MA58093B1 - Nouveaux analogues d'insuline et leurs utilisations - Google Patents

Nouveaux analogues d'insuline et leurs utilisations

Info

Publication number
MA58093B1
MA58093B1 MA58093A MA58093A MA58093B1 MA 58093 B1 MA58093 B1 MA 58093B1 MA 58093 A MA58093 A MA 58093A MA 58093 A MA58093 A MA 58093A MA 58093 B1 MA58093 B1 MA 58093B1
Authority
MA
Morocco
Prior art keywords
insulin analogues
new insulin
analogs
diabetes
relates
Prior art date
Application number
MA58093A
Other languages
English (en)
Inventor
Peter Madsen
Thomas Børglum KJELDSEN
Mathias Norrman
Jeppe Sturis
Helle Birk Olsen
Frantisek Hubalek
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of MA58093B1 publication Critical patent/MA58093B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention s'inscrit dans le domaine thérapeutique des médicaments pour traiter des états médicaux associés au diabète. Plus spécifiquement, l'invention concerne des analogues d'insuline de l'insuline humaine. L'invention concerne des compositions pharmaceutiques comprenant de tels analogues d'insuline et les utilisations de tels analogues pour le traitement ou la prévention d'états médicaux associés au diabète.
MA58093A 2019-12-11 2020-12-10 Nouveaux analogues d'insuline et leurs utilisations MA58093B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19215315 2019-12-11
EP20820432.1A EP4073097B1 (fr) 2019-12-11 2020-12-10 Nouveaux analogues d'insuline et leurs utilisations
PCT/EP2020/085541 WO2021116292A1 (fr) 2019-12-11 2020-12-10 Nouveaux analogues de l'insuline et leurs utilisations

Publications (1)

Publication Number Publication Date
MA58093B1 true MA58093B1 (fr) 2024-09-30

Family

ID=68886882

Family Applications (1)

Application Number Title Priority Date Filing Date
MA58093A MA58093B1 (fr) 2019-12-11 2020-12-10 Nouveaux analogues d'insuline et leurs utilisations

Country Status (29)

Country Link
US (3) US11498951B2 (fr)
EP (2) EP4480492A3 (fr)
JP (2) JP6995284B2 (fr)
KR (1) KR102427426B1 (fr)
CN (1) CN114787184A (fr)
AR (1) AR120717A1 (fr)
AU (1) AU2020402135A1 (fr)
BR (1) BR112022009510A2 (fr)
CA (1) CA3159114A1 (fr)
CL (1) CL2023000086A1 (fr)
CO (1) CO2022007273A2 (fr)
DK (1) DK4073097T3 (fr)
ES (1) ES2985989T3 (fr)
FI (1) FI4073097T3 (fr)
HR (1) HRP20241042T1 (fr)
HU (1) HUE067827T2 (fr)
IL (2) IL319162A (fr)
LT (1) LT4073097T (fr)
MA (1) MA58093B1 (fr)
MX (2) MX2022006251A (fr)
MY (1) MY208364A (fr)
PE (1) PE20221260A1 (fr)
PH (1) PH12022551094A1 (fr)
PL (1) PL4073097T3 (fr)
PT (1) PT4073097T (fr)
RS (1) RS65822B1 (fr)
SI (1) SI4073097T1 (fr)
TW (1) TWI773009B (fr)
WO (1) WO2021116292A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR106364A1 (es) 2015-08-25 2018-01-10 Novo Nordisk As Derivados de insulina y sus usos médicos
DK4073097T3 (da) * 2019-12-11 2024-08-19 Novo Nordisk As Nye insulinanaloger og anvendelser heraf
KR20230057686A (ko) 2021-10-22 2023-05-02 주식회사 엘지에너지솔루션 캡 어셈블리 및 이를 포함하는 이차 전지

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DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
CA2070814A1 (fr) 1989-12-21 1991-06-22 Klavs H. Jorgensen Preparations d'insuline renfermant de l'acide nicotinique ou du nicotinamide
SI0792290T1 (en) 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
IL114160A (en) 1994-06-17 2006-12-31 Novo Nordisk As Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5922678A (en) 1996-06-28 1999-07-13 Eli Lilly And Company Methods for treating diabetes
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JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
JP2008533100A (ja) 2005-03-18 2008-08-21 ノボ ノルディスク アクティーゼルスカブ Ｐｅｇ化された単鎖インスリン
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JP5762001B2 (ja) * 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
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US9242011B2 (en) 2008-04-01 2016-01-26 Novo Nordisk A/S Insulin albumin conjugates
EP2448962B1 (fr) 2009-06-30 2016-10-19 Novo Nordisk A/S Dérivés d'insuline
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AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
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US20190010206A1 (en) * 2015-08-25 2019-01-10 Novo Nordisk A/S Novel Insulin Derivatives and the Medical Uses Hereof
CN105440125B (zh) 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
WO2019125879A2 (fr) 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Systèmes à base de conjugués pour l'administration contrôlée d'insuline
DK4073097T3 (da) * 2019-12-11 2024-08-19 Novo Nordisk As Nye insulinanaloger og anvendelser heraf

Also Published As

Publication number Publication date
US11498951B2 (en) 2022-11-15
US20230192801A1 (en) 2023-06-22
IL292762B1 (en) 2025-06-01
TW202136289A (zh) 2021-10-01
IL292762B2 (en) 2025-10-01
PL4073097T3 (pl) 2024-10-28
TWI773009B (zh) 2022-08-01
EP4073097B1 (fr) 2024-07-03
CO2022007273A2 (es) 2022-08-19
US20240141011A1 (en) 2024-05-02
MY208364A (en) 2025-05-01
EP4073097A1 (fr) 2022-10-19
ES2985989T3 (es) 2024-11-08
PH12022551094A1 (en) 2024-06-24
CA3159114A1 (fr) 2021-06-17
RS65822B1 (sr) 2024-09-30
IL292762A (en) 2022-07-01
US12122818B2 (en) 2024-10-22
PE20221260A1 (es) 2022-08-16
EP4480492A3 (fr) 2025-03-19
CL2023000086A1 (es) 2023-08-04
IL319162A (en) 2025-04-01
MX2023000398A (es) 2023-02-02
JP2021091685A (ja) 2021-06-17
SI4073097T1 (sl) 2024-09-30
US12152063B2 (en) 2024-11-26
AU2020402135A1 (en) 2022-06-02
BR112022009510A2 (pt) 2022-08-16
PT4073097T (pt) 2024-08-16
DK4073097T3 (da) 2024-08-19
LT4073097T (lt) 2024-09-10
HUE067827T2 (hu) 2024-11-28
KR102427426B1 (ko) 2022-08-01
KR20210141748A (ko) 2021-11-23
EP4480492A2 (fr) 2024-12-25
JP6995284B2 (ja) 2022-01-14
US20210179685A1 (en) 2021-06-17
JP2021119193A (ja) 2021-08-12
FI4073097T3 (fi) 2024-08-13
HRP20241042T1 (hr) 2024-11-08
CN114787184A (zh) 2022-07-22
MX2022006251A (es) 2022-06-22
AR120717A1 (es) 2022-03-09
WO2021116292A1 (fr) 2021-06-17

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