IN192874B - - Google Patents
Info
- Publication number
- IN192874B IN192874B IN601DE1997A IN192874B IN 192874 B IN192874 B IN 192874B IN 601DE1997 A IN601DE1997 A IN 601DE1997A IN 192874 B IN192874 B IN 192874B
- Authority
- IN
- India
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN39DE2001 IN189770B (fr) | 1996-03-11 | 2001-01-19 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1310696P | 1996-03-11 | 1996-03-11 | |
| US1979396P | 1996-06-14 | 1996-06-14 | |
| US72525196A | 1996-10-04 | 1996-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN192874B true IN192874B (fr) | 2004-05-29 |
Family
ID=27359773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN601DE1997 IN192874B (fr) | 1996-03-11 | 1997-03-11 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6583108B1 (fr) |
| EP (1) | EP0891426B1 (fr) |
| JP (2) | JP3469584B2 (fr) |
| KR (1) | KR100356956B1 (fr) |
| AR (3) | AR006188A1 (fr) |
| AT (1) | ATE328083T1 (fr) |
| AU (1) | AU716923B2 (fr) |
| BR (1) | BR9708021A (fr) |
| CA (1) | CA2247888A1 (fr) |
| CO (1) | CO4600683A1 (fr) |
| DE (1) | DE69735996T2 (fr) |
| DK (1) | DK0891426T3 (fr) |
| ES (1) | ES2263174T3 (fr) |
| HR (1) | HRP970144B1 (fr) |
| HU (1) | HU226419B1 (fr) |
| ID (1) | ID16224A (fr) |
| IL (1) | IL126115A (fr) |
| IN (1) | IN192874B (fr) |
| MY (1) | MY120693A (fr) |
| NZ (1) | NZ331540A (fr) |
| PA (1) | PA8426301A1 (fr) |
| PL (1) | PL188387B1 (fr) |
| PT (1) | PT891426E (fr) |
| SV (1) | SV1997000018A (fr) |
| TR (1) | TR199801794T2 (fr) |
| WO (1) | WO1997033996A2 (fr) |
| YU (1) | YU8997A (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| DE69632435T2 (de) * | 1995-07-24 | 2005-05-12 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
| WO1997033996A2 (fr) | 1996-03-11 | 1997-09-18 | Bayer Corporation | Bikunine humaine |
| WO1998033920A2 (fr) * | 1997-01-31 | 1998-08-06 | Human Genome Sciences, Inc. | Inhibiteur des voies de la thromboplastine tissulaire 3 |
| WO2000037099A2 (fr) * | 1998-12-22 | 2000-06-29 | Bayer Aktiengesellschaft | Technique permettant d'accelerer le debit de clairance mucociliaire en utilisant un inhibiteur de serine protease de type kunitz |
| AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| US6489308B1 (en) | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
| US20040235715A1 (en) * | 1999-11-12 | 2004-11-25 | Bayer Corporation | Method of producing glycosylated bikunin |
| IL140993A0 (en) | 2000-05-15 | 2002-02-10 | Bayer Ag | Trypsin substrate and diagnostic device, and method of using same |
| IL140994A (en) * | 2000-05-15 | 2005-12-18 | Bayer Ag | Urinary trypsin inhibitor assay containing a chelating agent |
| US6955921B2 (en) * | 2001-04-30 | 2005-10-18 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
| WO2003040330A2 (fr) * | 2001-11-05 | 2003-05-15 | Curagen Corporation | Polypeptides therapeutiques, acides nucleiques les codant et procedes d'utilisation correspondant |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| DK2311432T3 (en) | 2002-06-07 | 2015-02-02 | Dyax Corp | Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure |
| CN1747747B (zh) | 2003-01-06 | 2012-09-05 | 安吉奥开米公司 | 作为穿过血脑屏障的载体的抑酶肽及类似物 |
| US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
| US7244616B2 (en) | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
| US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
| PL2520654T3 (pl) | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
| JP2007508019A (ja) * | 2003-10-10 | 2007-04-05 | マルチセル テクノロジーズ、インコーポレイテッド | 活性のある治療用タンパク質を生成するための細胞系の使用 |
| JP2007536206A (ja) * | 2003-10-16 | 2007-12-13 | バイエル・ヘルスケア・エルエルシー | 尿中トリプシンインヒビターを検出するためのモノクローナル抗体 |
| EP1586587A1 (fr) * | 2004-04-16 | 2005-10-19 | Exonhit Therapeutics SA | Préparations et méthodes pour détecter l'angiogenèse |
| CA3110101A1 (fr) | 2004-06-04 | 2005-12-15 | Abbott Diabetes Care Inc. | Systemes et methodes pour gerer les donnees de soin du diabete |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| CN101160403B (zh) | 2005-02-18 | 2014-08-13 | 安吉奥开米公司 | 转运化合物穿过血脑屏障的分子 |
| WO2007011693A2 (fr) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions de cellules souches derivees du placenta, utilisees dans le traitement de cancers |
| JP5436856B2 (ja) | 2005-07-15 | 2014-03-05 | アンジオケム インコーポレーティッド | 薬学的複合体における担体としてのアプロチニンポリペプチドの使用 |
| US8093017B2 (en) | 2005-12-07 | 2012-01-10 | Siemens Heathcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
| US8828703B2 (en) * | 2005-12-29 | 2014-09-09 | Dyax Corp. | Protease inhibition |
| US8063012B2 (en) * | 2006-09-19 | 2011-11-22 | Phylogica Limited | Neuroprotective peptide inhibitors of AP-1 signaling and uses therefor |
| WO2008058167A2 (fr) * | 2006-11-07 | 2008-05-15 | Case Western Reserve University | Méthodes de traitement de troubles associés à l'activation du complément |
| WO2008077478A1 (fr) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Préparation et utilisation de variants du domaine 2 de kunitz du gène de la bikunine placentaire humaine |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| US8822409B2 (en) * | 2007-06-20 | 2014-09-02 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith |
| WO2009026334A2 (fr) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Traitement par des inhibiteurs de la kallikréine |
| DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
| RU2518240C2 (ru) * | 2008-04-18 | 2014-06-10 | Ангиочем Инк. | Композиция, на основе гидрофобных агентов и способ ее получения(варианты) |
| RU2531591C2 (ru) | 2008-10-15 | 2014-10-20 | Ангиокем Инк. | Конъюгаты этопозида и доксорубицина для доставки лекарственных средств |
| US8921314B2 (en) | 2008-10-15 | 2014-12-30 | Angiochem, Inc. | Conjugates of GLP-1 agonists and uses thereof |
| MX2011005963A (es) | 2008-12-05 | 2011-09-01 | Angiochem Inc | Conjugados de neurotensina o analogos de neurotensina y sus usos. |
| CN102300987A (zh) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | 膜型-1基质金属蛋白抑制剂及其用途 |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| AU2010239069B2 (en) | 2009-04-20 | 2015-05-14 | Angiochem Inc | Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog |
| MX2012000016A (es) | 2009-07-02 | 2012-03-26 | Angiochem Inc | Conjugados de peptidos multimericos y sus usos. |
| ES2688093T3 (es) | 2010-01-06 | 2018-10-30 | Dyax Corp. | Proteínas de unión a calicreína plasmática |
| EP2371857A1 (fr) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Inhibiteurs de facteur XII pour traiter la maladie de poumon interstitiel |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
| KR20200044138A (ko) | 2011-06-24 | 2020-04-28 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| JP2015504675A (ja) | 2012-01-10 | 2015-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１アンチトリプシン融合分子の組成物、方法、及び使用 |
| WO2014026283A1 (fr) | 2012-08-14 | 2014-02-20 | Angiochem Inc. | Conjugués peptides-dendrimères et leurs utilisations |
| MA39347B2 (fr) | 2014-02-24 | 2020-05-29 | Takeda Pharmaceuticals Co | Protéines de fusion d'uti |
| EP3122782A4 (fr) | 2014-03-27 | 2017-09-13 | Dyax Corp. | Compositions et procédés pour le traitement de l'oedème maculaire diabétique |
| US10980892B2 (en) | 2015-06-15 | 2021-04-20 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| BR112018011622A2 (pt) | 2015-12-11 | 2018-11-27 | Dyax Corp | método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae |
| CA3167336A1 (fr) | 2020-01-13 | 2021-07-22 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la kallicreine plasmatique et leurs utilisations pour traiter une crise d'angio-deme hereditaire pediatrique |
| BR112022017718A2 (pt) | 2020-03-05 | 2022-11-16 | Diamedica Usa Inc | Polipeptídeos de ulinastatina |
Family Cites Families (28)
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|---|---|---|---|---|
| US5223482A (en) | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
| US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| WO1992015605A2 (fr) | 1991-03-01 | 1992-09-17 | Protein Engineering Corporation | Inhibiteurs de l'elastase neutrophile et de la cathepsine g chez l'homme |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| ES2066033T3 (es) * | 1989-05-13 | 1995-03-01 | Bayer Ag | Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| EP0439442B1 (fr) | 1990-01-25 | 1996-03-06 | Washington University | Protéine hybride, facteur X-LACI |
| RU2054180C1 (ru) | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
| IL104325A (en) | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
| IL104326A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| JPH07509229A (ja) | 1992-07-13 | 1995-10-12 | コルバス・インターナショナル、インコーポレイテッド | ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子 |
| US5436153A (en) | 1992-12-02 | 1995-07-25 | Sprecher; Cindy A. | Human amyloid protein precursor homolog and Kunitz-type inhibitor |
| AU5684594A (en) | 1992-12-02 | 1994-06-22 | Novo Nordisk A/S | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
| JP2769083B2 (ja) | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| DE69533472T2 (de) | 1994-01-11 | 2006-01-12 | Dyax Corp., Cambridge | Kallikreinhemmende "kunitz-domäne"-proteine und derivaten davon |
| ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| WO1996003503A1 (fr) | 1994-07-21 | 1996-02-08 | The Green Cross Corporation | Procede de production d'un inhibiteur de la trypsine urinaire et des domaines de celui-ci, nouveau polypeptide associe et procede de production de ce polypeptide |
| US5541228A (en) * | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
| JPH11504938A (ja) | 1995-05-08 | 1999-05-11 | サイオス インク． | クニッツ型プロテアーゼ阻害因子 |
| US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| DE69632435T2 (de) | 1995-07-24 | 2005-05-12 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
| US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| WO1997033996A2 (fr) | 1996-03-11 | 1997-09-18 | Bayer Corporation | Bikunine humaine |
| WO1998033920A2 (fr) | 1997-01-31 | 1998-08-06 | Human Genome Sciences, Inc. | Inhibiteur des voies de la thromboplastine tissulaire 3 |
| US6294648B1 (en) * | 1999-07-20 | 2001-09-25 | Bayer Corporation | Protein having proteinase inhibitor activity |
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1997
- 1997-03-10 WO PCT/US1997/003894 patent/WO1997033996A2/fr not_active Ceased
- 1997-03-10 IL IL126115A patent/IL126115A/en not_active IP Right Cessation
- 1997-03-10 YU YU8997A patent/YU8997A/sh unknown
- 1997-03-10 EP EP97915029A patent/EP0891426B1/fr not_active Expired - Lifetime
- 1997-03-10 DE DE69735996T patent/DE69735996T2/de not_active Expired - Fee Related
- 1997-03-10 JP JP53280497A patent/JP3469584B2/ja not_active Expired - Fee Related
- 1997-03-10 BR BR9708021A patent/BR9708021A/pt not_active Application Discontinuation
- 1997-03-10 KR KR10-1998-0707163A patent/KR100356956B1/ko not_active Expired - Fee Related
- 1997-03-10 DK DK97915029T patent/DK0891426T3/da active
- 1997-03-10 AU AU22077/97A patent/AU716923B2/en not_active Ceased
- 1997-03-10 PL PL97328822A patent/PL188387B1/pl not_active IP Right Cessation
- 1997-03-10 NZ NZ331540A patent/NZ331540A/en unknown
- 1997-03-10 HU HU9902698A patent/HU226419B1/hu not_active IP Right Cessation
- 1997-03-10 PT PT97915029T patent/PT891426E/pt unknown
- 1997-03-10 AT AT97915029T patent/ATE328083T1/de not_active IP Right Cessation
- 1997-03-10 CA CA002247888A patent/CA2247888A1/fr not_active Abandoned
- 1997-03-10 TR TR1998/01794T patent/TR199801794T2/xx unknown
- 1997-03-10 ES ES97915029T patent/ES2263174T3/es not_active Expired - Lifetime
- 1997-03-11 SV SV1997000018A patent/SV1997000018A/es not_active Application Discontinuation
- 1997-03-11 PA PA19978426301A patent/PA8426301A1/es unknown
- 1997-03-11 AR ARP970100967A patent/AR006188A1/es active IP Right Grant
- 1997-03-11 IN IN601DE1997 patent/IN192874B/en unknown
- 1997-03-11 HR HR970144A patent/HRP970144B1/xx not_active IP Right Cessation
- 1997-03-11 CO CO97013175A patent/CO4600683A1/es unknown
- 1997-03-11 MY MYPI97001015A patent/MY120693A/en unknown
- 1997-03-11 ID IDP970779A patent/ID16224A/id unknown
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1998
- 1998-08-31 US US09/144,428 patent/US6583108B1/en not_active Expired - Fee Related
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2001
- 2001-10-10 US US09/974,026 patent/US7019123B2/en not_active Expired - Fee Related
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2003
- 2003-04-23 JP JP2003119118A patent/JP2004000208A/ja active Pending
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2006
- 2006-03-27 US US11/390,775 patent/US7452859B2/en not_active Expired - Fee Related
- 2006-04-20 AR ARP060101562A patent/AR053063A2/es unknown
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2007
- 2007-01-11 AR ARP070100116A patent/AR058982A1/es unknown