-1h-(1,4) benzodiazepin-5-amine derivatives
IL10807493A IL108074A0 (en)	1989-09-13	1993-12-17	Tetrahydro (1.4) benzodiazepines

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL10807490A IL108074A (en)	1989-09-13	1990-09-11	5-alkyl-2,3,4,5- tetrahydro-1h-(1,4) benzodiazepin-5-amine derivatives
IL10807493A IL108074A0 (en)	1989-09-13	1993-12-17	Tetrahydro (1.4) benzodiazepines

Country Status (30)

Country	Link
EP (2)	EP0417840B1 (de)
JP (1)	JPH05500053A (de)
KR (1)	KR927003596A (de)
CN (1)	CN1029971C (de)
AP (1)	AP174A (de)
AT (1)	ATE115144T1 (de)
AU (1)	AU635328B2 (de)
BG (1)	BG60681B1 (de)
CA (1)	CA2064782A1 (de)
DE (1)	DE69014784T2 (de)
DK (1)	DK0417840T3 (de)
ES (1)	ES2067652T3 (de)
FI (1)	FI98816C (de)
GR (1)	GR3015270T3 (de)
HU (1)	HUT62297A (de)
IE (1)	IE65357B1 (de)
IL (3)	IL95638A (de)
MA (1)	MA21948A1 (de)
MY (1)	MY106961A (de)
NO (1)	NO300328B1 (de)
NZ (1)	NZ235137A (de)
OA (1)	OA09565A (de)
PT (1)	PT95303B (de)
RO (1)	RO109199B1 (de)
RU (1)	RU2099341C1 (de)
TN (1)	TNSN90121A1 (de)
TW (1)	TW199160B (de)
WO (1)	WO1991004255A1 (de)
YU (1)	YU169090A (de)
ZA (1)	ZA907278B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ238664A (en) *	1990-07-06	1992-12-23	Janssen Pharmaceutica Nv	Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
GB9018601D0 (en) *	1990-08-24	1990-10-10	Fujisawa Pharmaceutical Co	Tricyclic compounds
EP0475231A1 (de) *	1990-09-10	1992-03-18	F. Hoffmann-La Roche Ag	Benzodiazepine
US7067148B2 (en)	2001-02-15	2006-06-27	King Pharmaceutical Research & Development, Inc.	Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4075206A (en) *	1977-02-25	1978-02-21	Eli Lilly And Company	Substituted pyrroloquinoxalinones and diones
GB8806449D0 (en) *	1988-03-18	1988-04-20	Janssen Pharmaceutica Nv	Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) *	1989-02-23	1995-01-24	Janssen Pharmaceutica Nv	Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them

1990
- 1990-08-31 NZ NZ235137A patent/NZ235137A/en unknown
- 1990-09-05 YU YU169090A patent/YU169090A/sh unknown
- 1990-09-06 JP JP2512169A patent/JPH05500053A/ja active Pending
- 1990-09-06 RU SU925011526A patent/RU2099341C1/ru active
- 1990-09-06 DE DE69014784T patent/DE69014784T2/de not_active Expired - Lifetime
- 1990-09-06 DK DK90202369.6T patent/DK0417840T3/da active
- 1990-09-06 AU AU62934/90A patent/AU635328B2/en not_active Ceased
- 1990-09-06 RO RO92-200221A patent/RO109199B1/ro unknown
- 1990-09-06 ES ES90202369T patent/ES2067652T3/es not_active Expired - Lifetime
- 1990-09-06 AT AT90202369T patent/ATE115144T1/de not_active IP Right Cessation
- 1990-09-06 HU HU92816A patent/HUT62297A/hu unknown
- 1990-09-06 WO PCT/EP1990/001546 patent/WO1991004255A1/en not_active Ceased
- 1990-09-06 KR KR1019920700394A patent/KR927003596A/ko not_active Ceased
- 1990-09-06 CA CA002064782A patent/CA2064782A1/en not_active Abandoned
- 1990-09-06 EP EP90202369A patent/EP0417840B1/de not_active Expired - Lifetime
- 1990-09-06 EP EP90913194A patent/EP0491751A1/de active Pending
- 1990-09-10 MA MA22220A patent/MA21948A1/fr unknown
- 1990-09-11 MY MYPI90001567A patent/MY106961A/en unknown
- 1990-09-11 AP APAP/P/1990/000205A patent/AP174A/en active
- 1990-09-11 IL IL9563890A patent/IL95638A/en not_active IP Right Cessation
- 1990-09-11 IL IL10807490A patent/IL108074A/en not_active IP Right Cessation
- 1990-09-12 IE IE331390A patent/IE65357B1/en not_active IP Right Cessation
- 1990-09-12 ZA ZA907278A patent/ZA907278B/xx unknown
- 1990-09-13 CN CN90107656A patent/CN1029971C/zh not_active Expired - Fee Related
- 1990-09-13 TN TNTNSN90121A patent/TNSN90121A1/fr unknown
- 1990-09-13 PT PT95303A patent/PT95303B/pt not_active IP Right Cessation
- 1990-10-08 TW TW079108420A patent/TW199160B/zh active
1992
- 1992-02-07 NO NO920505A patent/NO300328B1/no unknown
- 1992-03-12 BG BG96041A patent/BG60681B1/bg unknown
- 1992-03-12 FI FI921070A patent/FI98816C/fi not_active IP Right Cessation
- 1992-03-13 OA OA60163A patent/OA09565A/fr unknown
1993
- 1993-12-17 IL IL10807493A patent/IL108074A0/xx unknown
1995
- 1995-03-03 GR GR940403886T patent/GR3015270T3/el unknown

Also Published As

Publication number	Publication date
AU6293490A (en)	1991-04-18
TW199160B (de)	1993-02-01
PT95303A (pt)	1991-05-22
YU169090A (sh)	1993-10-20
IE903313A1 (en)	1991-04-10
BG96041A (bg)	1993-12-24
RO109199B1 (ro)	1994-12-30
CN1029971C (zh)	1995-10-11
ZA907278B (en)	1992-05-27
IE65357B1 (en)	1995-10-18
NO300328B1 (no)	1997-05-12
NO920505D0 (no)	1992-02-07
EP0491751A1 (de)	1992-07-01
MY106961A (en)	1995-08-30
EP0417840B1 (de)	1994-12-07
MA21948A1 (fr)	1991-04-01
WO1991004255A1 (en)	1991-04-04
AP174A (en)	1992-03-16
FI921070A0 (fi)	1992-03-12
EP0417840A1 (de)	1991-03-20
OA09565A (fr)	1993-01-31
CA2064782A1 (en)	1991-03-14
DK0417840T3 (da)	1995-02-13
DE69014784T2 (de)	1995-04-13
ES2067652T3 (es)	1995-04-01
FI98816C (fi)	1997-08-25
IL95638A0 (en)	1991-06-30
GR3015270T3 (en)	1995-06-30
AU635328B2 (en)	1993-03-18
CN1050192A (zh)	1991-03-27
PT95303B (pt)	1997-06-30
AP9000205A0 (en)	1990-10-31
TNSN90121A1 (fr)	1991-03-05
DE69014784D1 (de)	1995-01-19
ATE115144T1 (de)	1994-12-15
NZ235137A (en)	1992-02-25
FI98816B (fi)	1997-05-15
NO920505L (no)	1992-02-07
IL108074A0 (en)	1994-04-12
BG60681B1 (bg)	1995-12-29
HUT62297A (en)	1993-04-28
RU2099341C1 (ru)	1997-12-20
JPH05500053A (ja)	1993-01-14
KR927003596A (ko)	1992-12-18
IL108074A (en)	1995-06-29

Legal Events

Date	Code	Title	Description
1996-11-14	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
EP0384522B1 (de)	1993-01-13	Antivirale Tetrahydroimidazo[1,4]benzodiazepin-2-thione
EP0336466B1 (de)	1992-12-30	Antivirale Tetrahydroimidazo(1,4)benzodiazepin-2-one
AU635328B2 (en)	1993-03-18	Antiviral tetrahydroimidazo (1,4) benzodiazepines
AP262A (en)	1993-06-03	Novel antiviral tetrahydroimidazo (1,4) benzodiazepin-2-(thi) ones.
US6201119B1 (en)	2001-03-13	Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2(thi) ones