IN2013CH05537A - - Google Patents
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- Publication number
- IN2013CH05537A IN2013CH05537A IN5537CH2013A IN2013CH05537A IN 2013CH05537 A IN2013CH05537 A IN 2013CH05537A IN 5537CH2013 A IN5537CH2013 A IN 5537CH2013A IN 2013CH05537 A IN2013CH05537 A IN 2013CH05537A
- Authority
- IN
- India
- Prior art keywords
- methyl
- cognition
- schizophrenia
- bromophenyl
- piperazinyl
- Prior art date
Links
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 4-methyl-l-piperazinyl Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000003751 serotonin 6 antagonist Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 238000002636 symptomatic treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5537CH2013 IN2013CH05537A (de) | 2013-12-02 | 2014-02-20 | |
| BR112016010788-8A BR112016010788B1 (pt) | 2013-12-02 | 2014-02-20 | Processo para a produção em grande escala de monohidrato de dimesilato de 1-[(2-bromofenil)sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1h- indola |
| EA201691161A EA028038B1 (ru) | 2013-12-02 | 2014-02-20 | Способ для промышленного производства 1-[(2-бромфенил)сульфонил]-5-метокси-3-[(4-метил-1-пиперазинил)метил]-1h-индол димезилат моногидрата |
| LTEP14725245.6T LT3077375T (lt) | 2013-12-02 | 2014-02-20 | 1-[(2-bromfenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indolo dimezilato monohidrato didelio našumo gamybos būdas |
| MEP-2017-193A ME02843B (de) | 2013-12-02 | 2014-02-20 | Verfahren zur massenherstellung von 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indol-dimesylat-monohydrat |
| SI201430348T SI3077375T1 (sl) | 2013-12-02 | 2014-02-20 | Postopek za obsežno pripravo 1-((2-bromofenil)sulfonil)-5-metoksi-3- ((4-metil-1-piperazinil)metil)-1h-indol dimesilat monohidrata |
| HUE14725245A HUE036008T2 (hu) | 2013-12-02 | 2014-02-20 | Eljárás 1-[(2-brómfenil)szulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1H-indol-dimezilát-monohidrát nagyüzemi léptékben történõ elõállítására |
| HK16114655.9A HK1226396B (zh) | 2013-12-02 | 2014-02-20 | 用於大规模生产1-[(2-溴苯基)磺醯基]-5-甲氧基-3-[(4-甲基-1-呱嗪基)甲基]-1h-吲哚二甲磺酸盐一水合物的方法 |
| CA2929309A CA2929309C (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| DK14725245.6T DK3077375T3 (en) | 2013-12-02 | 2014-02-20 | PROCEDURE FOR LARGE SCALE PREPARATION OF 1 - [(2-BROMPHENYL) SULPHONYL] -5-METHOXY-3 - [(4-METHYL-1-PIPERAZINYL) METHYL] -1H-INDOL-DIMESYLATE-MONOHYDRATE |
| RS20170853A RS56323B1 (sr) | 2013-12-02 | 2014-02-20 | Proces za masovnu proizvodnju monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata |
| PCT/IN2014/000109 WO2015083179A1 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| KR1020167013965A KR101808792B1 (ko) | 2013-12-02 | 2014-02-20 | 1-[(2-브로모페닐)술포닐]-5-메톡시-3-[(4-메틸-1-피페라지닐)메틸]-1h-인돌 디메실레이트 모노히드레이트의 대규모 생산 방법 |
| HRP20171245TT HRP20171245T1 (hr) | 2013-12-02 | 2014-02-20 | Postupak za proizvodnju velikih razmjera monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata |
| AU2014358682A AU2014358682B2 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate |
| JP2016535680A JP6151453B2 (ja) | 2013-12-02 | 2014-02-20 | １−［（２−ブロモフェニル）スルホニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシラート一水和物の大規模合成法 |
| SM20170408T SMT201700408T1 (it) | 2013-12-02 | 2014-02-20 | Processo per la produzione su larga scala di 1-[(2-bromofenil)solfonil)-5-metossi-3-[( 4-metil-1-piperazinil)metil)-1 h-indolo dimesilato monoidrato |
| MX2016006629A MX364930B (es) | 2013-12-02 | 2014-02-20 | Proceso de producción a gran escala de dimesilato de 1-[(2-bromofenil]sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)met il]-1h-indol monohidratado. |
| PT147252456T PT3077375T (pt) | 2013-12-02 | 2014-02-20 | Processo para produção em massa de 1-[(2- bromofenil)sulfonilo]-5-metoxi-3-[(4-metilo-1- piperazinil)metilo]-dimesilato de 1h-indol mono-hidratado |
| AP2016009224A AP2016009224A0 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| EP14725245.6A EP3077375B1 (de) | 2013-12-02 | 2014-02-20 | Verfahren zur herstellung von 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylat monohydrat in grosstechnischem massstab |
| US15/100,489 US9540321B2 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate |
| NZ719671A NZ719671A (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| PL14725245T PL3077375T3 (pl) | 2013-12-02 | 2014-02-20 | Sposób wytwarzania na dużą skalę monohydratu dimesylanu 1-[(2 bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu |
| CN201480065601.9A CN105814020B (zh) | 2013-12-02 | 2014-02-20 | 用于大规模生产1‑[(2‑溴苯基)磺酰基]‑5‑甲氧基‑3‑[(4‑甲基‑1‑哌嗪基)甲基]‑1h‑吲哚二甲磺酸盐一水合物的方法 |
| ES14725245.6T ES2638856T3 (es) | 2013-12-02 | 2014-02-20 | Procedimiento para la producción a gran escala de dimesilato de 1-[(2-bromofenil)sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1H-indol monohidrato |
| ZA2016/02954A ZA201602954B (en) | 2013-12-02 | 2016-05-03 | Process for large scale production of 1-{(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| IL245619A IL245619B (en) | 2013-12-02 | 2016-05-11 | Process for the high-volume production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate salt monohydrate |
| CY20171100904T CY1119298T1 (el) | 2013-12-02 | 2017-08-28 | Διαδικασια για παραγωγη μεγαλης κλιμακας του 1-(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-1 νdole dimesylate mono-enyδρου |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5537CH2013 IN2013CH05537A (de) | 2013-12-02 | 2014-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013CH05537A true IN2013CH05537A (de) | 2015-06-12 |
Family
ID=54199404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN5537CH2013 IN2013CH05537A (de) | 2013-12-02 | 2014-02-20 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9540321B2 (de) |
| EP (1) | EP3077375B1 (de) |
| JP (1) | JP6151453B2 (de) |
| KR (1) | KR101808792B1 (de) |
| CN (1) | CN105814020B (de) |
| AP (1) | AP2016009224A0 (de) |
| AU (1) | AU2014358682B2 (de) |
| BR (1) | BR112016010788B1 (de) |
| CA (1) | CA2929309C (de) |
| CY (1) | CY1119298T1 (de) |
| DK (1) | DK3077375T3 (de) |
| EA (1) | EA028038B1 (de) |
| ES (1) | ES2638856T3 (de) |
| HK (1) | HK1226396B (de) |
| HR (1) | HRP20171245T1 (de) |
| HU (1) | HUE036008T2 (de) |
| IL (1) | IL245619B (de) |
| IN (1) | IN2013CH05537A (de) |
| LT (1) | LT3077375T (de) |
| ME (1) | ME02843B (de) |
| MX (1) | MX364930B (de) |
| NZ (1) | NZ719671A (de) |
| PL (1) | PL3077375T3 (de) |
| PT (1) | PT3077375T (de) |
| RS (1) | RS56323B1 (de) |
| SI (1) | SI3077375T1 (de) |
| SM (1) | SMT201700408T1 (de) |
| WO (1) | WO2015083179A1 (de) |
| ZA (1) | ZA201602954B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA036301B1 (ru) * | 2016-05-18 | 2020-10-23 | Сувен Лайф Сайенсиз Лимитед | Комбинация высокоселективных антагонистов 5-ht6 рецептора с антагонистом nmda рецептора |
| US11253514B2 (en) * | 2016-05-18 | 2022-02-22 | Suven Life Sciences Limited | Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist |
| KR102015484B1 (ko) | 2016-05-18 | 2019-08-28 | 수벤 라이프 사이언시스 리미티드 | 순수한 5-ht6 수용체 길항제와 아세틸콜린에스테라제 저해제의 조합물 |
| US12629365B2 (en) * | 2016-10-03 | 2026-05-19 | Suven Life Sciences Limited | Pharmaceutical compositions of 5-HT6 receptor antagonist |
| ES2879675T3 (es) * | 2016-10-03 | 2021-11-22 | Suven Life Sciences Ltd | Composición farmacéutica de antagonista de 5-HT6 |
| NZ761037A (en) * | 2017-07-03 | 2022-10-28 | Suven Life Sciences Ltd | New uses of a pure 5-ht6 receptor antagonist |
| HRP20250882T1 (hr) | 2019-12-02 | 2025-09-26 | Suven Life Sciences Limited | Kombinacije masupirdina sa donepezilom ili memantinom za liječenje bihevioralnih i psiholoških simptoma kod pacijenata sa demencijom |
| BR112022010493A2 (pt) | 2019-12-02 | 2022-09-06 | Suven Life Sciences Ltd | Métodos para tratar sintomas comportamentais e psicológicos em pacientes com demência |
| CN111362859B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111233737B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111362858B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| KR20230088761A (ko) | 2020-10-13 | 2023-06-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 재가공하는 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2749846B1 (fr) * | 1996-06-17 | 1998-09-11 | Pf Medicament | Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique |
| ATE401307T1 (de) * | 2002-11-28 | 2008-08-15 | Suven Life Sciences Ltd | N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
| JP4571507B2 (ja) * | 2002-12-18 | 2010-10-27 | スベン ライフ サイエンシズ リミティド | セロトニン受容体親和性を有する四環系３−置換インドール |
| AU2007257882B2 (en) * | 2006-06-12 | 2011-09-08 | Secura Bio Inc. | Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide |
-
2014
- 2014-02-20 CA CA2929309A patent/CA2929309C/en active Active
- 2014-02-20 EP EP14725245.6A patent/EP3077375B1/de active Active
- 2014-02-20 SM SM20170408T patent/SMT201700408T1/it unknown
- 2014-02-20 HK HK16114655.9A patent/HK1226396B/zh unknown
- 2014-02-20 AP AP2016009224A patent/AP2016009224A0/en unknown
- 2014-02-20 HU HUE14725245A patent/HUE036008T2/hu unknown
- 2014-02-20 PT PT147252456T patent/PT3077375T/pt unknown
- 2014-02-20 SI SI201430348T patent/SI3077375T1/sl unknown
- 2014-02-20 DK DK14725245.6T patent/DK3077375T3/en active
- 2014-02-20 NZ NZ719671A patent/NZ719671A/en unknown
- 2014-02-20 EA EA201691161A patent/EA028038B1/ru unknown
- 2014-02-20 MX MX2016006629A patent/MX364930B/es active IP Right Grant
- 2014-02-20 ME MEP-2017-193A patent/ME02843B/de unknown
- 2014-02-20 IN IN5537CH2013 patent/IN2013CH05537A/en unknown
- 2014-02-20 LT LTEP14725245.6T patent/LT3077375T/lt unknown
- 2014-02-20 KR KR1020167013965A patent/KR101808792B1/ko active Active
- 2014-02-20 CN CN201480065601.9A patent/CN105814020B/zh active Active
- 2014-02-20 HR HRP20171245TT patent/HRP20171245T1/hr unknown
- 2014-02-20 US US15/100,489 patent/US9540321B2/en active Active
- 2014-02-20 PL PL14725245T patent/PL3077375T3/pl unknown
- 2014-02-20 BR BR112016010788-8A patent/BR112016010788B1/pt active IP Right Grant
- 2014-02-20 WO PCT/IN2014/000109 patent/WO2015083179A1/en not_active Ceased
- 2014-02-20 JP JP2016535680A patent/JP6151453B2/ja active Active
- 2014-02-20 RS RS20170853A patent/RS56323B1/sr unknown
- 2014-02-20 AU AU2014358682A patent/AU2014358682B2/en active Active
- 2014-02-20 ES ES14725245.6T patent/ES2638856T3/es active Active
-
2016
- 2016-05-03 ZA ZA2016/02954A patent/ZA201602954B/en unknown
- 2016-05-11 IL IL245619A patent/IL245619B/en active IP Right Grant
-
2017
- 2017-08-28 CY CY20171100904T patent/CY1119298T1/el unknown
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