DK408089D0 - Proteiner - Google Patents

Proteiner

Info

Publication number
DK408089D0
DK408089D0 DK408089A DK408089A DK408089D0 DK 408089 D0 DK408089 D0 DK 408089D0 DK 408089 A DK408089 A DK 408089A DK 408089 A DK408089 A DK 408089A DK 408089 D0 DK408089 D0 DK 408089D0
Authority
DK
Denmark
Prior art keywords
pct
epi
novel
sec
date
Prior art date
Application number
DK408089A
Other languages
English (en)
Inventor
Ole Juul Nordfang
Jesper Skou Rasmussen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK408089A priority Critical patent/DK408089D0/da
Publication of DK408089D0 publication Critical patent/DK408089D0/da
Priority to PCT/DK1990/000212 priority patent/WO1991002753A1/en
Priority to EP90912756A priority patent/EP0487591B1/en
Priority to DK90912756.5T priority patent/DK0487591T3/da
Priority to US07/828,920 priority patent/US5312736A/en
Priority to DE90912756T priority patent/DE69004966T2/de
Priority to ES90912756T priority patent/ES2062549T3/es
Priority to AT90912756T priority patent/ATE97918T1/de
Priority to AU62852/90A priority patent/AU6285290A/en
Priority to JP02511983A priority patent/JP3122127B2/ja
Priority to US08/026,145 priority patent/US5378614A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK408089A 1989-08-18 1989-08-18 Proteiner DK408089D0 (da)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DK408089A DK408089D0 (da) 1989-08-18 1989-08-18 Proteiner
JP02511983A JP3122127B2 (ja) 1989-08-18 1990-08-17 抗凝血タンパク質
US07/828,920 US5312736A (en) 1989-08-18 1990-08-17 Anticoagulant analogues of the tissue factor extrinsic pathway inhibitor (EPI) with reduced affinity for heparin
EP90912756A EP0487591B1 (en) 1989-08-18 1990-08-17 Anticoagulant protein
DK90912756.5T DK0487591T3 (da) 1989-08-18 1990-08-17 Antikoagulerende protein
PCT/DK1990/000212 WO1991002753A1 (en) 1989-08-18 1990-08-17 Anticoagulant protein
DE90912756T DE69004966T2 (de) 1989-08-18 1990-08-17 Antikoagulierendes protein.
ES90912756T ES2062549T3 (es) 1989-08-18 1990-08-17 Proteina anticoagulante.
AT90912756T ATE97918T1 (de) 1989-08-18 1990-08-17 Antikoagulierendes protein.
AU62852/90A AU6285290A (en) 1989-08-18 1990-08-17 Anticoagulant protein
US08/026,145 US5378614A (en) 1989-08-18 1993-03-02 Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK408089A DK408089D0 (da) 1989-08-18 1989-08-18 Proteiner

Publications (1)

Publication Number Publication Date
DK408089D0 true DK408089D0 (da) 1989-08-18

Family

ID=8129972

Family Applications (2)

Application Number Title Priority Date Filing Date
DK408089A DK408089D0 (da) 1989-08-18 1989-08-18 Proteiner
DK90912756.5T DK0487591T3 (da) 1989-08-18 1990-08-17 Antikoagulerende protein

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK90912756.5T DK0487591T3 (da) 1989-08-18 1990-08-17 Antikoagulerende protein

Country Status (9)

Country Link
US (1) US5312736A (da)
EP (1) EP0487591B1 (da)
JP (1) JP3122127B2 (da)
AT (1) ATE97918T1 (da)
AU (1) AU6285290A (da)
DE (1) DE69004966T2 (da)
DK (2) DK408089D0 (da)
ES (1) ES2062549T3 (da)
WO (1) WO1991002753A1 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
DK148890D0 (da) * 1990-06-19 1990-06-19 Novo Nordisk As Farmaceutisk praeparat
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ATE187648T1 (de) * 1992-06-01 2000-01-15 Chiron Corp Zusammensetzungen enthaltend lipoprotein- associated-coagulation-inhibitor (laci) zur herstellung eines medikaments zur behandlung von akuten oder chronischen enzündungen
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
IL108798A0 (en) * 1993-03-02 1994-06-24 Novo Nordisk As Non-glycosylated tfpi analogues
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5650391A (en) * 1994-03-21 1997-07-22 Jewish Hospital Of St. Louis Methods and compositions for inhibition of hepatic clearance of tissue factor pathway inhibitor
US5824644A (en) * 1994-07-07 1998-10-20 G. D. Searle & Co. Method of attenuating arterial stenosis
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
AU707762B2 (en) * 1994-08-05 1999-07-22 Novartis Vaccines And Diagnostics, Inc. Production of tissue factor pathway inhibitor
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US6090916A (en) 1994-10-18 2000-07-18 Corvas International, Inc. Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
WO1997033996A2 (en) * 1996-03-11 1997-09-18 Bayer Corporation Human bikunin
US5977057A (en) * 1996-05-08 1999-11-02 The University Of Vermont And State Agricultural College Thrombosis prophylaxis for factor VLEIDEN carriers
ATE254473T1 (de) * 1998-12-22 2003-12-15 Bayer Ag Verwendung eines serinproteaseinhibitors vom kunitz-typ zur beschleunigung der schleimauflöserate
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
BR0213293A (pt) 2001-10-15 2004-12-21 Chiron Corp Uso de tfpi ou de um análogo de tfpi no tratamento de septicemia
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT2298278E (pt) 2002-06-07 2016-02-25 Dyax Corp Prevenção e redução da perda de sangue e resposta inflamatória
EP1513929A4 (en) * 2002-06-18 2006-04-19 Zymogenetics Inc HYBRID VECTOR WITH A CYTOMEGALOVIRUS ENHANCER AND PROMOTER OF MYELOPROLIFERATIVE SARCOMA VIRUS
PT1589949E (pt) * 2003-01-08 2008-11-06 Novartis Vaccines & Diagnostic Composições liofilizadas estabilizadas compreendendo inibidor da coagulação por factores tecidulares ou variante de inibidor da coagulação por factores tecidulares
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2006066960A1 (en) * 2004-12-23 2006-06-29 Ludwig-Maximilians- Universität München Variant tfpi with increased anti-thrombotic activity
ZA200800251B (en) * 2005-06-24 2009-04-29 Drugrecure Aps Airway administration of tissue factor pathway inhibitor in inflammatory conditions affecting the respiratory track
WO2007014749A2 (en) * 2005-07-29 2007-02-08 Universiteit Van Maastricht Regulation of tissue factor activity by protein s and tissue factor pathway inhibitor
EP1981519B1 (en) 2005-12-29 2017-12-27 Dyax Corp. Protease inhibition
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
JP2013516389A (ja) * 2009-01-06 2013-05-13 ダイアックス コーポレーション カリクレイン阻害剤による粘膜炎治療
ES2905545T3 (es) * 2010-01-06 2022-04-11 Takeda Pharmaceuticals Co Proteínas de unión a calicreína plasmática
KR102011156B1 (ko) 2011-01-06 2019-08-16 다이액스 코포레이션 혈장 칼리크레인 결합 단백질
IL247942B (en) 2014-03-27 2022-09-01 Dyax Corp Compositions and methods for drops in macular edema as a result of diabetes
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
AU2021209045A1 (en) 2020-01-13 2022-07-28 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington Method of isolating highly purified tissue factor inhibitor
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co cDNA of human tissue factor inhibitor

Also Published As

Publication number Publication date
DK0487591T3 (da) 1994-04-18
DE69004966T2 (de) 1994-03-24
DE69004966D1 (de) 1994-01-13
EP0487591A1 (en) 1992-06-03
ES2062549T3 (es) 1994-12-16
WO1991002753A1 (en) 1991-03-07
ATE97918T1 (de) 1993-12-15
US5312736A (en) 1994-05-17
EP0487591B1 (en) 1993-12-01
AU6285290A (en) 1991-04-03
JP3122127B2 (ja) 2001-01-09
JPH04507252A (ja) 1992-12-17

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