IS6534A - Stytt efnasmíð á 3,3-díarýlprópýlamín afleiðum - Google Patents

Stytt efnasmíð á 3,3-díarýlprópýlamín afleiðum

Info

Publication number: IS6534A
Authority: IS; Iceland
Prior art keywords: phenylchromane; oxo; alkyl; formula; image
Prior art date: 2000-06-14

Application number

IS6534A

Other languages

English (en)

Inventor

Messe Claus

Original Assignee

Schwarz Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-14

Filing date

2002-08-30

Publication date

2002-08-30

2002-08-30 Application filed by Schwarz Pharma Ag filed Critical Schwarz Pharma Ag

2002-08-30 Publication of IS6534A publication Critical patent/IS6534A/is

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
-1 alkyl 4-hydroxybenzoate Chemical compound 0.000 abstract 10
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
238000006243 chemical reaction Methods 0.000 abstract 3
HFIYMVVVMUZHSJ-GFCCVEGCSA-N (4r)-2-oxo-4-phenyl-3,4-dihydrochromene-6-carboxylic acid Chemical compound C1([C@H]2CC(=O)OC3=CC=C(C=C32)C(=O)O)=CC=CC=C1 HFIYMVVVMUZHSJ-GFCCVEGCSA-N 0.000 abstract 2
WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 abstract 2
229940090248 4-hydroxybenzoic acid Drugs 0.000 abstract 2
WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 abstract 2
229930016911 cinnamic acid Natural products 0.000 abstract 2
235000013985 cinnamic acid Nutrition 0.000 abstract 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 abstract 2
JGDWYKQLFQQIDH-UHFFFAOYSA-N 2-phenyl-3,4-dihydrochromen-2-ol Chemical class C1CC2=CC=CC=C2OC1(O)C1=CC=CC=C1 JGDWYKQLFQQIDH-UHFFFAOYSA-N 0.000 abstract 1
LUZCIQGVIMIORG-UHFFFAOYSA-N 3-phenyl-3,4-dihydrochromen-2-one Chemical compound O=C1OC2=CC=CC=C2CC1C1=CC=CC=C1 LUZCIQGVIMIORG-UHFFFAOYSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
KMPWYEUPVWOPIM-KODHJQJWSA-N cinchonidine Chemical compound C1=CC=C2C([C@H]([C@H]3[N@]4CC[C@H]([C@H](C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-KODHJQJWSA-N 0.000 abstract 1
KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
238000006268 reductive amination reaction Methods 0.000 abstract 1
125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
150000003512 tertiary amines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IS6534A 2000-06-14 2002-08-30 Stytt efnasmíð á 3,3-díarýlprópýlamín afleiðum IS6534A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10028443A DE10028443C1 (de)	2000-06-14	2000-06-14	Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
PCT/EP2001/006577 WO2001096279A1 (de)	2000-06-14	2001-06-11	Verkürzte synthese von 3,3-diarylpropylamin-derivaten

Publications (1)

Publication Number	Publication Date
IS6534A true IS6534A (is)	2002-08-30

Family

ID=7645152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6534A IS6534A (is)	2000-06-14	2002-08-30	Stytt efnasmíð á 3,3-díarýlprópýlamín afleiðum

Country Status (23)

Country	Link
US (1)	US6809214B2 (is)
EP (1)	EP1289929B1 (is)
JP (2)	JP4002180B2 (is)
KR (1)	KR100580568B1 (is)
CN (1)	CN1234679C (is)
AT (1)	ATE368640T1 (is)
AU (2)	AU6906301A (is)
BR (1)	BR0111266A (is)
CA (1)	CA2412047C (is)
CZ (1)	CZ20023665A3 (is)
DE (2)	DE10028443C1 (is)
ES (1)	ES2290153T3 (is)
HU (1)	HUP0204563A3 (is)
IL (2)	IL151595A0 (is)
IS (1)	IS6534A (is)
MX (1)	MXPA02009643A (is)
NO (1)	NO20025967L (is)
NZ (1)	NZ521265A (is)
PL (1)	PL360845A1 (is)
RU (1)	RU2270188C2 (is)
SK (1)	SK142003A3 (is)
WO (1)	WO2001096279A1 (is)
ZA (1)	ZA200207204B (is)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957073A1 (en) *	1998-05-12	1999-11-17	Schwarz Pharma Ag	Novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (de) *	2003-04-08	2004-11-18	Schwarz Pharma Ag	Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
WO2005012227A2 (en) *	2003-08-05	2005-02-10	Ranbaxy Laboratories Limited	Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
JP4513535B2 (ja) *	2004-12-03	2010-07-28	住友化学株式会社	トルテロジンの製造方法
JP2007527922A (ja) *	2005-01-10	2007-10-04	テバファーマシューティカルインダストリーズリミティド	実質的に純粋なトルテロジンタルトレート及びその調製方法
KR101453318B1 (ko) *	2006-05-31	2014-10-21	유씨비 매뉴팩처링 아일랜드 리미티드	치환 히드록시메틸 페놀의 새로운 합성
KR101488740B1 (ko)	2006-06-12	2015-02-03	유씨비 파마 게엠베하	새로운 키랄 중간체, 그 키랄 중간체의 제조방법 및 톨테로딘, 페소테로딘 또는 그 활성대사물질의 제조에서 그키랄 중간체의 사용
ES2456866T3 (es) *	2009-07-27	2014-04-23	Crystal Pharma, S.A.U.	Procedimiento para la obtención de 3,3-difenilpropilaminas
IT1396373B1 (it) *	2009-10-29	2012-11-19	Dipharma Francis Srl	Procedimento per la preparazione di fesoterodina.
EP2364966A1 (en)	2010-03-09	2011-09-14	LEK Pharmaceuticals d.d.	Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-3-phenylpropylamines, intermediates for making hydroxytolterodine
WO2011141932A2 (en)	2010-05-11	2011-11-17	Intas Pharmaceuticals Limited	Process for preparation of phenolic monoesters of hydroxymethyl phenols
IT1401451B1 (it)	2010-06-10	2013-07-26	Chemi Spa	Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo.
WO2011158257A1 (en) *	2010-06-18	2011-12-22	Panacea Biotec Ltd	Preparation process of fesoterodine and intermediates
IT1403094B1 (it)	2010-12-09	2013-10-04	Dipharma Francis Srl	Procedimento per la preparazione di fesoterodina o un suo sale
CA2873721C (en)	2012-05-04	2021-06-22	Crystal Pharma, S.A.U.	Process for the preparation of optically active 3,3-diphenylpropylamines
HRP20160363T1 (hr)	2012-06-14	2016-06-17	Ratiopharm Gmbh	Soli desfesoterodina
ITMI20121232A1 (it)	2012-07-16	2014-01-17	Cambrex Profarmaco Milano Srl	Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
CN103193747A (zh) *	2013-04-18	2013-07-10	中国药科大学	一种富马酸弗斯特罗定中间体的制备方法
WO2017137955A1 (en)	2016-02-14	2017-08-17	Celestis Pharmaceuticals Pvt. Ltd.	Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8800207D0 (sv) *	1988-01-22	1988-01-22	Kabivitrum Ab	Nya aminer, deras anvendning och framstellning
SE9203318D0 (sv) *	1992-11-06	1992-11-06	Kabi Pharmacia Ab	Novel 3,3-diphenylpropylamines, their use and preparation
KR20000057548A (ko) *	1996-12-13	2000-09-25	알프레드 엘. 미첼슨	광학적 전송물질 및 결합재
SE9701144D0 (sv) *	1997-03-27	1997-03-27	Pharmacia & Upjohn Ab	Novel compounds, their use and preparation
JP3913329B2 (ja) *	1997-09-11	2007-05-09	株式会社クラレ	（±）−クロマンカルボン酸の光学分割法
EP0957073A1 (en) *	1998-05-12	1999-11-17	Schwarz Pharma Ag	Novel derivatives of 3,3-diphenylpropylamines
DE19955190A1 (de) *	1999-11-16	2001-06-21	Sanol Arznei Schwarz Gmbh	Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen

2000
- 2000-06-14 DE DE10028443A patent/DE10028443C1/de not_active Expired - Fee Related
2001
- 2001-06-11 EP EP01947355A patent/EP1289929B1/de not_active Expired - Lifetime
- 2001-06-11 AU AU6906301A patent/AU6906301A/xx active Pending
- 2001-06-11 DE DE50112793T patent/DE50112793D1/de not_active Expired - Fee Related
- 2001-06-11 IL IL15159501A patent/IL151595A0/xx active IP Right Grant
- 2001-06-11 CA CA002412047A patent/CA2412047C/en not_active Expired - Fee Related
- 2001-06-11 AU AU2001269063A patent/AU2001269063B2/en not_active Ceased
- 2001-06-11 AT AT01947355T patent/ATE368640T1/de not_active IP Right Cessation
- 2001-06-11 US US10/297,778 patent/US6809214B2/en not_active Expired - Fee Related
- 2001-06-11 ES ES01947355T patent/ES2290153T3/es not_active Expired - Lifetime
- 2001-06-11 BR BR0111266-0A patent/BR0111266A/pt not_active IP Right Cessation
- 2001-06-11 NZ NZ521265A patent/NZ521265A/en unknown
- 2001-06-11 WO PCT/EP2001/006577 patent/WO2001096279A1/de not_active Ceased
- 2001-06-11 HU HU0204563A patent/HUP0204563A3/hu unknown
- 2001-06-11 CN CNB018095259A patent/CN1234679C/zh not_active Expired - Fee Related
- 2001-06-11 RU RU2002132900/04A patent/RU2270188C2/ru not_active IP Right Cessation
- 2001-06-11 PL PL36084501A patent/PL360845A1/xx unknown
- 2001-06-11 JP JP2002510423A patent/JP4002180B2/ja not_active Expired - Fee Related
- 2001-06-11 SK SK14-2003A patent/SK142003A3/sk unknown
- 2001-06-11 KR KR1020027013004A patent/KR100580568B1/ko not_active Expired - Fee Related
- 2001-06-11 MX MXPA02009643A patent/MXPA02009643A/es active IP Right Grant
- 2001-06-11 CZ CZ20023665A patent/CZ20023665A3/cs unknown
2002
- 2002-08-30 IS IS6534A patent/IS6534A/is unknown
- 2002-09-04 IL IL151595A patent/IL151595A/en not_active IP Right Cessation
- 2002-09-09 ZA ZA200207204A patent/ZA200207204B/en unknown
- 2002-12-12 NO NO20025967A patent/NO20025967L/no not_active Application Discontinuation
2007
- 2007-06-05 JP JP2007149492A patent/JP2007231024A/ja active Pending

Also Published As

Publication number	Publication date
CA2412047A1 (en)	2001-12-20
IL151595A0 (en)	2003-04-10
DE10028443C1 (de)	2002-05-29
NO20025967D0 (no)	2002-12-12
US6809214B2 (en)	2004-10-26
NZ521265A (en)	2004-06-25
JP4002180B2 (ja)	2007-10-31
ZA200207204B (en)	2003-05-23
SK142003A3 (en)	2003-04-01
AU2001269063B2 (en)	2005-03-24
KR100580568B1 (ko)	2006-05-16
PL360845A1 (en)	2004-09-20
AU6906301A (en)	2001-12-24
HK1050518A1 (en)	2003-06-27
MXPA02009643A (es)	2003-03-10
ES2290153T3 (es)	2008-02-16
JP2004503520A (ja)	2004-02-05
ATE368640T1 (de)	2007-08-15
EP1289929B1 (de)	2007-08-01
CN1429197A (zh)	2003-07-09
EP1289929A1 (de)	2003-03-12
BR0111266A (pt)	2003-12-16
RU2270188C2 (ru)	2006-02-20
CA2412047C (en)	2008-09-09
HUP0204563A2 (en)	2003-05-28
KR20020093870A (ko)	2002-12-16
NO20025967L (no)	2002-12-12
JP2007231024A (ja)	2007-09-13
WO2001096279A1 (de)	2001-12-20
CZ20023665A3 (cs)	2003-02-12
DE50112793D1 (de)	2007-09-13
IL151595A (en)	2007-03-08
CN1234679C (zh)	2006-01-04
HUP0204563A3 (en)	2004-12-28
US20030212292A1 (en)	2003-11-13

Publication	Publication Date	Title
NO20025967L (no)	2002-12-12	Forkortet syntese av 3,3-diarylpropylaminderivater
CA2312935A1 (en)	1999-06-17	Hydroxamic acid derivatives as matrix metalloprotease (mmp) inhibitors
PL1781683T3 (pl)	2012-04-30	Sposób wytwarzania 17-winylo-trifluorometanosulfonianów jako związków pośrednich
JPS57193485A (en)	1982-11-27	1-substituted-spiro(piperidine-oxobenzoxazine)s, manufacture and use for blood pressure fall
BR0109048A (pt)	2003-06-03	Processo para a sìntese de citalopram
ATE226200T1 (de)	2002-11-15	Asymmetrische synthese von chiralen sekondären alkoholen
CO5720995A2 (es)	2007-01-31	Compuesto novedoso
NO20040388L (no)	2004-01-29	Fremgangsmåte for fremstilling av beraprost og salter derav, samt forbindelser som er mellomprodukter i fremgangsmåten
RU2002132900A (ru)	2004-07-10	Способ получения 3,3-диарилпропиламинов
CO4700300A1 (es)	1998-12-29	Procedimiento para preparar olanzapina
EA200200939A1 (ru)	2003-02-27	Способ получения циталопрама
JP2005538949A5 (is)	2006-06-29
MX9204457A (es)	1993-05-01	Compuestos de 6-oxo-azepinoidol, asi como procedimientos y productos intermedios para su preparacion, y medicamentos que contienen estos compuestos.
AU2003227075A1 (en)	2004-06-23	Method for producing salts of tolperisone
ES2200594T3 (es)	2004-03-01	Procedimiento para la preparacion de 4-((2`,5`-diamino-6`-halogenopirimidin-4il)amino)-ciclopent-2-enilmetanoles.
DK1257523T3 (da)	2006-10-23	Fremgangsmåde til fremstilling af 3-aminoalkansyreestere
DK1581504T3 (da)	2009-06-29	Fremgangsmåde til fremstilling af subsituterede imidazolderivater og intermediater anvendt i fremgangsmåden
PL363756A1 (en)	2004-11-29	Process for preparing fluconazole and its crystal modifications
CY1106126T1 (el)	2011-06-08	Μεθοδος δια την παρασκευην ενωσεων 2-(4-αλκυλο-1-πιπepαζινυλο)-βενζαλδεϋδης και-βενζυλιδενυλιου δια νουκλεοφιλικης αρωματικης υποκαταστασεως 2-φθοροβενζαλδεϋδης δια 4-αλκυλο-1-πιπepαζινης, εις υδωρ ως διαλυτην
BR0302681A (pt)	2004-08-24	Método para a produção de um composto de éter
PL348863A1 (en)	2002-06-17	Method for preparing azoiminoethers and azocarboxylic acid esters and novel azocarboxylic acid mixed esters
Divakar et al.	2000	A novel route to thymol from m-cresol
DK0539330T3 (da)	1995-07-17	Fremgangsmåde til fremstilling af substituerede indoler
SE8301817L (sv)	1983-10-02	Forfarande for framsellning av 2-(e)-fenylmetylencykloheptan-1-on-(e)-oxim
BR0105022A (pt)	2002-06-04	Método para preparação de citalopram, métodos para preparação de compostos utilizados na preparação do mesmo, citalopram e sua composição farmacêutica