DK408089D0 - Proteiner - Google Patents

Proteiner

Info

Publication number
DK408089D0
DK408089D0 DK408089A DK408089A DK408089D0 DK 408089 D0 DK408089 D0 DK 408089D0 DK 408089 A DK408089 A DK 408089A DK 408089 A DK408089 A DK 408089A DK 408089 D0 DK408089 D0 DK 408089D0
Authority
DK
Denmark
Prior art keywords
pct
epi
novel
sec
date
Prior art date
Application number
DK408089A
Other languages
English (en)
Inventor
Ole Juul Nordfang
Jesper Skou Rasmussen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK408089A priority Critical patent/DK408089D0/da
Publication of DK408089D0 publication Critical patent/DK408089D0/da
Priority to DE90912756T priority patent/DE69004966T2/de
Priority to JP02511983A priority patent/JP3122127B2/ja
Priority to ES90912756T priority patent/ES2062549T3/es
Priority to DK90912756.5T priority patent/DK0487591T3/da
Priority to EP90912756A priority patent/EP0487591B1/en
Priority to US07/828,920 priority patent/US5312736A/en
Priority to AT90912756T priority patent/ATE97918T1/de
Priority to AU62852/90A priority patent/AU6285290A/en
Priority to PCT/DK1990/000212 priority patent/WO1991002753A1/en
Priority to US08/026,145 priority patent/US5378614A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK408089A 1989-08-18 1989-08-18 Proteiner DK408089D0 (da)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DK408089A DK408089D0 (da) 1989-08-18 1989-08-18 Proteiner
PCT/DK1990/000212 WO1991002753A1 (en) 1989-08-18 1990-08-17 Anticoagulant protein
DK90912756.5T DK0487591T3 (da) 1989-08-18 1990-08-17 Antikoagulerende protein
JP02511983A JP3122127B2 (ja) 1989-08-18 1990-08-17 抗凝血タンパク質
ES90912756T ES2062549T3 (es) 1989-08-18 1990-08-17 Proteina anticoagulante.
DE90912756T DE69004966T2 (de) 1989-08-18 1990-08-17 Antikoagulierendes protein.
EP90912756A EP0487591B1 (en) 1989-08-18 1990-08-17 Anticoagulant protein
US07/828,920 US5312736A (en) 1989-08-18 1990-08-17 Anticoagulant analogues of the tissue factor extrinsic pathway inhibitor (EPI) with reduced affinity for heparin
AT90912756T ATE97918T1 (de) 1989-08-18 1990-08-17 Antikoagulierendes protein.
AU62852/90A AU6285290A (en) 1989-08-18 1990-08-17 Anticoagulant protein
US08/026,145 US5378614A (en) 1989-08-18 1993-03-02 Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK408089A DK408089D0 (da) 1989-08-18 1989-08-18 Proteiner

Publications (1)

Publication Number Publication Date
DK408089D0 true DK408089D0 (da) 1989-08-18

Family

ID=8129972

Family Applications (2)

Application Number Title Priority Date Filing Date
DK408089A DK408089D0 (da) 1989-08-18 1989-08-18 Proteiner
DK90912756.5T DK0487591T3 (da) 1989-08-18 1990-08-17 Antikoagulerende protein

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK90912756.5T DK0487591T3 (da) 1989-08-18 1990-08-17 Antikoagulerende protein

Country Status (9)

Country Link
US (1) US5312736A (da)
EP (1) EP0487591B1 (da)
JP (1) JP3122127B2 (da)
AT (1) ATE97918T1 (da)
AU (1) AU6285290A (da)
DE (1) DE69004966T2 (da)
DK (2) DK408089D0 (da)
ES (1) ES2062549T3 (da)
WO (1) WO1991002753A1 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
DK148890D0 (da) * 1990-06-19 1990-06-19 Novo Nordisk As Farmaceutisk praeparat
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
PT643585E (pt) * 1992-06-01 2000-05-31 Chiron Corp Utilizacao de inibidor da coagulacao associado a lipoproteinas (laci) para a preparacao de um medicamento para o tratamento de inflamacao aguda ou cronica
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ZA941414B (en) * 1993-03-02 1994-09-28 Novo Nordisk A G Non-glycosylated TFPI analogues
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5650391A (en) * 1994-03-21 1997-07-22 Jewish Hospital Of St. Louis Methods and compositions for inhibition of hepatic clearance of tissue factor pathway inhibitor
US5824644A (en) * 1994-07-07 1998-10-20 G. D. Searle & Co. Method of attenuating arterial stenosis
JP3779728B2 (ja) * 1994-08-05 2006-05-31 カイロン コーポレイション 組織因子活性インヒビターの産生
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
AU711405B2 (en) * 1994-10-18 1999-10-14 Dendreon Corporation Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
IL126115A (en) 1996-03-11 2007-03-08 Aerovance Inc Significantly purified protein with suppressive activity for sirin protease and its pharmaceutical preparations
US5977057A (en) 1996-05-08 1999-11-02 The University Of Vermont And State Agricultural College Thrombosis prophylaxis for factor VLEIDEN carriers
DK1140150T3 (da) * 1998-12-22 2004-03-22 Bayer Ag Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
EP1446140A4 (en) 2001-10-15 2007-03-07 Novartis Vaccines & Diagnostic TREATMENT OF HEAVY PNEUMONIA BY ADMINISTRATION OF TFPI (TISSUE FACTOR PATHWAY INHIBITOR)
WO2003103475A2 (en) 2002-06-07 2003-12-18 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
AU2003267967B2 (en) * 2002-06-18 2008-11-20 Zymogenetics, Inc. Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter
CA2512680A1 (en) * 2003-01-08 2004-07-29 Chiron Corporation Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2006066960A1 (en) * 2004-12-23 2006-06-29 Ludwig-Maximilians- Universität München Variant tfpi with increased anti-thrombotic activity
ZA200800251B (en) * 2005-06-24 2009-04-29 Drugrecure Aps Airway administration of tissue factor pathway inhibitor in inflammatory conditions affecting the respiratory track
WO2007014749A2 (en) * 2005-07-29 2007-02-08 Universiteit Van Maastricht Regulation of tissue factor activity by protein s and tissue factor pathway inhibitor
SI1981519T1 (en) 2005-12-29 2018-05-31 Dyax Corp. INHIBITION PROTEAZE
CA2696208A1 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
CA2744235A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (en) 2010-01-06 2021-10-27 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
CA2823776A1 (en) 2011-01-06 2012-07-12 Dyax Corp. Plasma kallikrein binding proteins
IL295414B2 (en) 2014-03-27 2026-02-01 Takeda Pharmaceuticals Co Compositions and methods for treating macular edema due to diabetes
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US12528880B2 (en) 2020-01-13 2026-01-20 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington Method of isolating highly purified tissue factor inhibitor
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co cDNA of human tissue factor inhibitor

Also Published As

Publication number Publication date
JPH04507252A (ja) 1992-12-17
DE69004966D1 (de) 1994-01-13
ATE97918T1 (de) 1993-12-15
ES2062549T3 (es) 1994-12-16
WO1991002753A1 (en) 1991-03-07
EP0487591B1 (en) 1993-12-01
AU6285290A (en) 1991-04-03
JP3122127B2 (ja) 2001-01-09
DK0487591T3 (da) 1994-04-18
US5312736A (en) 1994-05-17
DE69004966T2 (de) 1994-03-24
EP0487591A1 (en) 1992-06-03

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