IL97800A - Thiophene sulfonamide derivatives and pharmaceutical compositons containing the same - Google Patents

Thiophene sulfonamide derivatives and pharmaceutical compositons containing the same

Info

Publication number
IL97800A
IL97800A IL9780091A IL9780091A IL97800A IL 97800 A IL97800 A IL 97800A IL 9780091 A IL9780091 A IL 9780091A IL 9780091 A IL9780091 A IL 9780091A IL 97800 A IL97800 A IL 97800A
Authority
IL
Israel
Prior art keywords
same
sulfonamide derivatives
thiophene sulfonamide
pharmaceutical compositons
compositons containing
Prior art date
Application number
IL9780091A
Other languages
English (en)
Other versions
IL97800A0 (en
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of IL97800A0 publication Critical patent/IL97800A0/xx
Publication of IL97800A publication Critical patent/IL97800A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL9780091A 1990-04-09 1991-04-09 Thiophene sulfonamide derivatives and pharmaceutical compositons containing the same IL97800A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors

Publications (2)

Publication Number Publication Date
IL97800A0 IL97800A0 (en) 1992-06-21
IL97800A true IL97800A (en) 1997-08-14

Family

ID=27055558

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9780091A IL97800A (en) 1990-04-09 1991-04-09 Thiophene sulfonamide derivatives and pharmaceutical compositons containing the same

Country Status (19)

Country Link
US (2) US5153192A (fr)
EP (1) EP0527801B1 (fr)
JP (1) JP2562394B2 (fr)
KR (1) KR100196414B1 (fr)
AT (1) ATE221527T1 (fr)
AU (1) AU655924B2 (fr)
BR (1) BR9106330A (fr)
CA (1) CA2080223C (fr)
DE (3) DE69133080T2 (fr)
DK (1) DK0527801T3 (fr)
ES (1) ES2180530T3 (fr)
FI (2) FI924553A7 (fr)
IL (1) IL97800A (fr)
LU (2) LU90935I2 (fr)
NL (2) NL300098I2 (fr)
NO (1) NO923948L (fr)
NZ (1) NZ237754A (fr)
WO (1) WO1991015486A1 (fr)
ZA (1) ZA912580B (fr)

Families Citing this family (82)

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SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
ES2118941T3 (es) 1992-02-21 1998-10-01 Alcon Lab Inc Composiciones antiglaucoma topicas que comprenden inhibidores de anhidrasa carbonica y bloqueantes beta.
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
US5308842A (en) * 1992-09-09 1994-05-03 Merck & Co., Inc. Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds
AU3722793A (en) * 1992-09-17 1994-04-12 Alcon Laboratories, Inc. Topical carbonic anhydrase inhibitor composition
US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
AU1684895A (en) * 1994-01-21 1995-08-08 Alcon Laboratories, Inc. Thienothiazine sulfonamide derivatives process and intermediates for their preparation and their use as carbonic anhydrase inhibitors
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US5646142A (en) * 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5464831A (en) * 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
AU2998995A (en) * 1995-07-12 1997-02-10 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
CA2237898A1 (fr) * 1995-11-17 1997-05-29 Louis Desantis Jr. Therapie combinee pour le traitement du glaucome
WO1997030704A2 (fr) * 1996-02-26 1997-08-28 Advanced Research And Technology Institute Traitement contre l'oedeme maculaire par utilisation d'inhibiteurs d'anhydrase carbonique
US5900427A (en) * 1996-05-03 1999-05-04 Wisconsin Alumni Research Foundation N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis
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US6242441B1 (en) 1997-12-23 2001-06-05 Alcon Laboratories, Inc. Use of brinzolamide to prevent visual field loss
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US5948801A (en) * 1998-03-09 1999-09-07 Alcon Laboratories, Inc. Treatment of retinal edema with brinzolamide
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WO2002040030A1 (fr) * 2000-11-16 2002-05-23 Alcon Manufacturing, Ltd. Therapie combinee abaissant et regulant la tension intraoculaire
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US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
EP1487438A4 (fr) * 2002-03-15 2007-08-15 Merck & Co Inc Compositions et methodes de traitement du glaucome et de l'hypertension oculaire
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CA2488802A1 (fr) * 2002-06-14 2003-12-24 Merck & Co., Inc. Compositions ophthalmiques pour traiter l'hypertension oculaire
CA2488884A1 (fr) * 2002-06-17 2003-12-24 Merck & Co., Inc. Nouveaux inhibiteurs de canaux maxi k, methodes d'utilisation et procede de fabrication associe
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US20040216749A1 (en) * 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
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US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
EP2414343A1 (fr) * 2009-03-13 2012-02-08 Azad Pharmaceutical Ingredients AG Procédé de préparation de brinzolamide
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
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EP2394637A1 (fr) 2010-05-21 2011-12-14 Zaklady Farmaceutyczne Polpharma SA Procédé pour l'obtention de suspensions stériles de brinzolamide
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US20110021974A1 (en) * 2010-10-05 2011-01-27 Shantha Totada R Retinitis pigmentosa treatment and prophalaxis
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EP4193907B1 (fr) 2011-09-13 2026-04-15 Glaukos Corporation Capteur physiologique intraoculaire
JP5836851B2 (ja) * 2012-03-12 2015-12-24 株式会社トクヤマ ブリンゾラミドの製造方法
EP2638909A1 (fr) 2012-03-15 2013-09-18 Azad Pharmaceutical Ingredients AG Procédé de préparation stérile brinzolamide
JP5881514B2 (ja) * 2012-04-09 2016-03-09 株式会社トクヤマ アミン誘導体の製造方法
JP5914246B2 (ja) * 2012-08-10 2016-05-11 株式会社トクヤマ ブリンゾラミドの精製方法
CN102936236A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种布林佐胺中间体(3-乙酰基-5-氯-2-(苄基巯基)噻酚)的制备方法
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
EP3057576A1 (fr) 2013-10-17 2016-08-24 Sentiss Pharma Private Limited Formulation pharmaceutique ophtalmique sans conservateur
US10463674B2 (en) 2013-11-08 2019-11-05 Sentiss Pharma Private Limited Process for manufacturing sterile ophthalmic pharmaceutical suspensions
US9820991B2 (en) 2013-11-08 2017-11-21 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
EA036820B1 (ru) * 2014-01-24 2020-12-23 Сентисс Фарма Прайвет Лимитед Фармацевтическая композиция, содержащая бринзоламид
WO2016063184A1 (fr) 2014-10-20 2016-04-28 Sentiss Pharma Private Limited Solution ophtalmique
JP6192878B1 (ja) * 2015-12-10 2017-09-06 千寿製薬株式会社 眼科用医薬製品
AU2017382176A1 (en) 2016-12-21 2019-05-30 Biotheryx, Inc. Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof
JP2021521240A (ja) 2018-04-25 2021-08-26 シルパ メディケア リミテッドＳｈｉｌｐａ Ｍｅｄｉｃａｒｅ Ｌｉｍｉｔｅｄ ブリンゾラミドの眼科用組成物
EP4712945A1 (fr) 2023-05-16 2026-03-25 Micro Labs Limited Solution ophtalmique de brinzolamide

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CA661731A (en) * 1963-04-23 Farbwerke Hoechst Aktiengesellschaft Vormals Meister Lucius And Bruning Substituted thiophene-3,5-disulfonamides and a process for preparing them
DE1096916B (de) * 1957-12-17 1961-01-12 Hoechst Ag Verfahren zur Herstellung von Thiophen-3, 5-disulfonamiden
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Also Published As

Publication number Publication date
BR9106330A (pt) 1993-04-20
ES2180530T3 (es) 2003-02-16
US5240923A (en) 1993-08-31
HK1014186A1 (en) 1999-09-24
FI924553A0 (fi) 1992-10-08
JPH05508832A (ja) 1993-12-09
EP0527801A1 (fr) 1993-02-24
NL300098I2 (nl) 2003-01-06
FI963424A0 (fi) 1996-09-02
NL300389I1 (nl) 2009-07-01
NZ237754A (en) 1992-08-26
DE10299054I1 (de) 2006-06-08
ZA912580B (en) 1992-01-29
EP0527801B1 (fr) 2002-07-31
CA2080223C (fr) 2000-11-07
FI963424A7 (fi) 1996-09-02
JP2562394B2 (ja) 1996-12-11
LU90935I2 (en) 2002-09-05
FI924553L (fi) 1992-10-08
KR930700490A (ko) 1993-03-15
KR100196414B1 (ko) 1999-06-15
NO923948L (no) 1992-12-08
ATE221527T1 (de) 2002-08-15
US5153192A (en) 1992-10-06
AU655924B2 (en) 1995-01-19
FI924553A7 (fi) 1992-10-08
DK0527801T3 (da) 2002-11-25
DE122009000026I1 (de) 2010-01-28
NO923948D0 (no) 1992-10-09
DE69133080D1 (de) 2002-09-05
IL97800A0 (en) 1992-06-21
EP0527801A4 (en) 1993-03-10
DE69133080T2 (de) 2003-03-27
AU7746791A (en) 1991-10-30
LU91555I2 (fr) 2009-06-22
NL300098I1 (nl) 2002-11-01
CA2080223A1 (fr) 1991-10-10
FI963424L (fi) 1996-09-02
WO1991015486A1 (fr) 1991-10-17

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