IN2014KN01211A - - Google Patents

Info

Publication number: IN2014KN01211A
Authority: IN; India
Prior art keywords: nalmefene; hydrochloride; methylenemorphinan; cyclopropylmethyl; recovery
Prior art date: 2011-12-06

Application number

Other languages

English (en)

Inventor

Faveri Carla De

Mariano Stivanello

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-06

Filing date

2012-12-06

Publication date

2015-10-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48573602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014KN01211(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-12-06 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2015-10-16 Publication of IN2014KN01211A publication Critical patent/IN2014KN01211A/en

Links

GYWMRGWFQPSQLK-OPHZJPRHSA-N (4r,4as,7as,12bs)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;hydron;chloride Chemical compound Cl.N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 GYWMRGWFQPSQLK-OPHZJPRHSA-N 0.000 abstract 1
239000004593 Epoxy Substances 0.000 abstract 1
WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
-1 diol hydrochloride Chemical class 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229960005297 nalmefene Drugs 0.000 abstract 1
229960000677 nalmefene hydrochloride Drugs 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IN1211KON2014 2011-12-06 2012-12-06 IN2014KN01211A (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201161567148P	2011-12-06	2011-12-06
DKPA201100948		2011-12-06
PCT/EP2012/074623 WO2013083685A1 (fr)	2011-12-06	2012-12-06	Procédé pour la récupération de chlorhydrate de nalméfène

Publications (1)

Publication Number	Publication Date
IN2014KN01211A true IN2014KN01211A (fr)	2015-10-16

Family

ID=48573602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN1211KON2014 IN2014KN01211A (fr)	2011-12-06	2012-12-06

Country Status (32)

Country	Link
US (1)	US8841452B1 (fr)
EP (1)	EP2788357B1 (fr)
JP (1)	JP6086925B2 (fr)
KR (1)	KR20140103288A (fr)
CN (1)	CN104093721B (fr)
AR (1)	AR089080A1 (fr)
AU (1)	AU2012347261B2 (fr)
BR (1)	BR112014013541B1 (fr)
CA (1)	CA2857096C (fr)
CL (1)	CL2014001454A1 (fr)
CO (1)	CO6970605A2 (fr)
CY (1)	CY1118785T1 (fr)
DK (1)	DK2788357T3 (fr)
ES (1)	ES2622156T3 (fr)
HR (1)	HRP20170497T1 (fr)
HU (1)	HUE033717T2 (fr)
IL (1)	IL232826A (fr)
IN (1)	IN2014KN01211A (fr)
JO (1)	JO3251B1 (fr)
LT (1)	LT2788357T (fr)
ME (1)	ME02668B (fr)
MX (1)	MX354331B (fr)
PL (1)	PL2788357T3 (fr)
PT (1)	PT2788357T (fr)
RS (1)	RS55817B1 (fr)
RU (1)	RU2631652C2 (fr)
SG (1)	SG11201402956UA (fr)
SI (1)	SI2788357T1 (fr)
SM (1)	SMT201700200T1 (fr)
TW (1)	TWI560170B (fr)
WO (1)	WO2013083685A1 (fr)
ZA (1)	ZA201404100B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105646508B (zh) *	2016-02-17	2018-02-27	南京卓康医药科技有限公司	一种盐酸纳美芬一水合物的制备方法
US10927121B1 (en)	2019-12-20	2021-02-23	Southwest Research Institute	Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate
US20240109907A1 (en)	2021-01-28	2024-04-04	Rhodes Technologies	Process for crystallizing nalmefene hydrochloride
CN117986261B (zh) *	2024-04-02	2024-06-18	成都瑞尔医药科技有限公司	一种盐酸纳美芬母液的回收套用方法
CN119080788A (zh) *	2024-08-19	2024-12-06	南京海鲸药业股份有限公司	一种盐酸纳美芬杂质的去除监控系统及去除方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2577947A (en) *		1951-12-11		Manufacture of dihydrocodeinone
US3814768A (en) *	1971-11-26	1974-06-04	Lewenstein E	6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts
US3896226A (en) *	1971-11-26	1975-07-22	Lewinstein Evalina	6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts thereof, and use of the same as a narcotic antagonist
US4535157A (en)	1983-11-01	1985-08-13	Key Pharmaceuticals, Inc.	Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4751307A (en)	1985-01-17	1988-06-14	Mallinckrodt, Inc.	Wittig-reaction processes
US5869669A (en) *	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6512117B1 (en) *	1999-11-09	2003-01-28	Abbott Laboratories	Hydromorphone and hydrocodone compositions and methods for their synthesis
ATE510534T1 (de) *	2002-03-14	2011-06-15	Euro Celtique Sa	Naltrexonhydrochlorid-zusammensetzungen
CN101395159A (zh) *	2006-03-02	2009-03-25	马林克罗特公司	制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
JP2010511726A (ja) *	2006-12-04	2010-04-15	ノランコ・インコーポレーテツド	１４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
WO2008094574A2 (fr)	2007-01-30	2008-08-07	Biogen Idec Ma Inc.	Composés de furanone et procédés de fabrication et d'utilisation de ceux-ci
UA102128C2 (en)	2008-12-05	2013-06-10	Х. Луннбек А/С	Nalmefene hydrochloride dihydrate
MY158251A (en) *	2009-05-25	2016-09-30	H Lundbeck As	Method for the preparation of nalmefene hydrochloride
CN101768164B (zh) *	2010-01-25	2011-09-14	海南数尔药物研究有限公司	一种高纯度的盐酸纳洛酮化合物

2012
- 2012-11-22 TW TW101143647A patent/TWI560170B/zh not_active IP Right Cessation
- 2012-12-04 JO JOP/2012/0364A patent/JO3251B1/ar active
- 2012-12-04 AR ARP120104552A patent/AR089080A1/es unknown
- 2012-12-06 LT LTEP12797909.4T patent/LT2788357T/lt unknown
- 2012-12-06 SG SG11201402956UA patent/SG11201402956UA/en unknown
- 2012-12-06 EP EP12797909.4A patent/EP2788357B1/fr active Active
- 2012-12-06 ME MEP-2017-75A patent/ME02668B/fr unknown
- 2012-12-06 HU HUE12797909A patent/HUE033717T2/en unknown
- 2012-12-06 PL PL12797909T patent/PL2788357T3/pl unknown
- 2012-12-06 CN CN201280067483.6A patent/CN104093721B/zh not_active Expired - Fee Related
- 2012-12-06 CA CA2857096A patent/CA2857096C/fr active Active
- 2012-12-06 US US14/294,707 patent/US8841452B1/en active Active
- 2012-12-06 IN IN1211KON2014 patent/IN2014KN01211A/en unknown
- 2012-12-06 PT PT127979094T patent/PT2788357T/pt unknown
- 2012-12-06 MX MX2014006705A patent/MX354331B/es active IP Right Grant
- 2012-12-06 KR KR1020147016975A patent/KR20140103288A/ko not_active Ceased
- 2012-12-06 RU RU2014126489A patent/RU2631652C2/ru active
- 2012-12-06 JP JP2014545252A patent/JP6086925B2/ja active Active
- 2012-12-06 SI SI201230923A patent/SI2788357T1/sl unknown
- 2012-12-06 HR HRP20170497TT patent/HRP20170497T1/hr unknown
- 2012-12-06 AU AU2012347261A patent/AU2012347261B2/en not_active Ceased
- 2012-12-06 WO PCT/EP2012/074623 patent/WO2013083685A1/fr not_active Ceased
- 2012-12-06 SM SM20170200T patent/SMT201700200T1/it unknown
- 2012-12-06 DK DK12797909.4T patent/DK2788357T3/en active
- 2012-12-06 RS RS20170349A patent/RS55817B1/sr unknown
- 2012-12-06 BR BR112014013541-0A patent/BR112014013541B1/pt not_active IP Right Cessation
- 2012-12-06 ES ES12797909.4T patent/ES2622156T3/es active Active
2014
- 2014-05-27 IL IL232826A patent/IL232826A/en active IP Right Grant
- 2014-06-03 CL CL2014001454A patent/CL2014001454A1/es unknown
- 2014-06-05 ZA ZA2014/04100A patent/ZA201404100B/en unknown
- 2014-06-06 CO CO14122226A patent/CO6970605A2/es active IP Right Grant
2017
- 2017-03-31 CY CY20171100389T patent/CY1118785T1/el unknown

Also Published As

Publication number	Publication date
ES2622156T3 (es)	2017-07-05
EP2788357A1 (fr)	2014-10-15
JP2015504856A (ja)	2015-02-16
WO2013083685A1 (fr)	2013-06-13
LT2788357T (lt)	2017-04-25
SI2788357T1 (sl)	2017-06-30
SMT201700200T1 (it)	2017-05-08
CL2014001454A1 (es)	2014-10-03
BR112014013541B1 (pt)	2022-02-15
MX2014006705A (es)	2014-07-09
EP2788357B1 (fr)	2017-03-01
RU2631652C2 (ru)	2017-09-26
CA2857096C (fr)	2021-01-19
CN104093721B (zh)	2016-05-18
RS55817B1 (sr)	2017-08-31
KR20140103288A (ko)	2014-08-26
IL232826A (en)	2016-10-31
CY1118785T1 (el)	2017-07-12
HRP20170497T1 (hr)	2017-06-02
MX354331B (es)	2018-02-27
RU2014126489A (ru)	2016-01-27
DK2788357T3 (en)	2017-04-24
CA2857096A1 (fr)	2013-06-13
TW201335110A (zh)	2013-09-01
TWI560170B (en)	2016-12-01
US20140296525A1 (en)	2014-10-02
AU2012347261B2 (en)	2016-12-01
JO3251B1 (ar)	2018-09-16
SG11201402956UA (en)	2014-07-30
PT2788357T (pt)	2017-04-24
PL2788357T3 (pl)	2017-07-31
US8841452B1 (en)	2014-09-23
ZA201404100B (en)	2015-11-25
HK1202874A1 (en)	2015-10-09
ME02668B (fr)	2017-06-20
JP6086925B2 (ja)	2017-03-01
HUE033717T2 (en)	2017-12-28
IL232826A0 (en)	2014-08-03
CO6970605A2 (es)	2014-06-13
CN104093721A (zh)	2014-10-08
AR089080A1 (es)	2014-07-30
BR112014013541A2 (pt)	2017-06-13
AU2012347261A1 (en)	2014-06-19

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