PL3077375T3 - Sposób wytwarzania na dużą skalę monohydratu dimesylanu 1-[(2 bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu - Google Patents

Sposób wytwarzania na dużą skalę monohydratu dimesylanu 1-[(2 bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu

Info

Publication number
PL3077375T3
PL3077375T3 PL14725245T PL14725245T PL3077375T3 PL 3077375 T3 PL3077375 T3 PL 3077375T3 PL 14725245 T PL14725245 T PL 14725245T PL 14725245 T PL14725245 T PL 14725245T PL 3077375 T3 PL3077375 T3 PL 3077375T3
Authority
PL
Poland
Prior art keywords
methyl
bromophenyl
piperazinyl
sulfonyl
methoxy
Prior art date
Application number
PL14725245T
Other languages
English (en)
Inventor
Ramakrishna Nirogi
Rama Sastri Kambhampati
Anil Karbhari Shinde
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Limited filed Critical Suven Life Sciences Limited
Publication of PL3077375T3 publication Critical patent/PL3077375T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
PL14725245T 2013-12-02 2014-02-20 Sposób wytwarzania na dużą skalę monohydratu dimesylanu 1-[(2 bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu PL3077375T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5537CH2013 IN2013CH05537A (pl) 2013-12-02 2014-02-20
EP14725245.6A EP3077375B1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate

Publications (1)

Publication Number Publication Date
PL3077375T3 true PL3077375T3 (pl) 2017-11-30

Family

ID=54199404

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14725245T PL3077375T3 (pl) 2013-12-02 2014-02-20 Sposób wytwarzania na dużą skalę monohydratu dimesylanu 1-[(2 bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu

Country Status (29)

Country Link
US (1) US9540321B2 (pl)
EP (1) EP3077375B1 (pl)
JP (1) JP6151453B2 (pl)
KR (1) KR101808792B1 (pl)
CN (1) CN105814020B (pl)
AP (1) AP2016009224A0 (pl)
AU (1) AU2014358682B2 (pl)
BR (1) BR112016010788B1 (pl)
CA (1) CA2929309C (pl)
CY (1) CY1119298T1 (pl)
DK (1) DK3077375T3 (pl)
EA (1) EA028038B1 (pl)
ES (1) ES2638856T3 (pl)
HK (1) HK1226396B (pl)
HR (1) HRP20171245T1 (pl)
HU (1) HUE036008T2 (pl)
IL (1) IL245619B (pl)
IN (1) IN2013CH05537A (pl)
LT (1) LT3077375T (pl)
ME (1) ME02843B (pl)
MX (1) MX364930B (pl)
NZ (1) NZ719671A (pl)
PL (1) PL3077375T3 (pl)
PT (1) PT3077375T (pl)
RS (1) RS56323B1 (pl)
SI (1) SI3077375T1 (pl)
SM (1) SMT201700408T1 (pl)
WO (1) WO2015083179A1 (pl)
ZA (1) ZA201602954B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3458040B1 (en) * 2016-05-18 2021-01-27 Suven Life Sciences Limited Combination of pure 5-ht6 receptor antagonists with nmda receptor antagonist
DK3458039T3 (da) 2016-05-18 2020-09-14 Suven Life Sciences Ltd Tripelkombination af rene 5-ht6-receptorantagonister, acetylcholinesterasehæmmere og nmda-receptorantagonist
EA036347B1 (ru) 2016-05-18 2020-10-29 Сувен Лайф Сайенсиз Лимитед Комбинация чистых антагонистов 5-ht6 рецепторов с ингибиторами ацетилхолинэстеразы
SMT202100403T1 (it) * 2016-10-03 2021-09-14 Suven Life Sciences Ltd Composizioni farmaceutiche di antagonista di 5-ht6
US20210346374A1 (en) * 2016-10-03 2021-11-11 Suven Life Sciences Limited Pharmaceutical compositions of 5-ht6 receptor antagonist
CN110799189A (zh) * 2017-07-03 2020-02-14 苏文生命科学有限公司 纯5-ht6受体拮抗剂的新用途
AU2020398082A1 (en) 2019-12-02 2022-06-16 Suven Life Sciences Limited Treating behavioral and psychological symptoms in dementia patients
JP2023510082A (ja) 2019-12-02 2023-03-13 スヴェン・ライフ・サイエンシーズ・リミテッド 認知症患者における行動・心理症状を治療するための方法
CN111233737B (zh) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 芳杂环类衍生物的盐及其用途
CN111362859B (zh) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 芳杂环类衍生物的盐及其用途
CN111362858B (zh) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 芳杂环类衍生物的盐及其用途
IL301829A (en) 2020-10-13 2023-06-01 Boehringer Ingelheim Int Process of reworking

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
JP4559230B2 (ja) * 2002-11-28 2010-10-06 スベン ライフ サイエンシズ リミティド セロトニン受容体に対する親和性を有する新規n−アリールスルホニル−3−置換されたインドール、その調製方法、それを含有する医薬組成物
EA009367B1 (ru) * 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА
RU2008151724A (ru) * 2006-06-12 2010-07-20 Новартис АГ (CH) Способ получения солей n-гидрокси-3-[4-[[[2-(2-метил-1н-индол-3-ил)этил]амино]метил]фенил]-2е-2-пропенамида

Also Published As

Publication number Publication date
WO2015083179A1 (en) 2015-06-11
ES2638856T3 (es) 2017-10-24
AP2016009224A0 (en) 2016-05-31
AU2014358682B2 (en) 2016-10-20
EA201691161A1 (ru) 2016-09-30
SMT201700408T1 (it) 2017-09-07
US9540321B2 (en) 2017-01-10
JP6151453B2 (ja) 2017-06-21
EP3077375B1 (en) 2017-07-19
ZA201602954B (en) 2017-07-26
CY1119298T1 (el) 2018-02-14
US20160297759A1 (en) 2016-10-13
BR112016010788B1 (pt) 2023-03-21
HUE036008T2 (hu) 2018-06-28
CA2929309A1 (en) 2015-06-11
DK3077375T3 (en) 2017-09-11
JP2016539133A (ja) 2016-12-15
CA2929309C (en) 2018-07-03
CN105814020B (zh) 2018-04-17
LT3077375T (lt) 2017-09-11
SI3077375T1 (sl) 2017-10-30
BR112016010788A8 (pt) 2018-01-30
ME02843B (me) 2018-01-20
EP3077375A1 (en) 2016-10-12
HRP20171245T1 (hr) 2017-10-20
KR20160094945A (ko) 2016-08-10
RS56323B1 (sr) 2017-12-29
IN2013CH05537A (pl) 2015-06-12
MX2016006629A (es) 2016-08-08
KR101808792B1 (ko) 2017-12-13
HK1226396B (zh) 2017-09-29
PT3077375T (pt) 2017-09-05
IL245619A0 (en) 2016-06-30
CN105814020A (zh) 2016-07-27
NZ719671A (en) 2017-03-31
AU2014358682A1 (en) 2016-06-02
EA028038B1 (ru) 2017-09-29
IL245619B (en) 2018-12-31
MX364930B (es) 2019-05-14

Similar Documents

Publication Publication Date Title
IL245619A0 (en) A process for the high-volume production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate salt monohydrate
EP3368474A4 (en) ELECTROCHEMICAL GAS SEPARATION METHOD
GB201309639D0 (en) Electrochemical process for production of graphene
EP3020688A4 (en) ZEOLITE PROCESS
EP3015467A4 (en) MORPHOLINE-OLIGONUCLEOTIDE METHOD
PL3074360T3 (pl) Sposób wytwarzania cementu portlandzkiego
EP3000803A4 (en) PROCESS FOR PREPARING DIAMINO-DICYCLOHEXYL-METHANE
EP2951141A4 (en) PROCESS FOR THE PRODUCTION OF POLYOLES
PT3055280T (pt) Processo de remoção de enxofre de metanol em bruto
EP2957543A4 (en) PROCESS FOR THE PREPARATION OF TRICHLOROSILANE
EP2891710A4 (en) METHOD FOR PRODUCING A CELL CONCENTRATE
EP2939978A4 (en) PROCESS FOR PREPARING DIFLUORO PHOSPHATE
EP3024081A4 (en) Method for producing cell
EP2899157A4 (en) PREPARATION OF DIFLUORPHOSPHATE
FR3014349B1 (fr) Procede de decoupe de secteurs pour moules de pneumatiques
GB201223271D0 (en) Process for production of an alkylmethacrylate
PL3087058T3 (pl) Sposób regioselektywnej syntezy pirazoli
EP3029145A4 (en) PROCESS FOR PREPARING METHACRYLYL COA
SG11201509952PA (en) Process for producing polyhydric alcohol
EP2962989A4 (en) PROCESS FOR THE PREPARATION OF PYROPHOSPHATE
EP2966173A4 (en) PROCESS FOR THE PRODUCTION OF MOLASSE
FR3008093B1 (fr) Procede de fluoration de composes halogenures de sulfonyle
ZA201603839B (en) Process for the production of synthesis gas
PT2799426T (pt) Novo processo para a síntese de aminaftona
ZA201700915B (en) Active metabolite of 1-[(2-bromophenyl) sulfonyl]-5-methoxy-3- [(4-methyl-1-piperazinyl) methyl]-1h-indole dimesylate monohydrate and dimesylate dihydrate salt of active metabolite