IL97815A0 - Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases - Google Patents

Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Info

Publication number
IL97815A0
IL97815A0 IL97815A IL9781591A IL97815A0 IL 97815 A0 IL97815 A0 IL 97815A0 IL 97815 A IL97815 A IL 97815A IL 9781591 A IL9781591 A IL 9781591A IL 97815 A0 IL97815 A0 IL 97815A0
Authority
IL
Israel
Prior art keywords
folates
treatment
neoplastic diseases
acid conjugates
difluoroglutamic acid
Prior art date
Application number
IL97815A
Other languages
English (en)
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc filed Critical Health Research Inc
Publication of IL97815A0 publication Critical patent/IL97815A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL97815A 1990-04-12 1991-04-10 Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases IL97815A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/508,873 US5286726A (en) 1990-04-12 1990-04-12 Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Publications (1)

Publication Number Publication Date
IL97815A0 true IL97815A0 (en) 1992-06-21

Family

ID=24024425

Family Applications (1)

Application Number Title Priority Date Filing Date
IL97815A IL97815A0 (en) 1990-04-12 1991-04-10 Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Country Status (17)

Country Link
US (1) US5286726A (fr)
EP (1) EP0451836B1 (fr)
JP (1) JP2894576B2 (fr)
KR (1) KR910018383A (fr)
CN (1) CN1057653A (fr)
AT (1) ATE132149T1 (fr)
AU (1) AU631055B2 (fr)
CA (1) CA2039855C (fr)
DE (1) DE69115744T2 (fr)
ES (1) ES2082029T3 (fr)
FI (1) FI911788A7 (fr)
HU (1) HUT57793A (fr)
IE (1) IE911234A1 (fr)
IL (1) IL97815A0 (fr)
NO (1) NO911415L (fr)
PT (1) PT97337B (fr)
ZA (1) ZA912555B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
WO1993020075A1 (fr) * 1992-04-01 1993-10-14 The University Of Sydney N5-desazapterines substituees en position 8, utilisees comme antifolates
DE69327312T2 (de) * 1992-04-29 2000-07-13 Sri International, Menlo Park Deazaaminopterine für behandlung von entzündungen
US5547954A (en) * 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
US6323205B1 (en) * 1996-07-17 2001-11-27 Sloan-Kettering Institute For Cancer Research Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors
DE19830599A1 (de) * 1998-07-09 2000-01-13 Basf Ag Verfahren zur stereoselektiven Herstellung von Grignardverbindungen und deren Verwendung
CN101646639A (zh) * 2007-04-11 2010-02-10 默克阿泼洛发股份公司 18f-标记的叶酸
WO2008125615A1 (fr) * 2007-04-11 2008-10-23 Merck Eprova Ag Folates marqués au 18f
US20100248249A1 (en) * 2007-08-17 2010-09-30 Allos Therapeutics, Inc. Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels
US20090048262A1 (en) * 2007-08-17 2009-02-19 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
US9901578B2 (en) 2007-08-17 2018-02-27 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
SG195545A1 (en) 2008-10-10 2013-12-30 Merck & Cie 18f-labelled folates as pet radiotracers
AU2010345065B2 (en) 2010-02-02 2014-06-05 Allos Therapeutics, Inc. Optically pure diastereomers of 10-propargyl-10-deazaaminopterin and methods of using same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520392A (en) * 1947-06-27 1950-08-29 Flenghi Louis Disk and pin game
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
EP0031237B1 (fr) * 1979-12-19 1984-10-17 National Research Development Corporation Dérivés de la quinazoline, procédés pour leur préparation, compositions les contenant et leur utilisation comme agents anticancéreux
US4853221A (en) * 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
US4628089A (en) * 1982-01-11 1986-12-09 Southern Research Institute Pyrido(2,3-D)pyrimidines
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4628090A (en) * 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US4584375A (en) * 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
JPS6281385A (ja) * 1985-10-02 1987-04-14 Shionogi & Co Ltd 新規メトトレキサ−ト誘導体
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US5223620A (en) * 1988-04-01 1993-06-29 Takeda Chemical Industries, Ltd. Pyrido[2,3-d]pyrimidine compounds useful as intermediates
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
US4882333A (en) * 1988-05-25 1989-11-21 The Trustess Of Princeton University N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
AU3843189A (en) * 1988-07-01 1990-01-23 Sloan-Kettering Institute For Cancer Research 5-deaza-5,7-disubstituted-aminopterin analogues
EP0388456A1 (fr) * 1988-09-16 1990-09-26 Sri International Derives de l'acide 8,10-dideazatetrahydrofolique
CA2001458A1 (fr) * 1989-08-14 1991-02-14 James R. Piper 5-methyl-5-deaza-10-propargylaminopterine
US4996207A (en) * 1990-01-18 1991-02-26 Nair Madhavan G Three new non-polyglutamatable deazaaminopterins
US5066828A (en) * 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Also Published As

Publication number Publication date
JP2894576B2 (ja) 1999-05-24
FI911788L (fi) 1991-10-13
IE911234A1 (en) 1991-10-23
HU911193D0 (en) 1991-10-28
NO911415L (no) 1991-10-14
CA2039855C (fr) 2001-08-21
FI911788A7 (fi) 1991-10-13
EP0451836A3 (en) 1992-07-01
EP0451836A2 (fr) 1991-10-16
CA2039855A1 (fr) 1991-10-13
US5286726A (en) 1994-02-15
PT97337B (pt) 1998-08-31
ZA912555B (en) 1992-04-29
HUT57793A (en) 1991-12-30
AU7417591A (en) 1991-10-17
CN1057653A (zh) 1992-01-08
AU631055B2 (en) 1992-11-12
ATE132149T1 (de) 1996-01-15
FI911788A0 (fi) 1991-04-12
EP0451836B1 (fr) 1995-12-27
DE69115744D1 (de) 1996-02-08
DE69115744T2 (de) 1996-05-30
ES2082029T3 (es) 1996-03-16
PT97337A (pt) 1992-01-31
KR910018383A (ko) 1991-11-30
NO911415D0 (no) 1991-04-11
JPH04234854A (ja) 1992-08-24

Similar Documents

Publication Publication Date Title
EP0451836A3 (en) Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
GR20010300006T1 (en) Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas
EP0335901A4 (en) Methods and compositions for the treatment of non-ige-mediated diseases
IL136737A0 (en) Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
UA39158C2 (uk) Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
IL97819A0 (en) Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
ZA886125B (en) 5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents
RU1833372C (ru) Cпocoб пoлучehия пpoизboдhыx 2,4,5-зameщehhыx бehзoлa
ATE258797T1 (de) Verwendung von amifostin
ATE372774T1 (de) Medikament zur verabreichung von amifostin und verwandten wirkstoffen
ATE151776T1 (de) Cytotoxische und antivirale verbindung
TR199802200A2 (xx) S�lfonamid s�bstit�e edilmi� benzopiran t�revleri, �retilme y�ntemi.
AU1506692A (en) Pharmaceutical compositions
PL341707A1 (en) Compounds exibiting growth hormone releasing properties
TR199701605A2 (xx) S�lfonamid-substit�e edilmi� bile�ikler
EP0495226A3 (en) 3-aryl-5-alkylthio-4h-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma
UA40656C2 (uk) Засіб "феррофол" для лікування залізодефіцитної анемії