IL99585A0 - Aprotinin analogues,their production and pharmaceutical compositions containing them - Google Patents

Aprotinin analogues,their production and pharmaceutical compositions containing them

Info

Publication number: IL99585A0
Authority: IL; Israel
Prior art keywords: aminoacid; production; pharmaceutical compositions; compositions containing; replaced
Prior art date: 1990-10-01

Application number

IL99585A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-01

Filing date

1991-09-27

Publication date

1992-08-18

1990-10-01 Priority claimed from DK236190A external-priority patent/DK236190D0/da

1991-06-12 Priority claimed from DK111891A external-priority patent/DK111891D0/da

1991-09-27 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1992-08-18 Publication of IL99585A0 publication Critical patent/IL99585A0/xx

Links

ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 7
230000007935 neutral effect Effects 0.000 abstract 2
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
231100000417 nephrotoxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL99585A 1990-10-01 1991-09-27 Aprotinin analogues,their production and pharmaceutical compositions containing them IL99585A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK236190A DK236190D0 (da)	1990-10-01	1990-10-01	Polypeptid
DK111891A DK111891D0 (da)	1991-06-12	1991-06-12	Polypeptid

Publications (1)

Publication Number	Publication Date
IL99585A0 true IL99585A0 (en)	1992-08-18

Family

ID=26065261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL99585A IL99585A0 (en)	1990-10-01	1991-09-27	Aprotinin analogues,their production and pharmaceutical compositions containing them

Country Status (21)

Country	Link
EP (1)	EP0551329B1 (de)
JP (1)	JP3614850B2 (de)
KR (1)	KR100250391B1 (de)
AT (1)	ATE168414T1 (de)
AU (1)	AU659100B2 (de)
CA (1)	CA2092920A1 (de)
CZ (1)	CZ285225B6 (de)
DE (1)	DE69129809T2 (de)
DK (1)	DK0551329T3 (de)
ES (1)	ES2121787T3 (de)
FI (1)	FI105036B (de)
HU (1)	HU219302B (de)
IE (1)	IE913433A1 (de)
IL (1)	IL99585A0 (de)
MX (1)	MX9101382A (de)
NO (1)	NO309529B1 (de)
NZ (1)	NZ240014A (de)
PT (1)	PT99124B (de)
SK (1)	SK281540B6 (de)
UA (1)	UA34422C2 (de)
WO (1)	WO1992006111A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
AU715747B2 (en) *	1994-11-21	2000-02-10	University Of Leeds, The	Modified proteinase inhibitors
AU738766B2 (en) *	1994-11-21	2001-09-27	University Of Leeds, The	Modified proteinase inhibitors
DE19629982A1 (de) *	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
CA2402310A1 (en)	2000-03-08	2001-09-13	Complexe Hospitalier De La Sagamie	Very low density lipoprotein receptor polymorphisms and uses therefor
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
WO2003103475A2 (en)	2002-06-07	2003-12-18	Dyax Corp.	Prevention and reduction of blood loss
JP2005537006A (ja)	2002-08-28	2005-12-08	ダイアックス、コープ	臓器及び組織の保存方法
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) *	2006-12-22	2008-07-03	Bayer Schering Pharma Aktiengesellschaft	Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
CA2744235A1 (en)	2009-01-06	2010-07-15	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (de)	2010-01-06	2021-10-27	Takeda Pharmaceutical Company Limited	Plasmakallikreinbindende proteine
CA2823776A1 (en)	2011-01-06	2012-07-12	Dyax Corp.	Plasma kallikrein binding proteins
AU2016366557B2 (en)	2015-12-11	2024-01-25	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US12528880B2 (en)	2020-01-13	2026-01-20	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK450187D0 (da) *	1987-08-28	1987-08-28	Novo Industri As	Fremgangsmaade til fremstilling af proteiner
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1991
- 1991-09-27 IL IL99585A patent/IL99585A0/xx unknown
- 1991-09-30 IE IE343391A patent/IE913433A1/en not_active Application Discontinuation
- 1991-09-30 NZ NZ240014A patent/NZ240014A/en unknown
- 1991-09-30 PT PT99124A patent/PT99124B/pt not_active IP Right Cessation
- 1991-10-01 SK SK264-93A patent/SK281540B6/sk unknown
- 1991-10-01 EP EP91917143A patent/EP0551329B1/de not_active Expired - Lifetime
- 1991-10-01 HU HU9300943A patent/HU219302B/hu not_active IP Right Cessation
- 1991-10-01 WO PCT/DK1991/000299 patent/WO1992006111A1/en not_active Ceased
- 1991-10-01 JP JP51609991A patent/JP3614850B2/ja not_active Expired - Fee Related
- 1991-10-01 CA CA002092920A patent/CA2092920A1/en not_active Abandoned
- 1991-10-01 AU AU85460/91A patent/AU659100B2/en not_active Ceased
- 1991-10-01 DK DK91917143T patent/DK0551329T3/da active
- 1991-10-01 DE DE69129809T patent/DE69129809T2/de not_active Expired - Fee Related
- 1991-10-01 CZ CZ93517A patent/CZ285225B6/cs not_active IP Right Cessation
- 1991-10-01 MX MX9101382A patent/MX9101382A/es not_active IP Right Cessation
- 1991-10-01 ES ES91917143T patent/ES2121787T3/es not_active Expired - Lifetime
- 1991-10-01 UA UA93002097A patent/UA34422C2/uk unknown
- 1991-10-01 AT AT91917143T patent/ATE168414T1/de not_active IP Right Cessation
1993
- 1993-03-31 NO NO931220A patent/NO309529B1/no not_active IP Right Cessation
- 1993-03-31 KR KR1019930701001A patent/KR100250391B1/ko not_active Expired - Fee Related
- 1993-03-31 FI FI931457A patent/FI105036B/fi active

Also Published As

Publication number	Publication date
CA2092920A1 (en)	1992-04-02
AU659100B2 (en)	1995-05-11
NO309529B1 (no)	2001-02-12
HU219302B (en)	2001-03-28
JPH06501158A (ja)	1994-02-10
HUT69955A (en)	1995-09-28
SK26493A3 (en)	1993-10-06
NO931220L (no)	1993-04-01
NZ240014A (en)	1992-08-26
CZ285225B6 (cs)	1999-06-16
SK281540B6 (sk)	2001-04-09
PT99124B (pt)	1999-03-31
WO1992006111A1 (en)	1992-04-16
IE913433A1 (en)	1992-04-08
HU9300943D0 (en)	1993-06-28
UA34422C2 (uk)	2001-03-15
ES2121787T3 (es)	1998-12-16
NO931220D0 (no)	1993-03-31
PT99124A (pt)	1992-08-31
EP0551329A1 (de)	1993-07-21
DE69129809D1 (de)	1998-08-20
CZ51793A3 (en)	1994-01-19
KR100250391B1 (ko)	2000-05-01
AU8546091A (en)	1992-04-28
EP0551329B1 (de)	1998-07-15
FI931457A0 (fi)	1993-03-31
DE69129809T2 (de)	1998-11-19
FI105036B (fi)	2000-05-31
ATE168414T1 (de)	1998-08-15
FI931457L (fi)	1993-03-31
MX9101382A (es)	1992-06-05
DK0551329T3 (da)	1999-04-19
JP3614850B2 (ja)	2005-01-26

Publication	Publication Date	Title
IL99585A0 (en)	1992-08-18	Aprotinin analogues,their production and pharmaceutical compositions containing them
GB8920597D0 (en)	1989-10-25	Pharmaceutical compositions comprising cyclosporins
NZ224992A (en)	1991-07-26	Factor viii analogues and their preparation
NZ227384A (en)	1991-09-25	Ciclosporin in non-solvate orthorhombic crystal form; pharmaceutical compositions
IL74681A0 (en)	1985-06-30	Cyclosporins,their production and pharmaceutical compositions containing them
DE69417252D1 (de)	1999-04-22	Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
IL85312A (en)	1991-08-16	Injectable pharmaceutical compositions having improved stability
EP0286441A3 (de)	1989-09-06	Zytotoxisches Protein
EP0082568A3 (en)	1983-10-26	Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
HUT59655A (en)	1992-06-29	Process for producing retroviral protease inhibiting 3-chloro-2-/chloro-methyl/-l-porpene derivatives and pharmaceutical compositions containing them as active component
EP0287308A3 (en)	1990-05-09	N-methyl-2-pyrrolidone compositions
NZ211858A (en)	1988-08-30	Heterocyclic-substituted cephalosporins and analogues thereof and pharmaceutical compositions
GB8819759D0 (en)	1988-09-21	Novel prepolymer compositions
DE69722618D1 (en)	2003-07-10	Peptide
AU625839B2 (en)	1992-07-16	Stabilized sulfur dissolving compositions
IE781291L (en)	1979-01-13	Psychopharmacological peptides
NO923333L (no)	1992-10-16	Vasoaktive vasotocinderivater
ZA903255B (en)	1991-02-27	Moisture-curing,one-part polyurethane compositions
MY104912A (en)	1994-06-30	New pentapeptide and a process for the preparation thereof.
GB9026747D0 (en)	1991-01-30	Electrolyte compositions
JPS51130519A (en)	1976-11-12	Process for preparating collagen powder for hemostasis
JPS51119744A (en)	1976-10-20	Rubber compositions
KR100235524B1 (en)	1999-12-15	Pharmaceutical compositions comprising cyclosporins
IL86576A0 (en)	1988-11-15	Pharmaceutical compositions containing 16alpha,17alpha-substituted pregnanes
IL98644A0 (en)	1992-07-15	Purified placental derived endothelium cell growth factor and pharmaceutical compositions containing the same