IL96549A - Production of biologically active transforming growth factor type B-like protein or salts thereof - Google Patents

Production of biologically active transforming growth factor type B-like protein or salts thereof

Info

Publication number: IL96549A
Authority: IL; Israel
Prior art keywords: production; biologically active; protein; salts; growth factor
Prior art date: 1989-12-06

Application number

IL9654990A

Other languages

English (en)

Other versions

IL96549A0 (en

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-06

Filing date

1990-12-05

Publication date

2000-10-31

1990-12-05 Application filed by Novartis Ag filed Critical Novartis Ag

1991-09-16 Publication of IL96549A0 publication Critical patent/IL96549A0/xx

2000-10-31 Publication of IL96549A publication Critical patent/IL96549A/xx

Links

102000009618 Transforming Growth Factors Human genes 0.000 title 1
108010009583 Transforming Growth Factors Proteins 0.000 title 1
102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Crystallography & Structural Chemistry (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

IL9654990A 1989-12-06 1990-12-05 Production of biologically active transforming growth factor type B-like protein or salts thereof IL96549A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898927546A GB8927546D0 (en)	1989-12-06	1989-12-06	Process for the production of biologically active tgf-beta

Publications (2)

Publication Number	Publication Date
IL96549A0 IL96549A0 (en)	1991-09-16
IL96549A true IL96549A (en)	2000-10-31

Family

ID=10667491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9654990A IL96549A (en)	1989-12-06	1990-12-05	Production of biologically active transforming growth factor type B-like protein or salts thereof

Country Status (23)

Country	Link
US (2)	US5650494A (de)
EP (2)	EP0891985A1 (de)
JP (1)	JP3048061B2 (de)
KR (1)	KR100203230B1 (de)
AT (1)	ATE178616T1 (de)
AU (1)	AU638075B2 (de)
CA (1)	CA2031430C (de)
DE (1)	DE69033040T2 (de)
DK (1)	DK0433225T3 (de)
ES (1)	ES2132066T3 (de)
FI (1)	FI103278B1 (de)
GB (1)	GB8927546D0 (de)
GR (1)	GR3030703T3 (de)
HU (1)	HU218144B (de)
IE (2)	IE990992A1 (de)
IL (1)	IL96549A (de)
MX (1)	MX172600B (de)
NO (1)	NO301768B1 (de)
NZ (1)	NZ236333A (de)
PH (1)	PH31649A (de)
PT (1)	PT96068B (de)
SG (1)	SG52690A1 (de)
ZA (1)	ZA909762B (de)

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1989
- 1989-12-06 GB GB898927546A patent/GB8927546D0/en active Pending
1990
- 1990-11-27 AU AU67018/90A patent/AU638075B2/en not_active Expired
- 1990-11-27 AT AT90810922T patent/ATE178616T1/de not_active IP Right Cessation
- 1990-11-27 DE DE69033040T patent/DE69033040T2/de not_active Expired - Lifetime
- 1990-11-27 SG SG1996007909A patent/SG52690A1/en unknown
- 1990-11-27 DK DK90810922T patent/DK0433225T3/da active
- 1990-11-27 EP EP98113487A patent/EP0891985A1/de not_active Withdrawn
- 1990-11-27 EP EP90810922A patent/EP0433225B1/de not_active Expired - Lifetime
- 1990-11-27 ES ES90810922T patent/ES2132066T3/es not_active Expired - Lifetime
- 1990-11-30 JP JP2330871A patent/JP3048061B2/ja not_active Expired - Lifetime
- 1990-12-03 FI FI905956A patent/FI103278B1/fi active IP Right Grant
- 1990-12-04 MX MX023579A patent/MX172600B/es unknown
- 1990-12-04 CA CA002031430A patent/CA2031430C/en not_active Expired - Lifetime
- 1990-12-04 NZ NZ236333A patent/NZ236333A/en unknown
- 1990-12-04 PT PT96068A patent/PT96068B/pt not_active IP Right Cessation
- 1990-12-05 IL IL9654990A patent/IL96549A/xx not_active IP Right Cessation
- 1990-12-05 NO NO905264A patent/NO301768B1/no not_active IP Right Cessation
- 1990-12-05 HU HU084/90A patent/HU218144B/hu unknown
- 1990-12-05 IE IE19990992A patent/IE990992A1/en not_active IP Right Cessation
- 1990-12-05 KR KR1019900019881A patent/KR100203230B1/ko not_active Expired - Lifetime
- 1990-12-05 IE IE438690A patent/IE904386A1/en not_active IP Right Cessation
- 1990-12-05 ZA ZA909762A patent/ZA909762B/xx unknown
1994
- 1994-03-25 PH PH8001A patent/PH31649A/en unknown
1995
- 1995-06-07 US US08/486,057 patent/US5650494A/en not_active Expired - Lifetime
1997
- 1997-01-24 US US08/789,588 patent/US5922846A/en not_active Expired - Fee Related
1999
- 1999-07-07 GR GR990401786T patent/GR3030703T3/el unknown

Also Published As

Publication number	Publication date
AU6701890A (en)	1991-06-13
US5650494A (en)	1997-07-22
FI905956L (fi)	1991-06-07
ZA909762B (en)	1991-08-28
HU218144B (hu)	2000-06-28
ES2132066T3 (es)	1999-08-16
AU638075B2 (en)	1993-06-17
CA2031430A1 (en)	1991-06-07
NO905264L (no)	1991-06-07
FI905956A0 (fi)	1990-12-03
US5922846A (en)	1999-07-13
EP0433225A1 (de)	1991-06-19
JPH03191791A (ja)	1991-08-21
KR100203230B1 (ko)	1999-06-15
EP0433225B1 (de)	1999-04-07
HUT56880A (en)	1991-10-28
FI103278B (fi)	1999-05-31
FI103278B1 (fi)	1999-05-31
IL96549A0 (en)	1991-09-16
ATE178616T1 (de)	1999-04-15
CA2031430C (en)	2003-05-27
IE990992A1 (en)	2000-12-13
NO301768B1 (no)	1997-12-08
PT96068B (pt)	1998-02-27
KR910012240A (ko)	1991-08-07
EP0891985A1 (de)	1999-01-20
NZ236333A (en)	1992-03-26
HU908084D0 (en)	1991-06-28
PT96068A (pt)	1991-09-30
JP3048061B2 (ja)	2000-06-05
DK0433225T3 (da)	1999-10-25
DE69033040T2 (de)	1999-09-09
DE69033040D1 (de)	1999-05-12
GR3030703T3 (en)	1999-11-30
GB8927546D0 (en)	1990-02-07
MX172600B (es)	1994-01-03
PH31649A (en)	1999-01-12
SG52690A1 (en)	1998-09-28
IE904386A1 (en)	1991-06-19
NO905264D0 (no)	1990-12-05

Legal Events

Date	Code	Title
2001-03-19	FF	Patent granted
2001-06-14	KB	Patent renewed
2005-02-20	KB	Patent renewed
2009-06-15	KB	Patent renewed
2011-07-31	EXP	Patent expired

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