IS2127B - Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar - Google Patents

Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar

Info

Publication number
IS2127B
IS2127B IS4790A IS4790A IS2127B IS 2127 B IS2127 B IS 2127B IS 4790 A IS4790 A IS 4790A IS 4790 A IS4790 A IS 4790A IS 2127 B IS2127 B IS 2127B
Authority
IS
Iceland
Prior art keywords
magnetic resonance
resonance imaging
containing perfluoroalkyl
metallic constituents
constituents containing
Prior art date
Application number
IS4790A
Other languages
English (en)
Other versions
IS4790A (is
Inventor
Platzek Johannes
Schlecker Wolfgang
Niedballa Ulrich
Raduechel Bernd
Weinmann Hanns-Joachim
Frenzel Thomas
Misselwitz Bernd
Ebert Wolfgang
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IS4790A publication Critical patent/IS4790A/is
Publication of IS2127B publication Critical patent/IS2127B/is

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/14—Linings or internal coatings
    • B65D25/16—Loose, or loosely-attached, linings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/08—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures
    • B65D47/0804—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures integrally formed with the base element provided with the spout or discharge passage
    • B65D47/0833—Hinges without elastic bias
    • B65D47/0847—Hinges without elastic bias located within a flat surface of the base element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/771—Containers or packages with special means for dispensing contents for dispensing fluent contents by means of a flexible bag or a deformable membrane or diaphragm
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IS4790A 1996-01-19 1998-06-30 Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar IS2127B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19603033A DE19603033A1 (de) 1996-01-19 1996-01-19 Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
PCT/EP1997/000209 WO1997026017A2 (de) 1996-01-19 1997-01-16 Perfluoralkylhaltige metallkomplexe und ihre verwendung in der nmr-diagnostik

Publications (2)

Publication Number Publication Date
IS4790A IS4790A (is) 1998-06-30
IS2127B true IS2127B (is) 2006-07-14

Family

ID=7783921

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4790A IS2127B (is) 1996-01-19 1998-06-30 Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar

Country Status (27)

Country Link
US (3) US6468502B1 (is)
EP (1) EP0874645B1 (is)
JP (1) JP2000506511A (is)
KR (1) KR100539041B1 (is)
CN (1) CN1203898C (is)
AT (1) ATE215386T1 (is)
AU (1) AU716788B2 (is)
BG (1) BG62914B1 (is)
BR (1) BR9707053B1 (is)
CZ (1) CZ298769B6 (is)
DE (2) DE19603033A1 (is)
DK (1) DK0874645T3 (is)
EE (1) EE04298B1 (is)
ES (1) ES2174215T3 (is)
HU (1) HU226199B1 (is)
IL (1) IL125311A (is)
IS (1) IS2127B (is)
NO (1) NO319680B1 (is)
NZ (1) NZ330579A (is)
PL (1) PL187466B1 (is)
PT (1) PT874645E (is)
RU (1) RU2242477C2 (is)
SK (1) SK283576B6 (is)
TW (1) TW542841B (is)
UA (1) UA65533C2 (is)
WO (1) WO1997026017A2 (is)
ZA (1) ZA97419B (is)

Families Citing this family (44)

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DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
UA59384C2 (uk) * 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6495118B1 (en) * 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
DE19948650A1 (de) * 1999-09-29 2001-07-19 Diagnostikforschung Inst Galenische Formulierungen
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE10066210B4 (de) * 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
US6641797B2 (en) 2000-08-11 2003-11-04 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
DE10040380B4 (de) * 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
US6818203B2 (en) * 2000-08-11 2004-11-16 Schering Aktiengesellschaft Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
HUP0401194A2 (hu) * 2001-08-03 2004-11-29 Glaxo Group Limited Új felületaktív anyagok, ezeket tartalmazó aeroszol készítmények és alkalmazásuk
NO20015814D0 (no) * 2001-11-28 2001-11-28 Amersham Health As Metallkompleksforbindelser
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
AU2003249999A1 (en) * 2002-07-10 2004-02-02 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecanes as modulators of the guanine-binding protein for treating tumours
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
EA011516B1 (ru) 2005-01-13 2009-04-28 Синвеншен Аг Композиционный материал и способ его изготовления
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102005033903B4 (de) * 2005-07-15 2007-08-09 Bayer Schering Pharma Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102005033902B3 (de) * 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
RU2308290C1 (ru) * 2006-03-10 2007-10-20 Общество с ограниченной ответственностью "ЛЧЗ" Магнитно-резонансная и рентгеновская контрастная композиция
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
WO2007141767A2 (en) * 2006-06-09 2007-12-13 Koninklijke Philips Electronics N.V. Elimination of contrast agent concentration dependency in mri
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
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RU2391347C1 (ru) * 2008-10-23 2010-06-10 Государственное образовательное учреждение высшего профессионального образования "Казанский государственный университет им. В.И. Ульянова-Ленина" Высокорелаксивные комплексы гадолиния
WO2010056590A2 (en) * 2008-11-14 2010-05-20 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
CN107001918A (zh) * 2014-12-08 2017-08-01 3M创新有限公司 氢氟烯烃及其使用方法
HUP1500076A2 (hu) * 2015-02-25 2016-09-28 Debreceni Egyetem Új helyettesített etilén-diamin-tetraecetsav-bisz(amid) származékok és alkalmazásuk Mn(II)-alapú MRI kontrasztanyag ligandumként
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10835623B2 (en) 2015-08-13 2020-11-17 The General Hospital Corporation Manganese-based chelate conjugates for molecular MR imaging
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
EP3883613A1 (en) 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
US20230251217A1 (en) * 2019-10-17 2023-08-10 Riken Detection method and detection system for mastitis in domestic animal
WO2021106468A1 (ja) * 2019-11-26 2021-06-03 東ソー・ファインケム株式会社 含フッ素アニオン性界面活性剤
CN110922365B (zh) * 2019-12-13 2021-04-27 山东铂源药业有限公司 一种高纯度轮环藤宁的制备方法

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Also Published As

Publication number Publication date
CZ298769B6 (cs) 2008-01-23
DE19603033A1 (de) 1997-07-24
BG62914B1 (bg) 2000-11-30
NO983287L (no) 1998-09-21
BG102632A (bg) 1999-06-30
UA65533C2 (en) 2004-04-15
IL125311A (en) 2002-11-10
DK0874645T3 (da) 2002-07-01
US20030232012A1 (en) 2003-12-18
IS4790A (is) 1998-06-30
EP0874645B1 (de) 2002-04-03
NO319680B1 (no) 2005-09-05
KR19990077374A (ko) 1999-10-25
HUP9901295A3 (en) 2004-05-28
IL125311A0 (en) 1999-03-12
BR9707053B1 (pt) 2008-11-18
JP2000506511A (ja) 2000-05-30
US20050147563A1 (en) 2005-07-07
EE04298B1 (et) 2004-06-15
WO1997026017A3 (de) 1997-11-20
ATE215386T1 (de) 2002-04-15
PL187466B1 (pl) 2004-07-30
CZ226398A3 (cs) 1998-11-11
DE59706863D1 (de) 2002-05-08
BR9707053A (pt) 1999-07-20
SK283576B6 (sk) 2003-09-11
NZ330579A (en) 2000-01-28
ZA97419B (en) 1997-07-30
US6916461B2 (en) 2005-07-12
WO1997026017A2 (de) 1997-07-24
AU1597797A (en) 1997-08-11
HUP9901295A2 (hu) 1999-07-28
ES2174215T3 (es) 2002-11-01
PT874645E (pt) 2002-09-30
AU716788B2 (en) 2000-03-09
EP0874645A2 (de) 1998-11-04
HU226199B1 (en) 2008-06-30
NO983287D0 (no) 1998-07-16
PL327931A1 (en) 1999-01-04
EE9800204A (et) 1998-12-15
US6468502B1 (en) 2002-10-22
CN1209754A (zh) 1999-03-03
SK99098A3 (en) 1998-12-02
KR100539041B1 (ko) 2006-04-12
US7226578B2 (en) 2007-06-05
CN1203898C (zh) 2005-06-01
HK1018404A1 (en) 1999-12-24
RU2242477C2 (ru) 2004-12-20
TW542841B (en) 2003-07-21

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