IS7095A - Arýlamín til meðhöndlunar á ástandi sem tengist GSK-3 - Google Patents
Arýlamín til meðhöndlunar á ástandi sem tengist GSK-3Info
- Publication number
- IS7095A IS7095A IS7095A IS7095A IS7095A IS 7095 A IS7095 A IS 7095A IS 7095 A IS7095 A IS 7095A IS 7095 A IS7095 A IS 7095A IS 7095 A IS7095 A IS 7095A
- Authority
- IS
- Iceland
- Prior art keywords
- gsk
- arylamine
- treatment
- condition related
- condition
- Prior art date
Links
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 title 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title 1
- 150000004982 aromatic amines Chemical class 0.000 title 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102439A SE0102439D0 (sv) | 2001-07-05 | 2001-07-05 | New compounds |
| PCT/SE2002/001339 WO2003004472A1 (en) | 2001-07-05 | 2002-07-03 | Arylamines for the treatment of conditions associated with gsk-3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS7095A true IS7095A (is) | 2003-12-31 |
Family
ID=20284777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7095A IS7095A (is) | 2001-07-05 | 2003-12-31 | Arýlamín til meðhöndlunar á ástandi sem tengist GSK-3 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20060052396A1 (is) |
| EP (1) | EP1414801A1 (is) |
| JP (1) | JP2005505515A (is) |
| KR (1) | KR20040013102A (is) |
| CN (1) | CN1551869A (is) |
| AR (1) | AR036132A1 (is) |
| BR (1) | BR0210838A (is) |
| CA (1) | CA2452686A1 (is) |
| CO (1) | CO5540341A2 (is) |
| HU (1) | HUP0500339A2 (is) |
| IL (1) | IL159347A0 (is) |
| IS (1) | IS7095A (is) |
| MX (1) | MXPA03011972A (is) |
| NO (1) | NO20040014L (is) |
| PL (1) | PL367782A1 (is) |
| RU (1) | RU2004102389A (is) |
| SE (1) | SE0102439D0 (is) |
| WO (1) | WO2003004472A1 (is) |
| ZA (1) | ZA200309977B (is) |
Families Citing this family (83)
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| JP4901102B2 (ja) * | 2002-05-03 | 2012-03-21 | エクセリクシス, インク. | プロテインキナーゼモジュレーターおよびその使用方法 |
| US7704995B2 (en) | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| DE60305053T2 (de) | 2002-08-19 | 2006-08-31 | Glaxo Group Ltd., Greenford | Pyrimidinderivate als selektive cox-2-inhibitoren |
| GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
| SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| JP2006519833A (ja) | 2003-03-11 | 2006-08-31 | ファイザー・プロダクツ・インク | トランスフォーミング成長因子(tgf)阻害剤としてのピラジン化合物 |
| JP4058368B2 (ja) * | 2003-03-27 | 2008-03-05 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 超音波診断装置 |
| RU2006138036A (ru) * | 2004-03-30 | 2008-05-10 | Чирон Корпорейшн (Us) | Производные замещенного тиофена в качестве противораковых средств |
| NZ552946A (en) * | 2004-08-26 | 2010-09-30 | Pfizer | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors |
| BRPI0513915A (pt) | 2004-08-26 | 2008-05-20 | Pfizer | compostos aminoeteroarila enantiomericamente puros como inibidores de proteìna quinase |
| JP2008521900A (ja) | 2004-11-30 | 2008-06-26 | アムジエン・インコーポレーテツド | キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| EP1885454A2 (en) | 2005-05-04 | 2008-02-13 | DeveloGen Aktiengesellschaft | Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders |
| EP1749523A1 (en) * | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
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| TW200730512A (en) * | 2005-12-12 | 2007-08-16 | Astrazeneca Ab | Novel compounds |
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| EA031116B1 (ru) | 2009-04-03 | 2018-11-30 | Ф. Хоффманн-Ля Рош Аг | КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ |
| UA105813C2 (uk) | 2009-11-06 | 2014-06-25 | Плексікон, Інк. | Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти) |
| US8198285B2 (en) | 2010-01-19 | 2012-06-12 | Astrazeneca Ab | Pyrazine derivatives |
| WO2011143419A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Pyrazines useful as inhibitors of atr kinase |
| US8969356B2 (en) | 2010-05-12 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
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| MX336726B (es) | 2010-09-27 | 2016-01-27 | Abbott Gmbh & Co Kg | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. |
| US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
| PL2672967T3 (pl) | 2011-02-07 | 2019-04-30 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania ku temu |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| CN102718745A (zh) * | 2011-03-30 | 2012-10-10 | 中国科学院上海药物研究所 | 新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
| AU2012240030A1 (en) | 2011-04-05 | 2013-10-24 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of TRA kinase |
| BR112013029640A2 (pt) * | 2011-05-23 | 2017-06-13 | Merck Patent Gmbh | derivados de piridina e pirazina |
| EP2723747A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| WO2012178123A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CA2850564A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP3878851A1 (en) | 2011-09-30 | 2021-09-15 | Vertex Pharmaceuticals Incorporated | Process for making compounds useful as inhibitors of atr kinase |
| WO2013049720A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| RU2018108589A (ru) | 2011-09-30 | 2019-02-25 | Вертекс Фармасьютикалз Инкорпорейтед | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
| US8765751B2 (en) | 2011-09-30 | 2014-07-01 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2776429A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| JP2015502925A (ja) | 2011-11-09 | 2015-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用なピラジン化合物 |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8846917B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| PT2833973T (pt) | 2012-04-05 | 2017-12-21 | Vertex Pharma | Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| WO2014055756A1 (en) | 2012-10-04 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| EP2909202A1 (en) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2014089379A1 (en) | 2012-12-07 | 2014-06-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2015085132A1 (en) | 2013-12-06 | 2015-06-11 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| HRP20200186T1 (hr) | 2014-06-05 | 2020-05-29 | Vertex Pharmaceuticals Inc. | Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici |
| JP6936007B2 (ja) | 2014-06-17 | 2021-09-15 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Chk1阻害剤とatr阻害剤との組み合わせを使用してがんを処置する方法 |
| WO2016008966A1 (en) | 2014-07-17 | 2016-01-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| EP3355926B1 (en) | 2015-09-30 | 2025-12-24 | Vertex Pharmaceuticals Inc. | Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| ES2997263T3 (en) | 2016-01-11 | 2025-02-14 | Celator Pharmaceuticals Inc | Inhibiting ataxia telangiectasia and rad3-related protein (atr) |
| WO2017216342A1 (en) | 2016-06-16 | 2017-12-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for preparing induced hepatic progenitor cells |
| US10710980B2 (en) | 2016-07-20 | 2020-07-14 | Novartis Ag | Aminopyridine derivatives and their use as selective ALK-2 inhibitors |
| TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
| JP7717065B2 (ja) | 2019-11-22 | 2025-08-01 | インサイト コーポレーション | Alk2阻害剤及びjak2阻害剤を含む併用療法 |
| AU2021292484A1 (en) | 2020-06-16 | 2023-01-19 | Incyte Corporation | ALK2 inhibitors for the treatment of anemia |
| US12036292B2 (en) | 2020-08-06 | 2024-07-16 | Chdi Foundation, Inc. | Heterobiaryl compounds and imaging agents for imaging huntingtin protein |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0624143B1 (en) * | 1992-01-28 | 1996-04-10 | Klöckner Hänsel Tevopharm B.V. | Method and device for arranging a stream of products |
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| AP2002002620A0 (en) * | 2000-02-16 | 2002-09-30 | Neurogen Corp | Substituted arylpyrazines |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
-
2001
- 2001-07-05 SE SE0102439A patent/SE0102439D0/xx unknown
-
2002
- 2002-07-03 US US10/481,721 patent/US20060052396A1/en not_active Abandoned
- 2002-07-03 PL PL02367782A patent/PL367782A1/xx not_active Application Discontinuation
- 2002-07-03 BR BR0210838-0A patent/BR0210838A/pt not_active Application Discontinuation
- 2002-07-03 CA CA002452686A patent/CA2452686A1/en not_active Abandoned
- 2002-07-03 MX MXPA03011972A patent/MXPA03011972A/es unknown
- 2002-07-03 JP JP2003510640A patent/JP2005505515A/ja active Pending
- 2002-07-03 RU RU2004102389/04A patent/RU2004102389A/ru not_active Application Discontinuation
- 2002-07-03 KR KR10-2004-7000080A patent/KR20040013102A/ko not_active Withdrawn
- 2002-07-03 HU HU0500339A patent/HUP0500339A2/hu unknown
- 2002-07-03 CN CNA028135458A patent/CN1551869A/zh active Pending
- 2002-07-03 EP EP02747795A patent/EP1414801A1/en not_active Withdrawn
- 2002-07-03 IL IL15934702A patent/IL159347A0/xx unknown
- 2002-07-03 WO PCT/SE2002/001339 patent/WO2003004472A1/en not_active Ceased
- 2002-07-05 AR ARP020102533A patent/AR036132A1/es unknown
-
2003
- 2003-12-23 ZA ZA200309977A patent/ZA200309977B/xx unknown
- 2003-12-30 CO CO03113306A patent/CO5540341A2/es not_active Application Discontinuation
- 2003-12-31 IS IS7095A patent/IS7095A/is unknown
-
2004
- 2004-01-02 NO NO20040014A patent/NO20040014L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2452686A1 (en) | 2003-01-16 |
| KR20040013102A (ko) | 2004-02-11 |
| NO20040014L (no) | 2004-03-02 |
| WO2003004472A8 (en) | 2003-03-13 |
| MXPA03011972A (es) | 2004-03-26 |
| JP2005505515A (ja) | 2005-02-24 |
| US20060052396A1 (en) | 2006-03-09 |
| RU2004102389A (ru) | 2005-07-10 |
| SE0102439D0 (sv) | 2001-07-05 |
| ZA200309977B (en) | 2005-03-23 |
| CO5540341A2 (es) | 2005-07-29 |
| IL159347A0 (en) | 2004-06-01 |
| EP1414801A1 (en) | 2004-05-06 |
| WO2003004472A1 (en) | 2003-01-16 |
| BR0210838A (pt) | 2004-07-13 |
| HUP0500339A2 (hu) | 2005-07-28 |
| CN1551869A (zh) | 2004-12-01 |
| PL367782A1 (en) | 2005-03-07 |
| AR036132A1 (es) | 2004-08-11 |
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