IN2014MN00933A - - Google Patents

Info

Publication number: IN2014MN00933A
Authority: IN; India
Prior art keywords: insulin analogue; therapeutic agent; present; provides; preparation
Prior art date: 2011-12-15

Application number

Other languages

English (en)

Inventor

Piaoyang Sun

Lianshan Zhang

Jiajian Liu

Jijun Yuan

Chunqian Fang

Changan Sun

Hengli Yuan

Yali Wang

Original Assignee

Shanghai Hengrui Pharm Co Ltd

Jiangsu Hengrui Medicine Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-15

Filing date

2012-11-22

Publication date

2015-05-01

2012-11-22 Application filed by Shanghai Hengrui Pharm Co Ltd, Jiangsu Hengrui Medicine Co filed Critical Shanghai Hengrui Pharm Co Ltd

2015-05-01 Publication of IN2014MN00933A publication Critical patent/IN2014MN00933A/en

Links

239000003814 drug Substances 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
239000004026 insulin derivative Substances 0.000 abstract 2
229940124597 therapeutic agent Drugs 0.000 abstract 2
206010012601 diabetes mellitus Diseases 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Obesity (AREA)
Epidemiology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Mycology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IN933MUN2014 2011-12-15 2012-11-22 IN2014MN00933A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CN201110422095		2011-12-15
PCT/CN2012/085054 WO2013086927A1 (zh)	2011-12-15	2012-11-22	人胰岛素类似物及其酰化衍生物

Publications (1)

Publication Number	Publication Date
IN2014MN00933A true IN2014MN00933A (pt)	2015-05-01

Family

ID=48611849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN933MUN2014 IN2014MN00933A (pt)	2011-12-15	2012-11-22

Country Status (14)

Country	Link
US (1)	US9458219B2 (pt)
EP (1)	EP2784085A4 (pt)
JP (1)	JP6153206B2 (pt)
KR (1)	KR20140104994A (pt)
CN (2)	CN103443122B (pt)
AU (1)	AU2012350586B2 (pt)
BR (1)	BR112014013483A2 (pt)
CA (1)	CA2858253A1 (pt)
IN (1)	IN2014MN00933A (pt)
MX (1)	MX2014006698A (pt)
RU (1)	RU2014127270A (pt)
TW (1)	TW201323439A (pt)
WO (1)	WO2013086927A1 (pt)
ZA (1)	ZA201404417B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR106364A1 (es)	2015-08-25	2018-01-10	Novo Nordisk As	Derivados de insulina y sus usos médicos
CN106496322A (zh) *	2015-09-07	2017-03-15	江苏恒瑞医药股份有限公司	人胰岛素或其类似物的酰化衍生物的制备方法
CN105491227A (zh) *	2015-11-20	2016-04-13	努比亚技术有限公司	一种消息排列方法和终端
EP3260548A1 (en)	2016-06-21	2017-12-27	Enzypep B.V.	Enzymatic coupling of (oligo)peptides to the b-chain of an insulin receptor ligand
WO2018024186A1 (zh) *	2016-08-02	2018-02-08	江苏恒瑞医药股份有限公司	一种人胰岛素或其类似物的酰化衍生物
US20210040171A1 (en) *	2018-02-01	2021-02-11	Jiangsu Hengrui Medicine Co., Ltd.	Pharmaceutical composition comprising acylated derivative of human insulin analog and preparation method thereof
US20210032307A1 (en) *	2018-02-09	2021-02-04	Jiangsu Hengrui Medicine Co., Ltd.	Codon optimized precursor gene and signal peptide gene of human insulin analogue
WO2020120477A1 (en)	2018-12-11	2020-06-18	Sanofi	Insulin analogs having reduced insulin receptor binding affinity
CN111909255A (zh) *	2019-05-10	2020-11-10	宁波鲲鹏生物科技有限公司	胰岛素衍生物及其制备方法
DK4073097T3 (da)	2019-12-11	2024-08-19	Novo Nordisk As	Nye insulinanaloger og anvendelser heraf
CN118420744A (zh)	2019-12-30	2024-08-02	甘李药业股份有限公司	胰岛素衍生物
CN113773398B (zh) *	2020-06-10	2023-05-23	宁波鲲鹏生物科技有限公司	一种德谷胰岛素衍生物及其应用
EP4347632A4 (en) *	2021-05-24	2025-03-26	Sunshine Lake Pharma Co., Ltd.	A novel acylated insulin analog
WO2022268208A1 (zh)	2021-06-25	2022-12-29	甘李药业股份有限公司	含酰化胰岛素的药物组合物
US20250340610A1 (en)	2022-01-28	2025-11-06	Gan & Lee Pharmaceuticals Co., Ltd.	Acylated insulin
CN118063589A (zh) *	2024-02-04	2024-05-24	乐普健糖药业(重庆)有限公司	一种超长效胰岛素类似物及其制备方法和用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008241A (en)	1985-03-12	1991-04-16	Novo Nordisk A/S	Novel insulin peptides
PH25772A (en)	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
DK257988D0 (da)	1988-05-11	1988-05-11	Novo Industri As	Nye peptider
KR900701842A (ko)	1988-07-20	1990-12-04	헨리 브뢰늄	인간 인슐린 동족체와 그를 포함하는 제제
AU641631B2 (en)	1988-12-23	1993-09-30	Novo Nordisk A/S	Human insulin analogues
SI0792290T1 (en) *	1993-09-17	2001-12-31	Novo Nordisk As	Acylated insulin
CN1195777A (zh)	1997-05-28	1998-10-14	姚维明	电力拖动实验仪
JP4773023B2 (ja) *	1999-12-29	2011-09-14	ノボノルディスクアクティーゼルスカブ	インスリン前駆体及びインスリン前駆体類似体の製造方法
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
US6770625B2 (en) *	2001-09-07	2004-08-03	Nobex Corporation	Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7193035B2 (en)	2002-10-29	2007-03-20	Sanofi-Aventis Deutschland Gmbh	Crystals of insulin analogs and processes for their preparation
CN1780854A (zh)	2003-04-29	2006-05-31	伊莱利利公司	具有延长时间作用的胰岛素类似物
ES2472421T3 (es)	2003-08-05	2014-07-01	Novo Nordisk A/S	Nuevos derivados de insulina
EP2107069B1 (en) *	2003-08-05	2013-01-16	Novo Nordisk A/S	Novel insulin derivatives
CN101721712A (zh) *	2008-10-21	2010-06-09	何明磊	一种双链聚乙二醇－胰岛素复合物及其制备方法

2012
- 2012-11-22 RU RU2014127270A patent/RU2014127270A/ru not_active Application Discontinuation
- 2012-11-22 CN CN201280011736.8A patent/CN103443122B/zh active Active
- 2012-11-22 CA CA2858253A patent/CA2858253A1/en not_active Abandoned
- 2012-11-22 EP EP12857862.2A patent/EP2784085A4/en not_active Withdrawn
- 2012-11-22 AU AU2012350586A patent/AU2012350586B2/en not_active Ceased
- 2012-11-22 WO PCT/CN2012/085054 patent/WO2013086927A1/zh not_active Ceased
- 2012-11-22 BR BR112014013483A patent/BR112014013483A2/pt not_active IP Right Cessation
- 2012-11-22 JP JP2014546293A patent/JP6153206B2/ja not_active Expired - Fee Related
- 2012-11-22 MX MX2014006698A patent/MX2014006698A/es unknown
- 2012-11-22 CN CN201510174792.9A patent/CN104788556A/zh active Pending
- 2012-11-22 US US14/363,328 patent/US9458219B2/en not_active Expired - Fee Related
- 2012-11-22 IN IN933MUN2014 patent/IN2014MN00933A/en unknown
- 2012-11-22 KR KR1020147018616A patent/KR20140104994A/ko not_active Withdrawn
- 2012-11-30 TW TW101144976A patent/TW201323439A/zh unknown
2014
- 2014-06-17 ZA ZA2014/04417A patent/ZA201404417B/en unknown

Also Published As

Publication number	Publication date
AU2012350586A1 (en)	2014-07-03
JP6153206B2 (ja)	2017-06-28
EP2784085A1 (en)	2014-10-01
CN103443122A (zh)	2013-12-11
TW201323439A (zh)	2013-06-16
RU2014127270A (ru)	2016-02-10
HK1188795A1 (zh)	2014-05-16
CN104788556A (zh)	2015-07-22
BR112014013483A2 (pt)	2019-09-24
KR20140104994A (ko)	2014-08-29
MX2014006698A (es)	2014-07-09
CN103443122B (zh)	2016-05-11
CA2858253A1 (en)	2013-06-20
AU2012350586B2 (en)	2017-02-02
US20140329745A1 (en)	2014-11-06
US9458219B2 (en)	2016-10-04
EP2784085A4 (en)	2015-07-08
ZA201404417B (en)	2016-07-27
JP2015501819A (ja)	2015-01-19
WO2013086927A1 (zh)	2013-06-20

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