IN2014DN09073A - - Google Patents

Download PDF

Info

Publication number
IN2014DN09073A
IN2014DN09073A IN9073DEN2014A IN2014DN09073A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A IN 9073DEN2014 A IN9073DEN2014 A IN 9073DEN2014A IN 2014DN09073 A IN2014DN09073 A IN 2014DN09073A
Authority
IN
India
Prior art keywords
methods
disease
diagnose
practicing
toxicity
Prior art date
Application number
Other languages
English (en)
Inventor
Karl A Deisseroth
Kwanghun Chung
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of IN2014DN09073A publication Critical patent/IN2014DN09073A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N2001/4038—Concentrating samples electric methods, e.g. electromigration, electrophoresis, ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)
IN9073DEN2014 2012-08-09 2013-03-13 IN2014DN09073A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681551P 2012-08-09 2012-08-09
PCT/US2013/031066 WO2014025392A1 (fr) 2012-08-09 2013-03-13 Procédés et compositions pour préparer des échantillons biologiques pour une analyse microscopique

Publications (1)

Publication Number Publication Date
IN2014DN09073A true IN2014DN09073A (fr) 2015-05-22

Family

ID=50068460

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9073DEN2014 IN2014DN09073A (fr) 2012-08-09 2013-03-13

Country Status (8)

Country Link
US (3) US10545075B2 (fr)
EP (2) EP2883030B1 (fr)
JP (1) JP6228205B2 (fr)
KR (1) KR102148747B1 (fr)
CN (1) CN104350372B (fr)
AU (1) AU2013300171B2 (fr)
IN (1) IN2014DN09073A (fr)
WO (1) WO2014025392A1 (fr)

Families Citing this family (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP2766498B1 (fr) 2011-10-14 2019-06-19 President and Fellows of Harvard College Séquençage par assemblage structurel
EP2794928B1 (fr) 2011-12-22 2019-02-20 President and Fellows of Harvard College Compositions et procédés pour la détection d'analytes
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
IN2014DN09073A (fr) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
EP3901280B1 (fr) 2012-10-17 2025-03-12 10x Genomics Sweden AB Procédés et produits pour optimiser la detection localisée ou spatiale de l'expression génique dans un échantillon de tissu
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
DE102013205115A1 (de) * 2013-03-22 2014-09-25 Leica Microsystems Cms Gmbh SPIM-Anordnung
CN111500680B (zh) 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
DE102013216934A1 (de) * 2013-08-26 2015-02-26 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe
US9778154B2 (en) 2013-09-20 2017-10-03 California Institute Of Technology Methods for phenotyping of intact whole tissues
US10794802B2 (en) 2013-09-20 2020-10-06 California Institute Of Technology Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping
CN103558055B (zh) * 2013-09-29 2016-01-06 中国疾病预防控制中心病毒病预防控制所 一种针对感染病毒的病变细胞的定位超薄切片方法
EP3108218A4 (fr) * 2014-02-21 2017-11-15 Massachusetts Institute Of Technology Microscopie d'expansion
WO2015154000A1 (fr) 2014-04-04 2015-10-08 Massachusetts Institute Of Technology Transport actif de molécules chargées dans des matrices chargées, à l'intérieur de celles-ci et/ou à partir de celles-ci
WO2015184124A1 (fr) * 2014-05-30 2015-12-03 The Board Of Trustees Of The Leland Stanford Junior University Procédés et dispositifs pour l'imagerie de grands échantillons de tissus intacts
WO2016006861A1 (fr) * 2014-07-07 2016-01-14 (주)로고스바이오시스템스 Appareil pour l'élimination de tissus à l'aide d'une électrophorèse
WO2016007839A1 (fr) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Méthodes de marquage et de détection à haut rendement de caractéristiques biologiques in situ à l'aide de microscopie
EP4273263A3 (fr) 2014-07-30 2024-01-31 President and Fellows of Harvard College Systèmes et méthodes permettant de déterminer des acides nucléiques
US10571371B2 (en) 2014-08-07 2020-02-25 Wake Forest University Health Sciences Compositions and methods for clearing a biological sample
KR101563826B1 (ko) * 2014-12-31 2015-10-28 계명대학교 산학협력단 조직 투명화 방법
EP3256844B1 (fr) * 2015-02-09 2021-04-14 Ventana Medical Systems, Inc. Systeme et procede de normalisation de diffusion d'un fluide dans des tissus
EP4321627A3 (fr) 2015-04-10 2024-04-17 10x Genomics Sweden AB Analyse de plusieurs acides nucléiques spatialement différenciés de spécimens biologiques
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
US10526649B2 (en) 2015-04-14 2020-01-07 Massachusetts Institute Of Technology Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
CN111579769B (zh) * 2015-04-30 2023-10-27 李小卫 一种对组织样本进行免疫标记的方法
CN104965016A (zh) * 2015-06-15 2015-10-07 南昌大学 一体化的生物组织透明装置
WO2017027368A1 (fr) * 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Microscopie d'expansion de rétention de protéine
EP3332029B1 (fr) * 2015-08-07 2021-10-06 Massachusetts Institute of Technology Imagerie à l'échelle nanométrique de protéines et d'acides nucléiques par microscopie d'expansion
WO2017031249A1 (fr) * 2015-08-17 2017-02-23 California Institute Of Technology Stabilisation de tissu de tout le corps et extractions sélectives par le biais d'hybrides hydrogel-tissu pour un phénotypage et un appariement de circuit intact à haute résolution
US11092607B2 (en) * 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
CN108474022A (zh) 2015-11-03 2018-08-31 哈佛学院董事及会员团体 用于包含三维核酸的基质容积成像的设备和方法
HK1254531A1 (zh) * 2015-12-02 2019-07-19 Clearlight Diagnostics Llc 用於癌症检测和监测肿瘤组织样品的制备和分析方法
CN108431664B (zh) * 2015-12-23 2021-11-02 皇家飞利浦有限公司 荧光校准载片
CN108472021B (zh) 2015-12-24 2022-05-13 皇家飞利浦有限公司 用于对3d活检组织进行染色的设备
CN105823807B (zh) * 2016-01-04 2018-04-20 浙江农林大学 抗癌药物羟喜树碱药效检测装置及检测方法
US11254974B2 (en) 2016-02-10 2022-02-22 The Board Of Trustees Of The Leland Stanford Junior University RNA fixation and detection in clarity-based hydrogel tissue
SG11201807053TA (en) * 2016-03-07 2018-09-27 X Zell Inc Compositions and methods for identifying rare cells
JP6721899B2 (ja) * 2016-03-30 2020-07-15 国立大学法人 大分大学 高親水性高分子モノマーを主剤とする電子顕微鏡用包埋方法
AU2017257624B2 (en) 2016-04-25 2023-05-25 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
US11397140B2 (en) * 2016-04-29 2022-07-26 Massachusetts Institute Of Technology Methods for reversible and tunable tissue magnification
US10852290B2 (en) 2016-05-11 2020-12-01 Bonraybio Co., Ltd. Analysis accuracy improvement in automated testing apparatus
US10324022B2 (en) 2016-05-11 2019-06-18 Bonraybio Co., Ltd. Analysis accuracy improvement in automated testing apparatus
US10281386B2 (en) * 2016-05-11 2019-05-07 Bonraybio Co., Ltd. Automated testing apparatus
US10495554B2 (en) * 2016-05-25 2019-12-03 The Board Of Trustees Of The Leland Stanford Junior University Method and system for imaging and analysis of a biological specimen
WO2017205531A1 (fr) * 2016-05-25 2017-11-30 The Board Of Trustees Of The Leland Stanford Junior University Procédés de visualisation et de quantification de structures de type fibre
US11352667B2 (en) 2016-06-21 2022-06-07 10X Genomics, Inc. Nucleic acid sequencing
CN107621462B (zh) * 2016-07-13 2020-03-31 王志伟 一种组织透明化液sut及其制备和应用
CN107674879A (zh) * 2016-08-01 2018-02-09 深圳先进技术研究院 一种光‑基因质粒及其应用
WO2018044899A1 (fr) 2016-08-29 2018-03-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procédé et composition de clarification optique de tissus
EP4582805A3 (fr) 2016-08-31 2025-10-08 President And Fellows Of Harvard College Procédés de génération de bibliothèques de séquences d'acides nucléiques pour la détection par séquençage fluorescent in situ
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
US10538632B1 (en) 2016-09-30 2020-01-21 National Technology & Engineering Solutions Of Sandia, Llc Shape-preserving polymeric replication of biological matter
JP6898720B2 (ja) * 2016-10-14 2021-07-07 株式会社ファンケル 皮膚内部構造評価方法
CN110140175A (zh) * 2016-11-08 2019-08-16 哈佛学院院长及董事 基质印迹和清除
US20190276881A1 (en) * 2016-11-08 2019-09-12 President And Fellows Of Harvard College Multiplexed imaging using merfish, expansion microscopy, and related technologies
KR101866249B1 (ko) 2016-11-29 2018-06-12 박순현 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법
DE102016123458B3 (de) * 2016-12-05 2018-03-15 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Verfahren zur Herstellung transparenter biologischer Präparate für eine lichtmikroskopische Untersuchung
CN106682453B (zh) * 2016-12-28 2019-03-26 长春理工大学 一种dna分子的定点编辑方法
US10955322B2 (en) 2017-01-18 2021-03-23 California Institute Of Technology Methods and devices for soft and osseous tissue clearing and fluorescent imaging
CN106769350B (zh) * 2017-01-20 2019-11-22 上海交通大学 一种用于富含脂滴组织快速完全透明化的方法
US10995361B2 (en) 2017-01-23 2021-05-04 Massachusetts Institute Of Technology Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
KR101888782B1 (ko) * 2017-02-07 2018-08-14 고려대학교 산학협력단 피부 조직의 투명화 방법, 이를 이용한 피부 조직의 3차원 영상화 방법 및 평가 및 진단 방법
WO2018151223A1 (fr) * 2017-02-16 2018-08-23 国立大学法人京都大学 Procédé d'évaluation de cellule, dispositif d'évaluation de cellule et programme d'évaluation de cellule
WO2018157074A1 (fr) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Méthodes permettant de diagnostiquer des lésions néoplasiques
WO2018157048A1 (fr) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Procédés d'examen de processus de pied de podocytes dans des échantillons rénaux humains à l'aide d'une microscopie optique classique
WO2018155925A2 (fr) * 2017-02-27 2018-08-30 고려대학교 산학협력단 Procédé de production de tissu décellularisé à l'aide d'un polymère de type hydrogel et tissu décellularisé ainsi produit
KR20180099482A (ko) * 2017-02-27 2018-09-05 고려대학교 산학협력단 하이드로겔 중합체를 이용한 탈세포화 조직의 제조방법 및 이로부터 제조된 탈세포화 조직
TWI620927B (zh) * 2017-04-21 2018-04-11 胡宇光 神經組織樣本染色之方法及套組與顯現神經元之方法
WO2018218150A1 (fr) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systèmes et méthodes de criblage à base d'image à haut débit
MX2017008919A (es) * 2017-07-05 2018-03-01 Gabriela Reyes Fuchs Carmen Proceso para formar una imagen a color de materiales incinerados mediante tecnicas de microscopia.
WO2019009300A1 (fr) * 2017-07-06 2019-01-10 公立大学法人大阪府立大学 Procédé de fabrication d'un tissu biologique transparent et réactif associé
KR101996722B1 (ko) * 2017-07-07 2019-07-04 재단법인대구경북과학기술원 다채널 박막전극을 이용한 전기적 생체분자 이동방법
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
WO2019068880A1 (fr) 2017-10-06 2019-04-11 Cartana Ab Ligature à matrice d'arn
KR102200618B1 (ko) * 2018-01-12 2021-01-08 재단법인대구경북과학기술원 설포베타인계 쯔비터이온성 계면활성제를 포함하는 생물학적 분자의 조직침투용 조성물 및 이의 용도
WO2019078655A1 (fr) * 2017-10-19 2019-04-25 재단법인대구경북과학기술원 Composition pour infiltrer une biomolécule dans un tissu comprenant un tensioactif zwitterionique à base de sulfobétaïne, et son utilisation
US10488307B2 (en) * 2017-12-12 2019-11-26 Dignity Health Systems, devices, and methods for improved tissue treatment
KR102050248B1 (ko) * 2017-12-29 2019-11-29 연세대학교 산학협력단 조직 투명도 분석 방법
CN107966477A (zh) * 2018-01-22 2018-04-27 哈尔滨工业大学 一种生物敏感元件
WO2019156957A1 (fr) 2018-02-06 2019-08-15 Massachusetts Institute Of Technology Hydrogels gonflables et structurellement homogènes et leurs procédés d'utilisation
GB2571544B (en) 2018-02-28 2022-05-18 Bright Instrument Co Ltd Sectioning macrotome
TWI808138B (zh) * 2018-03-16 2023-07-11 法商克萊優卡普塞爾公司 用於以光及/或電子顯微術使其成像之生物樣本之包埋介質
WO2020011735A2 (fr) 2018-07-09 2020-01-16 Universität Zürich Systèmes, appareils et procédés de préparation d'échantillons de tissu
WO2020013833A1 (fr) 2018-07-13 2020-01-16 Massachusetts Institute Of Technology Hydrogel de diméthylacrylamide (dmaa) pour microscopie d'expansion (exm)
CN112770776B (zh) 2018-07-30 2025-08-19 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
KR102151128B1 (ko) * 2018-08-24 2020-09-02 주식회사 바이나리 질소 가스 가압식 조직 투명화 및 항체 침투 증진용 장치
JP7246752B2 (ja) * 2018-08-29 2023-03-28 国立研究開発法人物質・材料研究機構 測定装置、及び、評価方法
KR102368585B1 (ko) * 2018-09-28 2022-03-03 서울대학교산학협력단 온도에 따라 가역적 팽창/초기화가 가능한 하이드로젤을 이용한 생체조직 이미징
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
US11435302B2 (en) * 2018-11-13 2022-09-06 The Trustees Of Princeton University X-ray assisted electron microscopy staining procedure
GB201818567D0 (en) * 2018-11-14 2018-12-26 Francis Crick Institute Ltd Composition
CA3122569A1 (fr) 2018-12-13 2020-06-18 President And Fellows Of Harvard College Systemes et procedes d'amplification pour merfish et d'autres applications
CN109612811A (zh) * 2018-12-26 2019-04-12 华中科技大学苏州脑空间信息研究院 一种保护生物组织结构和荧光的水凝胶包埋方法
CN109781493A (zh) * 2018-12-26 2019-05-21 华中科技大学苏州脑空间信息研究院 一种可长时间连续精细切削成像的生物组织水凝胶包埋方法
US12405193B2 (en) 2019-02-22 2025-09-02 Massachusetts Institute Of Technology Iterative direct expansion microscopy
CN110006862B (zh) * 2019-03-29 2020-09-08 华中科技大学 膨胀切削显微成像方法及适用于该方法的超吸水水凝胶
WO2020226215A1 (fr) * 2019-05-09 2020-11-12 (주)크레용테크놀러지즈 Procédé et appareil de coloration électrophorétique d'un échantillon biologique en utilisant un film conducteur d'ions
CN114174799A (zh) * 2019-05-30 2022-03-11 贝克曼库尔特有限公司 用于固定生物标本以进行显微成像的方法和系统
CN119220641A (zh) 2019-05-31 2024-12-31 10X基因组学有限公司 检测目标核酸分子的方法
WO2021005399A1 (fr) * 2019-07-08 2021-01-14 The University Of Hong Kong Compositions et procédés de transparisation de tissu
US12265004B2 (en) 2019-11-05 2025-04-01 Massachusetts Institute Of Technology Membrane probes for expansion microscopy
WO2021095718A1 (fr) * 2019-11-11 2021-05-20 公立大学法人大阪 Procédé de fabrication de tissu biologique transparent et réactif associé
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
WO2021155063A1 (fr) 2020-01-29 2021-08-05 Readcoor, Llc Compositions et procédés pour la détection d'analytes
US12110548B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Bi-directional in situ analysis
WO2021167986A1 (fr) 2020-02-17 2021-08-26 10X Genomics, Inc. Analyse in situ de l'interaction chromatinienne
EP4107285B1 (fr) 2020-02-21 2024-10-09 10X Genomics, Inc. Méthodes et compositions pour dosage spatial in situ intégré
WO2021170710A1 (fr) * 2020-02-28 2021-09-02 Miltenyi Biotec B.V. & Co. KG Procédé d'extraction de cellules cibles à partir d'un tissu 3d par identification optique
US12188085B2 (en) 2020-03-05 2025-01-07 10X Genomics, Inc. Three-dimensional spatial transcriptomics with sequencing readout
CN115551638B (zh) 2020-03-13 2026-08-07 耶鲁大学 用于生物样品的物理膨胀和成像的方法和系统
WO2021226198A1 (fr) * 2020-05-05 2021-11-11 Massachusetts Institute Of Technology Compositions et procédés associés à des hybrides tissu-hydrogel compressibles de manière réversible
CN111397999B (zh) * 2020-05-09 2021-12-03 中国科学院植物研究所 一种增强显微ct植物样品对比度的简易方法
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
CN114129780B (zh) * 2020-09-03 2022-06-28 天津大学 一种光控释放一氧化氮的复合水凝胶的制备及应用
RU2752751C1 (ru) * 2020-09-28 2021-08-02 Ахмеджан Атаханович Аллаберганов Способ получения цифровых двойников документа в виде бумажного носителя текстовой информации или в виде изображения текстового документа
US20220121900A1 (en) * 2020-10-19 2022-04-21 Arizona Board Of Regents On Behalf Of Northern Arizona University Methods and systems for generating unclonable optical tags
CN112284861B (zh) * 2020-10-21 2023-02-17 上海市农业科学院 用于真姬菇担孢子显微观察的固定液、制备方法、固定方法及应用
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US11333588B1 (en) * 2020-12-07 2022-05-17 Nebulum Technologies Co., Ltd. Matrix-assisted methods and compositions to prepare biological samples for super-resolution imaging
EP4012046A1 (fr) 2020-12-11 2022-06-15 10X Genomics, Inc. Procédés et compositions pour l'analyse multimodale in situ
CN112665951B (zh) * 2020-12-22 2022-11-11 中国农业科学院作物科学研究所 一种胚乳组织包埋方法与应用
CN116848263A (zh) 2020-12-23 2023-10-03 10X基因组学有限公司 用于分析物检测的方法和组合物
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
EP4284945B1 (fr) 2021-01-26 2024-10-23 10X Genomics, Inc. Sondes analogiques d'acide nucléique pour analyse in situ
EP4738279A3 (fr) 2021-02-19 2026-05-13 The Broad Institute Inc. Analyse transcriptomique spatiale multi-échelle
KR102762387B1 (ko) * 2021-02-24 2025-02-05 한국과학기술원 화학적 염색과 팽창 이미징 기법의 최적화 방법
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
WO2022187366A1 (fr) 2021-03-03 2022-09-09 10X Genomics, Inc. Détection d'analytes in situ à l'aide d'origami d'acide nucléique
CN113004885B (zh) * 2021-03-08 2024-06-11 光华临港工程应用技术研发(上海)有限公司 一种用于膨胀超分辨成像的dna纳米结构染料及其应用
EP4334471A1 (fr) 2021-05-07 2024-03-13 The Broad Institute Inc. Transcriptomique à résolution spatio-temporelle avec résolution subcellulaire
CN117396613A (zh) 2021-06-01 2024-01-12 10X基因组学有限公司 用于分析物检测和探针解析的方法和组合物
US20230084407A1 (en) 2021-06-02 2023-03-16 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
EP4367262A1 (fr) 2021-07-09 2024-05-15 10X Genomics, Inc. Procédés de détection d'analytes à l'aide d'un marquage épars
EP4779305A2 (fr) 2021-07-13 2026-07-22 10X Genomics, Inc. Procédés de préparation d'une matrice polymérisée à épaisseur contrôlable
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
EP4326900B1 (fr) 2021-07-30 2024-09-04 10X Genomics, Inc. In situ procédés et compositions pour la synchronisation de réactions
CN115701534B (zh) * 2021-08-02 2025-11-25 锘海生物科学仪器(上海)有限公司 一种生物组织样品成像方法
EP4381095A1 (fr) 2021-08-03 2024-06-12 10X Genomics, Inc. Concatémères d'acide nucléique et procédés de stabilisation et/ou de compactage de ceux-ci
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
US12529096B2 (en) 2021-08-03 2026-01-20 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid structures
US12435364B2 (en) 2021-08-16 2025-10-07 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
EP4305195A2 (fr) 2021-12-01 2024-01-17 10X Genomics, Inc. Procédés, compositions et systèmes pour la détection améliorée d'analytes in situ et analyse spatiale
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US12674196B2 (en) 2022-01-18 2026-07-07 10X Genomics, Inc. Methods and compositions for improved probe specificity
EP4733410A3 (fr) 2022-01-21 2026-05-27 10X Genomics, Inc. Signaux de lecture multiples pour analyser un échantillon
WO2023172915A1 (fr) 2022-03-08 2023-09-14 10X Genomics, Inc. Procédés de conception de code in situ pour réduire à un minimum un chevauchement optique
US12703879B2 (en) 2022-03-29 2026-08-11 10X Genomics, Inc. RNase H assisted in situ rolling circle amplification
CN119032271A (zh) 2022-04-01 2024-11-26 10X基因组学有限公司 用于靶向掩蔽自发荧光的组合物和方法
US12687494B2 (en) 2022-04-04 2026-07-21 10X Genomics, Inc. Systems and methods for nearly isotropic optical resolution using tilted structured illumination microscopy
WO2023196526A1 (fr) 2022-04-06 2023-10-12 10X Genomics, Inc. Procédés d'analyse multiplex de cellules
WO2023204581A1 (fr) * 2022-04-20 2023-10-26 동국대학교 산학협력단 Composite hydrogel tridimensionnel présentant un effet de destruction de cellules cancéreuses et son procédé de production
US12559791B2 (en) 2022-05-06 2026-02-24 10X Genomics, Inc. Methods and compositions for in situ analysis of V(D)J sequences
US20240002902A1 (en) 2022-05-06 2024-01-04 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
CN119213143A (zh) 2022-05-11 2024-12-27 10X基因组学有限公司 用于原位测序的组合物和方法
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
KR102582110B1 (ko) * 2022-07-18 2023-09-21 (재)씨젠의료재단 3차원 세포 또는 생체 조직의 투명화 및 이미지 분석용 조성물
US12692484B2 (en) 2022-08-12 2026-07-28 10X Genomics, Inc. PUMA1 polymerases and uses thereof
US12116626B2 (en) 2022-08-16 2024-10-15 10X Genomics, Inc. AP50 polymerases and uses thereof
KR102982000B1 (ko) * 2022-09-26 2026-06-23 연세대학교 산학협력단 고배율의 세포 확대 분석을 위한 세포 필름, 이의 제조용 조성물 및 제조 방법
CN115656120B (zh) * 2022-10-09 2024-07-23 中国科学院深圳先进技术研究院 一种暗场反射紫外光学显微成像方法和系统
US20240191297A1 (en) 2022-10-14 2024-06-13 10X Genomics, Inc. Methods, compositions, and systems for assessing biological sample quality
US20240158852A1 (en) 2022-11-16 2024-05-16 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
US20240218437A1 (en) 2022-12-16 2024-07-04 10X Genomics, Inc. Methods and compositions for assessing performance
EP4638789A1 (fr) 2022-12-21 2025-10-29 10X Genomics, Inc. Procédés d'accroche d'acides ribonucléiques dans des échantillons biologiques
CN121014083A (zh) * 2023-03-31 2025-11-25 富士胶片株式会社 药物研发辅助装置、药物研发辅助装置的工作方法、及药物研发辅助装置的工作程序
EP4461816A1 (fr) 2023-05-10 2024-11-13 10X Genomics, Inc. Compositions d'acide boronique et procédés de fixation d'acides ribonucléiques dans des échantillons biologiques
TWI887661B (zh) * 2023-05-25 2025-06-21 國立清華大學 用於將生物組織透明化的電極組及裝置
WO2025029831A1 (fr) 2023-07-31 2025-02-06 10X Genomics, Inc. Procédés et systèmes de clivage d'arn ciblé et d'amplification de cercle roulant amorcé par arn cible
US20250163502A1 (en) 2023-11-22 2025-05-22 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
EP4578960A1 (fr) 2023-12-20 2025-07-02 10x Genomics, Inc. Détection in situ de variations du nombre de copies dans des échantillons biologiques
WO2025255457A1 (fr) 2024-06-07 2025-12-11 10X Genomics, Inc. Compositions et procédés de profilage spatial sur cible amélioré
WO2025264702A1 (fr) 2024-06-18 2025-12-26 10X Genomics, Inc. Hydrogels 3d pour le séquençage d'acides nucléiques
WO2026043885A1 (fr) 2024-08-20 2026-02-26 10X Genomics, Inc. Procédés et systèmes de préparation d'une bibliothèque d'acides nucléiques
WO2026055487A1 (fr) 2024-09-06 2026-03-12 10X Genomics, Inc. Nucléotides modifiés avec espaceurs oligomères
WO2026096758A1 (fr) 2024-11-01 2026-05-07 10X Genomics, Inc. Méthodes et compositions pour amplification de réactions in situ
WO2026097020A1 (fr) 2024-11-04 2026-05-07 10X Genomics, Inc. Polymérase pour séquençage par synthèse
WO2026136566A1 (fr) 2024-12-18 2026-06-25 10X Genomics, Inc. Procédés et compositions pour analyse cyclique
WO2026136945A1 (fr) 2024-12-20 2026-06-25 10X Genomics, Inc. Procédés et compositions pour la commande sélective de l'efficacité de génération de signal
WO2026148052A1 (fr) 2024-12-31 2026-07-09 10X Genomics, Inc. Nucléotides modifiés avec espaceurs chargés négativement
WO2026165121A1 (fr) 2025-01-29 2026-08-06 10X Genomics, Inc. Procédés d'amplification par cercles roulants utilisant des séquences à codes-barres pour l'amplification et compositions associées

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129158A (en) 1961-01-24 1964-04-14 Raymond Samuel Process for gel electrophoresis
US3208929A (en) 1962-09-11 1965-09-28 Robert H Raymond Apparatus for gel electrophoresis
US3346479A (en) 1964-04-09 1967-10-10 Scientific Industries Preparative separation by a combination of gel separation and electrophoresis
US3375187A (en) 1965-05-13 1968-03-26 Buchler Instr Inc Apparatus for temperature controlled preparative and analytical electrophoresis
US3576727A (en) 1968-05-23 1971-04-27 Bruce Lee Evatt Gel electrophoresis process
US3563880A (en) 1968-08-28 1971-02-16 Arthur W Anderson Gel electrophoresis unit
SE328135B (fr) 1968-09-19 1970-09-07 Lkb Produkter Ab
US3616454A (en) 1969-03-13 1971-10-26 Univ New York Method of and apparatus for electrophoretic separation in a gel column
US3674678A (en) 1970-10-28 1972-07-04 Millipore Corp Electrophoretic apparatus
US3865712A (en) 1972-04-13 1975-02-11 Lkb Produkter Ab Electrode arrangement for an electrophoretical separation performed in a gel plate
US3989613A (en) * 1973-05-16 1976-11-02 The Dow Chemical Company Continuous balanced flow fixed boundary electrophoresis
US4088561A (en) 1977-06-27 1978-05-09 The United States Of America As Represented By The United States Department Of Energy Apparatus for electrophoresis separation
US4151065A (en) 1978-01-30 1979-04-24 The Regents Of The University Of California Horizontal slab gel electrophoresis
US4292161A (en) 1979-01-03 1981-09-29 Hoefer Scientific Instruments Vertical gel slab electrophoresis apparatus
FR2496889A1 (fr) 1980-12-22 1982-06-25 Hours Michel Cuve de migration et de reaction utilisable pour des analyses par electrophorese
US4339327A (en) 1981-04-23 1982-07-13 Tyler Jonathan M Miniature slab gel electrophoresis system
US4375401A (en) 1981-05-20 1983-03-01 Nicholas Catsimpoolas Electrophoresis system
DE3374082D1 (en) 1982-07-23 1987-11-19 Matthias Hediger Apparatus for preparative gel electrophoresis, in particular for separating mixtures on a gradient gel polyacryl amide column
US4588491A (en) 1984-02-27 1986-05-13 International Biotechnologies, Inc. Horizontal gel electrophoresis device
DE3580418D1 (de) * 1984-07-31 1990-12-13 Hitachi Ltd Elektrophoretisches trennverfahren mit freier stroemung und apparat dafuer.
US4685025A (en) 1985-03-14 1987-08-04 Raychem Corporation Conductive polymer circuit protection devices having improved electrodes
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
JPH03167472A (ja) * 1989-11-27 1991-07-19 Sumitomo Chem Co Ltd 実験動物の胎児骨格染色法
JP3216907B2 (ja) 1992-05-18 2001-10-09 株式会社日立製作所 電子ズーム装置及び撮像装置
JP3049537B2 (ja) * 1995-02-03 2000-06-05 悌二 竹崎 生検試料の定着支持方法とその定着支持剤及び包埋カセット
WO1999036559A1 (fr) 1998-01-13 1999-07-22 Julien Jean Pierre Vecteurs viraux exprimant des filaments intermediaires neuronaux a auto-polymerisation et utilisation desdits vecteurs
US6722395B2 (en) 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
WO2000017355A2 (fr) 1998-09-18 2000-03-30 Incyte Pharmaceuticals, Inc. Proteines humaines associees au cytosquelette
US6232092B1 (en) 1998-10-02 2001-05-15 Rogers Imaging Corporation Method for preparing biological specimens for visual analysis
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
US6409774B1 (en) 1999-06-11 2002-06-25 Resolution Sciences Corporation Electrophoresis-assisted staining of materials
AU2002232892B2 (en) 2000-10-24 2008-06-26 Intrexon Corporation Method and device for selectively targeting cells within a three -dimensional specimen
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US6472216B1 (en) 2001-07-24 2002-10-29 Ann-Shyn Chiang Aqueous tissue clearing solution
MXPA04002967A (es) 2001-09-28 2004-07-15 Biopharma Dev Ltd Hidrogel biocompatible polifuncional y metodo para la produccion del mismo.
DE10209609A1 (de) 2002-03-05 2003-10-02 Europ Lab Molekularbiolog Verfahren und Vorrichtung zur Parallelanalyse von Bio-Molekülen
EP1649879A3 (fr) 2002-06-28 2006-05-03 Cardio, Inc. Tissu décellularisé
US7319035B2 (en) 2002-10-17 2008-01-15 Vbi Technologies, L.L.C. Biological scaffolding material
JP4361057B2 (ja) * 2003-04-30 2009-11-11 モイル，ウィリアム，アール 生体分子検出および細胞分類用センサ
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US7660620B2 (en) 2003-09-29 2010-02-09 Medtronic, Inc. Timing techniques for magnetic resonance imaging
US7955788B2 (en) * 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
WO2005062938A2 (fr) 2003-12-23 2005-07-14 The Regents Of The University Of California Agents chimiques et procedes de clarification optique de la peau et des membranes des muqueuses afin d'ameliorer le diagnostic et le traitement utilisant de la lumiere
DE602005023426D1 (de) 2004-03-25 2010-10-21 California Inst Of Techn Hybridisierungskettenreaktion
US7452491B2 (en) * 2004-05-13 2008-11-18 Chung Yuan Christian University Method for forming scaffolds
GB0414825D0 (en) * 2004-07-02 2004-08-04 Biostatus Ltd Gel formulations and uses thereof
CN1256579C (zh) * 2004-09-23 2006-05-17 上海交通大学 基于原子力显微镜观察的生物样品包埋块的制备方法
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
WO2007030012A2 (fr) 2005-09-05 2007-03-15 Stichting Voor De Technische Wetenscahappen Mise en image d'une matrice extracellulaire
US8163565B2 (en) * 2005-12-08 2012-04-24 Cytyc Corporation Light curing fixative
EP1801573A1 (fr) * 2005-12-21 2007-06-27 Boehringer Mannheim Gmbh Méthode et dispositif pour l'électrophorèse bidimensionnelle parallèle
CN101371125B (zh) * 2006-01-13 2013-05-29 文塔纳医疗系统公司 生物样品处理组合物与方法
EP2187985B1 (fr) 2007-08-14 2016-09-28 Smith & Nephew PLC Échafaudages
DE102007045897A1 (de) 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe
WO2010014244A2 (fr) 2008-07-30 2010-02-04 The Regents Of The University Of California, San Francisco Microscopie par éclairage de plan sélectif multi-directionnel
US20100055733A1 (en) 2008-09-04 2010-03-04 Lutolf Matthias P Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels
WO2010030358A1 (fr) 2008-09-12 2010-03-18 Quickmbed, Inc. Support pour orientation d’échantillons de tissus
JP5721639B2 (ja) * 2009-02-19 2015-05-20 ダコ・デンマーク・エー／エス 分子標的の検出のための方法と化合物
JP2012522221A (ja) 2009-03-25 2012-09-20 ロス アラモス ナショナル セキュリティー，エルエルシー 蛍光分光測定用光ファイバアセンブリ
WO2010126897A1 (fr) * 2009-04-27 2010-11-04 Protein Discovery, Inc. Systèmes et procédés à filtres réjecteurs électrophorétiques programmables
JP5858435B2 (ja) * 2010-03-12 2016-02-10 国立研究開発法人理化学研究所 生物材料用透明化試薬、及びその利用
US8852614B2 (en) 2010-03-12 2014-10-07 The Board Of Trustees Of The Leland Stanford Junior University Hydrogels with network defects enhanced by nanoparticle incorporation
US8867803B2 (en) 2010-04-20 2014-10-21 Eric J. Seibel Optical projection tomography microscopy (OPTM) for large specimen sizes
CN102883802B (zh) 2010-05-14 2015-07-01 富士胶片映像着色有限公司 分散体、制备分散体的方法和喷墨打印油墨
TWI425201B (zh) 2010-10-01 2014-02-01 Nat Univ Tsing Hua 觀察厚組織三維結構之方法
CN102072836B (zh) * 2010-11-12 2014-02-19 深圳华大基因科技有限公司 生物大分子浓缩除盐方法及试剂盒
WO2012103343A1 (fr) 2011-01-28 2012-08-02 The Board Of Trustees Of The Leland Stanford Junior University Endosquelettisation fonctionnelle ciblée du cerveau
US20140087419A1 (en) 2011-04-28 2014-03-27 Riken Method for making biological material transparent and use thereof
EP2711682B1 (fr) 2011-05-20 2019-07-10 Riken Réactif de clarification pour des matières biologiques et son utilisation
US9359636B2 (en) 2011-07-27 2016-06-07 The Rockefeller University Methods for fixing and detecting RNA
JP5967528B2 (ja) 2012-06-22 2016-08-10 国立研究開発法人理化学研究所 生物材料を透明化する方法および生物材料用透明化処理キット
DE102012211462A1 (de) 2012-07-03 2014-01-23 Carl Zeiss Microscopy Gmbh Verfahren zur Vorbereitung und Durchführung der Aufnahme von Bildstapeln einer Probe aus verschiedenen Orientierungswinkeln
IN2014DN09073A (fr) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
DE102012020240B4 (de) 2012-10-12 2026-07-09 Carl Zeiss Microscopy Gmbh Mikroskop und Verfahren zur SPIM Mikroskopie
KR102368591B1 (ko) 2013-04-30 2022-02-25 캘리포니아 인스티튜트 오브 테크놀로지 순차적 하이브리드화 바코딩에 의한 분자의 멀티플렉스 표지화
JP6433901B2 (ja) 2013-08-14 2018-12-05 国立研究開発法人理化学研究所 光透過性に優れた生物材料を調製するための組成物およびその利用
DE102013216934A1 (de) 2013-08-26 2015-02-26 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Erhöhung der optischen Transparenz von Bereichen einer Gewebeprobe
US9778154B2 (en) 2013-09-20 2017-10-03 California Institute Of Technology Methods for phenotyping of intact whole tissues
CN103513411B (zh) 2013-09-27 2016-02-03 香港应用科技研究院有限公司 荧光显微镜中聚焦的装置和方法
WO2015184124A1 (fr) 2014-05-30 2015-12-03 The Board Of Trustees Of The Leland Stanford Junior University Procédés et dispositifs pour l'imagerie de grands échantillons de tissus intacts
US10571371B2 (en) 2014-08-07 2020-02-25 Wake Forest University Health Sciences Compositions and methods for clearing a biological sample
US20160131560A1 (en) 2014-11-07 2016-05-12 California Institute Of Technology Methods for phenotyping of intact bones by tissue clearing and staining
JP6687949B2 (ja) 2015-01-20 2020-04-28 国立研究開発法人理化学研究所 生物材料用透明化試薬、システム及びその利用
EP3273218A4 (fr) 2015-03-18 2018-12-26 Riken Procédé d'observation d'un matériel biologique et procédé d'éclaircissement
HK1254531A1 (zh) 2015-12-02 2019-07-19 Clearlight Diagnostics Llc 用於癌症检测和监测肿瘤组织样品的制备和分析方法

Also Published As

Publication number Publication date
AU2013300171B2 (en) 2017-09-14
US10545075B2 (en) 2020-01-28
KR20150043241A (ko) 2015-04-22
EP2883030A4 (fr) 2016-03-02
WO2014025392A1 (fr) 2014-02-13
US20150144490A1 (en) 2015-05-28
CN104350372A (zh) 2015-02-11
US20210215581A1 (en) 2021-07-15
HK1204677A1 (en) 2015-11-27
CN104350372B (zh) 2018-03-02
US20170219465A1 (en) 2017-08-03
AU2013300171A1 (en) 2014-11-06
JP6228205B2 (ja) 2017-11-08
EP4163617A1 (fr) 2023-04-12
EP2883030B1 (fr) 2022-08-31
EP2883030A1 (fr) 2015-06-17
JP2015533210A (ja) 2015-11-19
KR102148747B1 (ko) 2020-08-27

Similar Documents

Publication Publication Date Title
Morgan et al. What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease
BR112014018970A8 (pt) Dispositivos de coleta de amostra com agentes de estabilização sanguínea
MA52909A (fr) Procédés d'augmentation des taux de globules rouges et de traitement de la drépanocytose
MX362545B (es) Analisis de imagen y medicion de muestras biologicas.
MX2016014496A (es) Dispositivo de recoleccion de muestras.
EP4491726A3 (fr) Microvésicules enrichies en protéines et leurs procédés de fabrication et d'utilisation
EP3259067A4 (fr) Dispositifs pour collecte et analyse d'échantillon biologique et leurs procédés d'utilisation
WO2016109813A3 (fr) Modèles de prédiction de la toxicité neurale basés sur des cellules souches pluripotentes humaines
WO2014093838A3 (fr) Systèmes de microscopie robotique automatisée
MX2022002738A (es) Agentes de union a cd8 y uso de los mismos.
CR20130175A (es) Métodos y composiciones que contienen jasmonato o compuestos relacionados para promover la actividad de biodefensa en las plantas
EP2864467A4 (fr) Dispositif de transport d'échantillon de tissu de biopsie et son procédé d'utilisation
BR112015022934A2 (pt) esteroides neuroativos, composições, e uso do mesmo
MX2015005448A (es) Metodos de terapia y diagnostico relacionados con lisil oxidasa-tipo 2 (loxl2).
MX2018011832A (es) Metodos y composiciones para uso en diagnostico de pacientes con cancer.
EP3526341A4 (fr) Compositions et méthodes de diagnostic de maladie utilisant l'analyse cellulaire unique
ZA201500584B (en) Matrix and system for preserving biological specimens for qualitative and quantitative analysis
FR2997502B1 (fr) Procede d'observation d'especes biologiques.
CO2017000056A2 (es) Moléculas que tienen cierta utilidad plaguicida e intermediarios, composiciones y procedimientos relacionados con las mismas
EP3260035A4 (fr) Système d'observation biologique
EP3705052A4 (fr) Dispositif de collecte d'échantillon biologique
MX2015018035A (es) Metodos para predecir respuestas a sustancias quimicas o biologicas.
PH12015500662A1 (en) Antigens associated with inflammatory bowel disease
GB2515713A (en) Methods, packaging and apparatus for collection of biological samples
WO2014042771A3 (fr) Méthodes analytiques