IL99585A0 - Aprotinin analogues,their production and pharmaceutical compositions containing them - Google Patents

Aprotinin analogues,their production and pharmaceutical compositions containing them

Info

Publication number: IL99585A0
Authority: IL; Israel
Prior art keywords: aminoacid; production; pharmaceutical compositions; compositions containing; replaced
Prior art date: 1990-10-01

Application number

IL99585A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-01

Filing date

1991-09-27

Publication date

1992-08-18

1990-10-01 Priority claimed from DK236190A external-priority patent/DK236190D0/da

1991-06-12 Priority claimed from DK111891A external-priority patent/DK111891D0/da

1991-09-27 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1992-08-18 Publication of IL99585A0 publication Critical patent/IL99585A0/xx

Links

ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 7
230000007935 neutral effect Effects 0.000 abstract 2
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
231100000417 nephrotoxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IL99585A 1990-10-01 1991-09-27 Aprotinin analogues,their production and pharmaceutical compositions containing them IL99585A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK236190A DK236190D0 (da)	1990-10-01	1990-10-01	Polypeptid
DK111891A DK111891D0 (da)	1991-06-12	1991-06-12	Polypeptid

Publications (1)

Publication Number	Publication Date
IL99585A0 true IL99585A0 (en)	1992-08-18

Family

ID=26065261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL99585A IL99585A0 (en)	1990-10-01	1991-09-27	Aprotinin analogues,their production and pharmaceutical compositions containing them

Country Status (21)

Country	Link
EP (1)	EP0551329B1 (de)
JP (1)	JP3614850B2 (de)
KR (1)	KR100250391B1 (de)
AT (1)	ATE168414T1 (de)
AU (1)	AU659100B2 (de)
CA (1)	CA2092920A1 (de)
CZ (1)	CZ285225B6 (de)
DE (1)	DE69129809T2 (de)
DK (1)	DK0551329T3 (de)
ES (1)	ES2121787T3 (de)
FI (1)	FI105036B (de)
HU (1)	HU219302B (de)
IE (1)	IE913433A1 (de)
IL (1)	IL99585A0 (de)
MX (1)	MX9101382A (de)
NO (1)	NO309529B1 (de)
NZ (1)	NZ240014A (de)
PT (1)	PT99124B (de)
SK (1)	SK281540B6 (de)
UA (1)	UA34422C2 (de)
WO (1)	WO1992006111A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
AU738766B2 (en) *	1994-11-21	2001-09-27	University Of Leeds, The	Modified proteinase inhibitors
RU2182598C2 (ru) *	1994-11-21	2002-05-20	Новартис Аг	Модифицированные ингибиторы протеиназы
DE19629982A1 (de) *	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
CA2402310A1 (en)	2000-03-08	2001-09-13	Complexe Hospitalier De La Sagamie	Very low density lipoprotein receptor polymorphisms and uses therefor
DK2311432T3 (en)	2002-06-07	2015-02-02	Dyax Corp	Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
TR201900937T4 (tr)	2002-08-28	2019-02-21	Dyax Corp	Organların ve dokuların muhafaza edilmesine yönelik yöntem.
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) *	2006-12-22	2008-07-03	Bayer Schering Pharma Aktiengesellschaft	Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
US8637454B2 (en)	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
ES2688093T3 (es)	2010-01-06	2018-10-30	Dyax Corp.	Proteínas de unión a calicreína plasmática
IL269565B2 (en)	2011-01-06	2024-06-01	Dyax Corp	Plasma kallikrein binding proteins
BR112018011622A2 (pt)	2015-12-11	2018-11-27	Dyax Corp	método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae
CA3167336A1 (en)	2020-01-13	2021-07-22	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
DK450187D0 (da) *	1987-08-28	1987-08-28	Novo Industri As	Fremgangsmaade til fremstilling af proteiner
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1991
- 1991-09-27 IL IL99585A patent/IL99585A0/xx unknown
- 1991-09-30 IE IE343391A patent/IE913433A1/en not_active Application Discontinuation
- 1991-09-30 PT PT99124A patent/PT99124B/pt not_active IP Right Cessation
- 1991-09-30 NZ NZ240014A patent/NZ240014A/en unknown
- 1991-10-01 HU HU9300943A patent/HU219302B/hu not_active IP Right Cessation
- 1991-10-01 DK DK91917143T patent/DK0551329T3/da active
- 1991-10-01 MX MX9101382A patent/MX9101382A/es not_active IP Right Cessation
- 1991-10-01 WO PCT/DK1991/000299 patent/WO1992006111A1/en not_active Ceased
- 1991-10-01 CZ CZ93517A patent/CZ285225B6/cs not_active IP Right Cessation
- 1991-10-01 EP EP91917143A patent/EP0551329B1/de not_active Expired - Lifetime
- 1991-10-01 AU AU85460/91A patent/AU659100B2/en not_active Ceased
- 1991-10-01 CA CA002092920A patent/CA2092920A1/en not_active Abandoned
- 1991-10-01 SK SK264-93A patent/SK281540B6/sk unknown
- 1991-10-01 ES ES91917143T patent/ES2121787T3/es not_active Expired - Lifetime
- 1991-10-01 AT AT91917143T patent/ATE168414T1/de not_active IP Right Cessation
- 1991-10-01 JP JP51609991A patent/JP3614850B2/ja not_active Expired - Fee Related
- 1991-10-01 DE DE69129809T patent/DE69129809T2/de not_active Expired - Fee Related
- 1991-10-01 UA UA93002097A patent/UA34422C2/uk unknown
1993
- 1993-03-31 NO NO931220A patent/NO309529B1/no not_active IP Right Cessation
- 1993-03-31 FI FI931457A patent/FI105036B/fi active
- 1993-03-31 KR KR1019930701001A patent/KR100250391B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU8546091A (en)	1992-04-28
WO1992006111A1 (en)	1992-04-16
JP3614850B2 (ja)	2005-01-26
JPH06501158A (ja)	1994-02-10
NZ240014A (en)	1992-08-26
EP0551329A1 (de)	1993-07-21
DE69129809D1 (de)	1998-08-20
FI931457A0 (fi)	1993-03-31
DE69129809T2 (de)	1998-11-19
EP0551329B1 (de)	1998-07-15
SK281540B6 (sk)	2001-04-09
ES2121787T3 (es)	1998-12-16
CA2092920A1 (en)	1992-04-02
FI931457L (fi)	1993-03-31
CZ51793A3 (en)	1994-01-19
PT99124B (pt)	1999-03-31
MX9101382A (es)	1992-06-05
CZ285225B6 (cs)	1999-06-16
NO309529B1 (no)	2001-02-12
HU9300943D0 (en)	1993-06-28
NO931220L (no)	1993-04-01
HU219302B (en)	2001-03-28
NO931220D0 (no)	1993-03-31
SK26493A3 (en)	1993-10-06
IE913433A1 (en)	1992-04-08
DK0551329T3 (da)	1999-04-19
AU659100B2 (en)	1995-05-11
FI105036B (fi)	2000-05-31
UA34422C2 (uk)	2001-03-15
ATE168414T1 (de)	1998-08-15
PT99124A (pt)	1992-08-31
HUT69955A (en)	1995-09-28
KR100250391B1 (ko)	2000-05-01

Publication	Publication Date	Title
HUT69955A (en)	1995-09-28	Aprotinin analogues
PH31059A (en)	1998-02-05	Pharmaceutical compositions comprising cyclosporins.
NZ224992A (en)	1991-07-26	Factor viii analogues and their preparation
GB9101687D0 (en)	1991-03-06	Improved shotcrete compositions
NZ227384A (en)	1991-09-25	Ciclosporin in non-solvate orthorhombic crystal form; pharmaceutical compositions
GB2221674B (en)	1992-12-16	Cement compositions
DK0728148T3 (da)	1999-09-27	Forbedrede immunogene sammensætninger mod humant gastrin 17
EP0428342A3 (en)	1992-04-22	Stable thiol-ene compositions
AU4371589A (en)	1990-05-03	Cyclosporin opthalmic compositions
EP0607103A3 (de)	1997-07-09	Chelatbildende Gruppen enthaltende Somatostatinanaloge und deren radiomarkierten Zusammensetzungen.
AU625839B2 (en)	1992-07-16	Stabilized sulfur dissolving compositions
IL95863A0 (en)	1991-07-18	Anticoagulant peptides and compositions containing them
IE781291L (en)	1979-01-13	Psychopharmacological peptides
MY104912A (en)	1994-06-30	New pentapeptide and a process for the preparation thereof.
GB9026747D0 (en)	1991-01-30	Electrolyte compositions
RU93005177A (ru)	1995-07-20	Аналоги апротинина, днк, вектор, клетка, способ получения аналогов, фармацевтическая композиция, применение аналогов
JPS51119744A (en)	1976-10-20	Rubber compositions
GR3021467T3 (en)	1997-01-31	New peptide derivates active in the process of cell adhesion, a method to prepare them end pharmaceutical compositions containing them.
KR100235524B1 (en)	1999-12-15	Pharmaceutical compositions comprising cyclosporins
IL86576A0 (en)	1988-11-15	Pharmaceutical compositions containing 16alpha,17alpha-substituted pregnanes
IL98644A0 (en)	1992-07-15	Purified placental derived endothelium cell growth factor and pharmaceutical compositions containing the same
GB8803753D0 (en)	1988-03-16	Peat compositions & their manufacture
IL94511A0 (en)	1991-03-10	Pharmaceutical compositions containing 16alpha,17alpha substituted pregnanes
IE882739L (en)	1989-03-11	Antithrombotic compositions
IL59335A0 (en)	1980-05-30	Antithrombotic pharmaceutical compositions