IS6724A - Process for the preparation of N-aryl-anthranilic acids and their derivatives - Google Patents

Process for the preparation of N-aryl-anthranilic acids and their derivatives

Info

Publication number
IS6724A
IS6724A IS6724A IS6724A IS6724A IS 6724 A IS6724 A IS 6724A IS 6724 A IS6724 A IS 6724A IS 6724 A IS6724 A IS 6724A IS 6724 A IS6724 A IS 6724A
Authority
IS
Iceland
Prior art keywords
aryl
derivatives
preparation
anthranilic acids
anthranilic
Prior art date
Application number
IS6724A
Other languages
Icelandic (is)
Inventor
Huai Gu Chen Michael
Mark Davis Edward
Magano Javier
Norman Nanninga Thomas
Dale Winkle Derick
Original Assignee
Warner-Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc
Publication of IS6724A publication Critical patent/IS6724A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
IS6724A 2000-08-25 2003-02-20 Process for the preparation of N-aryl-anthranilic acids and their derivatives IS6724A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Publications (1)

Publication Number Publication Date
IS6724A true IS6724A (en) 2003-02-20

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6724A IS6724A (en) 2000-08-25 2003-02-20 Process for the preparation of N-aryl-anthranilic acids and their derivatives

Country Status (32)

Country Link
EP (1) EP1313694A1 (en)
JP (1) JP2004507518A (en)
KR (1) KR20030059115A (en)
CN (1) CN1458921A (en)
AP (1) AP2001002249A0 (en)
AR (1) AR032175A1 (en)
AU (1) AU2001277044A1 (en)
BG (1) BG107635A (en)
BR (1) BR0113520A (en)
CA (1) CA2420003A1 (en)
CZ (1) CZ2003477A3 (en)
DO (1) DOP2001000238A (en)
EA (1) EA200300187A1 (en)
GT (1) GT200100174A (en)
HN (1) HN2001000216A (en)
HU (1) HUP0300828A2 (en)
IL (1) IL154507A0 (en)
IS (1) IS6724A (en)
MA (1) MA26949A1 (en)
MX (1) MXPA03001654A (en)
NO (1) NO20030844L (en)
PA (1) PA8526501A1 (en)
PE (1) PE20020393A1 (en)
PL (1) PL360699A1 (en)
PY (1) PY0120841A (en)
SK (1) SK2072003A3 (en)
SV (1) SV2002000601A (en)
TN (1) TNSN01127A1 (en)
UY (1) UY26908A1 (en)
WO (1) WO2002018319A1 (en)
YU (1) YU14303A (en)
ZA (1) ZA200301182B (en)

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US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
DE60330227D1 (en) 2002-03-13 2010-01-07 Array Biopharma Inc N3-ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
EP1682495A1 (en) 2003-10-21 2006-07-26 Warner-Lambert Company LLC Polymorphic form of n- (r)-2,3-dihydroxy-propoxy -3,4-d ifluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
CN1905873A (en) 2003-11-19 2007-01-31 阵列生物制药公司 Heterocyclic inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
EP1684694A2 (en) 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors
UA89035C2 (en) * 2003-12-03 2009-12-25 Лео Фарма А/С Hydroxamic acid esters and pharmaceutical use thereof
EP1883402A2 (en) 2005-04-13 2008-02-06 Astex Therapeutics Limited Hydroxybenzamide derivatives and their use as inhibitors of hsp90
US8299076B2 (en) 2005-05-18 2012-10-30 Array Biopharma Inc. Crystalline forms of 2-(2-flouro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2054418B1 (en) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
CA2656618C (en) 2006-07-06 2014-08-26 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
DE602007011628D1 (en) 2006-07-06 2011-02-10 Array Biopharma Inc DIHYDROFUROPYRIMIDINES AS ACT PROTEIN KINASE INHIBITORS
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
JP5721949B2 (en) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ Compound drug
EP2081891A2 (en) 2006-10-12 2009-07-29 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
JP5528807B2 (en) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド Compound drug
WO2008044054A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in therapy
JP5528806B2 (en) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド Compound drug
ES2533557T3 (en) 2007-07-05 2015-04-13 Array Biopharma, Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
AR067413A1 (en) 2007-07-05 2009-10-07 Genentech Inc HETEROCICLICAL COMPOUNDS CONTAINING CYCLOPENTA [D] PYRIMIDINE INHIBITORS OF AKT PROTEINQUINASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, METHOD OF PREPARATION AND USE OF THE SAME FOR THE TREATMENT OF HYPER-TROLIFERATIVE TIPERIFERATIVE AS-ISSUES
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
MX2010007546A (en) 2008-01-09 2010-09-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor.
WO2009089459A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (en) * 2009-07-29 2014-02-12 杭州民生药业有限公司 O-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as preparation method and application thereof
CN102958892A (en) * 2010-02-19 2013-03-06 国家科学研究中心 Method for preparing chemical compounds of interest by aromatic nucleophilic substitution
CN102985399A (en) * 2010-02-19 2013-03-20 国家科学研究中心 Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group
CN103841976A (en) 2011-04-01 2014-06-04 基因泰克公司 Combinations of AKT and MEK inhibitor compounds and methods of use thereof
CN103841975A (en) 2011-04-01 2014-06-04 基因泰克公司 Combinations of akt inhibitor compounds and vemurafenib, and methods of use
JP6300042B2 (en) * 2012-10-12 2018-03-28 エグゼリクシス， インコーポレイテッド Method for producing a compound for use in the treatment of cancer
CN112745237B (en) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-arylamine compound and its preparation method and application
CN119948008A (en) * 2022-07-15 2025-05-06 南方科技大学 A method for preparing condensed ring aromatic amines using isonitrile and cyclopropene as raw materials

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
WO1998037881A1 (en) * 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
IL132840A (en) * 1997-07-01 2004-12-15 Warner Lambert Co 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and pharmaceutical compositions comprising them for use as mek inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
OA11861A (en) * 1999-04-21 2006-03-02 Warner Lambert Co Method for making 2-(N-phenylamino) benzoic acids.

Also Published As

Publication number Publication date
SK2072003A3 (en) 2004-01-08
KR20030059115A (en) 2003-07-07
PL360699A1 (en) 2004-09-20
DOP2001000238A (en) 2003-01-31
IL154507A0 (en) 2003-09-17
AR032175A1 (en) 2003-10-29
ZA200301182B (en) 2004-05-12
MA26949A1 (en) 2004-12-20
NO20030844L (en) 2003-02-25
CA2420003A1 (en) 2002-03-07
JP2004507518A (en) 2004-03-11
HUP0300828A2 (en) 2003-09-29
NO20030844D0 (en) 2003-02-24
PA8526501A1 (en) 2002-07-30
TNSN01127A1 (en) 2005-11-10
AU2001277044A1 (en) 2002-03-13
EA200300187A1 (en) 2003-08-28
YU14303A (en) 2006-08-17
BR0113520A (en) 2003-06-24
SV2002000601A (en) 2002-04-03
EP1313694A1 (en) 2003-05-28
UY26908A1 (en) 2001-11-30
AP2001002249A0 (en) 2001-09-30
GT200100174A (en) 2002-07-18
HN2001000216A (en) 2002-05-22
PY0120841A (en) 2004-06-01
BG107635A (en) 2004-09-30
WO2002018319A1 (en) 2002-03-07
CZ2003477A3 (en) 2003-10-15
CN1458921A (en) 2003-11-26
PE20020393A1 (en) 2002-05-09
MXPA03001654A (en) 2004-09-10

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