IN2015DN01331A - - Google Patents
Info
- Publication number
- IN2015DN01331A IN2015DN01331A IN1331DEN2015A IN2015DN01331A IN 2015DN01331 A IN2015DN01331 A IN 2015DN01331A IN 1331DEN2015 A IN1331DEN2015 A IN 1331DEN2015A IN 2015DN01331 A IN2015DN01331 A IN 2015DN01331A
- Authority
- IN
- India
- Prior art keywords
- trifluoromethylpyridin
- morpholinyl
- pyrimidinyl
- intermediates
- amine
- Prior art date
Links
- CWHUFRVAEUJCEF-UHFFFAOYSA-N BKM120 Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=CC(N2CCOCC2)=NC(N2CCOCC2)=N1 CWHUFRVAEUJCEF-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717237P | 2012-10-23 | 2012-10-23 | |
| US201361842101P | 2013-07-02 | 2013-07-02 | |
| PCT/EP2013/071996 WO2014064058A1 (fr) | 2012-10-23 | 2013-10-21 | Procédé amélioré pour la fabrication de 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluorométhylpyridin-2-amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01331A true IN2015DN01331A (fr) | 2015-07-03 |
Family
ID=49448162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1331DEN2015 IN2015DN01331A (fr) | 2012-10-23 | 2013-10-21 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9637468B2 (fr) |
| EP (1) | EP2912030B1 (fr) |
| JP (1) | JP6267213B2 (fr) |
| KR (1) | KR102128127B1 (fr) |
| CN (1) | CN104736532B (fr) |
| AU (2) | AU2013336807B2 (fr) |
| BR (1) | BR112015007243B1 (fr) |
| CA (1) | CA2885471C (fr) |
| ES (1) | ES2605638T3 (fr) |
| IN (1) | IN2015DN01331A (fr) |
| MX (1) | MX360703B (fr) |
| PL (1) | PL2912030T3 (fr) |
| PT (1) | PT2912030T (fr) |
| RU (1) | RU2646760C2 (fr) |
| WO (1) | WO2014064058A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12014500682A1 (en) | 2011-09-27 | 2014-05-12 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| CN105050602B (zh) * | 2013-01-12 | 2018-05-25 | 张大为 | 作为pi3激酶抑制剂的吡啶化合物 |
| GEP201706699B (en) | 2013-03-14 | 2017-07-10 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| RU2688665C2 (ru) | 2014-04-22 | 2019-05-22 | Университет Базель | Новый способ получения производных триазина, пиримидина и пиридина |
| WO2016050201A1 (fr) * | 2014-09-29 | 2016-04-07 | 山东轩竹医药科技有限公司 | Pyrimidine substituée en tant qu'inhibiteur de pi3k à sélectivité élevée |
| CN105085476B (zh) * | 2014-11-24 | 2018-03-09 | 苏州晶云药物科技有限公司 | 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺二盐酸盐的晶型及其制备方法 |
| CN105001151B (zh) * | 2015-08-28 | 2017-07-14 | 苏州明锐医药科技有限公司 | 布帕尼西中间体及其制备方法 |
| CN106543140A (zh) * | 2015-09-21 | 2017-03-29 | 苏州晶云药物科技有限公司 | 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺盐酸盐的晶型及其制备方法 |
| CN107793394A (zh) * | 2017-08-03 | 2018-03-13 | 上海厚璞生物科技有限公司 | 一种生产选择性pi3k抑制剂的系列关键中间体 |
| CN118834204A (zh) | 2018-12-18 | 2024-10-25 | 阿斯利康(瑞典)有限公司 | 制药方法和中间体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002062805A1 (fr) * | 2001-02-08 | 2002-08-15 | Toyama Chemical Co., Ltd. | Derive d'acide 6-substitue alkylamino-3-pyridylborique ou d'un sel de celui-ci et leurs procedes de fabrication |
| AU2003295776B2 (en) * | 2002-11-21 | 2011-05-12 | Novartis Vaccines And Diagnostics, Inc. | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| KR20130119928A (ko) * | 2010-10-01 | 2013-11-01 | 노파르티스 아게 | 피리미딘 유도체의 제조 방법 |
-
2013
- 2013-10-21 KR KR1020157010087A patent/KR102128127B1/ko active Active
- 2013-10-21 MX MX2015005188A patent/MX360703B/es active IP Right Grant
- 2013-10-21 RU RU2015119259A patent/RU2646760C2/ru active
- 2013-10-21 EP EP13779841.9A patent/EP2912030B1/fr active Active
- 2013-10-21 PL PL13779841T patent/PL2912030T3/pl unknown
- 2013-10-21 WO PCT/EP2013/071996 patent/WO2014064058A1/fr not_active Ceased
- 2013-10-21 CA CA2885471A patent/CA2885471C/fr active Active
- 2013-10-21 PT PT137798419T patent/PT2912030T/pt unknown
- 2013-10-21 JP JP2015538398A patent/JP6267213B2/ja active Active
- 2013-10-21 AU AU2013336807A patent/AU2013336807B2/en active Active
- 2013-10-21 US US14/437,177 patent/US9637468B2/en active Active
- 2013-10-21 IN IN1331DEN2015 patent/IN2015DN01331A/en unknown
- 2013-10-21 CN CN201380055482.4A patent/CN104736532B/zh active Active
- 2013-10-21 ES ES13779841.9T patent/ES2605638T3/es active Active
- 2013-10-21 BR BR112015007243-7A patent/BR112015007243B1/pt active IP Right Grant
-
2016
- 2016-10-07 AU AU2016238941A patent/AU2016238941A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2605638T3 (es) | 2017-03-15 |
| US9637468B2 (en) | 2017-05-02 |
| KR102128127B1 (ko) | 2020-06-30 |
| US20150246897A1 (en) | 2015-09-03 |
| MX2015005188A (es) | 2015-09-07 |
| RU2646760C2 (ru) | 2018-03-07 |
| KR20150072408A (ko) | 2015-06-29 |
| AU2016238941A1 (en) | 2016-11-03 |
| AU2013336807B2 (en) | 2016-10-27 |
| CN104736532A (zh) | 2015-06-24 |
| JP2016502510A (ja) | 2016-01-28 |
| EP2912030B1 (fr) | 2016-08-31 |
| PT2912030T (pt) | 2016-11-30 |
| JP6267213B2 (ja) | 2018-01-24 |
| MX360703B (es) | 2018-11-14 |
| PL2912030T3 (pl) | 2017-02-28 |
| CN104736532B (zh) | 2017-04-05 |
| BR112015007243A2 (pt) | 2017-07-04 |
| CA2885471A1 (fr) | 2014-05-01 |
| CA2885471C (fr) | 2021-02-23 |
| WO2014064058A1 (fr) | 2014-05-01 |
| AU2013336807A1 (en) | 2015-03-05 |
| RU2015119259A (ru) | 2016-12-20 |
| BR112015007243B1 (pt) | 2022-02-08 |
| EP2912030A1 (fr) | 2015-09-02 |
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