DK0551329T3 - Aprotininanaloger - Google Patents

Aprotininanaloger

Info

Publication number: DK0551329T3
Authority: DK; Denmark
Prior art keywords: aminoacid; replaced; residue; negatively charged; aminoacid residue
Prior art date: 1990-10-01

Application number

DK91917143T

Other languages

English (en)

Inventor

Soren Erik Bjorn

Kjeld Norris

Viggo Diness

Leif Birkeve Norskov-Lauritsen

Niels Dyhr Christensen

Claus Bregengaard

Leif Norskov-Lauritsen

Soeren Erik Bjirn

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-01

Filing date

1991-10-01

Publication date

1999-04-19

1990-10-01 Priority claimed from DK236190A external-priority patent/DK236190D0/da

1991-06-12 Priority claimed from DK111891A external-priority patent/DK111891D0/da

1991-10-01 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1999-04-19 Application granted granted Critical

1999-04-19 Publication of DK0551329T3 publication Critical patent/DK0551329T3/da

Links

ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
108010039627 Aprotinin Proteins 0.000 title 1
229960004405 aprotinin Drugs 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 7
230000007935 neutral effect Effects 0.000 abstract 2
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
231100000417 nephrotoxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK91917143T 1990-10-01 1991-10-01 Aprotininanaloger DK0551329T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK236190A DK236190D0 (da)	1990-10-01	1990-10-01	Polypeptid
DK111891A DK111891D0 (da)	1991-06-12	1991-06-12	Polypeptid
PCT/DK1991/000299 WO1992006111A1 (en)	1990-10-01	1991-10-01	Aprotinin analogues

Publications (1)

Publication Number	Publication Date
DK0551329T3 true DK0551329T3 (da)	1999-04-19

Family

ID=26065261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91917143T DK0551329T3 (da)	1990-10-01	1991-10-01	Aprotininanaloger

Country Status (21)

Country	Link
EP (1)	EP0551329B1 (da)
JP (1)	JP3614850B2 (da)
KR (1)	KR100250391B1 (da)
AT (1)	ATE168414T1 (da)
AU (1)	AU659100B2 (da)
CA (1)	CA2092920A1 (da)
CZ (1)	CZ285225B6 (da)
DE (1)	DE69129809T2 (da)
DK (1)	DK0551329T3 (da)
ES (1)	ES2121787T3 (da)
FI (1)	FI105036B (da)
HU (1)	HU219302B (da)
IE (1)	IE913433A1 (da)
IL (1)	IL99585A0 (da)
MX (1)	MX9101382A (da)
NO (1)	NO309529B1 (da)
NZ (1)	NZ240014A (da)
PT (1)	PT99124B (da)
SK (1)	SK281540B6 (da)
UA (1)	UA34422C2 (da)
WO (1)	WO1992006111A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
CA2205356A1 (en) *	1994-11-21	1996-05-30	Peter Edward Urwin	Modified proteinase inhibitors
AU738766B2 (en) *	1994-11-21	2001-09-27	University Of Leeds, The	Modified proteinase inhibitors
DE19629982A1 (de) *	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6833240B2 (en)	2000-03-08	2004-12-21	Mcgill University	Very low density lipoprotein receptor polymorphisms and uses therefor
ES2348230T3 (es)	2002-06-07	2010-12-01	Dyax Corp.	Prevención y reducción de la isquemia.
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
EP2386310B1 (en)	2002-08-28	2018-11-07	Dyax Corp.	Methods for preserving organs and tissues
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) *	2006-12-22	2008-07-03	Bayer Schering Pharma Aktiengesellschaft	Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
US8637454B2 (en)	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
SMT201800552T1 (it)	2010-01-06	2018-11-09	Dyax Corp	Proteine che legano la callicreina plasmatica
KR102320178B1 (ko)	2011-01-06	2021-11-02	다케다 파머수티컬 컴패니 리미티드	혈장 칼리크레인 결합 단백질
EP3387018A1 (en)	2015-12-11	2018-10-17	Dyax Corp.	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
EP4090427A1 (en)	2020-01-13	2022-11-23	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
DK450187D0 (da) *	1987-08-28	1987-08-28	Novo Industri As	Fremgangsmaade til fremstilling af proteiner
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1991
- 1991-09-27 IL IL99585A patent/IL99585A0/xx unknown
- 1991-09-30 NZ NZ240014A patent/NZ240014A/en unknown
- 1991-09-30 PT PT99124A patent/PT99124B/pt not_active IP Right Cessation
- 1991-09-30 IE IE343391A patent/IE913433A1/en not_active Application Discontinuation
- 1991-10-01 AT AT91917143T patent/ATE168414T1/de not_active IP Right Cessation
- 1991-10-01 HU HU9300943A patent/HU219302B/hu not_active IP Right Cessation
- 1991-10-01 CA CA002092920A patent/CA2092920A1/en not_active Abandoned
- 1991-10-01 CZ CZ93517A patent/CZ285225B6/cs not_active IP Right Cessation
- 1991-10-01 EP EP91917143A patent/EP0551329B1/en not_active Expired - Lifetime
- 1991-10-01 JP JP51609991A patent/JP3614850B2/ja not_active Expired - Fee Related
- 1991-10-01 AU AU85460/91A patent/AU659100B2/en not_active Ceased
- 1991-10-01 ES ES91917143T patent/ES2121787T3/es not_active Expired - Lifetime
- 1991-10-01 SK SK264-93A patent/SK281540B6/sk unknown
- 1991-10-01 DK DK91917143T patent/DK0551329T3/da active
- 1991-10-01 WO PCT/DK1991/000299 patent/WO1992006111A1/en not_active Ceased
- 1991-10-01 DE DE69129809T patent/DE69129809T2/de not_active Expired - Fee Related
- 1991-10-01 MX MX9101382A patent/MX9101382A/es not_active IP Right Cessation
- 1991-10-01 UA UA93002097A patent/UA34422C2/uk unknown
1993
- 1993-03-31 KR KR1019930701001A patent/KR100250391B1/ko not_active Expired - Fee Related
- 1993-03-31 FI FI931457A patent/FI105036B/fi active
- 1993-03-31 NO NO931220A patent/NO309529B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0551329A1 (en)	1993-07-21
FI931457L (fi)	1993-03-31
WO1992006111A1 (en)	1992-04-16
UA34422C2 (uk)	2001-03-15
SK281540B6 (sk)	2001-04-09
MX9101382A (es)	1992-06-05
JPH06501158A (ja)	1994-02-10
HUT69955A (en)	1995-09-28
ES2121787T3 (es)	1998-12-16
AU8546091A (en)	1992-04-28
FI931457A0 (fi)	1993-03-31
ATE168414T1 (de)	1998-08-15
NO931220L (no)	1993-04-01
JP3614850B2 (ja)	2005-01-26
EP0551329B1 (en)	1998-07-15
IL99585A0 (en)	1992-08-18
SK26493A3 (en)	1993-10-06
PT99124A (pt)	1992-08-31
CZ51793A3 (en)	1994-01-19
IE913433A1 (en)	1992-04-08
HU9300943D0 (en)	1993-06-28
NO931220D0 (no)	1993-03-31
FI105036B (fi)	2000-05-31
CZ285225B6 (cs)	1999-06-16
KR100250391B1 (ko)	2000-05-01
HU219302B (en)	2001-03-28
DE69129809D1 (de)	1998-08-20
AU659100B2 (en)	1995-05-11
CA2092920A1 (en)	1992-04-02
PT99124B (pt)	1999-03-31
NO309529B1 (no)	2001-02-12
NZ240014A (en)	1992-08-26
DE69129809T2 (de)	1998-11-19

Publication	Publication Date	Title
DK0551329T3 (da)	1999-04-19	Aprotininanaloger
DE68900991D1 (de)	1992-04-23	Cyclosporin-zusammensetzungen.
FI912714L (fi)	1991-12-08	Hoelje foer batteri i armbandsur.
DE59006232D1 (de)	1994-07-28	Getriebe-Turboverdichter.
SE8903042L (sv)	1990-05-11	Pharmaceutical compositions comprising cyklosporins
DE68918088D1 (de)	1994-10-13	Integriertes rastertunnelmikroskop.
DE68904101D1 (de)	1993-02-11	Polymerzusammensetzungen.
IT9047609A0 (it)	1990-02-08	Composizioni galeniche a base di ciclosporina.
IT1231852B (it)	1992-01-14	Perfezionamenti alle pinze ad espansione
FI944231L (fi)	1995-03-15	Antitromboottiset tripeptidiaineet
DE68913050D1 (de)	1994-03-24	Antithrombotische zusammensetzung.
MX9100599A (es)	1992-07-08	Juego con pala
DE3765338D1 (de)	1990-11-08	Auslegerverlaengerung fuer einen hauptausleger.
DE69021872D1 (de)	1995-09-28	Modifizierte Lösungsmittelzusammensetzungen.
DE69433062D1 (de)	2003-09-25	Ceramid i analoge auf basis von phytosphingosine
DE68905762D1 (de)	1993-05-06	Perorale zusammensetzungen.
DK0437556T3 (da)	1996-12-30	Substitutionsanaloger af magaininpeptider
NO912598D0 (no)	1991-07-02	Hypokalori-matsammensetning.
NO902871D0 (no)	1990-06-27	Fremgangsmaate for innfoering av et peptid i cytosol.
NO942348L (no)	1994-12-23	Brennstoffsammensetninger
DE68916717D1 (de)	1994-08-18	Selbstverlöschende Polymer-Zusammensetzung.
DE68914047D1 (de)	1994-04-28	Polymer-Zusammensetzungen.
ITRM920320A0 (it)	1992-04-28	composizione propellente
FI914018A7 (fi)	1992-02-28	Parannetut gemfibrotsiilikoostumukset
NO891483D0 (no)	1989-04-11	Arcelin fra lagringsproteiner fra phaseolus vulgaris.