IL96124A - Method for solubilization and naturation of somatotropins utilizing low urea concentration - Google Patents

Method for solubilization and naturation of somatotropins utilizing low urea concentration

Info

Publication number: IL96124A
Authority: IL; Israel
Prior art keywords: naturation; somatotropins; solubilization; urea concentration; utilizing low
Prior art date: 1989-12-05

Application number

IL96124A

Other languages

English (en)

Other versions

IL96124A0 (en

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-05

Filing date

1990-10-25

Publication date

1998-06-15

1990-10-25 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1991-07-18 Publication of IL96124A0 publication Critical patent/IL96124A0/xx

1998-06-15 Publication of IL96124A publication Critical patent/IL96124A/xx

Links

238000000034 method Methods 0.000 title abstract 3
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title abstract 2
239000004202 carbamide Substances 0.000 title abstract 2
230000007928 solubilization Effects 0.000 title abstract 2
238000005063 solubilization Methods 0.000 title abstract 2
239000012670 alkaline solution Substances 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Crystallography & Structural Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Beans For Foods Or Fodder (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Fertilizers (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

IL96124A 1989-12-05 1990-10-25 Method for solubilization and naturation of somatotropins utilizing low urea concentration IL96124A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US44628089A	1989-12-05	1989-12-05

Publications (2)

Publication Number	Publication Date
IL96124A0 IL96124A0 (en)	1991-07-18
IL96124A true IL96124A (en)	1998-06-15

Family

ID=23772005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL96124A IL96124A (en)	1989-12-05	1990-10-25	Method for solubilization and naturation of somatotropins utilizing low urea concentration

Country Status (16)

Country	Link
EP (1)	EP0432419B1 (da)
JP (1)	JPH03181500A (da)
KR (1)	KR0160975B1 (da)
AT (1)	ATE113060T1 (da)
AU (1)	AU628695B2 (da)
CA (1)	CA2031369A1 (da)
DE (1)	DE69013475T2 (da)
DK (1)	DK0432419T3 (da)
ES (1)	ES2062253T3 (da)
FI (1)	FI97296C (da)
HU (1)	HU214249B (da)
IE (1)	IE66142B1 (da)
IL (1)	IL96124A (da)
NZ (1)	NZ236141A (da)
PT (1)	PT96058B (da)
ZA (1)	ZA909745B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU674568B2 (en) *	1993-02-04	1997-01-02	Anaphore, Inc.	Improved method for the refolding of proteins
US5912327A (en) *	1996-09-30	1999-06-15	Human Genome Sciences, Inc.	Method of purifying chemokines from inclusion bodies
US6632425B1 (en)	1997-03-20	2003-10-14	Human Genome Sciences, Inc.	Chemokine compositions
BRPI9913018B8 (pt) *	1998-08-27	2021-07-06	Lg Chemical Ltd	processo para a preparaÇço de somatotropina ativa a partir de corpésculos de inclusço.
DE10044360A1 (de)	2000-09-08	2002-03-21	Merck Patent Gmbh	Verfahren zur Aufreinigung von rekombinanten als unlösliche Aggregate exprimierte Proteinen
US20040116663A1 (en) *	2001-01-16	2004-06-17	Soren Buus	Method for refolding of proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1267615A (en) *	1984-08-27	1990-04-10	Dan Hadary	Method for recovering purified growth hormones from genetically engineered microorganisms
AU612133B2 (en) *	1987-02-20	1991-07-04	Natinco Nv	Production of proteins in active forms
JPH01257491A (ja) *	1988-04-08	1989-10-13	Tosoh Corp	不溶性融合異種蛋白質の処理方法

1990
- 1990-10-23 DK DK90120309.1T patent/DK0432419T3/da active
- 1990-10-23 DE DE69013475T patent/DE69013475T2/de not_active Expired - Fee Related
- 1990-10-23 AT AT90120309T patent/ATE113060T1/de not_active IP Right Cessation
- 1990-10-23 EP EP90120309A patent/EP0432419B1/en not_active Expired - Lifetime
- 1990-10-23 ES ES90120309T patent/ES2062253T3/es not_active Expired - Lifetime
- 1990-10-25 IL IL96124A patent/IL96124A/xx active IP Right Grant
- 1990-11-20 NZ NZ236141A patent/NZ236141A/xx unknown
- 1990-11-21 IE IE420490A patent/IE66142B1/en not_active IP Right Cessation
- 1990-11-27 KR KR1019900019285A patent/KR0160975B1/ko not_active Expired - Fee Related
- 1990-11-30 JP JP2331005A patent/JPH03181500A/ja active Pending
- 1990-12-03 CA CA002031369A patent/CA2031369A1/en not_active Abandoned
- 1990-12-03 PT PT96058A patent/PT96058B/pt not_active IP Right Cessation
- 1990-12-04 AU AU67736/90A patent/AU628695B2/en not_active Ceased
- 1990-12-04 ZA ZA909745A patent/ZA909745B/xx unknown
- 1990-12-04 FI FI905985A patent/FI97296C/fi not_active IP Right Cessation
- 1990-12-05 HU HU908077A patent/HU214249B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6773690A (en)	1991-06-13
KR910012235A (ko)	1991-08-07
EP0432419B1 (en)	1994-10-19
PT96058A (pt)	1991-09-30
FI905985L (fi)	1991-06-06
DK0432419T3 (da)	1994-11-14
IE904204A1 (en)	1991-06-05
NZ236141A (en)	1993-01-27
DE69013475T2 (de)	1995-05-04
FI97296C (fi)	1996-11-25
IE66142B1 (en)	1995-12-13
JPH03181500A (ja)	1991-08-07
ZA909745B (en)	1991-10-30
CA2031369A1 (en)	1991-06-06
HUT58762A (en)	1992-03-30
FI905985A0 (fi)	1990-12-04
HU214249B (hu)	1998-03-02
PT96058B (pt)	1998-07-31
KR0160975B1 (ko)	1998-11-16
ES2062253T3 (es)	1994-12-16
HU908077D0 (en)	1991-06-28
IL96124A0 (en)	1991-07-18
DE69013475D1 (de)	1994-11-24
FI97296B (fi)	1996-08-15
EP0432419A1 (en)	1991-06-19
ATE113060T1 (de)	1994-11-15
AU628695B2 (en)	1992-09-17

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Legal Events

Date	Code	Title	Description
1998-11-26	FF	Patent granted