IS6695A - Skilvirk bindilmiðlun Ullmann-tenging anilína og azóla - Google Patents
Skilvirk bindilmiðlun Ullmann-tenging anilína og azólaInfo
- Publication number
- IS6695A IS6695A IS6695A IS6695A IS6695A IS 6695 A IS6695 A IS 6695A IS 6695 A IS6695 A IS 6695A IS 6695 A IS6695 A IS 6695A IS 6695 A IS6695 A IS 6695A
- Authority
- IS
- Iceland
- Prior art keywords
- azoles
- binding agent
- ullmann coupling
- efficient binding
- anilines
- Prior art date
Links
- 238000006887 Ullmann reaction Methods 0.000 title abstract 2
- 150000001448 anilines Chemical class 0.000 title abstract 2
- 150000003851 azoles Chemical class 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- -1 phenyl-substituted azoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Executing Machine-Instructions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22093200P | 2000-07-26 | 2000-07-26 | |
| PCT/US2001/023541 WO2002008199A2 (en) | 2000-07-26 | 2001-07-26 | Efficient ligand-mediated ullmann coupling of anilines and azoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS6695A true IS6695A (is) | 2003-01-22 |
Family
ID=22825611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS6695A IS6695A (is) | 2000-07-26 | 2003-01-22 | Skilvirk bindilmiðlun Ullmann-tenging anilína og azóla |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6541639B2 (is) |
| EP (1) | EP1307431B1 (is) |
| JP (1) | JP2004504384A (is) |
| KR (1) | KR20030060872A (is) |
| CN (1) | CN1444565A (is) |
| AT (1) | ATE307804T1 (is) |
| AU (1) | AU2001280813A1 (is) |
| BR (1) | BR0112746A (is) |
| CA (1) | CA2417426A1 (is) |
| DE (1) | DE60114424T2 (is) |
| EC (1) | ECSP034453A (is) |
| ES (1) | ES2251501T3 (is) |
| HU (1) | HUP0301699A3 (is) |
| IL (1) | IL153547A0 (is) |
| IS (1) | IS6695A (is) |
| MX (1) | MXPA03000686A (is) |
| NO (1) | NO20030393L (is) |
| NZ (1) | NZ523271A (is) |
| PL (1) | PL361233A1 (is) |
| RU (1) | RU2003103706A (is) |
| WO (1) | WO2002008199A2 (is) |
| ZA (1) | ZA200300039B (is) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085838A1 (en) * | 2001-04-24 | 2002-10-31 | Massachusetts Institute Of Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
| EP2324830A1 (en) * | 2002-03-05 | 2011-05-25 | TransTech Pharma Inc. | Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage |
| JP2006501159A (ja) * | 2002-05-31 | 2006-01-12 | ロデイア・シミ | 炭素−炭素結合又は炭素−ヘテロ原子結合の形成方法 |
| EP1534671A4 (en) | 2002-08-02 | 2007-10-24 | Massachusetts Inst Technology | FORMATION OF CARBON-HETEROATOME AND CARBON-CARBON BONDS CATALYZED WITH COPPER |
| WO2004031143A2 (en) * | 2002-10-02 | 2004-04-15 | Bristol-Myers Squibb Company | Novel combination of a factor xa inhibitor and clopidogrel |
| WO2005000295A1 (en) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| US20090012300A1 (en) * | 2004-07-16 | 2009-01-08 | Mathilda Maria Henrica Lambers | Process for the Preparation of an (Hetero) Arylamine |
| EP3663294A1 (en) | 2007-03-12 | 2020-06-10 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| CA2772797C (en) | 2009-09-30 | 2018-09-25 | Transtech Pharma, Inc. | Substituted imidazole derivatives |
| ES2727815T3 (es) | 2012-04-14 | 2019-10-18 | Intra Cellular Therapies Inc | Tratamiento del TEPT y de trastornos del control de impulsos |
| DK2968320T3 (da) | 2013-03-15 | 2021-02-01 | Intra Cellular Therapies Inc | Organiske forbindelser |
| KR102692169B1 (ko) | 2013-12-03 | 2024-08-05 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| WO2015154025A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| KR20170012209A (ko) | 2014-04-04 | 2017-02-02 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| WO2015171951A1 (en) * | 2014-05-07 | 2015-11-12 | The Regents Of The University Of Colorado, A Body Corporate | 2-(4-aryl-1h-imidazol-1-yl)aniline compounds |
| IL318649A (en) | 2016-01-26 | 2025-03-01 | Intra Cellular Therapies Inc | Organic compounds |
| IL297676B2 (en) | 2016-03-25 | 2023-12-01 | Intra Cellular Therapies Inc | A controlled or delayed release pharmaceutical preparation containing a deuterated compound |
| EP3436455A4 (en) | 2016-03-28 | 2019-09-04 | Intra-Cellular Therapies, Inc. | NOVEL SALTS AND CRYSTALS |
| WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| WO2017172811A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel co-crystals |
| WO2018071233A1 (en) | 2016-10-12 | 2018-04-19 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3562484B1 (en) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders |
| RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
| CN111093665A (zh) | 2017-07-26 | 2020-05-01 | 细胞内治疗公司 | 有机化合物 |
| US11427587B2 (en) | 2017-07-26 | 2022-08-30 | Intra-Cellular Therapies, Inc. | Organic compounds |
| MD3762368T2 (ro) | 2018-03-08 | 2022-07-31 | Incyte Corp | Compuși diol aminopirazină ca inhibitori ai PI3K-Y |
| CA3094949A1 (en) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Deuterated heterocycle fused gamma-carbolines |
| AU2019280850C1 (en) | 2018-06-06 | 2025-02-13 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| ES3028377T3 (en) | 2018-06-08 | 2025-06-19 | Intra Cellular Therapies Inc | Fused gamma-carbolines for acute treatment of anxiety or depression |
| CA3106447A1 (en) | 2018-06-11 | 2019-12-19 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| WO2020047241A1 (en) | 2018-08-29 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| CN112584837A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
| CN112584838A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP7520013B2 (ja) | 2018-12-17 | 2024-07-22 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換複素環縮合γ－カルボリンの合成 |
| EP3898580A4 (en) | 2018-12-17 | 2022-08-10 | Intra-Cellular Therapies, Inc. | SYNTHESIS OF CONDENSED GAMMA-CARBOLINES WITH SUBSTITUTED HETEROCYCLE |
| JP7673040B2 (ja) | 2019-07-07 | 2025-05-08 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6372658A (ja) | 1986-09-17 | 1988-04-02 | Sumitomo Chem Co Ltd | ニトロジフエニルアミン類の製造方法 |
| US5705697A (en) | 1997-01-30 | 1998-01-06 | Xerox Corporation | Arylamine processes |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
-
2001
- 2001-07-25 US US09/912,950 patent/US6541639B2/en not_active Expired - Fee Related
- 2001-07-26 CA CA002417426A patent/CA2417426A1/en not_active Abandoned
- 2001-07-26 DE DE60114424T patent/DE60114424T2/de not_active Expired - Fee Related
- 2001-07-26 NZ NZ523271A patent/NZ523271A/en unknown
- 2001-07-26 KR KR10-2003-7001155A patent/KR20030060872A/ko not_active Withdrawn
- 2001-07-26 WO PCT/US2001/023541 patent/WO2002008199A2/en not_active Ceased
- 2001-07-26 PL PL36123301A patent/PL361233A1/xx not_active Application Discontinuation
- 2001-07-26 BR BR0112746-2A patent/BR0112746A/pt not_active IP Right Cessation
- 2001-07-26 JP JP2002514105A patent/JP2004504384A/ja active Pending
- 2001-07-26 AU AU2001280813A patent/AU2001280813A1/en not_active Abandoned
- 2001-07-26 CN CN01813378A patent/CN1444565A/zh active Pending
- 2001-07-26 RU RU2003103706/04A patent/RU2003103706A/ru not_active Application Discontinuation
- 2001-07-26 MX MXPA03000686A patent/MXPA03000686A/es unknown
- 2001-07-26 ES ES01959231T patent/ES2251501T3/es not_active Expired - Lifetime
- 2001-07-26 IL IL15354701A patent/IL153547A0/xx unknown
- 2001-07-26 AT AT01959231T patent/ATE307804T1/de not_active IP Right Cessation
- 2001-07-26 HU HU0301699A patent/HUP0301699A3/hu unknown
- 2001-07-26 EP EP01959231A patent/EP1307431B1/en not_active Expired - Lifetime
-
2003
- 2003-01-02 ZA ZA200300039A patent/ZA200300039B/en unknown
- 2003-01-22 IS IS6695A patent/IS6695A/is unknown
- 2003-01-24 NO NO20030393A patent/NO20030393L/no not_active Application Discontinuation
- 2003-01-24 EC EC2003004453A patent/ECSP034453A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60114424T2 (de) | 2006-07-27 |
| ECSP034453A (es) | 2003-03-31 |
| WO2002008199A3 (en) | 2002-06-13 |
| JP2004504384A (ja) | 2004-02-12 |
| AU2001280813A1 (en) | 2002-02-05 |
| US20020099225A1 (en) | 2002-07-25 |
| ES2251501T3 (es) | 2006-05-01 |
| CN1444565A (zh) | 2003-09-24 |
| HUP0301699A3 (en) | 2004-03-29 |
| NZ523271A (en) | 2005-01-28 |
| DE60114424D1 (de) | 2005-12-01 |
| EP1307431B1 (en) | 2005-10-26 |
| HUP0301699A2 (hu) | 2003-12-29 |
| CA2417426A1 (en) | 2002-01-31 |
| PL361233A1 (en) | 2004-10-04 |
| BR0112746A (pt) | 2003-09-09 |
| ZA200300039B (en) | 2004-04-02 |
| NO20030393L (no) | 2003-03-24 |
| MXPA03000686A (es) | 2003-06-06 |
| US6541639B2 (en) | 2003-04-01 |
| EP1307431A2 (en) | 2003-05-07 |
| KR20030060872A (ko) | 2003-07-16 |
| WO2002008199A2 (en) | 2002-01-31 |
| IL153547A0 (en) | 2003-07-06 |
| RU2003103706A (ru) | 2004-08-10 |
| NO20030393D0 (no) | 2003-01-24 |
| ATE307804T1 (de) | 2005-11-15 |
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