IN2012DN06631A - - Google Patents
Info
- Publication number
- IN2012DN06631A IN2012DN06631A IN6631DEN2012A IN2012DN06631A IN 2012DN06631 A IN2012DN06631 A IN 2012DN06631A IN 6631DEN2012 A IN6631DEN2012 A IN 6631DEN2012A IN 2012DN06631 A IN2012DN06631 A IN 2012DN06631A
- Authority
- IN
- India
- Prior art keywords
- yloxy
- methyl
- isoxazol
- pyran
- piperidin
- Prior art date
Links
- WLLOFQROROXOMO-GOSISDBHSA-N 4-[[4-[[4-[(3r)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol Chemical compound C1CC(COC=2C3=C(O[C@H]4COCC4)C=CC=C3ON=2)CCN1CC1(O)CCOCC1 WLLOFQROROXOMO-GOSISDBHSA-N 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30492110P | 2010-02-16 | 2010-02-16 | |
| PCT/IB2011/050548 WO2011101774A1 (en) | 2010-02-16 | 2011-02-09 | (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN06631A true IN2012DN06631A (lt) | 2015-10-23 |
Family
ID=43904611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN6631DEN2012 IN2012DN06631A (lt) | 2010-02-16 | 2011-02-09 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120041026A1 (lt) |
| EP (1) | EP2536713A1 (lt) |
| JP (1) | JP2013519722A (lt) |
| KR (1) | KR20120123089A (lt) |
| CN (1) | CN102762554A (lt) |
| AR (1) | AR080172A1 (lt) |
| AU (1) | AU2011216950A1 (lt) |
| CA (1) | CA2788656A1 (lt) |
| IN (1) | IN2012DN06631A (lt) |
| MX (1) | MX2012008721A (lt) |
| SG (1) | SG183111A1 (lt) |
| TW (1) | TW201141856A (lt) |
| UY (1) | UY33225A (lt) |
| WO (1) | WO2011101774A1 (lt) |
| ZA (1) | ZA201206469B (lt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| WO2012157288A1 (en) * | 2011-05-18 | 2012-11-22 | Raqualia Pharma Inc. | Polymorph form of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid |
| BR112015011392A2 (pt) * | 2012-11-21 | 2017-07-11 | Raqualia Pharma Inc | formas polimórficas de ácidos, processo de preparação, composição farmacêutica e uso das mesmas |
| CN105164119B (zh) | 2013-03-20 | 2017-12-08 | 苏文生命科学有限公司 | 作为5‑ht4受体激动剂的5‑氨基‑喹啉‑8‑甲酰胺衍生物 |
| MX368017B (es) | 2013-12-16 | 2019-09-13 | Suven Life Sciences Ltd | Compuestos de indazol como agonistas del receptor de 5-ht4. |
| CA2944982C (en) | 2014-05-20 | 2022-06-07 | Raqualia Pharma Inc. | Benzisoxazole derivative salt |
| SG11201706501VA (en) | 2015-02-13 | 2017-09-28 | Suven Life Sciences Ltd | AMIDE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS |
| CN117796401A (zh) * | 2023-12-25 | 2024-04-02 | 江苏万隆化学有限公司 | 一种含2-羟基-6-氟苯甲酸甲酯中间体抗菌剂的制备工艺 |
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| JP3465794B2 (ja) | 1991-02-27 | 2003-11-10 | メレルファーマスーティカルズ インコーポレイテッド | Ｎｍｄａ拮抗剤 |
| US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| ES2187518T3 (es) * | 1992-11-23 | 2003-06-16 | Aventis Pharma Inc | 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados. |
| IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| PL186781B1 (pl) | 1995-09-29 | 2004-02-27 | Glaxo Wellcome Spa | Nowy związek, pochodna tetrahydrochinoliny, sposób wytwarzania pochodnej tetrahydrochinoliny, środek farmaceutyczny i zastosowanie |
| IL126003A0 (en) | 1996-04-10 | 1999-04-11 | Hoechst Marion Roussel Inc | Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors |
| JP4109718B2 (ja) | 1996-04-12 | 2008-07-02 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | アセチルコリンエステラーゼ阻害剤および鎮痛剤としてのイサチン誘導体 |
| ATE224884T1 (de) | 1996-07-01 | 2002-10-15 | Schering Corp | Muscarin-antagonisten |
| JP3390179B2 (ja) | 1996-08-15 | 2003-03-24 | シェーリング コーポレイション | エーテルムスカリン様アンタゴニスト |
| CA2266556C (en) | 1996-09-30 | 2007-11-06 | Hoechst Marion Roussel, Inc. | Nmda (n-methyl-d-aspartate) antagonists |
| WO2000018391A1 (en) | 1998-09-30 | 2000-04-06 | Takeda Chemical Industries, Ltd. | Drugs for improving vesical excretory strength |
| CA2435883A1 (en) | 2001-01-26 | 2002-08-01 | Sankyo Company, Limited | Benzylamine analogue |
| US7375136B2 (en) | 2001-03-08 | 2008-05-20 | Emory University | pH-dependent NMDA receptor antagonists |
| CA2443108A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| CA2453383C (en) | 2001-07-24 | 2010-04-06 | Richter Gedeon Vegyeszeti Gyar Rt | Piperidine derivatives as nmda receptor antagonists |
| SI1648882T1 (sl) | 2003-06-04 | 2009-02-28 | Merck & Co Inc | 3-fluoro-piperidini kot nmda/nr2b antagonisti |
| GB0316094D0 (en) | 2003-07-09 | 2003-08-13 | Neuropharma Sa | Acetylcholinesterase dual inhibitors |
| BRPI0508410B8 (pt) * | 2004-03-03 | 2021-05-25 | Revance Therapeutics Inc | composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas |
| HU227119B1 (en) | 2004-07-29 | 2010-07-28 | Richter Gedeon Nyrt | Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| HUP0401523A3 (en) | 2004-07-29 | 2007-05-02 | Richter Gedeon Vegyeszet | Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them |
| HU227000B1 (en) | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Nmda receptor antagonist benzoyl urea derivatives, and pharmaceutical compositions containing them |
| HUP0401522A2 (en) | 2004-07-29 | 2006-04-28 | Richter Gedeon Vegyeszet | New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation |
| HU226977B1 (en) | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them |
| TW200621677A (en) | 2004-09-21 | 2006-07-01 | Astellas Pharma Inc | Cyclic amine derivative or salt thereof |
| CA2582640A1 (en) | 2004-10-15 | 2006-04-20 | Universidade Federal Do Rio De Janeiro-Ufrj | Piperidinic derivatives, pharmaceutic compositions containing the same and preparation processes |
| CA2598516C (en) * | 2005-02-25 | 2010-05-11 | Pfizer Inc. | Benzisoxazole derivatives |
| US20090124600A1 (en) | 2005-04-19 | 2009-05-14 | Layton Mark E | N-Alkyl-Azacycloalkyl NMDA/NR2B Antagonists |
| JP2009503520A (ja) | 2005-07-29 | 2009-01-29 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ベータアミロイド受容体及びその使用 |
| WO2007107846A1 (en) | 2006-03-20 | 2007-09-27 | Council Of Scientific And Industrial Research | A pharmaceutical composition useful as acetyl cholinesterase inhibitors |
| ES2288406B1 (es) | 2006-04-20 | 2008-12-16 | Universidad De Barcelona | Compuestos inhibidores de acetilcolinesterasa para el tratamiento de la enfermedad de alzheimer. |
| KR20090116716A (ko) | 2006-12-20 | 2009-11-11 | 솔베이 파마슈티칼스 비. 브이 | 칸나비노이드-ｃｂ1 길항작용과 아세틸콜린에스테라제 억제가 조합된 화합물 |
| US7605265B2 (en) | 2007-01-22 | 2009-10-20 | Biotechnology Research Corporation Ltd. | Heterodimers and methods of using them |
| MX370608B (es) | 2007-05-01 | 2019-12-18 | Concert Pharmaceuticals Inc | Compuestos de morfinano. |
| CN101730706B (zh) | 2007-05-11 | 2015-04-15 | 生物科技研究有限公司 | 具有神经保护和增强记忆活性的受体拮抗剂 |
| EA201070077A1 (ru) | 2007-06-29 | 2010-08-30 | Эмори Юниверсити | Антагонисты nmda-рецепторов с нейропротективным действием |
| CA2699412A1 (en) | 2007-09-12 | 2009-03-19 | Virginia Tech Intellectual Properties, Inc. | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (ache) |
| CN102066345B (zh) | 2008-01-16 | 2013-07-17 | 生物科技研究有限公司 | *唑烷衍生物作为nmda拮抗剂 |
| EA014100B1 (ru) | 2008-02-21 | 2010-08-30 | Общество С Ограниченной Ответственностью "Валексфарм" | Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения |
| CN101440061B (zh) | 2008-04-08 | 2010-12-08 | 温州医学院 | 一类具有抑制乙酰胆碱酯酶活性的芳基吡啶酮类衍生物 |
| WO2009129181A1 (en) | 2008-04-14 | 2009-10-22 | Concert Pharmaceuticals Inc. | Propanediol-dicarbamate derivatives |
| JP2011520815A (ja) | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのｎｍｄａ受容体拮抗薬 |
-
2011
- 2011-02-09 CA CA2788656A patent/CA2788656A1/en not_active Abandoned
- 2011-02-09 SG SG2012053906A patent/SG183111A1/en unknown
- 2011-02-09 AU AU2011216950A patent/AU2011216950A1/en not_active Abandoned
- 2011-02-09 CN CN2011800099647A patent/CN102762554A/zh active Pending
- 2011-02-09 WO PCT/IB2011/050548 patent/WO2011101774A1/en not_active Ceased
- 2011-02-09 JP JP2012553423A patent/JP2013519722A/ja not_active Withdrawn
- 2011-02-09 EP EP11710564A patent/EP2536713A1/en not_active Withdrawn
- 2011-02-09 MX MX2012008721A patent/MX2012008721A/es not_active Application Discontinuation
- 2011-02-09 KR KR1020127021310A patent/KR20120123089A/ko not_active Ceased
- 2011-02-09 IN IN6631DEN2012 patent/IN2012DN06631A/en unknown
- 2011-02-14 AR ARP110100443A patent/AR080172A1/es not_active Application Discontinuation
- 2011-02-14 UY UY0001033225A patent/UY33225A/es not_active Application Discontinuation
- 2011-02-15 TW TW100104942A patent/TW201141856A/zh unknown
- 2011-02-16 US US13/028,368 patent/US20120041026A1/en not_active Abandoned
-
2012
- 2012-08-28 ZA ZA2012/06469A patent/ZA201206469B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG183111A1 (en) | 2012-09-27 |
| EP2536713A1 (en) | 2012-12-26 |
| AU2011216950A1 (en) | 2012-08-23 |
| WO2011101774A1 (en) | 2011-08-25 |
| KR20120123089A (ko) | 2012-11-07 |
| US20120041026A1 (en) | 2012-02-16 |
| TW201141856A (en) | 2011-12-01 |
| CN102762554A (zh) | 2012-10-31 |
| UY33225A (es) | 2011-09-30 |
| AR080172A1 (es) | 2012-03-21 |
| ZA201206469B (en) | 2013-05-29 |
| CA2788656A1 (en) | 2011-08-25 |
| JP2013519722A (ja) | 2013-05-30 |
| MX2012008721A (es) | 2012-08-17 |
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