IS2232B - Díarýl- og arýlheteróarýlþvagefnisafleiður sem stillar 5-HT2A serótónínviðtakans sem eru gagnlegar til að fyrirbyggja og meðhöndla sjúkdóma sem tengjast honum - Google Patents

Díarýl- og arýlheteróarýlþvagefnisafleiður sem stillar 5-HT2A serótónínviðtakans sem eru gagnlegar til að fyrirbyggja og meðhöndla sjúkdóma sem tengjast honum

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Publication number
IS2232B
IS2232B IS8241A IS8241A IS2232B IS 2232 B IS2232 B IS 2232B IS 8241 A IS8241 A IS 8241A IS 8241 A IS8241 A IS 8241A IS 2232 B IS2232 B IS 2232B
Authority
IS
Iceland
Prior art keywords
diaryl
prevention
adjust
treatment
diseases associated
Prior art date
Application number
IS8241A
Other languages
English (en)
Other versions
IS8241A (is
Inventor
Teegarden Bradley
Jayakumar Honnappa
Li Hongmei
Strah-Pleynet Sonja
I Dosa Peter
Original Assignee
Arena Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharmaceuticals, Inc. filed Critical Arena Pharmaceuticals, Inc.
Publication of IS8241A publication Critical patent/IS8241A/is
Publication of IS2232B publication Critical patent/IS2232B/is

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Addiction (AREA)
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IS8241A 2003-07-22 2006-01-19 Díarýl- og arýlheteróarýlþvagefnisafleiður sem stillar 5-HT2A serótónínviðtakans sem eru gagnlegar til að fyrirbyggja og meðhöndla sjúkdóma sem tengjast honum IS2232B (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48957203P 2003-07-22 2003-07-22
US50358603P 2003-09-16 2003-09-16
PCT/US2004/023488 WO2005012254A1 (en) 2003-07-22 2004-07-21 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto

Publications (2)

Publication Number Publication Date
IS8241A IS8241A (is) 2006-01-19
IS2232B true IS2232B (is) 2007-04-15

Family

ID=34118806

Family Applications (1)

Application Number Title Priority Date Filing Date
IS8241A IS2232B (is) 2003-07-22 2006-01-19 Díarýl- og arýlheteróarýlþvagefnisafleiður sem stillar 5-HT2A serótónínviðtakans sem eru gagnlegar til að fyrirbyggja og meðhöndla sjúkdóma sem tengjast honum

Country Status (29)

Country Link
US (9) US8754238B2 (is)
EP (1) EP1558582B1 (is)
JP (3) JP4198733B2 (is)
KR (1) KR101157272B1 (is)
CN (3) CN1826322B (is)
AR (1) AR045069A1 (is)
AT (1) ATE313532T1 (is)
AU (1) AU2004261582C1 (is)
BR (1) BRPI0412263B1 (is)
CA (1) CA2533369C (is)
DE (1) DE602004000260T2 (is)
DK (1) DK1558582T3 (is)
EA (1) EA009732B1 (is)
EC (1) ECSP066269A (is)
ES (1) ES2258760T3 (is)
HR (1) HRP20060100T3 (is)
IL (1) IL172582A0 (is)
IS (1) IS2232B (is)
MA (1) MA28066A1 (is)
MX (1) MXPA06000795A (is)
MY (1) MY141862A (is)
NO (1) NO20060877L (is)
NZ (1) NZ544331A (is)
PL (1) PL1558582T3 (is)
PT (1) PT1558582E (is)
RS (1) RS20060035A (is)
TN (1) TNSN06017A1 (is)
TW (1) TW200523253A (is)
WO (1) WO2005012254A1 (is)

Families Citing this family (52)

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PL1558582T3 (pl) 2003-07-22 2006-05-31 Arena Pharm Inc Diarylowe i aryloheteroarylowe pochodne mocznika jako modulatory receptora serotoninowego 5-HT2A użyteczne w profilaktyce i w leczeniu zaburzeń związanych z tym receptorem
CN1926114B (zh) * 2004-03-23 2011-08-24 艾尼纳制药公司 用于制备经取代n-芳基-n′-′3-(1h-吡唑-5-基)苯基脲及其中间体的方法
PE20061130A1 (es) * 2004-11-19 2007-01-05 Arena Pharm Inc Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a
WO2006060762A2 (en) * 2004-12-03 2006-06-08 Arena Pharmaceuticals, Inc. Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
WO2006078610A1 (en) * 2005-01-19 2006-07-27 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis or treatment of progressive multifocal leukoencephalopathy
AR052886A1 (es) * 2005-01-26 2007-04-11 Arena Pharm Inc Procedimientos para preparar fenilpirazol ureas sustituidas y para la obtencion de sus intermediarios de sintesis
WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
JP4559262B2 (ja) * 2005-03-07 2010-10-06 学校法人関西医科大学 動脈硬化および糖尿病性腎障害の判定方法
CA2621152A1 (en) * 2005-09-29 2007-04-12 Arena Pharmaceuticals, Inc. Pharmaceutical compositions of a 5-ht2a serotonin receptor modulator useful for the treatment of disorders related thereto
KR101514846B1 (ko) * 2006-05-18 2015-04-23 아레나 파마슈티칼스, 인크. ５-ｈｔ２ａ 세로토닌 수용체의 조절인자로서 유용한 페닐-피라졸의 결정질 형태 및 그의 제조 방법
WO2007136875A2 (en) * 2006-05-18 2007-11-29 Arena Pharmaceuticals, Inc. Acetamide derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
AU2007254244C1 (en) 2006-05-18 2014-07-31 Arena Pharmaceuticals, Inc. 3-pyrazolyl-benzamide-4-ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
EP2018371B1 (en) 2006-05-18 2015-03-04 Arena Pharmaceuticals, Inc. Primary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
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