IS6491A - Pteridínefnasambönd til meðhöndlunar á sóríasis - Google Patents

Pteridínefnasambönd til meðhöndlunar á sóríasis

Info

Publication number: IS6491A
Authority: IS; Iceland
Prior art keywords: psoriasis; treatment; pteridine compounds; formula; pteridine
Prior art date: 2000-02-23

Application number

IS6491A

Other languages

English (en)

Inventor

Bonnert Roger

Gardiner Stewart

Hunt Fraser

Walters Iain

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-23

Filing date

2002-08-07

Publication date

2002-08-07

2002-08-07 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-08-07 Publication of IS6491A publication Critical patent/IS6491A/is

Links

125000001042 pteridinyl group Chemical class N1=C(N=CC2=NC=CN=C12)* 0.000 title abstract 2
201000004681 Psoriasis Diseases 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IS6491A 2000-02-23 2002-08-07 Pteridínefnasambönd til meðhöndlunar á sóríasis IS6491A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0004128A GB2359551A (en)	2000-02-23	2000-02-23	Pharmaceutically active pyrimidine derivatives
PCT/SE2001/000374 WO2001062758A1 (en)	2000-02-23	2001-02-20	Pteridine compounds for the treatment of psoriasis

Publications (1)

Publication Number	Publication Date
IS6491A true IS6491A (is)	2002-08-07

Family

ID=9886153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6491A IS6491A (is)	2000-02-23	2002-08-07	Pteridínefnasambönd til meðhöndlunar á sóríasis

Country Status (32)

Country	Link
US (2)	US6875868B2 (is)
EP (1)	EP1259512B1 (is)
JP (1)	JP2003524012A (is)
KR (1)	KR100795758B1 (is)
CN (1)	CN1190437C (is)
AR (1)	AR029805A1 (is)
AT (1)	ATE250605T1 (is)
AU (1)	AU782509B2 (is)
BG (1)	BG107002A (is)
BR (1)	BR0108600A (is)
CA (1)	CA2400217C (is)
CO (1)	CO5290258A1 (is)
CZ (1)	CZ20022839A3 (is)
DE (1)	DE60100851T2 (is)
DK (1)	DK1259512T3 (is)
EE (1)	EE200200461A (is)
ES (1)	ES2206402T3 (is)
GB (1)	GB2359551A (is)
HU (1)	HUP0204399A3 (is)
IL (2)	IL151132A0 (is)
IS (1)	IS6491A (is)
MX (1)	MXPA02008233A (is)
NO (1)	NO329898B1 (is)
NZ (1)	NZ520355A (is)
PL (1)	PL358004A1 (is)
PT (1)	PT1259512E (is)
RU (1)	RU2002125451A (is)
SK (1)	SK12152002A3 (is)
TR (1)	TR200302214T4 (is)
UA (1)	UA72590C2 (is)
WO (1)	WO2001062758A1 (is)
ZA (1)	ZA200206590B (is)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9903544D0 (sv) *	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
GB2359078A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359551A (en) *	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
US6964967B2 (en) *	2000-12-11	2005-11-15	Amgen, Inc.	Substituted pyrido[2,3-d]pyrimidines and methods for their use
SE0101322D0 (sv) *	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
US6794379B2 (en)	2001-06-06	2004-09-21	Tularik Inc.	CXCR3 antagonists
SE0102716D0 (sv) *	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
GB0221828D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221829D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
US7067658B2 (en)	2002-09-30	2006-06-27	Bristol-Myers Squibb Company	Pyridino and pyrimidino pyrazinones
US6861422B2 (en)	2003-02-26	2005-03-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
GB0328243D0 (en) *	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
US7375102B2 (en)	2004-06-28	2008-05-20	Amgen Sf, Llc	Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
US7271271B2 (en)	2004-06-28	2007-09-18	Amgen Sf, Llc	Imidazolo-related compounds, compositions and methods for their use
US7939538B2 (en)	2004-06-28	2011-05-10	Amgen Inc.	Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
DE102004033670A1 (de) *	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US20060058311A1 (en)	2004-08-14	2006-03-16	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation
US7728134B2 (en)	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US7759485B2 (en)	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US20060035903A1 (en) *	2004-08-14	2006-02-16	Boehringer Ingelheim International Gmbh	Storage stable perfusion solution for dihydropteridinones
US20060074088A1 (en)	2004-08-14	2006-04-06	Boehringer Ingelheim International Gmbh	Dihydropteridinones for the treatment of cancer diseases
DE102004058337A1 (de)	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
EP1828186A1 (en) *	2004-12-13	2007-09-05	Sunesis Pharmaceuticals, Inc.	Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
AR053347A1 (es)	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
UA90707C2 (en)	2005-04-06	2010-05-25	Астразенека Аб	Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
US7439358B2 (en)	2006-02-08	2008-10-21	Boehringer Ingelheim International Gmbh	Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
TW200820973A (en) *	2006-09-29	2008-05-16	Astrazeneca Ab	Novel compounds 480
CN101522693B (zh) *	2006-09-29	2012-01-04	阿斯利康(瑞典)有限公司	5，7-二取代的[1，3]噻唑并[4，5-d]嘧啶-2(3h)-胺衍生物和它们在治疗中的用途
EP2185559A1 (en) *	2007-08-03	2010-05-19	Boehringer Ingelheim International GmbH	Crystalline form of a dihydropteridione derivative
KR20110031462A (ko) *	2008-07-16	2011-03-28	아스트라제네카 아베	피리미딜 술폰아미드 유도체 및 케모카인 매개 질환의 치료를 위한 그의 용도
US8546566B2 (en)	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
AU2012262014B2 (en) *	2011-06-01	2016-07-14	Janus Biotherapeutics, Inc.	Novel immune system modulators
CN110420316A (zh)	2013-06-18	2019-11-08	纽约大学	参与金黄色葡萄球菌杀白细胞素的细胞毒性的细胞因素：新型治疗靶点
WO2015011236A1 (en)	2013-07-26	2015-01-29	Boehringer Ingelheim International Gmbh	Treatment of myelodysplastic syndrome
US9867831B2 (en)	2014-10-01	2018-01-16	Boehringer Ingelheim International Gmbh	Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2924472A (en) *	1957-06-27	1960-02-09	Gen Motors Corp	Pipe joint seal
GB1009477A (en)	1962-02-13	1965-11-10	Smith Kline French Lab	Novel process for preparing heterocyclic compounds
US3318900A (en) *	1964-05-06	1967-05-09	Janssen Pharmaceutica Nv	Derivatives of benzimidazolinyl piperidine
BE668603A (is) *	1964-08-20
US3859287A (en) *	1971-05-05	1975-01-07	Walter Wesley Parish	Thiopteridines and process for producing same
DE2331223C2 (de)	1972-06-19	1984-11-22	Kohjin Co., Ltd., Tokio / Tokyo	S-substituierte-2-Thioadenosine, deren 5'-Monophosphate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
US4120521A (en) *	1975-08-28	1978-10-17	Rieber & Son Plastic-Industri A/S	Combined mould element and sealing ring
EG12406A (en) *	1976-08-12	1979-03-31	Janssen Pharmaceutica Nv	Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
GB1600293A (en) *	1977-02-04	1981-10-14	British Oceanics Ltd	Sealing arrangements
US4188040A (en) *	1977-04-06	1980-02-12	Firma WOCO Franz-Josef Wolf & Co.	Sealing ring
DE2726959A1 (de) *	1977-06-15	1979-01-18	Arlt Christian	Dichteinsatz zum dichten verbinden von zwei rohren
FR2421899A1 (fr) *	1978-01-16	1979-11-02	Roussel Uclaf	Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4410528A (en) *	1980-05-16	1983-10-18	Kyowa Hakko Kogyo Co., Ltd.	Hypotensive piperidine derivatives
DE3219522A1 (de) *	1981-10-28	1983-12-01	Denso-Chemie Wedekind Kg, 5090 Leverkusen	Steckmuffendichtung fuer rohre
FR2547888B1 (fr) *	1983-06-22	1985-12-13	Sabla Sa	Bague d'etancheite a implants pour tuyaux a emboitement
HU195822B (en) *	1985-12-30	1988-07-28	Gyogyszerkutato Intezet	Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives
CA1338012C (en) *	1987-04-27	1996-01-30	John Michael Mccall	Pharmaceutically active amines
SE8800348L (sv) *	1988-02-03	1989-08-04	Forsheda Ab	Taetningsring och verktyg foer framstaellning daerav
FR2659656B1 (fr) *	1990-03-15	1994-09-09	Sanofi Sa	Derives de pyrimidinedione-2,4 et medicaments les contenant.
DE4119767A1 (de)	1991-06-15	1992-12-17	Dresden Arzneimittel	Verfahren zur herstellung von (pyrimid-2-yl-thio- bzw. seleno)-essigsaeurederivaten
JP3100469B2 (ja) *	1991-07-03	2000-10-16	中外製薬株式会社	乾癬治療剤
US5169161A (en) *	1991-09-19	1992-12-08	Hail Mary Rubber Co., Inc.	Symmetrical gasket for pipe joints
DE4134089C2 (de) *	1991-10-15	1994-10-13	Dueker Eisenwerk	Schubgesicherte Muffenverbindung
JPH05188994A (ja)	1992-01-07	1993-07-30	Sony Corp	騒音抑圧装置
DE4229609C2 (de) *	1992-09-04	2003-05-08	Forsheda Stefa Gmbh	Abdichtung zwischen zwei ineinandersteckbaren Teilen
US5521197A (en)	1994-12-01	1996-05-28	Eli Lilly And Company	3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
ES2200039T3 (es)	1995-12-08	2004-03-01	Pfizer Inc.	Derivados heterociclicos sustituidos como antagonistas de crf.
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
SE515033C2 (sv) *	1995-12-27	2001-06-05	Forsheda Ab	Tätningsanordning
JP4471404B2 (ja)	1996-02-13	2010-06-02	アストラゼネカユーケイリミテッド	Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
ATE211134T1 (de)	1996-03-05	2002-01-15		4-anilinochinazolin derivate
US6180649B1 (en)	1996-04-19	2001-01-30	Nerosearch A/S	1-(4-piperidyl)-benzimidazoles having neurotrophic activity
ES2273369T3 (es)	1996-08-28	2007-05-01	Pfizer Inc.	Derivados 6,5 heterobiciclicos sustituidos.
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
WO1998025617A1 (en)	1996-12-13	1998-06-18	Merck & Co., Inc.	Substituted aryl piperazines as modulators of chemokine receptor activity
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
WO1999004794A1 (en)	1997-07-25	1999-02-04	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
AR013669A1 (es)	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
US6329381B1 (en) *	1997-11-28	2001-12-11	Sumitomo Pharmaceuticals Company, Limited	Heterocyclic compounds
WO1999036421A1 (en)	1998-01-19	1999-07-22	Pfizer Pharmaceuticals Inc.	4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists
WO1999047515A1 (en) *	1998-03-19	1999-09-23	Nihon Nohyaku Co., Ltd.	Arylpiperidine derivatives and use thereof
AU3213699A (en)	1998-04-03	1999-10-25	Du Pont Pharmaceuticals Company	Thiazolo(4,5-d)pyrimidines and pyridines as corticotropin releasing factor (CRF)antagonists
MA26659A1 (fr) *	1998-08-06	2004-12-20	Pfizer	Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9802729D0 (sv) *	1998-08-13	1998-08-13	Astra Pharma Prod	Novel Compounds
US5988695A (en) *	1998-08-26	1999-11-23	S&B Technical Products, Inc.	Pipe gasket with embedded ring
PE20001420A1 (es)	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
DE69920757T2 (de) *	1998-12-28	2005-12-15	4 AZA Bioscience N.V.	Immunosuppressive wirkungen von pteridinderivaten
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
GB9900752D0 (en)	1999-01-15	1999-03-03	Angiogene Pharm Ltd	Benzimidazole vascular damaging agents
JP2002536320A (ja) *	1999-02-02	2002-10-29	カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント	プテリジン誘導体の免疫抑制作用
US6248755B1 (en)	1999-04-06	2001-06-19	Merck & Co., Inc.	Pyrrolidine modulators of chemokine receptor activity
US6142484A (en) *	1999-04-15	2000-11-07	Vassallo Research & Development Corporation	Composite multi-pressure gasket
AU5600100A (en)	1999-06-11	2001-01-02	Merck & Co., Inc.	Cyclopentyl modulators of chemokine receptor activity
US6340681B1 (en)	1999-07-16	2002-01-22	Pfizer Inc	2-benzimidazolylamine compounds as ORL-1-receptor agonists
EA005287B1 (ru) *	1999-09-15	2004-12-30	Уорнер-Ламберт Компани	Птеридиноны в качестве ингибиторов киназ
AR025884A1 (es)	1999-10-01	2002-12-18	Takeda Pharmaceutical	Compuestos de amina ciclica, su produccion y su uso
SE9903544D0 (sv) *	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
ATE306488T1 (de)	2000-01-05	2005-10-15	Pfizer	Benzimidazol-verbindungen zur verwendung als orl1-rezeptor-antagonisten
GB2359081A (en) *	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
EP1257555B1 (en)	2000-02-11	2003-12-03	AstraZeneca AB	Pyrimidine compounds and their use as modulators of chemokine receptor activity
GB2359078A (en) *	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359079A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359551A (en) *	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) *	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
US6790854B2 (en) *	2000-03-24	2004-09-14	Meiji Seika Kaisha, Ltd.	Diphenylalkylamine derivatives useful as opioid receptor agonists
NZ522074A (en)	2000-05-31	2004-06-25	Astrazeneca Ab	Indole derivatives with vascular damaging activity
JP2004502766A (ja)	2000-07-07	2004-01-29	アンギオジェン・ファーマシューティカルズ・リミテッド	血管損傷剤としてのコルヒノール誘導体
CA2410562A1 (en)	2000-07-07	2002-01-31	Angiogene Pharmaceuticals Limited	Colchinol derivatives as angiogenesis inhibitors
SE0003828D0 (sv) *	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
SE0004110L (sv) *	2000-11-10	2002-05-11	Forsheda Ab	Tätningsring
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
SE0102716D0 (sv)	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
GB0221828D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221829D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
MXPA06003792A (es)	2003-10-07	2006-06-14	Astrazeneca Ab	Nuevas 4-amino-tiazolo[4,5-d]-pirimidinas 2-sustituidas, utiles como antagonistas del receptor de quimiocina, especialmente cx3cr1.
GB0328243D0 (en)	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
WO2005082865A1 (ja)	2004-02-27	2005-09-09	Astellas Pharma Inc.	縮合二環性ピリミジン誘導体
JP2008524186A (ja)	2004-12-17	2008-07-10	アストラゼネカ・アクチエボラーグ	ケモカイン受容体活性の調節のためのチアゾロピラミジン化合物

2000
- 2000-02-23 GB GB0004128A patent/GB2359551A/en not_active Withdrawn
2001
- 2001-02-20 CZ CZ20022839A patent/CZ20022839A3/cs unknown
- 2001-02-20 ES ES01906493T patent/ES2206402T3/es not_active Expired - Lifetime
- 2001-02-20 UA UA2002097583A patent/UA72590C2/uk unknown
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- 2001-02-20 JP JP2001562540A patent/JP2003524012A/ja active Pending
- 2001-02-20 WO PCT/SE2001/000374 patent/WO2001062758A1/en not_active Ceased
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- 2001-02-20 DK DK01906493T patent/DK1259512T3/da active
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- 2001-02-20 MX MXPA02008233A patent/MXPA02008233A/es active IP Right Grant
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- 2001-02-20 KR KR1020027011047A patent/KR100795758B1/ko not_active Expired - Fee Related
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- 2001-02-21 CO CO01013781A patent/CO5290258A1/es not_active Application Discontinuation
2002
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- 2002-08-14 BG BG107002A patent/BG107002A/bg unknown
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2004
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Also Published As

Publication number	Publication date
GB2359551A (en)	2001-08-29
HUP0204399A3 (en)	2004-11-29
EP1259512B1 (en)	2003-09-24
US7579342B2 (en)	2009-08-25
KR100795758B1 (ko)	2008-01-21
JP2003524012A (ja)	2003-08-12
RU2002125451A (ru)	2004-01-10
AU782509B2 (en)	2005-08-04
CN1190437C (zh)	2005-02-23
ATE250605T1 (de)	2003-10-15
PL358004A1 (en)	2004-08-09
HK1050899A1 (en)	2003-07-11
KR20030005207A (ko)	2003-01-17
CA2400217A1 (en)	2001-08-30
CA2400217C (en)	2009-02-17
IL151132A0 (en)	2003-04-10
PT1259512E (pt)	2004-02-27
IL151132A (en)	2010-11-30
AU3431601A (en)	2001-09-03
DE60100851D1 (de)	2003-10-30
EE200200461A (et)	2003-12-15
US20050171345A1 (en)	2005-08-04
ZA200206590B (en)	2003-11-17
WO2001062758A1 (en)	2001-08-30
BR0108600A (pt)	2002-11-12
NZ520355A (en)	2005-01-28
GB0004128D0 (en)	2000-04-12
NO329898B1 (no)	2011-01-24
CZ20022839A3 (cs)	2002-11-13
MXPA02008233A (es)	2004-04-05
US6875868B2 (en)	2005-04-05
EP1259512A1 (en)	2002-11-27
DK1259512T3 (da)	2003-12-29
AR029805A1 (es)	2003-07-16
ES2206402T3 (es)	2004-05-16
CN1404482A (zh)	2003-03-19
CO5290258A1 (es)	2003-06-27
US20030055250A1 (en)	2003-03-20
SK12152002A3 (sk)	2003-03-04
DE60100851T2 (de)	2004-07-15
NO20024005L (no)	2002-10-22
TR200302214T4 (tr)	2004-01-21
HUP0204399A2 (en)	2003-05-28
BG107002A (bg)	2003-04-30
NO20024005D0 (no)	2002-08-22
UA72590C2 (uk)	2005-03-15

Publication	Publication Date	Title
IS6491A (is)	2002-08-07	Pteridínefnasambönd til meðhöndlunar á sóríasis
SE0104140D0 (sv)	2001-12-07	Novel Compounds
SE0301700D0 (sv)	2003-06-10	Novel compounds
BG66080B1 (bg)	2011-03-31	Заместени тиоацетамиди
NO20026064D0 (no)	2002-12-17	Nye forbindelser
PT1263725E (pt)	2005-02-28	Novos compostos
SE9904505D0 (sv)	1999-12-09	Novel compounds
DK1206474T3 (da)	2004-10-04	Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
ATE365720T1 (de)	2007-07-15	Agonisten von beta-adrenorezeptoren
SE9802729D0 (sv)	1998-08-13	Novel Compounds
SE0103836D0 (sv)	2001-11-16	Novel compounds
ATE408601T1 (de)	2008-10-15	Fredericamycin-derivate
MY128924A (en)	2007-02-28	Novel compounds
BR0209129A (pt)	2005-12-20	Compostos, composições farmacêuticas, métodos para tratamento de dores, métodos para modulação de uma resposta farmacológica e usos de compostos
BR0209127A (pt)	2006-03-21	compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
SE0100569D0 (sv)	2001-02-20	New compounds
SE0102716D0 (sv)	2001-08-14	Novel compounds
DK1456212T3 (da)	2007-04-02	6-aminomorphinanderivater, fremgangsmåder til fremstilling heraf og disses anvendelse
SE9902765D0 (sv)	1999-07-21	Novel compounds
SE9804212D0 (sv)	1998-12-04	Compounds
SE0101038D0 (sv)	2001-03-23	Novel compounds
DE60129829D1 (de)	2007-09-20	Zyklisierte benzamid-neurokinin-antagonisten zur verwendung in therapie
MXPA04005809A (es)	2004-09-13	Inhibidores de proteinas quinasas.
SE9902551D0 (sv)	1999-07-02	Novel compounds
SE0202693D0 (sv)	2002-09-11	Compounds