IN2015DN03936A - - Google Patents

Info

Publication number: IN2015DN03936A
Authority: IN; India
Prior art keywords: plgas; pharmaceutically; acceptable salt; active ingredient; sustained release
Prior art date: 2005-12-22

Application number

Other languages

English (en)

Inventor

Holger Petersen

Markus Ahlheim

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-22

Filing date

2006-12-20

Publication date

2015-10-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37772904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2015DN03936(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-12-22 Priority claimed from GB0526247A external-priority patent/GB0526247D0/en

2006-12-20 Application filed by Novartis Ag filed Critical Novartis Ag

2015-10-02 Publication of IN2015DN03936A publication Critical patent/IN2015DN03936A/en

Links

DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 abstract 1
108010016076 Octreotide Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229960002700 octreotide Drugs 0.000 abstract 1
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Zoology (AREA)
Diabetes (AREA)
Inorganic Chemistry (AREA)
Dispersion Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Polyesters Or Polycarbonates (AREA)

IN3936DEN2015 2005-12-22 2006-12-20 IN2015DN03936A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0526247A GB0526247D0 (en)	2005-12-22	2005-12-22	Organic compounds
EP06119086		2006-08-17
PCT/EP2006/012313 WO2007071395A1 (en)	2005-12-22	2006-12-20	Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers

Publications (1)

Publication Number	Publication Date
IN2015DN03936A true IN2015DN03936A (da)	2015-10-02

Family

ID=37772904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN3936DEN2015 IN2015DN03936A (da)	2005-12-22	2006-12-20

Country Status (22)

Country	Link
US (7)	US20090004283A1 (da)
EP (3)	EP1968549B1 (da)
JP (4)	JP2009520727A (da)
KR (5)	KR101245919B1 (da)
CN (1)	CN103251929A (da)
AR (1)	AR058591A1 (da)
AU (1)	AU2006328950B2 (da)
BR (2)	BR122019027412B8 (da)
CA (1)	CA2631811C (da)
CL (1)	CL2018003398A1 (da)
EC (1)	ECSP088560A (da)
ES (2)	ES2755032T3 (da)
IL (1)	IL191842A0 (da)
IN (1)	IN2015DN03936A (da)
MA (1)	MA30064B1 (da)
NO (1)	NO20082988L (da)
PE (1)	PE20071139A1 (da)
PL (2)	PL1968549T3 (da)
PT (2)	PT1968549E (da)
RU (1)	RU2464972C2 (da)
TW (2)	TWI469788B (da)
WO (1)	WO2007071395A1 (da)

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AU2013201877B2 (en) *	2008-01-30	2015-01-29	Novartis Ag	Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
JP5791278B2 (ja) *	2008-01-30	2015-10-07	ノバルティスアーゲー	オクトレオチドおよび３種の線状ポリラクチド−コ−グリコリドポリマーを含む徐放性製剤
AU2015201581B2 (en) *	2008-09-17	2017-03-09	Amryt Endo, Inc.	Pharmaceutical Compositions and Related Methods of Delivery
CN102176900B (zh)	2008-09-17	2017-09-26	克艾思马有限公司	药物组合物和相关的给药方法
US20100151033A1 (en) *	2008-12-15	2010-06-17	Novartis Ag	Octreotide depot formulation with constantly high exposure levels
JP2012515791A (ja) *	2009-01-23	2012-07-12	サーモディクスファーマシューティカルズ，インコーポレイテッド	ポリマー混成物由来の放出制御システム
US20120022137A1 (en) *	2010-07-21	2012-01-26	Rivers Hongwen M	METHOD OF CONTROLLING INITIAL DRUG RELEASE OF siRNA FROM SUSTAINED-RELEASE IMPLANTS
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KR102142026B1 (ko) *	2017-05-31	2020-08-06	주식회사 대웅제약	방출제어가 용이한 서방성 약물 미립자의 제조방법
US12233177B2 (en)	2019-09-16	2025-02-25	Amgen Inc.	Method for external sterilization of drug delivery device
CN111214643A (zh) *	2020-03-11	2020-06-02	苏州善湾生物医药科技有限公司	一种基于皮下凝胶缓释的奥曲肽组合物、制备方法及应用
CN115551550A (zh) *	2020-05-08	2022-12-30	M技术株式会社	均匀分散有生理活性物质的微球及含有其的缓释制剂
JP6852943B1 (ja) *	2020-05-08	2021-03-31	エム・テクニック株式会社	主剤が均一に分散されたマイクロスフェアー及びそれを含有する徐放性製剤
KR102947972B1 (ko)	2020-05-08	2026-04-06	엠. 테크닉 가부시키가이샤	생리 활성 물질이 균일하게 분산된 마이크로스피어 및 그것을 함유하는 서방성 제제
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KR102464821B1 (ko) *	2022-04-13	2022-11-09	(주)인벤티지랩	목시덱틴을 포함하는 마이크로 입자 및 이를 포함하는 서방형 주사제 조성물

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MY158342A (en) *	2003-11-14	2016-09-30	Novartis Ag	Pharmaceutical composition
CN101035512B (zh) *	2004-08-12	2012-01-18	昌达生物科技公司	用于生物活性化合物可控制释放递送的药物组合物

2006
- 2006-12-20 CA CA2631811A patent/CA2631811C/en active Active
- 2006-12-20 PT PT68410596T patent/PT1968549E/pt unknown
- 2006-12-20 EP EP06841059.6A patent/EP1968549B1/en active Active
- 2006-12-20 BR BR122019027412A patent/BR122019027412B8/pt active IP Right Grant
- 2006-12-20 IN IN3936DEN2015 patent/IN2015DN03936A/en unknown
- 2006-12-20 WO PCT/EP2006/012313 patent/WO2007071395A1/en not_active Ceased
- 2006-12-20 PL PL06841059T patent/PL1968549T3/pl unknown
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Also Published As

Publication number	Publication date
WO2007071395A1 (en)	2007-06-28
US20200206306A1 (en)	2020-07-02
US20150037420A1 (en)	2015-02-05
KR101458728B1 (ko)	2014-11-05
BRPI0620063B8 (pt)	2021-05-25
IL191842A0 (en)	2008-12-29
ECSP088560A (es)	2008-07-30
JP2015044823A (ja)	2015-03-12
PL1968549T3 (pl)	2014-10-31
AR058591A1 (es)	2008-02-13
TWI468172B (zh)	2015-01-11
JP2009520727A (ja)	2009-05-28
CN103251929A (zh)	2013-08-21
EP1968549B1 (en)	2014-05-14
KR20130024988A (ko)	2013-03-08
NO20082988L (no)	2008-08-29
TW201424747A (zh)	2014-07-01
PE20071139A1 (es)	2007-11-16
US20090004283A1 (en)	2009-01-01
CL2018003398A1 (es)	2019-04-26
US20160120935A1 (en)	2016-05-05
KR101245919B1 (ko)	2013-03-20
EP1968549A1 (en)	2008-09-17
JP6239851B2 (ja)	2017-11-29
BRPI0620063A8 (pt)	2018-05-02
CA2631811A1 (en)	2007-06-28
JP2013177406A (ja)	2013-09-09
KR20080078000A (ko)	2008-08-26
PT2359809T (pt)	2019-11-04
US20250082718A1 (en)	2025-03-13
EP2359809A1 (en)	2011-08-24
AU2006328950B2 (en)	2010-07-29
MA30064B1 (fr)	2008-12-01
BR122019027412B8 (pt)	2021-07-27
ES2492641T3 (es)	2014-09-10
CA2631811C (en)	2017-06-20
PT1968549E (pt)	2014-08-29
BRPI0620063B1 (pt)	2020-09-08
EP3603623A1 (en)	2020-02-05
KR20140133968A (ko)	2014-11-20
RU2464972C2 (ru)	2012-10-27
KR20130024986A (ko)	2013-03-08
AU2006328950A1 (en)	2007-06-28
PL2359809T3 (pl)	2020-01-31
JP6178772B2 (ja)	2017-08-09
US20220296675A1 (en)	2022-09-22
RU2008129626A (ru)	2010-01-27
BRPI0620063A2 (pt)	2011-11-01
TWI469788B (zh)	2015-01-21
EP2359809B1 (en)	2019-08-14
TW200803921A (en)	2008-01-16
KR20130024987A (ko)	2013-03-08
JP2016216467A (ja)	2016-12-22
BR122019027412B1 (pt)	2020-12-01
US20180140662A1 (en)	2018-05-24
ES2755032T3 (es)	2020-04-21

Publication	Publication Date	Title
IN2015DN03936A (da)	2015-10-02
TN2011000261A1 (en)	2012-12-17	Octreotide depot formulation with constantly high exposure levels
PH12012501811A1 (en)	2013-09-30	A solid pharmaceutical dosage formulation
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