IS3906A - Hliðstæð aðferð við framleiðslu nýrra ísósterískra peptíða - Google Patents

Hliðstæð aðferð við framleiðslu nýrra ísósterískra peptíða

Info

Publication number
IS3906A
IS3906A IS3906A IS3906A IS3906A IS 3906 A IS3906 A IS 3906A IS 3906 A IS3906 A IS 3906A IS 3906 A IS3906 A IS 3906A IS 3906 A IS3906 A IS 3906A
Authority
IS
Iceland
Prior art keywords
production
analogous method
new
isosteric peptides
peptides
Prior art date
Application number
IS3906A
Other languages
English (en)
Inventor
Atrash Brutus
Michael Jones David
Szelke Michael
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Publication of IS3906A publication Critical patent/IS3906A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IS3906A 1991-08-28 1992-08-27 Hliðstæð aðferð við framleiðslu nýrra ísósterískra peptíða IS3906A (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9102462A SE9102462D0 (sv) 1991-08-28 1991-08-28 New isosteric peptides

Publications (1)

Publication Number Publication Date
IS3906A true IS3906A (is) 1993-03-01

Family

ID=20383557

Family Applications (1)

Application Number Title Priority Date Filing Date
IS3906A IS3906A (is) 1991-08-28 1992-08-27 Hliðstæð aðferð við framleiðslu nýrra ísósterískra peptíða

Country Status (27)

Country Link
US (1) US5424291A (is)
EP (2) EP0530167A1 (is)
JP (1) JP3353297B2 (is)
CN (1) CN1069736A (is)
AP (1) AP313A (is)
AT (1) ATE212643T1 (is)
AU (1) AU2499092A (is)
BG (1) BG98583A (is)
CA (1) CA2116527A1 (is)
CZ (1) CZ38094A3 (is)
DE (1) DE69232394T2 (is)
DZ (1) DZ1613A1 (is)
FI (1) FI940945L (is)
HU (1) HUT66060A (is)
IL (1) IL102840A0 (is)
IS (1) IS3906A (is)
MA (1) MA22632A1 (is)
MX (1) MX9204767A (is)
NO (1) NO940669L (is)
NZ (1) NZ243675A (is)
SE (1) SE9102462D0 (is)
SI (1) SI9200193A (is)
SK (1) SK23394A3 (is)
TN (1) TNSN92076A1 (is)
TW (1) TW221816B (is)
WO (1) WO1993005069A1 (is)
ZA (1) ZA925737B (is)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ333492A3 (en) * 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH06329627A (ja) * 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
CN1135717A (zh) * 1993-10-15 1996-11-13 罗纳-布朗克·罗莱尔药物有限公司 抗血栓形成的氮杂环烷基链烷酰肽和假肽
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
CZ245797A3 (cs) * 1995-02-17 1998-06-17 Basf Aktiengesellschaft Derivát amidinu dipeptidu jako inhibitor thrombinu
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) * 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
KR100689923B1 (ko) 1998-01-26 2007-03-09 애보트 게엠베하 운트 콤파니 카게 트롬빈 억제제
CA2329929A1 (en) 1998-04-24 1999-11-04 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
CN1170842C (zh) 1999-01-13 2004-10-13 阿斯特拉曾尼卡有限公司 新的脒基苄基胺衍生物及其作为凝血酶抑制剂的用途
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AU1226001A (en) * 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
SG11201702797RA (en) 2014-10-06 2017-05-30 Cortexyme Inc Inhibitors of lysine gingipain
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
MX2019003087A (es) 2016-09-16 2019-08-12 Cortexyme Inc Inhibidores cetónicos de gingipain de lisina.
KR20190063473A (ko) 2016-09-28 2019-06-07 블레이드 테라퓨틱스, 인크. 칼페인 조정자 및 그 치료학적 용도
MX2020010033A (es) * 2018-03-28 2020-10-14 Blade Therapeutics Inc Moduladores calpaina y usos terapeuticos de los mismos.
US20220204457A1 (en) * 2019-03-21 2022-06-30 Cortexyme, Inc. Arginine gingipain inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
SI9200193A (en) 1993-06-30
BG98583A (bg) 1994-09-30
US5424291A (en) 1995-06-13
HUT66060A (en) 1994-09-28
HU9400589D0 (en) 1994-05-30
ATE212643T1 (de) 2002-02-15
JP3353297B2 (ja) 2002-12-03
WO1993005069A1 (en) 1993-03-18
TW221816B (is) 1994-03-21
AU2499092A (en) 1993-04-05
SK23394A3 (en) 1994-08-10
CA2116527A1 (en) 1993-03-18
FI940945A7 (fi) 1994-02-28
NO940669L (no) 1994-04-19
AP313A (en) 1994-02-10
MA22632A1 (fr) 1993-04-01
JPH06510059A (ja) 1994-11-10
CZ38094A3 (en) 1994-08-17
MX9204767A (es) 1993-05-01
NZ243675A (en) 1994-06-27
DZ1613A1 (fr) 2002-02-17
DE69232394D1 (de) 2002-03-14
EP0605462A1 (en) 1994-07-13
NO940669D0 (no) 1994-02-25
TNSN92076A1 (fr) 1993-06-08
AP9200418A0 (en) 1992-10-31
CN1069736A (zh) 1993-03-10
EP0605462B1 (en) 2002-01-30
FI940945A0 (fi) 1994-02-28
FI940945L (fi) 1994-02-28
SE9102462D0 (sv) 1991-08-28
IL102840A0 (en) 1993-01-31
EP0530167A1 (en) 1993-03-03
DE69232394T2 (de) 2002-08-22
ZA925737B (en) 1993-03-01

Similar Documents

Publication Publication Date Title
IS3906A (is) Hliðstæð aðferð við framleiðslu nýrra ísósterískra peptíða
IS3954A (is) Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða
DK155690D0 (da) Nye peptider
IS1653B (is) Hliðstæð aðferð við framleiðslu nýrra sykursteraestera
FI951596L (fi) Menetelmä 10-desasetyylibakkatiini-III:n saamiseksi
FI883388L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten peptidien valmistamiseksi
DK257988D0 (da) Nye peptider
DK111489D0 (da) Peptider
FI101534B1 (fi) Uusi menetelmä levodopan syntetisoimiseksi
FI921621L (fi) Sprutmetod foer braensle
FI920861A7 (fi) Menetelmä antitrombiinisten polypeptidien valmistamiseksi
FI905741A7 (fi) Peptidit
DK0544805T3 (da) Fremgangsmåder til hormondetektering
FI915193A7 (fi) Liitosmenetelmä
FI904845L (fi) Kuvausmenetelmä kappaleiden rakenteen määrittämiseksi
FI906302A7 (fi) Pinnoitusmenetelmä
FI98549B (fi) Menetelmä pysyvämuotoisten tuotteiden valmistamiseksi
FI935592A7 (fi) Menetelmä polypeptidien valmistamiseksi
FI905453A7 (fi) Prokalsitoniinipeptidejä
GB9022152D0 (en) Improved methods for the production of proteins
FI901196A7 (fi) SKD-peptidien valmistusmenetelmä
FI894125A7 (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisen 3-piperidinyyli-indatsolin valmistamiseksi
IS1464B6 (is) Búnaður til framleiðslu grinda
FI891256L (fi) Aryylisulfonyylialkyyliamidien synteesimenetelmä
DK164962C (da) Taekkenaal til straatag