IS7302A - Bíkalútamíðkristallar og aðferð til að framleiða þá - Google Patents

Bíkalútamíðkristallar og aðferð til að framleiða þá

Info

Publication number: IS7302A
Authority: IS; Iceland
Prior art keywords: bicalutamide; crystal; producing; chem; formula
Prior art date: 2001-12-13

Application number

IS7302A

Other languages

English (en)

Other versions

IS2737B (is

Inventor

Shintaku Tetsuya

Katsura Tadashi

Itaya Nobushige

Original Assignee

Sumitomo Chemical Company, Limited.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-13

Filing date

2004-06-08

Publication date

2004-06-08

2004-06-08 Application filed by Sumitomo Chemical Company, Limited. filed Critical Sumitomo Chemical Company, Limited.

2004-06-08 Publication of IS7302A publication Critical patent/IS7302A/is

2011-06-15 Publication of IS2737B publication Critical patent/IS2737B/is

Links

LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 title abstract 6
229960000997 bicalutamide Drugs 0.000 title abstract 6
239000013078 crystal Substances 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 abstract 3
238000005481 NMR spectroscopy Methods 0.000 abstract 1
238000002441 X-ray diffraction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000007613 environmental effect Effects 0.000 abstract 1
239000007800 oxidant agent Substances 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/06—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Farming Of Fish And Shellfish (AREA)
Meat, Egg Or Seafood Products (AREA)
Peptides Or Proteins (AREA)

IS7302A 2001-12-13 2004-06-08 Fyrirkomulag til þess að rétta af fisk IS2737B (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001380686		2001-12-13
JP2002166213		2002-06-06
PCT/JP2002/013058 WO2003053920A1 (en)	2001-12-13	2002-12-13	Crystals of bicalutamide and process for their production

Publications (2)

Publication Number	Publication Date
IS7302A true IS7302A (is)	2004-06-08
IS2737B IS2737B (is)	2011-06-15

Family

ID=26625048

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7302A IS2737B (is)	2001-12-13	2004-06-08	Fyrirkomulag til þess að rétta af fisk

Country Status (20)

Country	Link
US (2)	US6740770B2 (is)
EP (1)	EP1462442B1 (is)
JP (2)	JP4255381B2 (is)
KR (1)	KR100938188B1 (is)
CN (1)	CN1602299A (is)
AT (1)	ATE440817T1 (is)
AU (2)	AU2002354475B2 (is)
BR (1)	BR0214933A (is)
CA (1)	CA2469594C (is)
CY (1)	CY1110550T1 (is)
DE (1)	DE60233526D1 (is)
DK (1)	DK1462442T3 (is)
ES (1)	ES2331178T3 (is)
IL (3)	IL162398A0 (is)
IS (1)	IS2737B (is)
NZ (1)	NZ533943A (is)
PT (1)	PT1462442E (is)
SI (1)	SI1462442T1 (is)
WO (1)	WO2003053920A1 (is)
ZA (1)	ZA200404891B (is)

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HU223950B1 (hu) *	1999-06-10	2005-03-29	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
AU7734800A (en) *	1999-09-29	2001-04-30	General Hospital Corporation, The	Polypeptide derivatives of parathyroid hormone (pth)
US7102026B2 (en)	2001-06-13	2006-09-05	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Process for preparing and isolating rac-bicalutamide and its intermediates
US6740770B2 (en) *	2001-12-13	2004-05-25	Sumika Fine Chemicals Co., Ltd.	Crystal of bicalutamide and production method thereof
US20040063782A1 (en) *	2002-09-27	2004-04-01	Westheim Raymond J.H.	Bicalutamide forms
WO2004074350A2 (en) *	2003-02-21	2004-09-02	Hetero Drugs Limited	Bicalutamide polymorphs
EP1558570A1 (en) *	2003-06-25	2005-08-03	Teva Gyogyszergyar Reszvenytarsasag	Process for purifying and isolating rac-bicalutamide
JP4322621B2 (ja) *	2003-10-16	2009-09-02	住友化学株式会社	４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
US8436029B2 (en)	2004-03-19	2013-05-07	Transform Pharmaceuticals, Inc.	Pharmaceutical forms, and methods of making and using the same
CA2573326C (en) *	2004-07-14	2012-09-11	Sumitomo Chemical Company, Limited	Method of crystallization of bicalutamide
KR20070114343A (ko) *	2005-03-29	2007-12-03	유에스브이 리미티드	비칼루타미드의 제조 방법
CA2513356A1 (en) *	2005-07-26	2007-01-26	Apotex Pharmachem Inc.	Process for production of bicalutamide
CA2635461A1 (en) *	2005-12-27	2007-07-05	Dabur Pharma Limited	An improved process for preparation of bicalutamide
JP2009067710A (ja) *	2007-09-12	2009-04-02	Sumitomo Chemical Co Ltd	Ｎ−メタクリロイル−４−シアノ−３−トリフルオロメチルアニリンの製造方法
WO2009087666A2 (en) *	2008-01-04	2009-07-16	Kekule Pharma	An improved process for production of bicalutamide useful in the treatment of prostate cancer
CN101987086B (zh) *	2009-08-03	2012-07-18	北京化工大学	一种超细比卡鲁胺口服片剂及其制备方法
WO2011056845A1 (en)	2009-11-03	2011-05-12	Howmedica Osteonics Corp.	Intervertebral implant with integrated fixation
CN101891663A (zh) *	2010-07-21	2010-11-24	杭州民生药业有限公司	一种比卡鲁胺中间体的制备方法
JP2013544768A (ja)	2010-09-29	2013-12-19	シルパメディケアリミテッド	ビカルタミドの調製方法
CN102321000A (zh) *	2011-07-21	2012-01-18	宁波人健药业集团有限公司	氧化制备比卡鲁胺的方法
DK2802563T3 (en)	2012-01-13	2017-09-18	Aranda Pharma Ltd	NEW HETEROARYLAMIDE DERIVATIVES THAT HAVE ANTI-DRUG PROPERTIES
CN105541680B (zh) *	2016-02-16	2017-12-22	重庆硕奥科技有限公司	一种比卡鲁胺的合成方法
CN105949095A (zh) *	2016-05-27	2016-09-21	山西振东制药股份有限公司	一种比卡鲁胺i晶型的制备方法
CN106748884B (zh) *	2016-12-13	2021-08-20	山西振东制药股份有限公司	一种比卡鲁胺中间体的制备方法
CN106905265A (zh) *	2017-03-09	2017-06-30	常州沃腾化工科技有限公司	N‑[4‑氰基‑3‑（三氟甲基）苯基]‑2,3‑环氧‑2‑甲基丙酰胺的制备方法
CN109336798B (zh) *	2018-11-19	2021-11-16	常州新星联生物科技有限公司	一种比卡鲁胺硫醚中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE225694C (is)
US4191775A (en)	1977-12-15	1980-03-04	Imperial Chemical Industries Limited	Amide derivatives
DE3372965D1 (en)	1982-07-23	1987-09-17	Ici Plc	Amide derivatives
DD225694A1 (de) *	1984-06-14	1985-08-07	Univ Leipzig	Verfahren zur darstellung substituierter 9-oxabicyclo/6.1.0/-nonane
HU223950B1 (hu)	1999-06-10	2005-03-29	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
PL354620A1 (en)	1999-10-19	2004-02-09	Nobex Corporation	Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof
NZ518552A (en)	1999-10-27	2003-10-31	Nobex Corp	Resolution of intermediates in the synthesis of substantially pure bicalutamide
KR20030048408A (ko) *	2000-09-21	2003-06-19	브리스톨-마이어즈 스퀴브 컴페니	Ｎ-(치환 페닐)-3-알킬-, 아릴- 및헤테로아릴설포닐-2-히드록시-2-알킬- 및할로알킬프로판아미드 화합물의 제조방법
US6479692B1 (en)	2001-05-02	2002-11-12	Nobex Corporation	Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
US6737550B2 (en)	2001-06-13	2004-05-18	Biogal Gryogyszergyar Rt.	Process for preparing rac-bicalutamide and its intermediates
US7102026B2 (en)	2001-06-13	2006-09-05	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Process for preparing and isolating rac-bicalutamide and its intermediates
US6740770B2 (en) *	2001-12-13	2004-05-25	Sumika Fine Chemicals Co., Ltd.	Crystal of bicalutamide and production method thereof
US20040063782A1 (en)	2002-09-27	2004-04-01	Westheim Raymond J.H.	Bicalutamide forms
US6818766B2 (en)	2002-10-02	2004-11-16	Synthon Bv	Process for making bicalutamide and intermediates thereof

2002
- 2002-12-13 US US10/362,410 patent/US6740770B2/en not_active Expired - Fee Related
- 2002-12-13 AT AT02788815T patent/ATE440817T1/de active
- 2002-12-13 CA CA2469594A patent/CA2469594C/en not_active Expired - Fee Related
- 2002-12-13 JP JP2003554637A patent/JP4255381B2/ja not_active Expired - Lifetime
- 2002-12-13 IL IL16239802A patent/IL162398A0/xx unknown
- 2002-12-13 DK DK02788815T patent/DK1462442T3/da active
- 2002-12-13 DE DE60233526T patent/DE60233526D1/de not_active Expired - Lifetime
- 2002-12-13 ES ES02788815T patent/ES2331178T3/es not_active Expired - Lifetime
- 2002-12-13 EP EP02788815A patent/EP1462442B1/en not_active Expired - Lifetime
- 2002-12-13 NZ NZ533943A patent/NZ533943A/en not_active IP Right Cessation
- 2002-12-13 KR KR1020047009014A patent/KR100938188B1/ko not_active Expired - Fee Related
- 2002-12-13 WO PCT/JP2002/013058 patent/WO2003053920A1/ja not_active Ceased
- 2002-12-13 BR BR0214933-8A patent/BR0214933A/pt not_active IP Right Cessation
- 2002-12-13 PT PT02788815T patent/PT1462442E/pt unknown
- 2002-12-13 AU AU2002354475A patent/AU2002354475B2/en not_active Ceased
- 2002-12-13 SI SI200230854T patent/SI1462442T1/sl unknown
- 2002-12-13 CN CNA028247019A patent/CN1602299A/zh active Pending
2003
- 2003-12-18 US US10/740,140 patent/US7132560B2/en not_active Expired - Fee Related
2004
- 2004-06-08 IS IS7302A patent/IS2737B/is unknown
- 2004-06-08 IL IL162398A patent/IL162398A/en not_active IP Right Cessation
- 2004-06-21 ZA ZA200404891A patent/ZA200404891B/en unknown
2008
- 2008-02-03 IL IL189180A patent/IL189180A/en not_active IP Right Cessation
- 2008-07-09 AU AU2008203026A patent/AU2008203026B2/en not_active Ceased
- 2008-11-14 JP JP2008291762A patent/JP4907634B2/ja not_active Expired - Lifetime
2009
- 2009-11-12 CY CY20091101187T patent/CY1110550T1/el unknown

Also Published As

Publication number	Publication date
IL162398A (en)	2009-08-03
ATE440817T1 (de)	2009-09-15
DK1462442T3 (da)	2009-12-14
CY1110550T1 (el)	2015-04-29
JPWO2003053920A1 (ja)	2005-04-28
WO2003053920A1 (en)	2003-07-03
JP2009108081A (ja)	2009-05-21
KR20040063947A (ko)	2004-07-14
IL189180A (en)	2010-12-30
US7132560B2 (en)	2006-11-07
EP1462442A4 (en)	2005-12-07
NZ533943A (en)	2006-06-30
US6740770B2 (en)	2004-05-25
SI1462442T1 (sl)	2010-01-29
AU2002354475A1 (en)	2003-07-09
US20030191337A1 (en)	2003-10-09
EP1462442A1 (en)	2004-09-29
JP4907634B2 (ja)	2012-04-04
ZA200404891B (en)	2005-06-21
PT1462442E (pt)	2009-10-09
IS2737B (is)	2011-06-15
ES2331178T3 (es)	2009-12-23
CA2469594C (en)	2011-01-25
CA2469594A1 (en)	2003-07-03
AU2008203026B2 (en)	2011-05-12
IL189180A0 (en)	2009-02-11
US20040133031A1 (en)	2004-07-08
BR0214933A (pt)	2004-12-14
EP1462442B1 (en)	2009-08-26
JP4255381B2 (ja)	2009-04-15
AU2008203026A1 (en)	2008-07-31
DE60233526D1 (de)	2009-10-08
IL162398A0 (en)	2005-11-20
KR100938188B1 (ko)	2010-01-21
AU2002354475B2 (en)	2008-08-14
CN1602299A (zh)	2005-03-30

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IL188716A0 (en)	2008-08-07	Method for preparing 4??-amino-4'-dimethyl-4-
IL174781A0 (en)	2006-08-20	Process for producing bicalutamide and method of purifying intermediate therefor
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DE60335865D1 (de)	2011-03-10	Verfahren zur herstellung von cilostazol
DK0782996T3 (da)	1999-09-20	Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
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TW200738717A (en)	2007-10-16	Manufacturing method of carbapenem derivative by continuous reaction
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