IL97944A - Peptides with bradykinin-antagonistic action their preparation and pharmaceutical compositions containing them - Google Patents

Peptides with bradykinin-antagonistic action their preparation and pharmaceutical compositions containing them

Info

Publication number: IL97944A
Authority: IL; Israel
Prior art keywords: formula; substituted; amino; peptide; aryl
Prior art date: 1990-04-26

Application number

IL9794491A

Other languages

English (en)

Other versions

IL97944A0 (en

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-26

Filing date

1991-04-24

Publication date

1995-05-26

1991-04-24 Application filed by Hoechst Ag filed Critical Hoechst Ag

1992-06-21 Publication of IL97944A0 publication Critical patent/IL97944A0/xx

1995-05-26 Publication of IL97944A publication Critical patent/IL97944A/en

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 68
238000002360 preparation method Methods 0.000 title claims description 6
239000008194 pharmaceutical composition Substances 0.000 title claims description 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract description 34
230000009471 action Effects 0.000 title abstract description 7
150000001413 amino acids Chemical class 0.000 claims abstract description 23
101800004538 Bradykinin Proteins 0.000 claims abstract description 9
102400000967 Bradykinin Human genes 0.000 claims abstract description 9
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims abstract description 9
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims abstract description 9
239000001257 hydrogen Substances 0.000 claims abstract description 9
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 9
125000001931 aliphatic group Chemical group 0.000 claims abstract description 7
125000004391 aryl sulfonyl group Chemical group 0.000 claims abstract description 7
125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 7
125000003118 aryl group Chemical group 0.000 claims abstract description 6
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 6
230000001404 mediated effect Effects 0.000 claims abstract description 4
230000001575 pathological effect Effects 0.000 claims abstract description 4
101710097732 Bradykinin-related peptides Proteins 0.000 claims abstract 2
-1 (Ci-C4) -alkylamino Chemical group 0.000 claims description 51
229940024606 amino acid Drugs 0.000 claims description 26
125000006239 protecting group Chemical group 0.000 claims description 22
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125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 11
150000001875 compounds Chemical class 0.000 claims description 11
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 11
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 11
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210000004899 c-terminal region Anatomy 0.000 claims description 6
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9794491A 1990-04-26 1991-04-24 Peptides with bradykinin-antagonistic action their preparation and pharmaceutical compositions containing them IL97944A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4013270A DE4013270A1 (de)	1990-04-26	1990-04-26	Peptide mit bradykinin-antagonistischer wirkung

Publications (2)

Publication Number	Publication Date
IL97944A0 IL97944A0 (en)	1992-06-21
IL97944A true IL97944A (en)	1995-05-26

Family

ID=6405107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9794491A IL97944A (en)	1990-04-26	1991-04-24	Peptides with bradykinin-antagonistic action their preparation and pharmaceutical compositions containing them

Country Status (25)

Country	Link
EP (1)	EP0455133B1 (cs)
JP (1)	JP2552402B2 (cs)
KR (1)	KR100195569B1 (cs)
CN (1)	CN1034416C (cs)
AT (1)	ATE149519T1 (cs)
AU (1)	AU641004B2 (cs)
CA (1)	CA2041268C (cs)
CY (1)	CY2113B1 (cs)
CZ (1)	CZ280682B6 (cs)
DE (2)	DE4013270A1 (cs)
DK (1)	DK0455133T3 (cs)
ES (1)	ES2099102T3 (cs)
FI (1)	FI109541B (cs)
GR (1)	GR3023172T3 (cs)
HK (1)	HK1006843A1 (cs)
HU (1)	HU208028B (cs)
IE (1)	IE911387A1 (cs)
IL (1)	IL97944A (cs)
LV (1)	LV10290B (cs)
NO (1)	NO300779B1 (cs)
NZ (1)	NZ237928A (cs)
PT (1)	PT97466B (cs)
RU (1)	RU2056432C1 (cs)
SK (1)	SK279286B6 (cs)
ZA (1)	ZA913121B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06508116A (ja) *	1991-04-01	1994-09-14	コルテク，インコーポレイテッド	ブラジキニンアンタゴニスト
TW199863B (cs) *	1991-12-21	1993-02-11	Hoechst Ag
TW258739B (cs) *	1992-04-04	1995-10-01	Hoechst Ag
KR100360639B1 (ko) *	1994-03-09	2003-01-30	코르텍, 인크.	N-치환글리신함유브라디키닌길항제펩티드
FR2739553B1 (fr) *	1995-10-06	1998-01-02	Oreal	Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) *	1996-03-27	1997-10-02	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4923963A (en) *	1987-09-02	1990-05-08	Nova Technology Limited Partnership	Bradykinin antagonist peptides
IE63490B1 (en) *	1988-11-24	1995-05-03	Hoechst Ag	Peptides having bradykinin antagonist action
DE3926822A1 (de) *	1989-08-14	1991-02-21	Hoechst Ag	Peptide mit bradykinin-antagonistischer wirkung

1990
- 1990-04-26 DE DE4013270A patent/DE4013270A1/de not_active Withdrawn
1991
- 1991-04-24 FI FI911978A patent/FI109541B/fi active
- 1991-04-24 AU AU75304/91A patent/AU641004B2/en not_active Expired
- 1991-04-24 CZ CS911165A patent/CZ280682B6/cs not_active IP Right Cessation
- 1991-04-24 PT PT97466A patent/PT97466B/pt not_active IP Right Cessation
- 1991-04-24 IL IL9794491A patent/IL97944A/en not_active IP Right Cessation
- 1991-04-24 SK SK1165-91A patent/SK279286B6/sk not_active IP Right Cessation
- 1991-04-24 NZ NZ237928A patent/NZ237928A/xx unknown
- 1991-04-25 ZA ZA913121A patent/ZA913121B/xx unknown
- 1991-04-25 EP EP91106663A patent/EP0455133B1/de not_active Expired - Lifetime
- 1991-04-25 AT AT91106663T patent/ATE149519T1/de not_active IP Right Cessation
- 1991-04-25 CA CA002041268A patent/CA2041268C/en not_active Expired - Lifetime
- 1991-04-25 IE IE138791A patent/IE911387A1/en unknown
- 1991-04-25 NO NO911649A patent/NO300779B1/no not_active IP Right Cessation
- 1991-04-25 ES ES91106663T patent/ES2099102T3/es not_active Expired - Lifetime
- 1991-04-25 CN CN91102638A patent/CN1034416C/zh not_active Expired - Lifetime
- 1991-04-25 DE DE59108573T patent/DE59108573D1/de not_active Expired - Lifetime
- 1991-04-25 DK DK91106663.7T patent/DK0455133T3/da active
- 1991-04-25 JP JP3121848A patent/JP2552402B2/ja not_active Expired - Lifetime
- 1991-04-25 KR KR1019910006649A patent/KR100195569B1/ko not_active Expired - Lifetime
- 1991-04-25 HU HU911392A patent/HU208028B/hu unknown
1992
- 1992-07-27 RU SU925052268A patent/RU2056432C1/ru active
- 1992-12-23 LV LVP-92-699A patent/LV10290B/lv unknown
1997
- 1997-04-18 GR GR970400829T patent/GR3023172T3/el unknown
1998
- 1998-06-22 HK HK98105879A patent/HK1006843A1/xx not_active IP Right Cessation
- 1998-09-29 CY CY9800030A patent/CY2113B1/xx unknown

Also Published As

Publication number	Publication date
KR910018405A (ko)	1991-11-30
LV10290B (en)	1995-08-20
ES2099102T3 (es)	1997-05-16
JP2552402B2 (ja)	1996-11-13
NO300779B1 (no)	1997-07-21
HU911392D0 (en)	1991-10-28
DE4013270A1 (de)	1991-10-31
IL97944A0 (en)	1992-06-21
KR100195569B1 (ko)	1999-06-15
CN1056105A (zh)	1991-11-13
ZA913121B (en)	1992-02-26
EP0455133A3 (en)	1992-01-08
GR3023172T3 (en)	1997-07-30
HK1006843A1 (en)	1999-03-19
CS9101165A2 (en)	1991-12-17
PT97466B (pt)	1998-08-31
CN1034416C (zh)	1997-04-02
CZ280682B6 (cs)	1996-04-17
CY2113B1 (en)	2002-04-26
RU2056432C1 (ru)	1996-03-20
FI911978L (fi)	1991-10-27
PT97466A (pt)	1992-01-31
FI911978A0 (fi)	1991-04-24
HUT60286A (en)	1992-08-28
EP0455133A2 (de)	1991-11-06
CA2041268A1 (en)	1991-10-27
DE59108573D1 (de)	1997-04-10
FI109541B (fi)	2002-08-30
HU208028B (en)	1993-07-28
NZ237928A (en)	1993-09-27
DK0455133T3 (da)	1997-08-25
AU7530491A (en)	1991-11-07
IE911387A1 (en)	1991-11-06
AU641004B2 (en)	1993-09-09
ATE149519T1 (de)	1997-03-15
LV10290A (lv)	1994-10-20
JPH04225997A (ja)	1992-08-14
NO911649D0 (no)	1991-04-25
NO911649L (no)	1991-10-28
CA2041268C (en)	2001-10-02
EP0455133B1 (de)	1997-03-05
SK279286B6 (sk)	1998-09-09

Legal Events

Date	Code	Title
1997-08-14	KB	Patent renewed
2001-07-24	KB	Patent renewed
2005-07-25	KB	Patent renewed
2009-11-18	KB	Patent renewed
2011-12-29	EXP	Patent expired

Publication	Publication Date	Title
KR0139632B1 (ko)	1998-07-01	브라디키닌 길항 작용을 갖는 펩티드
CA2023194C (en)	2001-09-11	Peptides having bradykinin antagonist action
US5597803A (en)	1997-01-28	Bradykinin peptides with modifications at the N terminus
US5648333A (en)	1997-07-15	Peptides having bradykinin antagonist action
CA2041268C (en)	2001-10-02	Peptides with a bradykinin-antagonistic action
CN1034416Y (zh)	1997-04-02	有舒缓激肽拮抗作用的肽的制备方法
LT3872B (en)	1996-04-25	Novel peptides and pharmaceutical compositions containing them