IN2014DN09073A - - Google Patents

Download PDF

Info

Publication number
IN2014DN09073A
IN2014DN09073A IN9073DEN2014A IN2014DN09073A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A IN 9073DEN2014 A IN9073DEN2014 A IN 9073DEN2014A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A
Authority
IN
India
Prior art keywords
methods
disease
diagnose
practicing
toxicity
Prior art date
Application number
Other languages
English (en)
Inventor
Karl A Deisseroth
Kwanghun Chung
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of IN2014DN09073A publication Critical patent/IN2014DN09073A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N2001/4038—Concentrating samples electric methods, e.g. electromigration, electrophoresis, ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)
IN9073DEN2014 2012-08-09 2013-03-13 IN2014DN09073A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681551P 2012-08-09 2012-08-09
PCT/US2013/031066 WO2014025392A1 (fr) 2012-08-09 2013-03-13 Procédés et compositions pour préparer des échantillons biologiques pour une analyse microscopique

Publications (1)

Publication Number Publication Date
IN2014DN09073A true IN2014DN09073A (fr) 2015-05-22

Family

ID=50068460

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9073DEN2014 IN2014DN09073A (fr) 2012-08-09 2013-03-13

Country Status (8)

Country Link
US (3) US10545075B2 (fr)
EP (2) EP4163617A1 (fr)
JP (1) JP6228205B2 (fr)
KR (1) KR102148747B1 (fr)
CN (1) CN104350372B (fr)
AU (1) AU2013300171B2 (fr)
IN (1) IN2014DN09073A (fr)
WO (1) WO2014025392A1 (fr)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP3604555B1 (fr) 2011-10-14 2024-12-25 President and Fellows of Harvard College Séquençage par assemblage de structure
WO2014163886A1 (fr) 2013-03-12 2014-10-09 President And Fellows Of Harvard College Procédé de génération d'une matrice tridimensionnelle contenant des acides nucléiques
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
EP2794928B1 (fr) 2011-12-22 2019-02-20 President and Fellows of Harvard College Compositions et procédés pour la détection d'analytes
WO2013184754A2 (fr) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Séquençage spatial d'acides nucléiques à l'aide de sondes d'origami d'adn
IN2014DN09073A (fr) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
WO2014060483A1 (fr) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Procédés et produit d'optimisation de la détection localisée ou spatiale de l'expression génique dans un échantillon de tissu
DE102013205115A1 (de) * 2013-03-22 2014-09-25 Leica Microsystems Cms Gmbh SPIM-Anordnung
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
DE102013216934A1 (de) * 2013-08-26 2015-02-26 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe
US10794802B2 (en) * 2013-09-20 2020-10-06 California Institute Of Technology Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping
WO2015041755A1 (fr) * 2013-09-20 2015-03-26 California Institute Of Technology Procédés de phénotypage de tissus totaux intacts
CN103558055B (zh) * 2013-09-29 2016-01-06 中国疾病预防控制中心病毒病预防控制所 一种针对感染病毒的病变细胞的定位超薄切片方法
WO2015127183A2 (fr) * 2014-02-21 2015-08-27 Massachusetts Institute Of Technology Microscopie d'expansion
US10416116B2 (en) 2014-04-04 2019-09-17 Massachusetts Institute Of Technology Active transport of charged molecules into, within, and/or from charged matrices
JP2017517761A (ja) * 2014-05-30 2017-06-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 大きなインタクトな組織試料を撮像するための方法及び装置
JP6778186B2 (ja) * 2014-07-07 2020-10-28 ロゴス バイオシステムズ， インコーポレイテッド 電気泳動を使用する組織クリアリング装置
WO2016007839A1 (fr) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Méthodes de marquage et de détection à haut rendement de caractéristiques biologiques in situ à l'aide de microscopie
ES2968004T3 (es) 2014-07-30 2024-05-06 Harvard College Construcción de bibliotecas de sondas
WO2016023009A1 (fr) * 2014-08-07 2016-02-11 Wake Forest University Health Sciences Compositions et procédés de clarification d'échantillon biologique
KR101563826B1 (ko) * 2014-12-31 2015-10-28 계명대학교 산학협력단 조직 투명화 방법
EP3885762A1 (fr) 2015-02-09 2021-09-29 Ventana Medical Systems, Inc. Procédés de normalisation de diffusion d'un fluide dans des tissus
EP4282977B1 (fr) 2015-04-10 2024-06-05 10x Genomics Sweden AB Analyse de plusieurs acides nucléiques spatialement différenciés de spécimens biologiques
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
US10526649B2 (en) 2015-04-14 2020-01-07 Massachusetts Institute Of Technology Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
CN106198990A (zh) * 2015-04-30 2016-12-07 上海交通大学 一种对组织样本进行免疫标记的方法
CN104965016A (zh) * 2015-06-15 2015-10-07 南昌大学 一体化的生物组织透明装置
US10317321B2 (en) 2015-08-07 2019-06-11 Massachusetts Institute Of Technology Protein retention expansion microscopy
WO2017027367A1 (fr) * 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Imagerie à l'échelle nanométrique de protéines et d'acides nucléiques par microscopie d'expansion
WO2017031249A1 (fr) * 2015-08-17 2017-02-23 California Institute Of Technology Stabilisation de tissu de tout le corps et extractions sélectives par le biais d'hybrides hydrogel-tissu pour un phénotypage et un appariement de circuit intact à haute résolution
WO2017075265A1 (fr) * 2015-10-28 2017-05-04 The Broad Institute, Inc. Analyse multiplexée de constituants unicellulaires
EP3371329B1 (fr) 2015-11-03 2026-03-25 President and Fellows of Harvard College Procédé et appareil pour imagerie volumétrique d'une matrice tridimensionnelle contenant des acides nucléiques
US20190113423A1 (en) * 2015-12-02 2019-04-18 Clearlight Diagnostics, LLC Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers
CN108431664B (zh) * 2015-12-23 2021-11-02 皇家飞利浦有限公司 荧光校准载片
RU2746895C2 (ru) 2015-12-24 2021-04-21 Конинклейке Филипс Н.В. Устройство для окрашивания трехмерной биопсийной ткани
CN105823807B (zh) * 2016-01-04 2018-04-20 浙江农林大学 抗癌药物羟喜树碱药效检测装置及检测方法
US11254974B2 (en) 2016-02-10 2022-02-22 The Board Of Trustees Of The Leland Stanford Junior University RNA fixation and detection in clarity-based hydrogel tissue
EP3974387B1 (fr) 2016-03-07 2025-10-29 X-Zell Inc. Compositions et procédés d'identification de cellules rares
JP6721899B2 (ja) * 2016-03-30 2020-07-15 国立大学法人 大分大学 高親水性高分子モノマーを主剤とする電子顕微鏡用包埋方法
CA3210120C (fr) 2016-04-25 2024-04-09 President And Fellows Of Harvard College Procedes de reaction en chaine d'hybridation pour la detection moleculaire in situ
US11397140B2 (en) * 2016-04-29 2022-07-26 Massachusetts Institute Of Technology Methods for reversible and tunable tissue magnification
US10324022B2 (en) 2016-05-11 2019-06-18 Bonraybio Co., Ltd. Analysis accuracy improvement in automated testing apparatus
US10281386B2 (en) * 2016-05-11 2019-05-07 Bonraybio Co., Ltd. Automated testing apparatus
US10852290B2 (en) 2016-05-11 2020-12-01 Bonraybio Co., Ltd. Analysis accuracy improvement in automated testing apparatus
EP3252452A1 (fr) * 2016-05-25 2017-12-06 The Board of Trustees of the Leland Stanford Junior University Procédé d'imagerie et d'analyse d'un échantillon biologique
WO2017205531A1 (fr) * 2016-05-25 2017-11-30 The Board Of Trustees Of The Leland Stanford Junior University Procédés de visualisation et de quantification de structures de type fibre
WO2017222453A1 (fr) 2016-06-21 2017-12-28 Hauling Thomas Séquençage d'acide nucléique
CN107621462B (zh) * 2016-07-13 2020-03-31 王志伟 一种组织透明化液sut及其制备和应用
CN107674879A (zh) * 2016-08-01 2018-02-09 深圳先进技术研究院 一种光‑基因质粒及其应用
US11480502B2 (en) 2016-08-29 2022-10-25 United States of America, as represented by the Secretary, Department of Heatlth and Human Service Method and composition for optical clearing of tissues
JP7239465B2 (ja) 2016-08-31 2023-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 蛍光ｉｎ ｓｉｔｕ配列決定による検出のための核酸配列ライブラリの作製法
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
US10538632B1 (en) 2016-09-30 2020-01-21 National Technology & Engineering Solutions Of Sandia, Llc Shape-preserving polymeric replication of biological matter
JP6898720B2 (ja) * 2016-10-14 2021-07-07 株式会社ファンケル 皮膚内部構造評価方法
EP3539036A4 (fr) * 2016-11-08 2020-06-17 President and Fellows of Harvard College Impression et élimination de matrices
US20190276881A1 (en) * 2016-11-08 2019-09-12 President And Fellows Of Harvard College Multiplexed imaging using merfish, expansion microscopy, and related technologies
KR101866249B1 (ko) 2016-11-29 2018-06-12 박순현 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법
DE102016123458B3 (de) * 2016-12-05 2018-03-15 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Verfahren zur Herstellung transparenter biologischer Präparate für eine lichtmikroskopische Untersuchung
CN106682453B (zh) * 2016-12-28 2019-03-26 长春理工大学 一种dna分子的定点编辑方法
US10955322B2 (en) 2017-01-18 2021-03-23 California Institute Of Technology Methods and devices for soft and osseous tissue clearing and fluorescent imaging
CN106769350B (zh) 2017-01-20 2019-11-22 上海交通大学 一种用于富含脂滴组织快速完全透明化的方法
US10995361B2 (en) * 2017-01-23 2021-05-04 Massachusetts Institute Of Technology Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
KR101888782B1 (ko) * 2017-02-07 2018-08-14 고려대학교 산학협력단 피부 조직의 투명화 방법, 이를 이용한 피부 조직의 3차원 영상화 방법 및 평가 및 진단 방법
US11436719B2 (en) 2017-02-16 2022-09-06 Kyoto University Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
WO2018157048A1 (fr) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Procédés d'examen de processus de pied de podocytes dans des échantillons rénaux humains à l'aide d'une microscopie optique classique
WO2018157074A1 (fr) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Méthodes permettant de diagnostiquer des lésions néoplasiques
WO2018155925A2 (fr) * 2017-02-27 2018-08-30 고려대학교 산학협력단 Procédé de production de tissu décellularisé à l'aide d'un polymère de type hydrogel et tissu décellularisé ainsi produit
KR20180099482A (ko) * 2017-02-27 2018-09-05 고려대학교 산학협력단 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직
TWI620927B (zh) * 2017-04-21 2018-04-11 胡宇光 神經組織樣本染色之方法及套組與顯現神經元之方法
WO2018218150A1 (fr) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systèmes et méthodes de criblage à base d'image à haut débit
MX2017008919A (es) * 2017-07-05 2018-03-01 Gabriela Reyes Fuchs Carmen Proceso para formar una imagen a color de materiales incinerados mediante tecnicas de microscopia.
JP7160350B2 (ja) * 2017-07-06 2022-10-25 公立大学法人大阪 生体組織透明化法及びその試薬
KR101996722B1 (ko) * 2017-07-07 2019-07-04 재단법인대구경북과학기술원 다채널 박막전극을 이용한 전기적 생체분자 이동방법
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
EP4589017A3 (fr) 2017-10-06 2025-10-08 10x Genomics, Inc. Ligature à matrice d'arn
KR102200618B1 (ko) * 2018-01-12 2021-01-08 재단법인대구경북과학기술원 설포베타인계 쯔비터이온성 계면활성제를 포함하는 생물학적 분자의 조직침투용 조성물 및 이의 용도
WO2019078655A1 (fr) * 2017-10-19 2019-04-25 재단법인대구경북과학기술원 Composition pour infiltrer une biomolécule dans un tissu comprenant un tensioactif zwitterionique à base de sulfobétaïne, et son utilisation
US10488307B2 (en) * 2017-12-12 2019-11-26 Dignity Health Systems, devices, and methods for improved tissue treatment
KR102050248B1 (ko) * 2017-12-29 2019-11-29 연세대학교 산학협력단 조직 투명도 분석 방법
CN107966477A (zh) * 2018-01-22 2018-04-27 哈尔滨工业大学 一种生物敏感元件
US11873374B2 (en) 2018-02-06 2024-01-16 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
GB2571544B (en) 2018-02-28 2022-05-18 Bright Instrument Co Ltd Sectioning macrotome
CN112188899B (zh) * 2018-03-16 2025-02-07 克里约凯珀赛尔公司 通过光学和/或电子显微技术成像的生物样品的包埋剂
WO2020011735A2 (fr) 2018-07-09 2020-01-16 Universität Zürich Systèmes, appareils et procédés de préparation d'échantillons de tissu
WO2020013833A1 (fr) 2018-07-13 2020-01-16 Massachusetts Institute Of Technology Hydrogel de diméthylacrylamide (dmaa) pour microscopie d'expansion (exm)
WO2020028194A1 (fr) 2018-07-30 2020-02-06 Readcoor, Inc. Procédés et systèmes de traitement ou d'analyse d'échantillons
KR102151128B1 (ko) * 2018-08-24 2020-09-02 주식회사 바이나리 질소 가스 가압식 조직 투명화 및 항체 침투 증진용 장치
JP7246752B2 (ja) * 2018-08-29 2023-03-28 国立研究開発法人物質・材料研究機構 測定装置、及び、評価方法
KR102368585B1 (ko) * 2018-09-28 2022-03-03 서울대학교산학협력단 온도에 따라 가역적 팽창/초기화가 가능한 하이드로젤을 이용한 생체조직 이미징
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
US11435302B2 (en) * 2018-11-13 2022-09-06 The Trustees Of Princeton University X-ray assisted electron microscopy staining procedure
GB201818567D0 (en) * 2018-11-14 2018-12-26 Francis Crick Institute Ltd Composition
CN113366116A (zh) 2018-12-13 2021-09-07 哈佛学院院长及董事 用于merfish和其他应用的扩增方法和系统
CN109612811A (zh) * 2018-12-26 2019-04-12 华中科技大学苏州脑空间信息研究院 一种保护生物组织结构和荧光的水凝胶包埋方法
CN109781493A (zh) * 2018-12-26 2019-05-21 华中科技大学苏州脑空间信息研究院 一种可长时间连续精细切削成像的生物组织水凝胶包埋方法
WO2020172247A1 (fr) 2019-02-22 2020-08-27 Massachusetts Institute Of Technology Microscopie d'expansion directe itérative
CN110006862B (zh) * 2019-03-29 2020-09-08 华中科技大学 膨胀切削显微成像方法及适用于该方法的超吸水水凝胶
CN112740013A (zh) * 2019-05-09 2021-04-30 科来旺科技公司 使用离子导电膜对生物样本进行电泳染色的方法和设备
CN114174799A (zh) * 2019-05-30 2022-03-11 贝克曼库尔特有限公司 用于固定生物标本以进行显微成像的方法和系统
AU2020282024A1 (en) 2019-05-31 2021-11-11 10X Genomics, Inc. Method of detecting target nucleic acid molecules
US20220276139A1 (en) * 2019-07-08 2022-09-01 The University Of Hong Kong Compositions and methods for clearing tissue
US12265004B2 (en) 2019-11-05 2025-04-01 Massachusetts Institute Of Technology Membrane probes for expansion microscopy
JPWO2021095718A1 (fr) * 2019-11-11 2021-05-20
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
WO2021155063A1 (fr) 2020-01-29 2021-08-05 Readcoor, Llc Compositions et procédés pour la détection d'analytes
US12110548B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Bi-directional in situ analysis
US12215379B2 (en) 2020-02-17 2025-02-04 10X Genomics, Inc. In situ analysis of chromatin interaction
JP2023514749A (ja) 2020-02-21 2023-04-07 １０エックス ジェノミクス インコーポレイテッド 統合型インサイチュ空間的アッセイのための方法および組成物
US12188085B2 (en) 2020-03-05 2025-01-07 10X Genomics, Inc. Three-dimensional spatial transcriptomics with sequencing readout
EP4117820B1 (fr) * 2020-03-13 2026-02-25 Yale University Procédés d'agrandissement physique et d'imagerie d'échantillons biologiques
WO2021226198A1 (fr) * 2020-05-05 2021-11-11 Massachusetts Institute Of Technology Compositions et procédés associés à des hybrides tissu-hydrogel compressibles de manière réversible
CN111397999B (zh) * 2020-05-09 2021-12-03 中国科学院植物研究所 一种增强显微ct植物样品对比度的简易方法
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
CN114129780B (zh) * 2020-09-03 2022-06-28 天津大学 一种光控释放一氧化氮的复合水凝胶的制备及应用
RU2752751C1 (ru) * 2020-09-28 2021-08-02 Ахмеджан Атаханович Аллаберганов Способ получения цифровых двойников документа в виде бумажного носителя текстовой информации или в виде изображения текстового документа
US20220121900A1 (en) * 2020-10-19 2022-04-21 Arizona Board Of Regents On Behalf Of Northern Arizona University Methods and systems for generating unclonable optical tags
CN112284861B (zh) * 2020-10-21 2023-02-17 上海市农业科学院 用于真姬菇担孢子显微观察的固定液、制备方法、固定方法及应用
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US11333588B1 (en) * 2020-12-07 2022-05-17 Nebulum Technologies Co., Ltd. Matrix-assisted methods and compositions to prepare biological samples for super-resolution imaging
EP4012046A1 (fr) 2020-12-11 2022-06-15 10X Genomics, Inc. Procédés et compositions pour l'analyse multimodale in situ
CN112665951B (zh) * 2020-12-22 2022-11-11 中国农业科学院作物科学研究所 一种胚乳组织包埋方法与应用
WO2022140570A1 (fr) 2020-12-23 2022-06-30 10X Genomics, Inc. Procédés et compositions pour une détection d'analyte
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
EP4284945B1 (fr) 2021-01-26 2024-10-23 10X Genomics, Inc. Sondes analogiques d'acide nucléique pour analyse in situ
KR102762387B1 (ko) * 2021-02-24 2025-02-05 한국과학기술원 화학적 염색과 팽창 이미징 기법의 최적화 방법
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
WO2022187366A1 (fr) 2021-03-03 2022-09-09 10X Genomics, Inc. Détection d'analytes in situ à l'aide d'origami d'acide nucléique
CN113004885B (zh) * 2021-03-08 2024-06-11 光华临港工程应用技术研发(上海)有限公司 一种用于膨胀超分辨成像的dna纳米结构染料及其应用
WO2022256324A1 (fr) 2021-06-01 2022-12-08 10X Genomics, Inc. Procédés et compositions pour la détection d'analytes et la résolution de sondes
WO2022256422A1 (fr) 2021-06-02 2022-12-08 10X Genomics, Inc. Analyse d'échantillon à l'aide de sondes circularisables asymétriques
US20230012607A1 (en) 2021-07-09 2023-01-19 10X Genomics, Inc. Methods for detecting analytes using sparse labelling
CN117651855A (zh) 2021-07-13 2024-03-05 10X基因组学有限公司 用于制备具有可控厚度的聚合基质的方法
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
ES2988400T3 (es) 2021-07-30 2024-11-20 10X Genomics Inc Métodos y composiciones para sincronizar reacciones in situ
WO2023015192A1 (fr) 2021-08-03 2023-02-09 10X Genomics, Inc. Concatémères d'acide nucléique et procédés de stabilisation et/ou de compactage de ceux-ci
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12529096B2 (en) 2021-08-03 2026-01-20 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid structures
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
EP4446426B1 (fr) 2021-08-16 2026-03-04 10X Genomics, Inc. Sondes comprenant une région de code-barres divisée et procédés d'utilisation
WO2023102118A2 (fr) 2021-12-01 2023-06-08 10X Genomics, Inc. Procédés, compositions et systèmes pour la détection améliorée d'analytes in situ et analyse spatiale
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
EP4466376B1 (fr) 2022-01-21 2026-03-04 10X Genomics, Inc. Signaux de lecture multiples pour analyser un échantillon
EP4490737A1 (fr) 2022-03-08 2025-01-15 10X Genomics, Inc. Procédés de conception de code in situ pour réduire à un minimum un chevauchement optique
CN119032271A (zh) 2022-04-01 2024-11-26 10X基因组学有限公司 用于靶向掩蔽自发荧光的组合物和方法
WO2023196526A1 (fr) 2022-04-06 2023-10-12 10X Genomics, Inc. Procédés d'analyse multiplex de cellules
WO2023204581A1 (fr) * 2022-04-20 2023-10-26 동국대학교 산학협력단 Composite hydrogel tridimensionnel présentant un effet de destruction de cellules cancéreuses et son procédé de production
WO2023215603A1 (fr) 2022-05-06 2023-11-09 10X Genomics, Inc. Procédés et compositions pour l'analyse in situ de séquences v(d)j
WO2023215612A1 (fr) 2022-05-06 2023-11-09 10X Genomics, Inc. Analyse d'un antigène et des interactions antigène-récepteur
US20240084378A1 (en) 2022-05-11 2024-03-14 10X Genomics, Inc. Compositions and methods for in situ sequencing
EP4540607A1 (fr) 2022-06-17 2025-04-23 10X Genomics, Inc. Dé-réticulation catalytique d'échantillons pour analyse in situ
KR102582110B1 (ko) * 2022-07-18 2023-09-21 (재)씨젠의료재단 3차원 세포 또는 생체 조직의 투명화 및 이미지 분석용 조성물
CN119677873A (zh) 2022-08-16 2025-03-21 10X基因组学有限公司 Ap50聚合酶及其用途
KR20240042887A (ko) * 2022-09-26 2024-04-02 연세대학교 산학협력단 고배율의 세포 확대 분석을 위한 세포 필름, 이의 제조용 조성물 및 제조 방법
CN115656120B (zh) * 2022-10-09 2024-07-23 中国科学院深圳先进技术研究院 一种暗场反射紫外光学显微成像方法和系统
WO2024081869A1 (fr) 2022-10-14 2024-04-18 10X Genomics, Inc. Procédés d'analyse d'échantillons biologiques
EP4573210A1 (fr) 2022-11-16 2025-06-25 10X Genomics, Inc. Procédés et compositions pour évaluer les performances de dosages in situ
EP4634404A1 (fr) 2022-12-16 2025-10-22 10X Genomics, Inc. Procédés et compositions d'évaluation de performances
EP4638789A1 (fr) 2022-12-21 2025-10-29 10X Genomics, Inc. Procédés d'accroche d'acides ribonucléiques dans des échantillons biologiques
CN121014083A (zh) * 2023-03-31 2025-11-25 富士胶片株式会社 药物研发辅助装置、药物研发辅助装置的工作方法、及药物研发辅助装置的工作程序
US20240376521A1 (en) 2023-05-10 2024-11-14 10X Genomics, Inc. Boronic acid compositions and methods for tethering ribonucleic acids in biological samples
TWI887661B (zh) * 2023-05-25 2025-06-21 國立清華大學 用於將生物組織透明化的電極組及裝置
WO2025029831A1 (fr) 2023-07-31 2025-02-06 10X Genomics, Inc. Procédés et systèmes de clivage d'arn ciblé et d'amplification de cercle roulant amorcé par arn cible
US20250163502A1 (en) 2023-11-22 2025-05-22 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
US20250207203A1 (en) 2023-12-20 2025-06-26 10X Genomics, Inc. In situ detection of copy number variations in biological samples
WO2025255457A1 (fr) 2024-06-07 2025-12-11 10X Genomics, Inc. Compositions et procédés de profilage spatial sur cible amélioré
WO2025264702A1 (fr) 2024-06-18 2025-12-26 10X Genomics, Inc. Hydrogels 3d pour le séquençage d'acides nucléiques
WO2026043885A1 (fr) 2024-08-20 2026-02-26 10X Genomics, Inc. Procédés et systèmes de préparation d'une bibliothèque d'acides nucléiques
WO2026055487A1 (fr) 2024-09-06 2026-03-12 10X Genomics, Inc. Nucléotides modifiés avec espaceurs oligomères

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129158A (en) 1961-01-24 1964-04-14 Raymond Samuel Process for gel electrophoresis
US3208929A (en) 1962-09-11 1965-09-28 Robert H Raymond Apparatus for gel electrophoresis
US3346479A (en) 1964-04-09 1967-10-10 Scientific Industries Preparative separation by a combination of gel separation and electrophoresis
US3375187A (en) 1965-05-13 1968-03-26 Buchler Instr Inc Apparatus for temperature controlled preparative and analytical electrophoresis
US3576727A (en) 1968-05-23 1971-04-27 Bruce Lee Evatt Gel electrophoresis process
US3563880A (en) 1968-08-28 1971-02-16 Arthur W Anderson Gel electrophoresis unit
SE328135B (fr) 1968-09-19 1970-09-07 Lkb Produkter Ab
US3616454A (en) 1969-03-13 1971-10-26 Univ New York Method of and apparatus for electrophoretic separation in a gel column
US3674678A (en) 1970-10-28 1972-07-04 Millipore Corp Electrophoretic apparatus
US3865712A (en) 1972-04-13 1975-02-11 Lkb Produkter Ab Electrode arrangement for an electrophoretical separation performed in a gel plate
US3989613A (en) * 1973-05-16 1976-11-02 The Dow Chemical Company Continuous balanced flow fixed boundary electrophoresis
US4088561A (en) 1977-06-27 1978-05-09 The United States Of America As Represented By The United States Department Of Energy Apparatus for electrophoresis separation
US4151065A (en) 1978-01-30 1979-04-24 The Regents Of The University Of California Horizontal slab gel electrophoresis
US4292161A (en) 1979-01-03 1981-09-29 Hoefer Scientific Instruments Vertical gel slab electrophoresis apparatus
FR2496889A1 (fr) 1980-12-22 1982-06-25 Hours Michel Cuve de migration et de reaction utilisable pour des analyses par electrophorese
US4339327A (en) 1981-04-23 1982-07-13 Tyler Jonathan M Miniature slab gel electrophoresis system
US4375401A (en) 1981-05-20 1983-03-01 Nicholas Catsimpoolas Electrophoresis system
EP0101859B1 (fr) 1982-07-23 1987-10-14 Matthias Hediger Appareil pour l'électrophorèse préparative sur gel, en particulier pour la séparation de mélanges sur une colonne à gradient en gel de polyacrylamide
US4588491A (en) 1984-02-27 1986-05-13 International Biotechnologies, Inc. Horizontal gel electrophoresis device
EP0171676B1 (fr) * 1984-07-31 1990-11-07 Hitachi, Ltd. Méthode de séparation électrophorétique à courant libre et appareil pour cela
US4685025A (en) 1985-03-14 1987-08-04 Raychem Corporation Conductive polymer circuit protection devices having improved electrodes
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
JPH03167472A (ja) * 1989-11-27 1991-07-19 Sumitomo Chem Co Ltd 実験動物の胎児骨格染色法
JP3216907B2 (ja) 1992-05-18 2001-10-09 株式会社日立製作所 電子ズーム装置及び撮像装置
JP3049537B2 (ja) * 1995-02-03 2000-06-05 悌二 竹崎 生検試料の定着支持方法とその定着支持剤及び包埋カセット
US6722395B2 (en) 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
WO1999036559A1 (fr) 1998-01-13 1999-07-22 Julien Jean Pierre Vecteurs viraux exprimant des filaments intermediaires neuronaux a auto-polymerisation et utilisation desdits vecteurs
WO2000017355A2 (fr) 1998-09-18 2000-03-30 Incyte Pharmaceuticals, Inc. Proteines humaines associees au cytosquelette
US6232092B1 (en) 1998-10-02 2001-05-15 Rogers Imaging Corporation Method for preparing biological specimens for visual analysis
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
US6409774B1 (en) 1999-06-11 2002-06-25 Resolution Sciences Corporation Electrophoresis-assisted staining of materials
JP2004512845A (ja) 2000-10-24 2004-04-30 オンコシス　リミテッド　ライアビリティ　カンパニー 三次元の検体内の細胞を選択的に標的化する方法およびデバイス
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US6472216B1 (en) 2001-07-24 2002-10-29 Ann-Shyn Chiang Aqueous tissue clearing solution
CN1257752C (zh) * 2001-09-28 2006-05-31 生物药开发有限公司 多功能生物相容性水凝胶及其制备方法
DE10209609A1 (de) 2002-03-05 2003-10-02 Europ Lab Molekularbiolog Verfahren und Vorrichtung zur Parallelanalyse von Bio-Molekülen
EP1517715A2 (fr) 2002-06-28 2005-03-30 Cardio, Inc. Tissu decellularise
US7319035B2 (en) 2002-10-17 2008-01-15 Vbi Technologies, L.L.C. Biological scaffolding material
JP4361057B2 (ja) * 2003-04-30 2009-11-11 モイル，ウィリアム，アール 生体分子検出および細胞分類用センサ
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US7660620B2 (en) 2003-09-29 2010-02-09 Medtronic, Inc. Timing techniques for magnetic resonance imaging
US7955788B2 (en) 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
WO2005062938A2 (fr) 2003-12-23 2005-07-14 The Regents Of The University Of California Agents chimiques et procedes de clarification optique de la peau et des membranes des muqueuses afin d'ameliorer le diagnostic et le traitement utilisant de la lumiere
ATE480550T1 (de) 2004-03-25 2010-09-15 California Inst Of Techn Hybridisierungskettenreaktion
US7452491B2 (en) * 2004-05-13 2008-11-18 Chung Yuan Christian University Method for forming scaffolds
GB0414825D0 (en) * 2004-07-02 2004-08-04 Biostatus Ltd Gel formulations and uses thereof
CN1256579C (zh) * 2004-09-23 2006-05-17 上海交通大学 基于原子力显微镜观察的生物样品包埋块的制备方法
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
WO2007030012A2 (fr) * 2005-09-05 2007-03-15 Stichting Voor De Technische Wetenscahappen Mise en image d'une matrice extracellulaire
US8163565B2 (en) 2005-12-08 2012-04-24 Cytyc Corporation Light curing fixative
EP1801573A1 (fr) * 2005-12-21 2007-06-27 Boehringer Mannheim Gmbh Méthode et dispositif pour l'électrophorèse bidimensionnelle parallèle
EP2469263A1 (fr) * 2006-01-13 2012-06-27 Ventana Medical Systems, Inc. Composition de traitement d'échantillons biologiques et procédé
EP2187985B1 (fr) 2007-08-14 2016-09-28 Smith & Nephew PLC Échafaudages
DE102007045897A1 (de) 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe
US9134521B2 (en) 2008-07-30 2015-09-15 The Regents Of The University Of California Multidirectional selective plane illumination microscopy
US20100055733A1 (en) 2008-09-04 2010-03-04 Lutolf Matthias P Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels
WO2010030358A1 (fr) 2008-09-12 2010-03-18 Quickmbed, Inc. Support pour orientation d’échantillons de tissus
WO2010094284A1 (fr) * 2009-02-19 2010-08-26 Dako Denmark A/S Procédés et composés pour la détection de cibles moléculaires
AU2010229858A1 (en) 2009-03-25 2011-09-22 Los Alamos National Security, Llc Fiber optical assembly for fluorescence spectrometry
CN102439398A (zh) * 2009-04-27 2012-05-02 蛋白质发现公司 可编程电泳凹口过滤器系统及方法
US8852614B2 (en) 2010-03-12 2014-10-07 The Board Of Trustees Of The Leland Stanford Junior University Hydrogels with network defects enhanced by nanoparticle incorporation
CN108061677B (zh) 2010-03-12 2021-10-29 国立研究开发法人理化学研究所 用于生物材料的澄清试剂和其用途
US8867803B2 (en) 2010-04-20 2014-10-21 Eric J. Seibel Optical projection tomography microscopy (OPTM) for large specimen sizes
JP5848331B2 (ja) 2010-05-14 2016-01-27 フジフィルム・イメイジング・カラランツ・リミテッド 分散物、分散物の調製方法およびインクジェット印刷インク
TWI425201B (zh) 2010-10-01 2014-02-01 Nat Univ Tsing Hua 觀察厚組織三維結構之方法
CN102072836B (zh) * 2010-11-12 2014-02-19 深圳华大基因科技有限公司 生物大分子浓缩除盐方法及试剂盒
US20140030192A1 (en) 2011-01-28 2014-01-30 Karl A. Deisseroth Functional Targeted Brain Endoskeletonization
WO2012147965A1 (fr) 2011-04-28 2012-11-01 独立行政法人理化学研究所 Procédé permettant de rendre transparent un matériau biologique et son utilisation
WO2012161143A1 (fr) 2011-05-20 2012-11-29 独立行政法人理化学研究所 Réactif de clarification pour des matières biologiques et son utilisation
US9359636B2 (en) 2011-07-27 2016-06-07 The Rockefeller University Methods for fixing and detecting RNA
JP5967528B2 (ja) 2012-06-22 2016-08-10 国立研究開発法人理化学研究所 生物材料を透明化する方法および生物材料用透明化処理キット
DE102012211462A1 (de) 2012-07-03 2014-01-23 Carl Zeiss Microscopy Gmbh Verfahren zur Vorbereitung und Durchführung der Aufnahme von Bildstapeln einer Probe aus verschiedenen Orientierungswinkeln
IN2014DN09073A (fr) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
DE102012020240A1 (de) 2012-10-12 2014-04-17 Carl Zeiss Microscopy Gmbh Mikroskop und Verfahren zur SPIM Mikroskopie
EP2992115B2 (fr) 2013-04-30 2025-03-12 California Institute of Technology Marquage multiplex de molécules par marquage par code-barres à hybridation séquentielle
WO2015022883A1 (fr) 2013-08-14 2015-02-19 独立行政法人理化学研究所 Composition pour la préparation d'un biomatériau possédant une excellente propriété de transmission de la lumière, et son utilisation
DE102013216934A1 (de) 2013-08-26 2015-02-26 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe
WO2015041755A1 (fr) 2013-09-20 2015-03-26 California Institute Of Technology Procédés de phénotypage de tissus totaux intacts
CN103513411B (zh) 2013-09-27 2016-02-03 香港应用科技研究院有限公司 荧光显微镜中聚焦的装置和方法
JP2017517761A (ja) 2014-05-30 2017-06-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 大きなインタクトな組織試料を撮像するための方法及び装置
WO2016023009A1 (fr) 2014-08-07 2016-02-11 Wake Forest University Health Sciences Compositions et procédés de clarification d'échantillon biologique
WO2016073941A1 (fr) 2014-11-07 2016-05-12 California Institute Of Technology Procédés pour le phénotypage d'os intacts par éclaircissement et coloration de tissue
WO2016117614A1 (fr) 2015-01-20 2016-07-28 国立研究開発法人理化学研究所 Agent de transparence d'éprouvettes biologiques, système, et utilisation associée
EP3273218A4 (fr) 2015-03-18 2018-12-26 Riken Procédé d'observation d'un matériel biologique et procédé d'éclaircissement
US20190113423A1 (en) 2015-12-02 2019-04-18 Clearlight Diagnostics, LLC Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers

Also Published As

Publication number Publication date
JP6228205B2 (ja) 2017-11-08
EP2883030B1 (fr) 2022-08-31
EP2883030A4 (fr) 2016-03-02
CN104350372B (zh) 2018-03-02
US20210215581A1 (en) 2021-07-15
KR20150043241A (ko) 2015-04-22
EP4163617A1 (fr) 2023-04-12
US20170219465A1 (en) 2017-08-03
AU2013300171B2 (en) 2017-09-14
US20150144490A1 (en) 2015-05-28
CN104350372A (zh) 2015-02-11
JP2015533210A (ja) 2015-11-19
EP2883030A1 (fr) 2015-06-17
KR102148747B1 (ko) 2020-08-27
US10545075B2 (en) 2020-01-28
HK1204677A1 (en) 2015-11-27
AU2013300171A1 (en) 2014-11-06
WO2014025392A1 (fr) 2014-02-13

Similar Documents

Publication Publication Date Title
IN2014DN09073A (fr)
IN2014CN03228A (fr)
Morgan et al. What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease
BR112014018970A8 (pt) Dispositivos de coleta de amostra com agentes de estabilização sanguínea
MA52909A (fr) Procédés d'augmentation des taux de globules rouges et de traitement de la drépanocytose
MX362545B (es) Analisis de imagen y medicion de muestras biologicas.
MX2016014496A (es) Dispositivo de recoleccion de muestras.
EP4491726A3 (fr) Microvésicules enrichies en protéines et leurs procédés de fabrication et d'utilisation
WO2016109813A3 (fr) Modèles de prédiction de la toxicité neurale basés sur des cellules souches pluripotentes humaines
WO2014093838A3 (fr) Systèmes de microscopie robotique automatisée
CR20130175A (es) Métodos y composiciones que contienen jasmonato o compuestos relacionados para promover la actividad de biodefensa en las plantas
EP2864467A4 (fr) Dispositif de transport d'échantillon de tissu de biopsie et son procédé d'utilisation
EA201101520A1 (ru) Способы диагностики онкологических заболеваний, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
EA201590630A1 (ru) Способы лечения и диагностики, связанные с лизилоксидазоподобным белком 2 (loxl2)
MX2018011832A (es) Metodos y composiciones para uso en diagnostico de pacientes con cancer.
EP3526341A4 (fr) Compositions et méthodes de diagnostic de maladie utilisant l'analyse cellulaire unique
EA201790504A1 (ru) Монослой мононуклеарных клеток периферической крови или клеток костного мозга и его применение
EP3260035A4 (fr) Système d'observation biologique
CR20130688A (es) Método, compuestos y dispositivo para preparar espécimenes citológicos
AR088244A1 (es) oxMIF COMO MARCADOR DE DIAGNOSTICO
CO2017000056A2 (es) Moléculas que tienen cierta utilidad plaguicida e intermediarios, composiciones y procedimientos relacionados con las mismas
EP3705052A4 (fr) Dispositif de collecte d'échantillon biologique
PH12015500662A1 (en) Antigens associated with inflammatory bowel disease
ZA201500584B (en) Matrix and system for preserving biological specimens for qualitative and quantitative analysis
GB2515713A (en) Methods, packaging and apparatus for collection of biological samples