IS5605A - Aðferð fyrir samruna á eyðniveiru (HIV) próteasa lötum - Google Patents

Aðferð fyrir samruna á eyðniveiru (HIV) próteasa lötum

Info

Publication number: IS5605A
Authority: IS; Iceland
Prior art keywords: lysis; protease inhibitors; hiv virus; virus protease; hiv
Prior art date: 1998-03-20

Application number

IS5605A

Other languages

English (en)

Other versions

IS2273B (is

Inventor

Al-Farhan Emile

D. Deininger David

Dennis Tung Roger

Mcghie Stephen

Rout Stephen

Singh Hardev

O'callaghan John

Stuart Robertson Mark

Rodgers Keith

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-20

Filing date

2000-08-29

Publication date

2000-08-29

2000-08-29 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2000-08-29 Publication of IS5605A publication Critical patent/IS5605A/is

2007-07-15 Publication of IS2273B publication Critical patent/IS2273B/is

Links

241000725303 Human immunodeficiency virus Species 0.000 title 1
230000009089 cytolysis Effects 0.000 title 1
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IS5605A 1998-03-20 2000-08-29 Aðferð fyrir nýsmíðina á HIV próteasa lötum IS2273B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9805898.5A GB9805898D0 (en)	1998-03-20	1998-03-20	Process for the sythesis of hiv protease inhibitors
PCT/GB1999/000852 WO1999048885A1 (en)	1998-03-20	1999-03-18	Process for the synthesis of hiv protease inhibitors

Publications (2)

Publication Number	Publication Date
IS5605A true IS5605A (is)	2000-08-29
IS2273B IS2273B (is)	2007-07-15

Family

ID=10828884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5605A IS2273B (is)	1998-03-20	2000-08-29	Aðferð fyrir nýsmíðina á HIV próteasa lötum

Country Status (31)

Country	Link
US (1)	US6281367B1 (is)
EP (1)	EP1066276B1 (is)
JP (1)	JP3363439B2 (is)
KR (1)	KR100555278B1 (is)
CN (1)	CN1308319C (is)
AP (1)	AP1226A (is)
AT (1)	ATE242772T1 (is)
AU (1)	AU751534B2 (is)
BR (1)	BR9908970A (is)
CA (1)	CA2324217C (is)
CZ (1)	CZ299193B6 (is)
DE (1)	DE69908761T2 (is)
DK (1)	DK1066276T3 (is)
EA (1)	EA003022B1 (is)
EE (1)	EE04750B1 (is)
ES (1)	ES2203090T3 (is)
GB (1)	GB9805898D0 (is)
HR (1)	HRP20000609B1 (is)
HU (1)	HUP0105439A3 (is)
ID (1)	ID26587A (is)
IL (1)	IL138127A (is)
IS (1)	IS2273B (is)
NO (1)	NO317648B1 (is)
NZ (1)	NZ506563A (is)
PL (1)	PL201810B1 (is)
PT (1)	PT1066276E (is)
RS (1)	RS49954B (is)
SK (1)	SK283939B6 (is)
TR (1)	TR200002698T2 (is)
WO (1)	WO1999048885A1 (is)
ZA (1)	ZA200004482B (is)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3657002B2 (ja)	1992-08-25	2005-06-08	ジー．ディー．サールアンドカンパニー	レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド
US6548706B2 (en) *	1999-12-23	2003-04-15	Aerojet Fine Chemicals Llc	Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
EP2319824A3 (en) *	1999-12-23	2012-04-11	Ampac Fine Chemicals LLC	Improved preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)amine
ES2503551T5 (es)	2002-05-16	2021-10-28	Janssen Sciences Ireland Unlimited Co	Formas pseudopolimórficas de un inhibidor de la proteasa de VIH
DE602004021640D1 (de) *	2003-12-23	2009-07-30	Tibotec Pharm Ltd	Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester
RS51073B (sr) *	2003-12-23	2010-10-31	Tibotec Pharmaceuticals Ltd.	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
AR073248A1 (es)	2008-09-01	2010-10-20	Tibotec Pharm Ltd	Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
UA105556C2 (uk)	2010-01-27	2014-05-26	Віів Гелскер Компані	Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
US8877947B2 (en)	2010-09-10	2014-11-04	Lupin Limited	Process for preparation of substantially pure fosamprenavir calcium and its intermediates
CN111233794A (zh) *	2020-03-27	2020-06-05	江巨东	一种安普那韦的精制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1071930A (zh) *	1991-07-10	1993-05-12	伊莱利利公司	用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
JP3657002B2 (ja) *	1992-08-25	2005-06-08	ジー．ディー．サールアンドカンパニー	レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða

1998
- 1998-03-20 GB GBGB9805898.5A patent/GB9805898D0/en not_active Ceased
1999
- 1999-03-18 IL IL13812799A patent/IL138127A/xx not_active IP Right Cessation
- 1999-03-18 DK DK99910543T patent/DK1066276T3/da active
- 1999-03-18 HR HR20000609A patent/HRP20000609B1/xx not_active IP Right Cessation
- 1999-03-18 TR TR2000/02698T patent/TR200002698T2/xx unknown
- 1999-03-18 DE DE69908761T patent/DE69908761T2/de not_active Expired - Lifetime
- 1999-03-18 SK SK1373-2000A patent/SK283939B6/sk not_active IP Right Cessation
- 1999-03-18 EP EP99910543A patent/EP1066276B1/en not_active Expired - Lifetime
- 1999-03-18 CN CNB998042242A patent/CN1308319C/zh not_active Expired - Fee Related
- 1999-03-18 BR BR9908970-0A patent/BR9908970A/pt not_active Application Discontinuation
- 1999-03-18 EA EA200000859A patent/EA003022B1/ru unknown
- 1999-03-18 WO PCT/GB1999/000852 patent/WO1999048885A1/en not_active Ceased
- 1999-03-18 CA CA002324217A patent/CA2324217C/en not_active Expired - Fee Related
- 1999-03-18 JP JP2000537868A patent/JP3363439B2/ja not_active Expired - Lifetime
- 1999-03-18 NZ NZ506563A patent/NZ506563A/en unknown
- 1999-03-18 EE EEP200000568A patent/EE04750B1/xx not_active IP Right Cessation
- 1999-03-18 AP APAP/P/2000/001911A patent/AP1226A/en active
- 1999-03-18 AU AU29475/99A patent/AU751534B2/en not_active Ceased
- 1999-03-18 AT AT99910543T patent/ATE242772T1/de not_active IP Right Cessation
- 1999-03-18 PL PL342602A patent/PL201810B1/pl not_active IP Right Cessation
- 1999-03-18 KR KR1020007010359A patent/KR100555278B1/ko not_active Expired - Fee Related
- 1999-03-18 US US09/646,277 patent/US6281367B1/en not_active Expired - Lifetime
- 1999-03-18 ID IDW20001857A patent/ID26587A/id unknown
- 1999-03-18 RS YUP-559/00A patent/RS49954B/sr unknown
- 1999-03-18 ES ES99910543T patent/ES2203090T3/es not_active Expired - Lifetime
- 1999-03-18 HU HU0105439A patent/HUP0105439A3/hu unknown
- 1999-03-18 CZ CZ20003457A patent/CZ299193B6/cs not_active IP Right Cessation
- 1999-03-18 PT PT99910543T patent/PT1066276E/pt unknown
2000
- 2000-08-29 ZA ZA200004482A patent/ZA200004482B/en unknown
- 2000-08-29 IS IS5605A patent/IS2273B/is unknown
- 2000-09-19 NO NO20004664A patent/NO317648B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IS2273B (is)	2007-07-15
CZ299193B6 (cs)	2008-05-14
AU2947599A (en)	1999-10-18
EP1066276A1 (en)	2001-01-10
US6281367B1 (en)	2001-08-28
CN1293668A (zh)	2001-05-02
EP1066276B1 (en)	2003-06-11
NO20004664L (no)	2000-09-19
DK1066276T3 (da)	2003-10-06
KR100555278B1 (ko)	2006-03-03
ATE242772T1 (de)	2003-06-15
JP3363439B2 (ja)	2003-01-08
WO1999048885A1 (en)	1999-09-30
CA2324217A1 (en)	1999-09-30
RS49954B (sr)	2008-09-29
EA003022B1 (ru)	2002-12-26
DE69908761D1 (de)	2003-07-17
JP2002507609A (ja)	2002-03-12
ID26587A (id)	2001-01-18
CZ20003457A3 (cs)	2001-04-11
TR200002698T2 (tr)	2000-12-21
PT1066276E (pt)	2003-10-31
HUP0105439A2 (en)	2002-06-29
PL342602A1 (en)	2001-06-18
EE04750B1 (et)	2006-12-15
NO20004664D0 (no)	2000-09-19
CN1308319C (zh)	2007-04-04
ES2203090T3 (es)	2004-04-01
SK13732000A3 (sk)	2001-08-06
AU751534B2 (en)	2002-08-22
NZ506563A (en)	2003-05-30
HRP20000609A2 (en)	2001-04-30
GB9805898D0 (en)	1998-05-13
HK1032047A1 (en)	2001-07-06
PL201810B1 (pl)	2009-05-29
DE69908761T2 (de)	2004-02-19
AP2000001911A0 (en)	2000-09-30
NO317648B1 (no)	2004-11-29
SK283939B6 (sk)	2004-05-04
AP1226A (en)	2003-11-21
EE200000568A (et)	2002-02-15
IL138127A (en)	2003-10-31
BR9908970A (pt)	2000-11-28
CA2324217C (en)	2008-02-19
ZA200004482B (en)	2001-11-28
HRP20000609B1 (en)	2006-05-31
YU55900A (sh)	2003-02-28
HUP0105439A3 (en)	2002-08-28
IL138127A0 (en)	2001-10-31
EA200000859A1 (ru)	2001-04-23
KR20010042022A (ko)	2001-05-25

Publication	Publication Date	Title
NO991832L (no)	1999-06-17	Inhibitorer for serin-proteaser, spesielt hepatitt - C - virus NS3-protease
EE04434B1 (et)	2005-02-15	HIV proteaasi inhibiitori bisulfaatsool
DE69823178D1 (de)	2004-05-19	Serine protease inhibitoren
DK1412486T3 (da)	2008-03-10	Fremgangsmåde til virusformering
ATE277074T1 (de)	2004-10-15	Serine-protease-inhibitoren
ATE221080T1 (de)	2002-08-15	Serine-protease-inhibitoren
NO20010674L (no)	2001-05-03	Forbedret fremgangsmåte for to-bölgefelts-forsterkning
SI0932617T1 (en)	2002-06-30	Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
EE200000568A (et)	2002-02-15	HIV-proteaasi inhibiitorite valmistamismeetod
FI963054L (fi)	1996-08-01	Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi
FI20000553L (fi)	2000-03-10	Proteaasi-inhibiittoreina käyttökelpoisten 4-hydroksi-2-oksopyraanijohdannaisten valmistusmenetelmä
FI960206L (fi)	1996-03-14	Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi
FI960184L (fi)	1996-03-14	Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi
IS5018A (is)	1999-10-11	Aðferð til alkýeringar á hindruðum súlfónamíðum
DK1361216T3 (da)	2006-01-23	Fremgangsmåde til fremstilling af en HIV-proteaseinhibitor
NO994415L (no)	1999-11-10	HIV proteaseinhibitorer
NO20054575L (no)	2000-09-06	Fremgangsmate ved kommunikasjon og anordning for samme
FI991301A0 (fi)	1999-06-08	Menetelmä elohopean talteenottamiseksi