MX2014009084A - Derivados de pirimidooxazocina como inhibidores de mtor. - Google Patents
Derivados de pirimidooxazocina como inhibidores de mtor.Info
- Publication number
- MX2014009084A MX2014009084A MX2014009084A MX2014009084A MX2014009084A MX 2014009084 A MX2014009084 A MX 2014009084A MX 2014009084 A MX2014009084 A MX 2014009084A MX 2014009084 A MX2014009084 A MX 2014009084A MX 2014009084 A MX2014009084 A MX 2014009084A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- pyrimidooxazocine
- mtor
- inhibitors
- preparing
- Prior art date
Links
- ZHKMLTCNJQHQMU-UHFFFAOYSA-N 2H-pyrimido[4,5-g]oxazocine Chemical class O1NC=CC=CC2=C1C=NC=N2 ZHKMLTCNJQHQMU-UHFFFAOYSA-N 0.000 title 1
- 229940124302 mTOR inhibitor Drugs 0.000 title 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a derivados heterocíclicos bicíclicos de fórmula general (I), a un proceso para prepararlos y al uso terapéutico de los mismos. Formula.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1250768A FR2986232B1 (fr) | 2012-01-26 | 2012-01-26 | Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique |
| PCT/IB2013/050656 WO2013111106A1 (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocine derivatives as mtor - inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014009084A true MX2014009084A (es) | 2015-02-05 |
| MX348841B MX348841B (es) | 2017-06-30 |
Family
ID=47997597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014009084A MX348841B (es) | 2012-01-26 | 2013-01-25 | Derivados de pirimidooxazocina como inhibidores de mtor. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9120812B2 (es) |
| EP (1) | EP2807172B1 (es) |
| JP (1) | JP6068508B2 (es) |
| KR (1) | KR20140125389A (es) |
| CN (1) | CN104203958B (es) |
| AR (1) | AR089782A1 (es) |
| AU (1) | AU2013213261B2 (es) |
| BR (1) | BR112014018226A8 (es) |
| CA (1) | CA2862747A1 (es) |
| CY (1) | CY1118852T1 (es) |
| DK (1) | DK2807172T3 (es) |
| ES (1) | ES2617880T3 (es) |
| FR (1) | FR2986232B1 (es) |
| HR (1) | HRP20170288T1 (es) |
| HU (1) | HUE031917T2 (es) |
| IL (1) | IL233774A (es) |
| LT (1) | LT2807172T (es) |
| MX (1) | MX348841B (es) |
| PL (1) | PL2807172T3 (es) |
| PT (1) | PT2807172T (es) |
| RU (1) | RU2627269C2 (es) |
| SG (1) | SG11201404325VA (es) |
| SI (1) | SI2807172T1 (es) |
| TW (1) | TWI572608B (es) |
| UY (1) | UY34594A (es) |
| WO (1) | WO2013111106A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015055071A1 (zh) | 2013-10-16 | 2015-04-23 | 上海璎黎药业有限公司 | 稠合杂环化合物、其制备方法、药物组合物和用途 |
| WO2016050201A1 (zh) * | 2014-09-29 | 2016-04-07 | 山东轩竹医药科技有限公司 | 高选择性取代嘧啶类pi3k抑制剂 |
| US10307707B2 (en) * | 2017-05-17 | 2019-06-04 | Thomas P. Daly | 1-amino-2-methyl-2-propanol derivatives |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995153B2 (en) * | 2002-01-18 | 2006-02-07 | Kyorin Pharmaceutical. Co., Ltd. | Fused bicyclic pyrimidine derivatives |
| RU2342388C2 (ru) * | 2002-11-22 | 2008-12-27 | Джапан Тобакко Инк. | Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием |
| WO2010056320A2 (en) * | 2008-11-11 | 2010-05-20 | Tyrogenex, Inc. | Pi3k/mtor kinase inhibitors |
| CA2763008A1 (en) * | 2009-05-26 | 2010-12-02 | Exelixis, Inc. | Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
| US8912178B2 (en) * | 2010-05-19 | 2014-12-16 | Xcovery Holdings Company, LLC | mTOR selective kinase inhibitors |
-
2012
- 2012-01-26 FR FR1250768A patent/FR2986232B1/fr not_active Expired - Fee Related
-
2013
- 2013-01-23 AR ARP130100196A patent/AR089782A1/es unknown
- 2013-01-25 SI SI201330547A patent/SI2807172T1/sl unknown
- 2013-01-25 PL PL13712331T patent/PL2807172T3/pl unknown
- 2013-01-25 WO PCT/IB2013/050656 patent/WO2013111106A1/en not_active Ceased
- 2013-01-25 MX MX2014009084A patent/MX348841B/es active IP Right Grant
- 2013-01-25 CN CN201380016539.XA patent/CN104203958B/zh active Active
- 2013-01-25 BR BR112014018226A patent/BR112014018226A8/pt not_active Application Discontinuation
- 2013-01-25 JP JP2014553846A patent/JP6068508B2/ja active Active
- 2013-01-25 HR HRP20170288TT patent/HRP20170288T1/hr unknown
- 2013-01-25 TW TW102102986A patent/TWI572608B/zh not_active IP Right Cessation
- 2013-01-25 CA CA2862747A patent/CA2862747A1/en not_active Abandoned
- 2013-01-25 SG SG11201404325VA patent/SG11201404325VA/en unknown
- 2013-01-25 PT PT137123311T patent/PT2807172T/pt unknown
- 2013-01-25 US US14/374,838 patent/US9120812B2/en active Active
- 2013-01-25 ES ES13712331.1T patent/ES2617880T3/es active Active
- 2013-01-25 KR KR1020147023238A patent/KR20140125389A/ko not_active Abandoned
- 2013-01-25 DK DK13712331.1T patent/DK2807172T3/en active
- 2013-01-25 LT LTEP13712331.1T patent/LT2807172T/lt unknown
- 2013-01-25 AU AU2013213261A patent/AU2013213261B2/en not_active Ceased
- 2013-01-25 UY UY0001034594A patent/UY34594A/es not_active Application Discontinuation
- 2013-01-25 EP EP13712331.1A patent/EP2807172B1/en active Active
- 2013-01-25 HU HUE13712331A patent/HUE031917T2/en unknown
- 2013-01-25 RU RU2014134640A patent/RU2627269C2/ru not_active IP Right Cessation
-
2014
- 2014-07-23 IL IL233774A patent/IL233774A/en active IP Right Grant
-
2017
- 2017-02-28 CY CY20171100270T patent/CY1118852T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |