ATE168414T1 - Aprotininanaloga - Google Patents

Aprotininanaloga

Info

Publication number: ATE168414T1
Authority: AT; Austria
Prior art keywords: aminoacid; replaced; residue; negatively charged; aminoacid residue
Prior art date: 1990-10-01

Application number

AT91917143T

Other languages

English (en)

Inventor

Soren Erik Bjorn

Kjeld Norris

Viggo Diness

Leif Birkeve Norskov-Lauritsen

Niels Dyhr Christensen

Claus Bregengaard

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-01

Filing date

1991-10-01

Publication date

1998-08-15

1990-10-01 Priority claimed from DK236190A external-priority patent/DK236190D0/da

1991-06-12 Priority claimed from DK111891A external-priority patent/DK111891D0/da

1991-10-01 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE168414T1 publication Critical patent/ATE168414T1/de

Links

ZPNFWUPYTFPOJU-MPSLMFKFSA-N aprotinin Chemical class CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H]3NC(=O)CNC(=O)CNC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC3=O)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H]3CCCN3C(=O)[C@H](N)CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N3CCC[C@@H]3C(=O)N3CCC[C@H]3C(=O)N[C@H](Cc3ccc(O)cc3)C(=O)N[C@H]([C@H](C)O)C(=O)NCC(=O)N3CCC[C@H]3C(=O)N2)C(=O)NCC(=O)NCC(=O)N[C@H](C)C(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](NC1=O)[C@H](C)CC)[C@@H](C)O)C(C)C ZPNFWUPYTFPOJU-MPSLMFKFSA-N 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 7
230000007935 neutral effect Effects 0.000 abstract 2
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
231100000417 nephrotoxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT91917143T 1990-10-01 1991-10-01 Aprotininanaloga ATE168414T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK236190A DK236190D0 (da)	1990-10-01	1990-10-01	Polypeptid
DK111891A DK111891D0 (da)	1991-06-12	1991-06-12	Polypeptid

Publications (1)

Publication Number	Publication Date
ATE168414T1 true ATE168414T1 (de)	1998-08-15

Family

ID=26065261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91917143T ATE168414T1 (de)	1990-10-01	1991-10-01	Aprotininanaloga

Country Status (21)

Country	Link
EP (1)	EP0551329B1 (de)
JP (1)	JP3614850B2 (de)
KR (1)	KR100250391B1 (de)
AT (1)	ATE168414T1 (de)
AU (1)	AU659100B2 (de)
CA (1)	CA2092920A1 (de)
CZ (1)	CZ285225B6 (de)
DE (1)	DE69129809T2 (de)
DK (1)	DK0551329T3 (de)
ES (1)	ES2121787T3 (de)
FI (1)	FI105036B (de)
HU (1)	HU219302B (de)
IE (1)	IE913433A1 (de)
IL (1)	IL99585A0 (de)
MX (1)	MX9101382A (de)
NO (1)	NO309529B1 (de)
NZ (1)	NZ240014A (de)
PT (1)	PT99124B (de)
SK (1)	SK281540B6 (de)
UA (1)	UA34422C2 (de)
WO (1)	WO1992006111A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO1996016173A2 (en) *	1994-11-21	1996-05-30	The University Of Leeds	Modified proteinase inhibitors
AU738766B2 (en) *	1994-11-21	2001-09-27	University Of Leeds, The	Modified proteinase inhibitors
DE19629982A1 (de)	1996-07-25	1998-01-29	Bayer Ag	Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6833240B2 (en)	2000-03-08	2004-12-21	Mcgill University	Very low density lipoprotein receptor polymorphisms and uses therefor
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
CA2488558C (en)	2002-06-07	2013-08-20	Dyax Corp.	Prevention and reduction of blood loss
ES2709103T3 (es)	2002-08-28	2019-04-15	Dyax Corp	Métodos para conservar órganos y tejidos
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) *	2006-12-22	2008-07-03	Bayer Schering Pharma Aktiengesellschaft	Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
US8637454B2 (en)	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
RS62853B1 (sr)	2010-01-06	2022-02-28	Takeda Pharmaceuticals Co	Proteini koji vezuju kalikrein plazme
AU2012204202A1 (en)	2011-01-06	2013-07-11	Dyax Corp.	Plasma kallikrein binding proteins
CN116077648A (zh)	2015-12-11	2023-05-09	武田药品工业株式会社	血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
MX2022008649A (es)	2020-01-13	2022-09-23	Takeda Pharmaceuticals Co	Inhibidores de calicreina plasmatica y sus usos para tratar episodios de angioedema hereditario pediatrico.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) *	1987-06-27	1989-01-05	Bayer Ag	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK450187D0 (da) *	1987-08-28	1987-08-28	Novo Industri As	Fremgangsmaade til fremstilling af proteiner
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

1991
- 1991-09-27 IL IL99585A patent/IL99585A0/xx unknown
- 1991-09-30 PT PT99124A patent/PT99124B/pt not_active IP Right Cessation
- 1991-09-30 NZ NZ240014A patent/NZ240014A/en unknown
- 1991-09-30 IE IE343391A patent/IE913433A1/en not_active Application Discontinuation
- 1991-10-01 AT AT91917143T patent/ATE168414T1/de not_active IP Right Cessation
- 1991-10-01 DE DE69129809T patent/DE69129809T2/de not_active Expired - Fee Related
- 1991-10-01 CA CA002092920A patent/CA2092920A1/en not_active Abandoned
- 1991-10-01 WO PCT/DK1991/000299 patent/WO1992006111A1/en not_active Ceased
- 1991-10-01 JP JP51609991A patent/JP3614850B2/ja not_active Expired - Fee Related
- 1991-10-01 CZ CZ93517A patent/CZ285225B6/cs not_active IP Right Cessation
- 1991-10-01 EP EP91917143A patent/EP0551329B1/de not_active Expired - Lifetime
- 1991-10-01 SK SK264-93A patent/SK281540B6/sk unknown
- 1991-10-01 AU AU85460/91A patent/AU659100B2/en not_active Ceased
- 1991-10-01 ES ES91917143T patent/ES2121787T3/es not_active Expired - Lifetime
- 1991-10-01 UA UA93002097A patent/UA34422C2/uk unknown
- 1991-10-01 DK DK91917143T patent/DK0551329T3/da active
- 1991-10-01 HU HU9300943A patent/HU219302B/hu not_active IP Right Cessation
- 1991-10-01 MX MX9101382A patent/MX9101382A/es not_active IP Right Cessation
1993
- 1993-03-31 NO NO931220A patent/NO309529B1/no not_active IP Right Cessation
- 1993-03-31 FI FI931457A patent/FI105036B/fi active
- 1993-03-31 KR KR1019930701001A patent/KR100250391B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ51793A3 (en)	1994-01-19
PT99124A (pt)	1992-08-31
PT99124B (pt)	1999-03-31
IL99585A0 (en)	1992-08-18
CA2092920A1 (en)	1992-04-02
NO931220L (no)	1993-04-01
NO309529B1 (no)	2001-02-12
HU219302B (en)	2001-03-28
SK26493A3 (en)	1993-10-06
KR100250391B1 (ko)	2000-05-01
AU8546091A (en)	1992-04-28
FI105036B (fi)	2000-05-31
NZ240014A (en)	1992-08-26
FI931457L (fi)	1993-03-31
WO1992006111A1 (en)	1992-04-16
DE69129809D1 (de)	1998-08-20
DE69129809T2 (de)	1998-11-19
HU9300943D0 (en)	1993-06-28
ES2121787T3 (es)	1998-12-16
NO931220D0 (no)	1993-03-31
IE913433A1 (en)	1992-04-08
AU659100B2 (en)	1995-05-11
JP3614850B2 (ja)	2005-01-26
MX9101382A (es)	1992-06-05
UA34422C2 (uk)	2001-03-15
EP0551329A1 (de)	1993-07-21
SK281540B6 (sk)	2001-04-09
HUT69955A (en)	1995-09-28
CZ285225B6 (cs)	1999-06-16
DK0551329T3 (da)	1999-04-19
JPH06501158A (ja)	1994-02-10
EP0551329B1 (de)	1998-07-15
FI931457A0 (fi)	1993-03-31

Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification
2004-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE168414T1 (de)	1998-08-15	Aprotininanaloga
SE8903042D0 (sv)	1989-09-15	Pharmaceutical compositions comprising cyklosporins
ATE154938T1 (de)	1997-07-15	Inhibitorvariante der menschlichen protease vom kunitz-typ
IT1231852B (it)	1992-01-14	Perfezionamenti alle pinze ad espansione
ATE152735T1 (de)	1997-05-15	Inhibitorvariante der menschlichen protease vom kunitz-typ
RU94036776A (ru)	1996-09-27	Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена ингибитора протеазы
DE69400872D1 (de)	1996-12-12	Kraftstoffzusammensetzungen
DE69021872D1 (de)	1995-09-28	Modifizierte Lösungsmittelzusammensetzungen.
TR26415A (tr)	1995-03-15	Yumusak sampuan terkipleri
ATE210149T1 (de)	2001-12-15	Entzündungshemmende zusammensetzung und methode, in welchen des-tyr dynorphin und analoge benutzt werden
EP0607103A3 (de)	1997-07-09	Chelatbildende Gruppen enthaltende Somatostatinanaloge und deren radiomarkierten Zusammensetzungen.
DK0437556T3 (da)	1996-12-30	Substitutionsanaloger af magaininpeptider
DE68905762D1 (de)	1993-05-06	Perorale zusammensetzungen.
FI910111A7 (fi)	1991-01-09	Suihkutettava koostumus
NO902871L (no)	1991-12-30	Fremgangsmaate for innfoering av et peptid i cytosol.
BE849803A (fr)	1977-06-23	Compositions photopolymerisables solubles dans des solubles aqueuses a l'etat non reticule
KR870700081A (ko)	1987-02-28	폴리사이클로알케닐-종결, 불포화폴리에스테르 또는 폴리에스테르아미드 조성물 및 이를 위한 비닐-반응성 가소제
NO942348L (no)	1994-12-23	Brennstoffsammensetninger
FI924321A7 (fi)	1992-09-25	Ruiskutettavat maataloudessa käytettävät koostumukset
FR2700262B1 (fr)	1995-03-17	Prothèse partielle du genou.
NL7902932A (nl)	1979-10-26	Aan somatostatine structureel verwante peptiden.
KR890022281U (ko)	1989-12-01	토양에 압축 공기의 주입장치
NL7904510A (nl)	1979-12-28	Steroidaal / 16alpha,17beta/cyclohexeen en naftaleno- 21-carbonzuren en esters daarvan.
FI991120A0 (fi)	1999-05-17	Vesiliukoisten peptidien pitkäaikaisesti vapautuvat koostumukset
NO891483D0 (no)	1989-04-11	Arcelin fra lagringsproteiner fra phaseolus vulgaris.