IS3509A7 - Aðferð við framleiðslu á forlyfi gegn bólgum, þ.e. 3-acyl-2-oxindole-1-carboxamides - Google Patents

Aðferð við framleiðslu á forlyfi gegn bólgum, þ.e. 3-acyl-2-oxindole-1-carboxamides

Info

Publication number: IS3509A7
Authority: IS; Iceland
Prior art keywords: oxindole; viz; carboxamide; acyl; inflammatory
Prior art date: 1988-10-18

Application number

IS3509A

Other languages

English (en)

Other versions

IS1598B (is

Inventor

Charles Crawford Thomas

Alan Reiter Lawrence

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-18

Filing date

1989-09-20

Publication date

1990-04-19

1989-09-20 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1990-04-19 Publication of IS3509A7 publication Critical patent/IS3509A7/is

1996-05-20 Publication of IS1598B publication Critical patent/IS1598B/is

Links

230000003110 anti-inflammatory effect Effects 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IS3509A 1988-10-18 1989-09-20 Aðferð við framleiðslu á forlyfi gegn bólgum, þ.e. 3-acyl-2-oxindole-1-carboxamides IS1598B (is)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1988/003658 WO1990004393A1 (en)	1988-10-18	1988-10-18	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (2)

Publication Number	Publication Date
IS3509A7 true IS3509A7 (is)	1990-04-19
IS1598B IS1598B (is)	1996-05-20

Family

ID=22208957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS3509A IS1598B (is)	1988-10-18	1989-09-20	Aðferð við framleiðslu á forlyfi gegn bólgum, þ.e. 3-acyl-2-oxindole-1-carboxamides

Country Status (33)

Country	Link
US (1)	US5118703A (is)
JP (1)	JPH07597B2 (is)
KR (1)	KR910007237B1 (is)
CN (1)	CN1022241C (is)
AP (1)	AP118A (is)
AR (1)	AR246519A1 (is)
AT (1)	ATE125794T1 (is)
AU (1)	AU606819B2 (is)
BG (1)	BG50834A3 (is)
CA (1)	CA1339558C (is)
CZ (1)	CZ278983B6 (is)
DD (1)	DD285604A5 (is)
DK (1)	DK514989A (is)
EG (1)	EG19887A (is)
FI (1)	FI95253C (is)
HU (1)	HU208421B (is)
IE (1)	IE66586B1 (is)
IL (1)	IL91960A (is)
IS (1)	IS1598B (is)
MA (1)	MA21657A1 (is)
MX (1)	MX18021A (is)
MY (1)	MY104238A (is)
NO (1)	NO178027C (is)
NZ (1)	NZ231044A (is)
OA (1)	OA09140A (is)
PH (1)	PH27554A (is)
PL (2)	PL163112B1 (is)
PT (1)	PT92000B (is)
RO (1)	RO109195B1 (is)
RU (1)	RU2036905C1 (is)
SK (1)	SK590689A3 (is)
WO (1)	WO1990004393A1 (is)
YU (1)	YU48070B (is)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5059693A (en) *	1989-10-06	1991-10-22	Pfizer Inc.	Process for making 3-aroyl-2-oxindole-1-carboxamides
ES2095080T3 (es) *	1992-11-23	1997-02-01	Pfizer	Sintesis regioselectiva del acido 4-cloro-2-tiofencarboxilico.
US5270331A (en) *	1993-01-26	1993-12-14	Pfizer, Inc.	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
WO1994018194A1 (en) *	1993-02-09	1994-08-18	Pfizer Inc.	Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents
US5449788A (en) *	1994-01-28	1995-09-12	Catalytica, Inc.	Process for preparing 2-oxindole-1-carboxamides
CN1094819C (zh) *	1997-04-30	2002-11-27	大兴株式会社	环状坯料之制造装置
EP0984012A3 (en) *	1998-08-31	2001-01-10	Pfizer Products Inc.	Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties
JP2003512396A (ja) *	1999-10-26	2003-04-02	ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター	インドリン化合物を投与することを含む脱毛症の処置方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE558210A (is) *	1956-06-08
US3564009A (en) *	1966-01-13	1971-02-16	Sumitomo Chemical Co	Process for producing 1-acylindole derivatives
BE756447A (fr) *	1969-10-15	1971-03-22	Pfizer	Oxindolecarboxamides
US3923996A (en) *	1972-07-31	1975-12-02	Sandoz Ag	3-Substituted-oxindoles in compositions and methods of treating obesity
IE53102B1 (en) *	1981-05-12	1988-06-22	Ici Plc	Pharmaceutical spiro-succinimide derivatives
EP0076606B1 (en) *	1981-10-06	1986-02-05	Imperial Chemical Industries Plc	Biochemical process
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4752609A (en) *	1985-06-20	1988-06-21	Pfizer Inc.	Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
RO105052B1 (en) *	1987-02-02	1994-12-01	Pfizer	Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide
ES2075055T3 (es) *	1988-10-18	1995-10-01	Pfizer	Profarmacos de 3-acil-2-oxindol-1-carboxamidas antiinflamatorias.
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives
US5059693A (en) *	1989-10-06	1991-10-22	Pfizer Inc.	Process for making 3-aroyl-2-oxindole-1-carboxamides

1988
- 1988-10-18 MX MX1802188A patent/MX18021A/es unknown
- 1988-10-18 RO RO147347A patent/RO109195B1/ro unknown
- 1988-10-18 WO PCT/US1988/003658 patent/WO1990004393A1/en not_active Ceased
- 1988-10-18 SK SK5906-89A patent/SK590689A3/sk unknown
- 1988-10-18 HU HU886740A patent/HU208421B/hu not_active IP Right Cessation
- 1988-10-18 US US07/675,883 patent/US5118703A/en not_active Expired - Lifetime
1989
- 1989-09-20 IS IS3509A patent/IS1598B/is unknown
- 1989-09-28 CA CA000614317A patent/CA1339558C/en not_active Expired - Fee Related
- 1989-10-04 PH PH39329A patent/PH27554A/en unknown
- 1989-10-09 AT AT89310319T patent/ATE125794T1/de active
- 1989-10-12 IL IL9196089A patent/IL91960A/xx not_active IP Right Cessation
- 1989-10-16 YU YU200589A patent/YU48070B/sh unknown
- 1989-10-16 BG BG090022A patent/BG50834A3/xx unknown
- 1989-10-16 MY MYPI89001415A patent/MY104238A/en unknown
- 1989-10-16 AP APAP/P/1989/000141A patent/AP118A/en active
- 1989-10-16 PT PT92000A patent/PT92000B/pt not_active IP Right Cessation
- 1989-10-17 DK DK514989A patent/DK514989A/da not_active Application Discontinuation
- 1989-10-17 PL PL89296831A patent/PL163112B1/pl unknown
- 1989-10-17 AR AR89315179A patent/AR246519A1/es active
- 1989-10-17 JP JP1270174A patent/JPH07597B2/ja not_active Expired - Lifetime
- 1989-10-17 KR KR1019890014914A patent/KR910007237B1/ko not_active Expired
- 1989-10-17 DD DD89333653A patent/DD285604A5/de not_active IP Right Cessation
- 1989-10-17 OA OA59665A patent/OA09140A/xx unknown
- 1989-10-17 IE IE333289A patent/IE66586B1/en not_active IP Right Cessation
- 1989-10-17 PL PL89281871A patent/PL162316B1/pl unknown
- 1989-10-17 MA MA21909A patent/MA21657A1/fr unknown
- 1989-10-17 AU AU42956/89A patent/AU606819B2/en not_active Ceased
- 1989-10-17 NZ NZ231044A patent/NZ231044A/en unknown
- 1989-10-17 CN CN89107943A patent/CN1022241C/zh not_active Expired - Fee Related
- 1989-10-18 CZ CS895906A patent/CZ278983B6/cs not_active IP Right Cessation
- 1989-10-18 EG EG49689A patent/EG19887A/xx active
1991
- 1991-04-17 RU SU914895525A patent/RU2036905C1/ru active
- 1991-04-17 NO NO911512A patent/NO178027C/no unknown
- 1991-04-17 FI FI911855A patent/FI95253C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1022241C (zh)	1993-09-29
AR246519A1 (es)	1994-08-31
HU208421B (en)	1993-10-28
RU2036905C1 (ru)	1995-06-09
DK514989A (da)	1990-04-19
OA09140A (fr)	1991-10-31
IE66586B1 (en)	1996-01-24
IL91960A0 (en)	1990-07-12
MY104238A (en)	1994-02-28
RO109195B1 (ro)	1994-12-30
KR900006285A (ko)	1990-05-07
AP8900141A0 (en)	1989-10-31
FI95253C (fi)	1996-01-10
FI911855A0 (fi)	1991-04-17
KR910007237B1 (ko)	1991-09-24
SK278175B6 (en)	1996-03-06
CA1339558C (en)	1997-11-25
HU886740D0 (en)	1991-07-29
NO178027B (no)	1995-10-02
PL163112B1 (pl)	1994-02-28
JPH02149559A (ja)	1990-06-08
EG19887A (en)	1996-03-31
AU4295689A (en)	1990-04-26
NO911512L (no)	1991-06-12
IL91960A (en)	1994-04-12
BG50834A3 (en)	1992-11-16
DK514989D0 (da)	1989-10-17
HUT58052A (en)	1992-01-28
PH27554A (en)	1993-08-18
YU200589A (en)	1991-02-28
US5118703A (en)	1992-06-02
YU48070B (sh)	1997-01-08
PL162316B1 (pl)	1993-09-30
AU606819B2 (en)	1991-02-14
WO1990004393A1 (en)	1990-05-03
ATE125794T1 (de)	1995-08-15
IS1598B (is)	1996-05-20
CZ590689A3 (en)	1994-04-13
CN1041938A (zh)	1990-05-09
MX18021A (es)	1993-11-01
NZ231044A (en)	1990-12-21
SK590689A3 (en)	1996-03-06
AP118A (en)	1991-02-22
NO178027C (no)	1996-01-10
PT92000A (pt)	1990-04-30
PT92000B (pt)	1995-06-30
CZ278983B6 (en)	1994-11-16
NO911512D0 (no)	1991-04-17
FI95253B (fi)	1995-09-29
MA21657A1 (fr)	1990-07-01
JPH07597B2 (ja)	1995-01-11
DD285604A5 (de)	1990-12-19
IE893332L (en)	1990-04-18

Publication	Publication Date	Title
MX9206450A (es)	1993-05-01	Proceso para la produccion de isoleucina-l.
DE3582760D1 (de)	1991-06-13	Mikrostrukturherstellungsverfahren.
ES556363A0 (es)	1988-04-01	Procedimiento para la produccion de tiazoles.,
DE3687729D1 (de)	1993-03-25	Papierherstellungsverfahren.
NO892198D0 (no)	1989-05-31	Produksjonssystem for undervanns-oljebroenner.
DE3679078D1 (de)	1991-06-13	Photomaskenherstellungsverfahren.
FI862520A7 (fi)	1986-12-16	Menetelmä uusien tienopyrodonien valmistamiseksi, jotka on terapeuttisesti käyttökelpoisia antihypertonisina lääkeaineina.
DE68909153D1 (de)	1993-10-21	Geschmackstoffproduktion.
FI880090L (fi)	1988-07-10	Tillverkning av papper.
IT1164106B (it)	1987-04-08	Procedimento per la produzione di 14,15-derivati metilenici della serie d'estrano
FI875454L (fi)	1988-06-24	Framstaellning av pasta.
NO862209D0 (no)	1986-06-03	Energiutvinning.
FI913864L (fi)	1992-02-17	Produktionsprocess.
DE68904329D1 (de)	1993-02-25	Chlorerzeugungsverfahren.
DE69000329D1 (de)	1992-10-29	Hydroxyfuranon-herstellung.
IS1598B (is)	1996-05-20	Aðferð við framleiðslu á forlyfi gegn bólgum, þ.e. 3-acyl-2-oxindole-1-carboxamides
DE3866330D1 (de)	1992-01-02	Produktionssteuerung.
DE3680297D1 (de)	1991-08-22	Verzierungsproduktion.
FI894947A0 (fi)	1989-10-18	Produktion av klordioxid.
FI893729A0 (fi)	1989-08-08	Produktion av klordioxid.
NO883233D0 (no)	1988-07-20	Hydrokanelsyrederivater.
NO880233L (no)	1988-07-22	Fremgangsmaate for fremstilling av hns ii.
NO885200D0 (no)	1988-11-22	Fremgangsmte for fremstilling av pro-legemidler.
DE68902821D1 (de)	1992-10-15	Elektrolytisches fertigstellungsverfahren.
DE3672424D1 (de)	1990-08-09	Herstellungsverfahren 16-substituierter prostaglandine-e.