IN2012DN02634A - - Google Patents

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Publication number
IN2012DN02634A
IN2012DN02634A IN2634DEN2012A IN2012DN02634A IN 2012DN02634 A IN2012DN02634 A IN 2012DN02634A IN 2634DEN2012 A IN2634DEN2012 A IN 2634DEN2012A IN 2012DN02634 A IN2012DN02634 A IN 2012DN02634A
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IN
India
Prior art keywords
binding proteins
activity
binding
methods
cdr
Prior art date
Application number
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English (en)
Inventor
Chung-Ming Hsieh
Chengbin Wu
Renee Miller
Dominic J Ambrosi
Original Assignee
Abbvie Inc
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Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of IN2012DN02634A publication Critical patent/IN2012DN02634A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/545—IL-1

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BR112012007365A2 (pt) 2016-11-22
UY32949A (es) 2011-02-28
US20110142761A1 (en) 2011-06-16
AR078650A1 (es) 2011-11-23
TW201124427A (en) 2011-07-16
EP2488201A4 (fr) 2013-12-25
EP2488201A1 (fr) 2012-08-22
US8398966B2 (en) 2013-03-19
US20130295004A1 (en) 2013-11-07
RU2012119788A (ru) 2013-11-20
WO2011047266A1 (fr) 2011-04-21
ZA201202610B (en) 2012-12-27
IL219202A0 (en) 2012-06-28
AU2010306681A1 (en) 2012-04-19
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MX2012004412A (es) 2012-05-08

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