NO20060877L - Dianyl- og arylheteroarylureaderivater som modulatorer for 5-HT2A-serotoninreseptorer nyttig for profylakse og behandling av forstyrrelser forbundet med denne - Google Patents

Dianyl- og arylheteroarylureaderivater som modulatorer for 5-HT2A-serotoninreseptorer nyttig for profylakse og behandling av forstyrrelser forbundet med denne

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Publication number
NO20060877L
NO20060877L NO20060877A NO20060877A NO20060877L NO 20060877 L NO20060877 L NO 20060877L NO 20060877 A NO20060877 A NO 20060877A NO 20060877 A NO20060877 A NO 20060877A NO 20060877 L NO20060877 L NO 20060877L
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Norway
Prior art keywords
disorders
prophylaxis
psychosis
treatment
schizophrenia
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NO20060877A
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English (en)
Inventor
Bradley Teegarden
Honnappa Jayakumar
Hongmei Li
Sonja Strah-Pleynet
Peter I Dosa
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Arena Pharm Inc
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Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of NO20060877L publication Critical patent/NO20060877L/no

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Urology & Nephrology (AREA)
  • Psychology (AREA)
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  • Pain & Pain Management (AREA)
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  • Endocrinology (AREA)
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Abstract

Foreliggende oppfirmelse angår spesielle pyrazolderivater med formel (I), og farmasøytiske sammensetninger derav som modulerer 5-HT2A- serotonin reseptoraktiviteten. Forbindelser og farmasøytiske sammensetninger derav er rettet mot fremgangsmåter som er nyttige i profylakse eller behandling av blodplateaggregering, hjertekarsykdom, hjerteinfarkt, forbigående iskemisk attakk, angina, slag, atrial fibrillering, reduksjon av risiko for blodproppdannelse, astma eller symptomer derav, agitasjon eller et symptom, atferdsforstyrrelser, medikamentindusert psykose, utagerende psykose. Grilles de la Tourettes syndrom, manisk forstyrrelse, organisk eller NOS-psykose, psykotisk forstyrrelse, psykose, akutt schizofreni, kronisk schizofreni, NOS schizofreni og henhørende forstyrrelser, søvnforstyrrelser, diabetesrelaterte forstyrrelser, og liknende. Foreliggende oppfirmelse angår også fremgangsmåter av profylakse eller behandling av 5-HT2A serotonin formidlete forstyrrelser i kombinasjon med en dopamin-D2-reseptorantagonist, slik som et haloperidol, tilført separat eller samtidig.
NO20060877A 2003-07-22 2006-02-22 Dianyl- og arylheteroarylureaderivater som modulatorer for 5-HT2A-serotoninreseptorer nyttig for profylakse og behandling av forstyrrelser forbundet med denne NO20060877L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48957203P 2003-07-22 2003-07-22
US50358603P 2003-09-16 2003-09-16
PCT/US2004/023488 WO2005012254A1 (en) 2003-07-22 2004-07-21 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto

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NO20060877L true NO20060877L (no) 2006-02-22

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US (9) US8754238B2 (no)
EP (1) EP1558582B1 (no)
JP (3) JP4198733B2 (no)
KR (1) KR101157272B1 (no)
CN (3) CN101871931A (no)
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DE (1) DE602004000260T2 (no)
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HR (1) HRP20060100T3 (no)
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MA (1) MA28066A1 (no)
MX (1) MXPA06000795A (no)
MY (1) MY141862A (no)
NO (1) NO20060877L (no)
NZ (1) NZ544331A (no)
PL (1) PL1558582T3 (no)
PT (1) PT1558582E (no)
RS (1) RS20060035A (no)
TN (1) TNSN06017A1 (no)
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PT1558582E (pt) 2003-07-22 2006-05-31 Arena Pharm Inc Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
CA2559038C (en) 2004-03-23 2013-09-10 Arena Pharmaceuticals, Inc. Processes for preparing substituted n-aryl-n'-[3-(1h-pyrazol-5-yl) phenyl] ureas and intermediates thereof
SA05260357B1 (ar) * 2004-11-19 2008-09-08 ارينا فارماسيتو تيكالز ، أنك مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به
WO2006060762A2 (en) * 2004-12-03 2006-06-08 Arena Pharmaceuticals, Inc. Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
EP1843762A1 (en) * 2005-01-19 2007-10-17 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis or treatment of progressive multifocal leukoencephalopathy
AR052886A1 (es) * 2005-01-26 2007-04-11 Arena Pharm Inc Procedimientos para preparar fenilpirazol ureas sustituidas y para la obtencion de sus intermediarios de sintesis
WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
JP4559262B2 (ja) * 2005-03-07 2010-10-06 学校法人関西医科大学 動脈硬化および糖尿病性腎障害の判定方法
CN101272771A (zh) * 2005-09-29 2008-09-24 艾尼纳制药公司 可用于治疗相关病症的5－ht2a血清素受体调节剂的医药组合物
EP2051978A2 (en) * 2006-05-18 2009-04-29 Arena Pharmaceuticals, Inc. Acetamide derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
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