IS7768A - Aðferðir til framleiðslu, einangrunar og hreinsunar epóþílóns B, og röntgengeisla kristallabyggingar epóþílóns B - Google Patents

Aðferðir til framleiðslu, einangrunar og hreinsunar epóþílóns B, og röntgengeisla kristallabyggingar epóþílóns B

Info

Publication number
IS7768A
IS7768A IS7768A IS7768A IS7768A IS 7768 A IS7768 A IS 7768A IS 7768 A IS7768 A IS 7768A IS 7768 A IS7768 A IS 7768A IS 7768 A IS7768 A IS 7768A
Authority
IS
Iceland
Prior art keywords
epothilone
isolation
purification
production
methods
Prior art date
Application number
IS7768A
Other languages
English (en)
Inventor
Benigni Daniel
Stankavage Robert
Chiang Shu-Jen
Hou Hsing
Eagan Bruce
Gu Dennis
Hou David
Mintzmyer Les
P. Tully Thomas
L. Davis Brian
Hargro Ivan
Mascari Mark
Galvin Gabriel
Stein Gregory
W. Mcconlogue Cary
T. Comezoglu Fahri
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of IS7768A publication Critical patent/IS7768A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IS7768A 2002-09-23 2005-03-22 Aðferðir til framleiðslu, einangrunar og hreinsunar epóþílóns B, og röntgengeisla kristallabyggingar epóþílóns B IS7768A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41299402P 2002-09-23 2002-09-23
PCT/US2003/029628 WO2004026254A2 (en) 2002-09-23 2003-09-22 Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b

Publications (1)

Publication Number Publication Date
IS7768A true IS7768A (is) 2005-03-22

Family

ID=32030950

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7768A IS7768A (is) 2002-09-23 2005-03-22 Aðferðir til framleiðslu, einangrunar og hreinsunar epóþílóns B, og röntgengeisla kristallabyggingar epóþílóns B

Country Status (22)

Country Link
US (4) US7172884B2 (is)
EP (3) EP2287168B1 (is)
JP (2) JP4523843B2 (is)
KR (2) KR20050053681A (is)
CN (2) CN101050445B (is)
AU (1) AU2003275068B2 (is)
BR (1) BRPI0314133A8 (is)
CA (3) CA2695720C (is)
CO (1) CO5540384A2 (is)
ES (2) ES2439995T3 (is)
GE (1) GEP20074017B (is)
HR (1) HRP20050278A2 (is)
IL (2) IL166868A (is)
IS (1) IS7768A (is)
MX (1) MXPA05003006A (is)
NO (1) NO334167B1 (is)
PL (1) PL375902A1 (is)
RS (1) RS20050235A (is)
RU (1) RU2368661C2 (is)
TW (1) TWI291464B (is)
WO (1) WO2004026254A2 (is)
ZA (1) ZA200501680B (is)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2312695T3 (es) * 1996-11-18 2009-03-01 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Epotilones e y f.
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6780620B1 (en) 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
RU2003128311A (ru) 2001-02-20 2005-03-10 Бристол-Маерс Сквибб Компани (Us) Способ лечения резистентных опухолей с применением аналогов эпотилона
PT1506203E (pt) 2002-08-23 2007-04-30 Sloan Kettering Inst Cancer Síntese de epotilonas, seus intermediários, seus análogos e suas utilizações
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
TWI291464B (en) * 2002-09-23 2007-12-21 Bristol Myers Squibb Co Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
US20090004277A1 (en) * 2004-05-18 2009-01-01 Franchini Miriam K Nanoparticle dispersion containing lactam compound
JP2008536479A (ja) 2005-02-11 2008-09-11 ユニバーシティ オブ サザン カリフォルニア ジスルフィド架橋を有するタンパク質の発現法
CA2645278A1 (en) * 2006-04-05 2007-10-25 Novartis Ag Combinations of therapeutic agents for treating cancer
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
AR062375A1 (es) * 2006-08-16 2008-11-05 Novartis Ag Cristal de epotilona b y composiciones farmaceuticas
JP5180321B2 (ja) * 2008-02-01 2013-04-10 浙江海正薬業股▲ふん▼有限公司 エポチロンの分離及び精製方法
CN104116736A (zh) 2008-04-24 2014-10-29 百时美施贵宝公司 埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途
US8802394B2 (en) 2008-11-13 2014-08-12 Radu O. Minea Method of expressing proteins with disulfide bridges with enhanced yields and activity
KR101372563B1 (ko) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN103183681B (zh) * 2013-03-06 2016-01-13 浙江海正药业股份有限公司 伊沙匹隆的新晶型及其制备方法
WO2015024883A1 (en) * 2013-08-19 2015-02-26 Sandoz Ag Method for the purification of epothilones via crystallization
WO2015024884A1 (en) * 2013-08-19 2015-02-26 Sandoz Ag Method for the purifiction of epothilones via crystallization
CN104046579B (zh) * 2014-05-16 2016-09-21 虞龙 一株埃博霉素高产菌及其在发酵产埃博霉素中的应用
CN106905338B (zh) * 2017-03-07 2020-06-23 鲁南制药集团股份有限公司 一种埃博霉素b的提纯方法
CN106834377B (zh) * 2017-03-07 2020-05-05 鲁南制药集团股份有限公司 一种生产埃博霉素b的方法
CN107827943B (zh) * 2017-11-28 2022-06-10 绍兴厚普生物科技有限责任公司 一种从发酵液中提取胞嘧啶核苷的方法
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法
KR102440644B1 (ko) * 2020-05-28 2022-09-05 공주대학교 산학협력단 파클리탁셀 정제 시 가스 버블을 이용한 분별침전방법
CN112409369B (zh) * 2020-11-30 2023-03-28 湖北宏中药业股份有限公司 一种埃博霉素b的高效提取纯化方法
CN112457320A (zh) * 2020-11-30 2021-03-09 湖北宏中药业股份有限公司 一种提高伊沙匹隆合成反应速率的方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE879605C (de) 1951-08-05 1953-06-15 Leitz Ernst Gmbh Optisches Instrument mit gekuppeltem Objektiv- und Kondensor-Wechsler
ATE51003T1 (de) * 1985-09-13 1990-03-15 Biotechnolog Forschung Gmbh Makrozyklische antibiotika.
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
DE19542986A1 (de) 1995-11-17 1997-05-22 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Verwendung
EP1440973A3 (de) * 1995-11-17 2004-10-20 Gesellschaft für biotechnologische Forschung mbH (GBF) Epothilonderivate, Herstellung und Mittel
DE19639456A1 (de) 1996-09-25 1998-03-26 Biotechnolog Forschung Gmbh Epothilon-Derivate, Herstellung und Mittel
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
DE19645362A1 (de) 1996-10-28 1998-04-30 Ciba Geigy Ag Verfahren zur Herstellung von Epothilon A und B und Derivaten
EP0923583A1 (de) 1996-08-30 1999-06-23 Novartis AG Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
DE19645361A1 (de) 1996-08-30 1998-04-30 Ciba Geigy Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II
ES2312695T3 (es) * 1996-11-18 2009-03-01 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Epotilones e y f.
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6380394B1 (en) 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
DE19880193D2 (de) 1997-02-25 2000-08-24 Biotechnolog Forschung Gmbh Seitenkettenmodifizierte Epothilone
DE19713970B4 (de) 1997-04-04 2006-08-31 R&D-Biopharmaceuticals Gmbh Epothilone-Synthesebausteine II - Prenylderivate
WO1998047891A1 (de) 1997-04-18 1998-10-29 Studiengesellschaft Kohle Mbh Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium
DE19821954A1 (de) 1997-05-15 1998-11-19 Biotechnolog Forschung Gmbh Verfahren zur Herstellung eines Epothilon-Derivats
DE19720312A1 (de) 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
DE19726627A1 (de) 1997-06-17 1998-12-24 Schering Ag Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6384230B1 (en) 1997-07-16 2002-05-07 Schering Aktiengesellschaft Thiazole derivatives, method for their production and use
ATE368036T1 (de) 1997-08-09 2007-08-15 Bayer Schering Pharma Ag Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
US6320045B1 (en) 1997-12-04 2001-11-20 Bristol-Myers Squibb Company Process for the reduction of oxiranyl epothilones to olefinic epothilones
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
HUP0101564A3 (en) 1998-02-05 2002-06-28 Novartis Ag Compositions containing epothilone
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
IL138113A0 (en) 1998-02-25 2001-10-31 Sloan Kettering Inst Cancer Synthesis of epothilones, intermediates thereto and analogues thereof
FR2776071B1 (fr) * 1998-03-13 2000-05-26 Eastman Kodak Co Dispositif de mesure automatique de la concentration d'un agent developpateur
US6380395B1 (en) 1998-04-21 2002-04-30 Bristol-Myers Squibb Company 12, 13-cyclopropane epothilone derivatives
WO2000000485A1 (de) 1998-06-30 2000-01-06 Schering Aktiengesellschaft Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung
US6303342B1 (en) * 1998-11-20 2001-10-16 Kason Biosciences, Inc. Recombinant methods and materials for producing epothilones C and D
BR9916833A (pt) 1998-12-22 2001-09-25 Novartis Ag Derivados de epotilona e seu uso como agentes antitumor
CA2356360A1 (en) 1998-12-23 2000-07-06 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
SK11852001A3 (sk) 1999-02-18 2002-04-04 Schering Aktiengesellschaft Deriváty epotiólonu, spôsoby ich výroby a ich farmaceutické použitie
SK287200B6 (sk) * 1999-02-22 2010-03-08 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) C-21 modifikované epotilóny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a použitie
US6211412B1 (en) 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
PE20010116A1 (es) 1999-04-30 2001-02-15 Schering Ag Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
CN1142163C (zh) * 2002-02-07 2004-03-17 山东大学 一种从粘细菌发酵液中分离提纯埃博霉素的方法
TW200303202A (en) * 2002-02-15 2003-09-01 Bristol Myers Squibb Co Method of preparation of 21-amino epothilone derivatives
TWI291464B (en) * 2002-09-23 2007-12-21 Bristol Myers Squibb Co Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B

Also Published As

Publication number Publication date
EP2280014A3 (en) 2011-08-03
PL375902A1 (en) 2005-12-12
GEP20074017B (en) 2007-01-10
KR20050053681A (ko) 2005-06-08
CN101050445B (zh) 2011-08-10
USRE42191E1 (en) 2011-03-01
US20060135474A1 (en) 2006-06-22
EP2280014A2 (en) 2011-02-02
CN1705662B (zh) 2011-07-06
ZA200501680B (en) 2006-05-31
RU2005112443A (ru) 2005-10-27
TWI291464B (en) 2007-12-21
CO5540384A2 (es) 2005-07-29
IL222455A0 (en) 2012-12-02
CA2695720C (en) 2013-04-02
CA2499600C (en) 2012-08-21
RS20050235A (sr) 2007-06-04
US7172884B2 (en) 2007-02-06
AU2003275068B2 (en) 2009-09-17
ES2405753T3 (es) 2013-06-03
CA2695720A1 (en) 2004-04-01
NO20050929L (no) 2005-04-08
JP4523843B2 (ja) 2010-08-11
HRP20050278A2 (en) 2005-10-31
BR0314133A (pt) 2005-07-12
US7767432B2 (en) 2010-08-03
JP2006500031A (ja) 2006-01-05
CN101050445A (zh) 2007-10-10
CA2695671A1 (en) 2004-04-01
BRPI0314133A8 (pt) 2017-09-19
US20040132146A1 (en) 2004-07-08
EP2287168A3 (en) 2011-03-16
MXPA05003006A (es) 2005-06-22
KR20120080649A (ko) 2012-07-17
EP2280014B1 (en) 2013-10-23
IL166868A (en) 2012-12-31
EP1542998A4 (en) 2007-01-31
US20070122891A1 (en) 2007-05-31
NO334167B1 (no) 2013-12-23
JP2010011873A (ja) 2010-01-21
JP5193983B2 (ja) 2013-05-08
ES2439995T3 (es) 2014-01-27
AU2003275068A1 (en) 2004-04-08
HK1113387A1 (en) 2008-10-03
EP2287168A2 (en) 2011-02-23
EP1542998A2 (en) 2005-06-22
KR101406635B1 (ko) 2014-06-11
EP2287168B1 (en) 2013-02-13
CN1705662A (zh) 2005-12-07
RU2368661C2 (ru) 2009-09-27
WO2004026254A3 (en) 2004-05-27
WO2004026254A2 (en) 2004-04-01
CA2499600A1 (en) 2004-04-01
TW200409773A (en) 2004-06-16
US7241899B2 (en) 2007-07-10

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