IS7095A - Arýlamín til meðhöndlunar á ástandi sem tengist GSK-3 - Google Patents
Arýlamín til meðhöndlunar á ástandi sem tengist GSK-3Info
- Publication number
- IS7095A IS7095A IS7095A IS7095A IS7095A IS 7095 A IS7095 A IS 7095A IS 7095 A IS7095 A IS 7095A IS 7095 A IS7095 A IS 7095A IS 7095 A IS7095 A IS 7095A
- Authority
- IS
- Iceland
- Prior art keywords
- gsk
- arylamine
- treatment
- condition related
- condition
- Prior art date
Links
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 title 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title 1
- 150000004982 aromatic amines Chemical class 0.000 title 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102439A SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | New compounds |
| PCT/SE2002/001339 WO2003004472A1 (en) | 2001-07-05 | 2002-07-03 | Arylamines for the treatment of conditions associated with gsk-3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS7095A true IS7095A (is) | 2003-12-31 |
Family
ID=20284777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7095A IS7095A (is) | 2001-07-05 | 2003-12-31 | Arýlamín til meðhöndlunar á ástandi sem tengist GSK-3 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20060052396A1 (is) |
| EP (1) | EP1414801A1 (is) |
| JP (1) | JP2005505515A (is) |
| KR (1) | KR20040013102A (is) |
| CN (1) | CN1551869A (is) |
| AR (1) | AR036132A1 (is) |
| BR (1) | BR0210838A (is) |
| CA (1) | CA2452686A1 (is) |
| CO (1) | CO5540341A2 (is) |
| HU (1) | HUP0500339A2 (is) |
| IL (1) | IL159347A0 (is) |
| IS (1) | IS7095A (is) |
| MX (1) | MXPA03011972A (is) |
| NO (1) | NO20040014L (is) |
| PL (1) | PL367782A1 (is) |
| RU (1) | RU2004102389A (is) |
| SE (1) | SE0102439D0 (is) |
| WO (1) | WO2003004472A1 (is) |
| ZA (1) | ZA200309977B (is) |
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| SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
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| JP4058368B2 (ja) * | 2003-03-27 | 2008-03-05 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 超音波診断装置 |
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| EP2568984A1 (en) | 2010-05-12 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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| US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| MX2013000103A (es) | 2010-06-23 | 2013-06-13 | Vertex Pharma | Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art. |
| MX336726B (es) | 2010-09-27 | 2016-01-27 | Abbott Gmbh & Co Kg | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. |
| US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| US9624213B2 (en) | 2011-02-07 | 2017-04-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| CN102718745A (zh) * | 2011-03-30 | 2012-10-10 | 中国科学院上海药物研究所 | 新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
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| LT2714677T (lt) * | 2011-05-23 | 2018-12-10 | Merck Patent Gmbh | Piridino ir pirazino dariniai |
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| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| CN108685922A (zh) | 2011-09-30 | 2018-10-23 | 沃泰克斯药物股份有限公司 | 用atr抑制剂治疗胰腺癌和非小细胞肺癌 |
| CN106496173A (zh) | 2011-09-30 | 2017-03-15 | 沃泰克斯药物股份有限公司 | 用于制备可用作atr激酶抑制剂的化合物的方法 |
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| US8846917B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| CN108478577A (zh) | 2012-04-05 | 2018-09-04 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物及其组合疗法 |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| EP2909202A1 (en) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| SI2941432T1 (en) | 2012-12-07 | 2018-07-31 | Vertex Pharmaceuticals Incorporated | 2-AMINO-6-FLUORO-N- (5-FLUORO-4- (4- (4- (OXETHAN-3-YL) PIPERAZIN-1-CARBONYL) PIPERIDIN-1-YLIPRIDIN-3-YL) 1,5 ALFA) PYRIMIDINE-3-CARBOXAMIDE AS ATR KINAZE INHIBITOR |
| WO2014143240A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| PT3077397T (pt) | 2013-12-06 | 2020-01-22 | Vertex Pharma | Composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor da atr quinase, a sua preparação, diferentes formas sólidas e derivados radiomarcados do mesmo |
| MX373102B (es) | 2014-06-05 | 2020-04-17 | Vertex Pharma | Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de ataxia telangiectasia mutada y rad3 relacionado (atr) cinasa, preparación de tal compuesto y diferentes formas sólidas del mismo. |
| SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| JO3589B1 (ar) * | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| MX2018008507A (es) | 2016-01-11 | 2019-07-04 | Merrimack Pharmaceuticals Inc | Inhibición de proteína relacionada con ataxia telangiectasia y rad3 (atr). |
| US20190177696A1 (en) | 2016-06-16 | 2019-06-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for preparing induced hepatic progenitor cells |
| MX388518B (es) | 2016-07-20 | 2025-03-19 | Novartis Ag | Derivados de aminopiridina y su uso como inhibidores selectivos de alk-2. |
| TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
| JP7717065B2 (ja) | 2019-11-22 | 2025-08-01 | インサイト コーポレーション | Alk2阻害剤及びjak2阻害剤を含む併用療法 |
| WO2021257532A1 (en) | 2020-06-16 | 2021-12-23 | Incyte Corporation | Alk2 inhibitors for the treatment of anemia |
| MX2023001384A (es) | 2020-08-06 | 2023-04-26 | Chdi Foundation Inc | Compuestos de heterobiarilo y agentes de imagenologia para imagenologia de proteina huntingtina. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5547004A (en) * | 1992-01-28 | 1996-08-20 | Klockner Hansel Tevopharm B.V. | Method and device for arranging a stream of products |
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| PL365238A1 (en) * | 2000-02-16 | 2004-12-27 | Neurogen Corporation | Substituted arylpyrazines |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
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2001
- 2001-07-05 SE SE0102439A patent/SE0102439D0/xx unknown
-
2002
- 2002-07-03 IL IL15934702A patent/IL159347A0/xx unknown
- 2002-07-03 CN CNA028135458A patent/CN1551869A/zh active Pending
- 2002-07-03 EP EP02747795A patent/EP1414801A1/en not_active Withdrawn
- 2002-07-03 CA CA002452686A patent/CA2452686A1/en not_active Abandoned
- 2002-07-03 HU HU0500339A patent/HUP0500339A2/hu unknown
- 2002-07-03 WO PCT/SE2002/001339 patent/WO2003004472A1/en not_active Ceased
- 2002-07-03 RU RU2004102389/04A patent/RU2004102389A/ru not_active Application Discontinuation
- 2002-07-03 BR BR0210838-0A patent/BR0210838A/pt not_active Application Discontinuation
- 2002-07-03 US US10/481,721 patent/US20060052396A1/en not_active Abandoned
- 2002-07-03 PL PL02367782A patent/PL367782A1/xx not_active Application Discontinuation
- 2002-07-03 MX MXPA03011972A patent/MXPA03011972A/es unknown
- 2002-07-03 JP JP2003510640A patent/JP2005505515A/ja active Pending
- 2002-07-03 KR KR10-2004-7000080A patent/KR20040013102A/ko not_active Withdrawn
- 2002-07-05 AR ARP020102533A patent/AR036132A1/es unknown
-
2003
- 2003-12-23 ZA ZA200309977A patent/ZA200309977B/xx unknown
- 2003-12-30 CO CO03113306A patent/CO5540341A2/es not_active Application Discontinuation
- 2003-12-31 IS IS7095A patent/IS7095A/is unknown
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2004
- 2004-01-02 NO NO20040014A patent/NO20040014L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL367782A1 (en) | 2005-03-07 |
| US20060052396A1 (en) | 2006-03-09 |
| CN1551869A (zh) | 2004-12-01 |
| EP1414801A1 (en) | 2004-05-06 |
| JP2005505515A (ja) | 2005-02-24 |
| ZA200309977B (en) | 2005-03-23 |
| BR0210838A (pt) | 2004-07-13 |
| SE0102439D0 (sv) | 2001-07-05 |
| KR20040013102A (ko) | 2004-02-11 |
| WO2003004472A8 (en) | 2003-03-13 |
| CO5540341A2 (es) | 2005-07-29 |
| WO2003004472A1 (en) | 2003-01-16 |
| AR036132A1 (es) | 2004-08-11 |
| RU2004102389A (ru) | 2005-07-10 |
| NO20040014L (no) | 2004-03-02 |
| MXPA03011972A (es) | 2004-03-26 |
| CA2452686A1 (en) | 2003-01-16 |
| IL159347A0 (en) | 2004-06-01 |
| HUP0500339A2 (hu) | 2005-07-28 |
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