IL99243A - Antibacterial penem esters and pharmaceutical compositions containing them - Google Patents

Antibacterial penem esters and pharmaceutical compositions containing them

Info

Publication number
IL99243A
IL99243A IL9924391A IL9924391A IL99243A IL 99243 A IL99243 A IL 99243A IL 9924391 A IL9924391 A IL 9924391A IL 9924391 A IL9924391 A IL 9924391A IL 99243 A IL99243 A IL 99243A
Authority
IL
Israel
Prior art keywords
group
groups
compound according
compound
aralkyl
Prior art date
Application number
IL9924391A
Other languages
English (en)
Other versions
IL99243A0 (en
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of IL99243A0 publication Critical patent/IL99243A0/xx
Publication of IL99243A publication Critical patent/IL99243A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/893—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero ring or a condensed hetero ring system, directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL9924391A 1990-08-20 1991-08-20 Antibacterial penem esters and pharmaceutical compositions containing them IL99243A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21705290 1990-08-20

Publications (2)

Publication Number Publication Date
IL99243A0 IL99243A0 (en) 1992-07-15
IL99243A true IL99243A (en) 1995-07-31

Family

ID=16698076

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9924391A IL99243A (en) 1990-08-20 1991-08-20 Antibacterial penem esters and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (2) US5830889A (de)
EP (2) EP0544907B1 (de)
JP (2) JP3148234B2 (de)
KR (1) KR0178956B1 (de)
AT (2) ATE242251T1 (de)
AU (1) AU652954B2 (de)
BR (1) BR9106789A (de)
CA (1) CA2089368C (de)
CZ (1) CZ282086B6 (de)
DE (2) DE69133273T2 (de)
DK (1) DK0544907T3 (de)
ES (2) ES2198455T3 (de)
FI (1) FI105186B (de)
GR (1) GR3032372T3 (de)
HU (1) HU213403B (de)
IE (1) IE20000929A1 (de)
IL (1) IL99243A (de)
MX (1) MX9203822A (de)
NO (1) NO302236B1 (de)
PL (1) PL169584B1 (de)
RU (1) RU2051919C1 (de)
SK (1) SK280188B6 (de)
WO (1) WO1992003442A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000076105A (ko) * 1998-01-13 2000-12-26 도리이 신이찌로 항생제를 함유한 국소 투여용 항균 조성물
GB9815532D0 (en) * 1998-07-17 1998-09-16 Lek Pharmaceutical & Cvhemical Pharmaceutical suspension formulation
WO2000076556A2 (en) * 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
EP1458416A1 (de) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Behandlung von osteomyelitis mit einer radiopharmazeutischen zusammensetzung
CN1314691C (zh) * 2005-08-22 2007-05-09 鲁南制药集团股份有限公司 法罗培南钠的制备方法
EP1934230A1 (de) * 2005-10-05 2008-06-25 Ranbaxy Laboratories, Ltd. Verfahren zur herstellung von faropenem
US20080125408A1 (en) * 2006-11-14 2008-05-29 Pfizer Inc Penem prodrug
CN101235044B (zh) * 2008-03-03 2010-11-03 南京华威医药科技开发有限公司 法罗培南酯的制备方法
CN116473936A (zh) * 2022-01-13 2023-07-25 山东新时代药业有限公司 一种法罗培南钠胶囊及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0275002A1 (de) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Verfahren zur Herstellung von 7-Oxo-4-thia-1-aza-bicyclo[3.2.0]-hept-2-en-Derivaten
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
JPH026728A (ja) 1988-06-23 1990-01-10 Japan Radio Co Ltd 弾性表面波による液体粘性測定装置
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung
EP0399228A1 (de) * 1989-04-29 1990-11-28 Hoechst Aktiengesellschaft Verfahren zur Herstellung von Penemverbindungen

Also Published As

Publication number Publication date
US5885981A (en) 1999-03-23
ATE242251T1 (de) 2003-06-15
DK0544907T3 (da) 2000-01-24
MX9203822A (es) 1992-09-01
HU213403B (en) 1997-06-30
US5830889A (en) 1998-11-03
EP0757050A1 (de) 1997-02-05
DE69131753T2 (de) 2000-05-04
IE20000929A1 (en) 2001-05-30
ES2137929T3 (es) 2000-01-01
DE69131753D1 (de) 1999-12-02
KR930701452A (ko) 1993-06-11
DE69133273D1 (de) 2003-07-10
BR9106789A (pt) 1993-06-29
IL99243A0 (en) 1992-07-15
GR3032372T3 (en) 2000-04-27
JPH06500769A (ja) 1994-01-27
RU2051919C1 (ru) 1996-01-10
AU652954B2 (en) 1994-09-15
CA2089368C (en) 2002-08-06
EP0757050B1 (de) 2003-06-04
FI930682A7 (fi) 1993-02-16
KR0178956B1 (ko) 1999-03-20
NO930588L (no) 1993-02-19
JP3274854B2 (ja) 2002-04-15
JP3148234B2 (ja) 2001-03-19
EP0544907A1 (de) 1993-06-09
FI930682A0 (fi) 1993-02-16
JP2000302786A (ja) 2000-10-31
WO1992003442A1 (en) 1992-03-05
AU8333391A (en) 1992-03-17
ATE186053T1 (de) 1999-11-15
CZ20993A3 (en) 1993-10-13
CA2089368A1 (en) 1992-02-21
PL169584B1 (pl) 1996-08-30
SK280188B6 (sk) 1999-09-10
SK10793A3 (en) 1993-09-08
ES2198455T3 (es) 2004-02-01
DE69133273T2 (de) 2004-05-13
FI105186B (fi) 2000-06-30
HUT64349A (en) 1993-12-28
NO302236B1 (no) 1998-02-09
CZ282086B6 (cs) 1997-05-14
NO930588D0 (no) 1993-02-19
EP0544907B1 (de) 1999-10-27
HU9300461D0 (en) 1993-05-28

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