IN2012DN02591A - - Google Patents
Info
- Publication number
- IN2012DN02591A IN2012DN02591A IN2591DEN2012A IN2012DN02591A IN 2012DN02591 A IN2012DN02591 A IN 2012DN02591A IN 2591DEN2012 A IN2591DEN2012 A IN 2591DEN2012A IN 2012DN02591 A IN2012DN02591 A IN 2012DN02591A
- Authority
- IN
- India
- Prior art keywords
- proteins
- plant
- fraction
- suprastructure
- apoplast
- Prior art date
Links
- 235000018102 proteins Nutrition 0.000 abstract 8
- 102000004169 proteins and genes Human genes 0.000 abstract 8
- 108090000623 proteins and genes Proteins 0.000 abstract 8
- 235000021118 plant-derived protein Nutrition 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 210000001938 protoplast Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/517—Plant cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24478609P | 2009-09-22 | 2009-09-22 | |
| PCT/CA2010/001489 WO2011035423A1 (fr) | 2009-09-22 | 2010-09-21 | Procédé de préparation de protéines dérivées de plantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02591A true IN2012DN02591A (fr) | 2015-08-28 |
Family
ID=43795254
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2637DEN2012 IN2012DN02637A (fr) | 2009-09-22 | 2010-09-21 | |
| IN2591DEN2012 IN2012DN02591A (fr) | 2009-09-22 | 2010-09-21 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2637DEN2012 IN2012DN02637A (fr) | 2009-09-22 | 2010-09-21 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11833200B2 (fr) |
| EP (3) | EP2480560B1 (fr) |
| JP (2) | JP5551780B2 (fr) |
| KR (4) | KR101773431B1 (fr) |
| CN (4) | CN107090021A (fr) |
| AR (2) | AR078432A1 (fr) |
| AU (2) | AU2010300033B2 (fr) |
| BR (2) | BR112012006414B1 (fr) |
| CA (2) | CA2772962C (fr) |
| DK (3) | DK2480658T3 (fr) |
| ES (3) | ES2911037T3 (fr) |
| HR (3) | HRP20220478T1 (fr) |
| HU (3) | HUE058165T2 (fr) |
| IL (4) | IL218393A0 (fr) |
| IN (2) | IN2012DN02637A (fr) |
| MX (2) | MX2012003372A (fr) |
| MY (2) | MY158475A (fr) |
| NO (2) | NO2480658T3 (fr) |
| NZ (2) | NZ598481A (fr) |
| PH (2) | PH12012500566A1 (fr) |
| PL (3) | PL2480658T3 (fr) |
| PT (3) | PT3354657T (fr) |
| RU (2) | RU2579903C2 (fr) |
| SG (2) | SG178918A1 (fr) |
| SI (3) | SI2480658T1 (fr) |
| TR (1) | TR201803560T4 (fr) |
| WO (2) | WO2011035422A1 (fr) |
| ZA (2) | ZA201202836B (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615372A1 (fr) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Particules semblables au virus grippal a comprenant de l'hemagglutinine |
| WO2009076778A1 (fr) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine |
| HUE039100T2 (hu) | 2009-06-24 | 2018-12-28 | Medicago Inc | Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék |
| KR101773431B1 (ko) * | 2009-09-22 | 2017-09-12 | 메디카고 인코포레이티드 | 식물-유래 vlp의 제조방법 |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| KR101963792B1 (ko) | 2011-06-13 | 2019-07-31 | 메디카고 인코포레이티드 | 식물에서 광견병 바이러스 유사 입자 생성 |
| EP2758038B1 (fr) * | 2011-09-23 | 2018-05-30 | The United States of America, as represented by The Secretary, Department of Health & Human Services | Nouveaux vaccins à base de protéine hémagglutinine de la grippe |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| NZ622731A (en) | 2011-09-30 | 2016-04-29 | Medicago Inc | Increasing virus-like particle yield in plants |
| EP2798059B1 (fr) * | 2011-12-21 | 2021-09-29 | Apse, Llc | Procédé de purification de vlp avec des capsides résistants aux hydrolases |
| JP6406655B2 (ja) * | 2012-02-22 | 2018-10-17 | 三菱商事フードテック株式会社 | 植物性食品素材の軟化方法、軟化製剤、軟化した植物性食品素材およびそれを用いた食品 |
| ES2657875T3 (es) * | 2012-03-22 | 2018-03-07 | Fraunhofer Usa Inc. | Partículas tipo virus que comprenden una proteína de la matriz de un virus encapsulado de plantas y usos de las mismas |
| JP2015528285A (ja) | 2012-09-05 | 2015-09-28 | メディカゴ インコーポレイテッド | 植物におけるピコルナウイルス様粒子の産生 |
| US9617297B2 (en) * | 2012-10-11 | 2017-04-11 | The Regents Of The University Of California | Apoplast wash fluid recovery for improved recombinant endoglucanase extraction in tabacco leaves |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| ES2803508T3 (es) * | 2013-03-28 | 2021-01-27 | Medicago Inc | Producción de partículas similares al virus de la gripe en plantas |
| JP6358257B2 (ja) * | 2013-09-06 | 2018-07-18 | 三菱ケミカル株式会社 | 植物を用いたタンパク質の製造方法 |
| WO2015054639A1 (fr) | 2013-10-11 | 2015-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Vaccins contre le virus d'epstein-barr |
| RU2699982C2 (ru) | 2014-01-10 | 2019-09-11 | Медикаго Инк. | Энхансерные элементы cpmv |
| RU2731295C2 (ru) | 2014-07-11 | 2020-09-01 | Медикаго Инк. | Модификация продуцирования белков в растениях |
| US11191727B2 (en) | 2014-12-31 | 2021-12-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Multivalent nanoparticle-based vaccines |
| JP2019129705A (ja) * | 2016-03-31 | 2019-08-08 | 日本たばこ産業株式会社 | 植物に物質を導入する方法 |
| SG10201912944QA (en) | 2016-09-02 | 2020-02-27 | The Usa As Represented By The Secretary | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
| WO2019104439A1 (fr) * | 2017-11-30 | 2019-06-06 | Medicago Inc. | Protéines vp1 de norovirus modifiées et protéines vp1 de norovirus comprenant des vlp |
| EP3814509A4 (fr) | 2018-06-27 | 2022-07-27 | Medicago Inc. | Mutants d'hémagglutinine du virus de la grippe |
| CA3106471A1 (fr) * | 2018-07-13 | 2020-01-16 | Medicago Inc. | Proteines vp1 de norovirus modifiees et vlp comprenant des proteines vp1 de norovirus |
| CN109112093B (zh) * | 2018-09-05 | 2021-11-09 | 上海交通大学 | 一种青蒿原生质体高效分离及瞬时转化的方法 |
| CA3137447A1 (fr) * | 2019-04-25 | 2020-10-29 | Flagship Pioneering Innovations Vi, Llc | Compositions et procedes se rapportant a des paquets de messagers vegetaux |
| CN110483616B (zh) * | 2019-07-31 | 2021-06-04 | 中国农业科学院农产品加工研究所 | 从感染病原菌的植物组织中分离病原菌分泌的质外体效应蛋白的方法 |
| CN111060696B (zh) * | 2019-12-27 | 2023-09-08 | 湖南农业大学 | 一种降低植物小分子信号肽假阳性率的方法 |
| CN111718394A (zh) * | 2020-06-28 | 2020-09-29 | 广西壮族自治区农业科学院 | 一种基于bpp法的甘蔗组织变性蛋白提取方法 |
| CN111826394A (zh) * | 2020-08-07 | 2020-10-27 | 浙江华缔药业集团医药开发有限公司 | 植物瞬时表达载体的构建及应用 |
| WO2022260849A1 (fr) | 2021-06-09 | 2022-12-15 | Nant Holdings Ip, Llc | Procédés et systèmes de production d'une protéine d'intérêt dans une plante |
| CN114934007B (zh) * | 2022-07-01 | 2023-11-24 | 广东省农业科学院作物研究所 | 一种甘薯原生质体的制备方法 |
| JP7745040B1 (ja) | 2024-06-21 | 2025-09-26 | デンカ株式会社 | 目的タンパク質の回収方法及び製造方法 |
| CN120082594B (zh) * | 2025-04-07 | 2025-10-28 | 贵州大学 | NbClpT2在调控植物抗PVY侵染中的应用 |
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| EP0203177A4 (fr) | 1984-11-29 | 1987-04-28 | Scripps Clinic Res | Polypeptides et anticorps associes a des glucoproteines virales depourvues de glucose. |
| JPS61265086A (ja) * | 1985-05-21 | 1986-11-22 | Mitsui Toatsu Chem Inc | プロトプラストの培養法 |
| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
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